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Evolving Frameworks for the Foundation and Practice of Electronic Fetal monitoring

maternal-Fetal medicine 2022年第2期4卷 141-151页

作者： mark I.evans David W.Britt shara m.evans Lawrence D.Devoe Fetal medicine Foundation of America New YorkNY 10065USA Comprehensive Genetics PLLCNew YorkNY 10065USA Department of Obstetrics&Gynecology Icahn School of Medicine at Mt.SinaiNew YorkNY10029USA Department of maternal Child Health Gillings School of Public Health University of North Carolina at Chapel HillChapel HillNY 27599USA Department of Obstetrics and Gynecology Medical College of GeorgiaAugusta UniversityAugustaGA 30907USA.

Since the 1970s,electronic fetal monitoring(EFm)also known as cardiotocography(CTG)has been used extensively in labor around the world,despite its known failure to help prevent many babies from developing neonatal encephalopathy and cerebral *** of EFm’s poor performance with respect to these outcomes arises from a fundamental misunderstanding of the differences between screening and diagnostic tests,subjective classifications of fetal heart rate(FHR)patterns that lead to large inter-observer variability in its interpretation,failure to appreciate early stages of fetal compromise,and poor statistical modeling for its use as a screening *** have developed a new approach to the practice and interpretation of EFm called the fetal reserve index(FRI)which does the following:(1)breaking FHR components down into 4 components,(heart rate,variability,accelerations,and decelerations);(2)contextualizing the metrics by adding increased uterine activity;(3)adding specific maternal,fetal,and obstetric risk *** result is an eight-point scoring metric that,when directly compared with current American College of Obstetricians and Gynecologists EFm categories,even in version 1.0 with equal weighting of variables,shows that the FRI has performed much better for identifying cases at risk before damage had occurred,reducing the need for emergency deliveries,and lowering overall Cesarean delivery *** increased data,we expect further refinements in the specifics of scoring that will allow even earlier detection of compromise in labor.

关键词： Fetal monitoring Cardiotocography Fetal reserve index

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Fire blight QTL analysis in a multi-family apple population identifies a reduced-susceptibility allele in ‘Honeycrisp’

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Horticulture Research 2021年第1期8卷 355-367页

作者： Sarah A.Kostick Soon Li Teh John L.Norelli Stijn Vanderzande Cameron Peace Kate m.evans Tree Fruit Research and Extension Center Department of HorticultureWashington State UniversityWenatcheeWA 98801USA United States Department of Agriculture Agricultural Research ServiceAppalachian Fruit Research LaboratoryKearneysvilleWV 25430USA Department of Horticulture Washington State UniversityPullmanWA 99164USA

Breeding apple cultivars with resistance offers a potential solution to fire blight,a damaging bacterial disease caused by Erwinia *** resistance alleles at quantitative trait loci(QTLs)were previously characterized in diverse malus germplasm with poor fruit quality,which reduces breeding *** study utilized a pedigree-based QTL analysis approach to elucidate the genetic basis of resistance/susceptibility to fire blight from multiple genetic sources in germplasm relevant to *** breeding ***-seven important breeding parents(IBPs)were represented by 314 offspring from 32 full-sib families,with‘Honeycrisp’being the most highly represented *** resistance/susceptibility data from a two-year replicated field inoculation study and previously curated genome-wide single nucleotide polymorphism data,QTLs were consistently mapped on chromosomes(Chrs.)6,7,and *** QTLs together explained~28% of phenotypic *** Chr.6 and Chr.15 QTLs colocalized with previously reported QTLs,while the Chr.7 QTL is possibly novel.‘Honeycrisp’inherited a rare reduced-susceptibility allele at the Chr.6 QTL from its grandparent‘Frostbite’.The highly resistant IBP‘Enterprise’had at least one putative reduced-susceptibility allele at all three *** general,lower susceptibility was observed for individuals with higher numbers of reduced-susceptibility alleles across *** study highlighted QTL mapping and allele characterization of resistance/susceptibility to fire blight in complex pedigree-connected apple breeding *** gained will enable more informed parental selection and development of trait-predictive DNA tests for pyramiding favorable alleles and selection of superior apple cultivars with resistance to fire blight.

关键词： blight breeding cultivar

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Prenatal Testing or Screening?

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maternal-Fetal medicine 2020年第4期2卷 217-222页

作者： evans mark I. evans shara m. Fetal medicine Foundation of America New YorkNY 10065USA Comprehensive Genetics New YorkNY 10065USA Department of Obstetrics&Gynecology Icahn School of Medicine at Mt.SinaiNew YorkNY 10029USA Department of maternal Child Health Gillings School of Public Health University of North Carolina at Chapel HillChapel HillNY 27599USA

Over the past 50 years,the scope and extent of prenatal diagnosis and screening for genetic disorders have improved *** has been a pendulum like swing from testing to screening back and forth as new technologies *** concurrent developments of cell free fetal DNA analysis of maternal blood has dramatically changed patient’s choices towards ***,with the use of array comparative genomic hybridization of fetal DNA that requires diagnostic procedures(Chorionic villus sampling and amniocentesis),much more extensive diagnosis can be *** noninvasive methods can replicate what can be done with diagnostic procedures there still will be a"price to be paid"for opting for the non-invasive methods.

关键词： Genetic counseling Prenatal diagnosis Chorionic villus sampling Amniocentesis Array comparative genomic hybridization Noninvasive prenatal testing

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Divergent Nanotube Synthesis through Reversible macrocycle Assembly

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Accounts of materials Research 2022年第9期3卷 935-947页

作者： michael J.Strauss Austin m.evans Emily K.Roesner Richard J.monsky madison I.Bardot William R.Dichtel Department of Chemistry Northwestern UniversityEvanstonIllinois 60208United States

CONSPECTUS:Nanotubes offer a unique combination of structural precision,tunable interior environments,and high aspect ratios that will be useful for many *** these desirable attributes,widespread explorations into the properties and applications of chemically designed nanotubes have been limited by challenges related to their *** realization has motivated developing a unified synthetic nanotube design,which would enable wide-reaching explorations into one-dimensional molecular architectures.

关键词： realization cycle interior

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Application of a long short-term memory for deconvoluting conductance contributions at charged ferroelectric domain walls

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npj Computational materials 2020年第1期6卷 319-325页

作者： Theodor S.Holstad Trygve m.Ræder Donald m.evans Didirk R.Småbråten Stephan Krohns Jakob Schaab Zewu Yan Edith Bourret Antonius T.Jvan Helvoort Tor Grande Sverre m.Selbach Joshua C.Agar Dennis meier Department of materials Science and Engineering Norwegian University of Science and Technology(NTNU)7491 TrondheimNorway Department of materials Science and Engineering Lehigh UniversityBethlehemPA 18015USA Experimental Physics V Center for Electronic Correlations and MagnetismUniversity of Augsburg86159 AugsburgGermany Department of materials ETH Zurich8093 ZürichSwitzerland materials Sciences Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Department of Physics ETH Zurich8093 ZürichSwitzerland Department of Physics Norwegian University of Science and Technology(NTNU)7491 TrondheimNorway

Ferroelectric domain walls are promising quasi-2D structures that can be leveraged for miniaturization of electronics components and new mechanisms to control electronic signals at the *** the significant progress in experiment and theory,however,most investigations on ferroelectric domain walls are still on a fundamental level,and reliable characterization of emergent transport phenomena remains a challenging task.

关键词： walls ferroelectric conductance

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Cost and accuracy of advanced breeding trial designs in apple

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Horticulture Research 2016年第1期3卷 267-276页

作者： Julia m Harshman Kate m.evans Craig m Hardner Department of Horticulture Washington State University Tree Fruit Research and Extension CenterWenatchee98801WAUSA Queensland Alliance for Agriculture and Food Innovation University of QueenslandSt Lucia4072QueenslandAustralia

Trialing advanced candidates in tree fruit crops is expensive due to the long-term nature of the planting and labor-intensive evaluations required to make selection *** closely the trait evaluations approximate the true trait value needs balancing with the cost of the *** of field trials of advanced apple candidates in which reduced number of locations,the number of years and the number of harvests per year were modeled to investigate the effect on the cost and accuracy in an operational breeding *** aim was to find designs that would allow evaluation of the most additional candidates while sacrificing the least *** percentage difference,response to selection,and correlated response were used to examine changes in accuracy of trait *** the quality traits evaluated,accuracy and response to selection were not substantially reduced for most trial *** management influences the decision to change trial design,and some designs had greater risk associated with *** cost and accuracy with risk yields valuable insight into advanced breeding trial *** methods outlined in this analysis would be well suited to other horticultural crop breeding programs.

关键词： breeding crops planting

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NCoR1 protects positive-selecting thymocytes from negative selection

NCoR1 protects positive-selecting thymocytes from negative s...

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第9届中国中西医结合学会妇产科专业委员会第二次学术会议

作者： Na Zhang Jianrong Wang Nanhai He Ronald m.evans Dajin Li Ling Wang Qibin Leng Laboratory for Reproductive Immunology Hospital & Institute of Obstetrics and Gynecology IBS Fudan University Shanghai Medical College The Academy of Integrative medicine of Fudan University Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Key Laboratory of molecular Virology and Immunology Institut Pasteur of Shanghai Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Gene Expression Laboratory Salk Institute for Biological Studies

机体自身的免疫调控、炎症反应以及抵抗外来感染的过程中,T细胞发挥着不可或缺的作用。在胸腺发育中,T细胞受体信号介导阳性选择和阴性选择,在这个过程中需要精密的转录调控以开启和关闭细胞的增殖与凋亡通道。之前研究表明,转录辅抑制...

机体自身的免疫调控、炎症反应以及抵抗外来感染的过程中,T细胞发挥着不可或缺的作用。在胸腺发育中,T细胞受体信号介导阳性选择和阴性选择,在这个过程中需要精密的转录调控以开启和关闭细胞的增殖与凋亡通道。之前研究表明,转录辅抑制子NCoR1很可能在T细胞胸腺发育中发挥重要作用。我们建立了T细胞特异性缺失NCoR的小鼠品系,发现与全身性NCoR1缺失小鼠胚胎胸腺

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Characteristics of hepatocellular carcinoma in cirrhotic and non-cirrhotic non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2015年第4期21卷 1189-1196页

作者： Christopher Leung Sern Wei Yeoh Desmond Patrick shara Ket Kaye marion Paul Gow Peter W Angus Liver Transplant Unit Austin HospitalHeidelbergVictoria 3084Australia Department of medicine The University of MelbourneAustin CampusHeidelbergVictoria 3084Australia Statistics and Operations Research Group School of Mathematical and Geospatial Sciences College of ScienceEngineering and HealthRMIT UniversityMelbourneVictoria 3000Australia

AIm: To determine characteristics and prognosticpredictors of patients with hepatocellular carcinoma(HCC) in association with non-alcoholic fatty liver disease(NAFLD).mETHODS: We reviewed the records of all patients with NAFLD associated HCC between 2000 and 2012. Data collected included demographics; histology; presence or absence of cirrhosis, size and number of HCC, alpha-fetoprotein, body mass index(BmI), and the presence of diabetes, hypertension, or ***: Fifty-four patients with NAFLD associated HCC were identified. mean age was 64 years with 87% male. Fifteen percent(8/54) were not cirrhotic. 11%, 24% and 50% had a BmI of m2, 25-29 kg/m2 and ≥ 30 kg/m2 respectively. Fifty-nine percent were diabetic, 44% hypertensive and 26% hyperlipidaemic. Thirty-four percent of the patients had ≤ 1 of these risk factors. Non-cirrhotics had a significantly larger mean tumour diameter at diagnosis than cirrhotics(P = 0.041). multivariate analysis did not identify any other patient characteristics that predicted the size or number of ***: HCC can develop in NAFLD without cirrhosis. At diagnosis such tumours are larger than those in cirrhotics, conferring a poorer prognosis.

关键词： Hepatocellular carcinoma Non-alcoholic fatty liver

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Evidence of a conservative gait strategy in athletes with a history of concussions

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Journal of Sport and Health Science 2016年第4期5卷 417-423页

作者： Thomas A.Buckley Srikant Vallabhajosula Jessie R.Oldham Barry A.munkasy Kelsey m.evans David A.Krazeise Caroline J.Ketcham Eric E.Hall Department of Kinesiology and Applied Physiology University of Delaware Department of Physical Therapy Education Elon University Department of Health and Kinesiology Georgia Southern University Department of Intercollegiate Athletics Stetson University Department of Exercise Science Elon University

Background：A history of 3 or more concussions is frequently associated with numerous short-and long-term *** in postural control are a known acute consequence of concussion;however,limited evidence exists on the effects of multiple concussions on *** purpose of this study was to assess gait stepping characteristics in collegiate aged student-athletes based on concussion ***：There were 63 participants divided into 3 even groups based on concussion history：≥3 concussions,1–2 concussions,and 0 *** participants completed 10 trials of gait on a 4.9 m instrumented *** dependent variables of interest included both gait stepping characteristics（step velocity,length,and width,double support time,and the percentage of the gait cycle in stance） and coefficien of variability（CoV） measures（step length,time,and width）.The gait stepping characteristics were compared firs with a mANOVA with follow-up 1-way ANOVAs and Tukey post hoc tests as *** Co V measures were compared with 1-way ANOVAs and Tukey post hoc ***：There were main effects for group for step velocity,length,width,and double support ***,the 0 concussion group displayed typical healthy young gait parameters and performed significant y better than either concussion *** 0 concussion group had a significant y greater step length Co V,but there were no differences in the step time or width Co ***：This findin provides evidence of subtle impairments in postural control during gait among individuals with prior history of concussion which could be an early indicator of future neurological deficiencies The limited difference in the variability measures is consistent with prior static stance studies and could suggest the individuals constrain their motor systems to reduce *** together,these findi gs suggest a conservative gait strategy which is adopted by individuals with a history of concussions.

关键词： Balance Brain injury Gait performance Locomotion mild traumatic Postural control Postural stability Variability

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为自由而生美国妇女历史

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丛书名：外国妇女丛书

1995年

作者：（美）萨拉·m.埃文斯（Sara m.evans）杨俊峰主译

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