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Preventing Implant Bacterial Infections with Interconnected 3D Porous Structures (I3D)— A Proof-of-Concept Study

Journal of Biosciences and Medicines 2021年第1期9卷 16-29页

作者： Steven Guo Alexandria Ramos Zhongqiang Li Hong yao Jian Xu shaomian yao Comparative Biomedical Sciences School of Veterinary Medicine Louisiana State University Baton Rouge LA USA Department of Biomedical Engineering Johns Hopkins University Baltimore MD USA Division of Electrical and Computer Engineering College of Engineering Louisiana State University Baton Rouge LA USA Department of Mechanical and Industrial Engineering Louisiana State University Baton Rouge LA USA

Oral antibiotics are often prescribed to prevent infection after implant surgery;however, only a small fraction of the antibiotics can reach the implants. Thus, there are concerns about overusing antibiotics. We designed and fabricated porous implants with interconnecting 3D structures (I3D) and hypothesized that such I3D structures could serve as a depository for antimicrobial agents to prevent infection locally. The implants were either treated with antibiotics or coated with silver nanoparticles (AgNPs) by electrodeposition to test this hypothesis. The antimicrobial assay was conducted, and bacterial growth zones of inhibition (ZOIs) were monitored. Overall, I3D implants resulted in larger ZOIs than did the solid implants, and the center I3D (cI3D)-implant produced the largest ZOI. In the antibiotic treatment testing, the diameters of ZOIs of the solid implant vs. I3D implant were about 14 mm vs. 15 to 18 mm on day 2;however, the diameter quickly reduced to 9 mm on day 3 and 5 mm on days 6 and 8 for the solid implant, while no obvious change of the zone was seen for I3D implants. For the AgNPs coated implants, the ZOIs for the I3D implants were generally greater than the solid implant over four weeks of incubation. A significantly larger ZOI (~1 - 2 mm larger on average) was seen for AgNPs coated I3D implants at 0.1 V - 0.01 M, 0.3 V - 0.01 M, and 1.5 V - 0.01 M treatments compared to AgNPs coated solid implants. Given that we have previously shown that I3D implants can reserve chemoattractants to recruit stem cells to enhance osseointegration, we conclude that implants with the I3D structures could be beneficial not only for osseointegration but also in preventing infection.

关键词： Dental Implant Antimicrobial Agents Peri-Implantitis Silver Nanoparticles 3D-Printing

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Hypoxia promotes growth of stem cells in dental follicle cell populations

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Journal of Biomedical Science and Engineering 2011年第6期4卷 454-461页

作者： Yuntao Dai Hongzhi He Gary E. Wise shaomian yao Department of Comparative Biomedical Sciences School of Veterinary Medicine Louisiana State University Baton Rouge Louisiana 70803 USA.

Adult stem cells (ASC) have been found in many tis-sues and are of great therapeutic potential due to their capability of differentiation. However, ASC comprise only a small fraction of the tissues. In order to use ASC for therapeutic purposes, it is important to obtain relatively pure stem cells in large quantities. Current methods for stem cell purification are mainly based on marker-dependent cell sorting techniques, which have various technical difficulties. In this study, we have attempted to develop novel conditions to favor the growth of the dental follicle stem cells (DFSC) such that the resultant cell populations are enriched in stem cells. Specifically, a heterogeneous dental follicle cell (H-DFC) population containing stem cells and homogenous non-stem cell dental follicle cell population were cultured at 1% or 5% hypoxic conditions. Only the heterogeneous population could increase proliferation in the hypoxic condition whereas the homogenous DFC did not change their proliferation rate. In addition, when the resultant cells from the heterogonous population were subjected to differentiation, they appeared to have a higher capacity of adipogenesis and osteogenesis as compared to the controls grown in the normal at-mosphere (normoxic condition). These hypoxia- treated cells also express higher levels of some stem cell markers. Together, these data suggest that stem cells are enriched by culturing the heterogeneous cell populations in a reduced O2 condition.

关键词： Hypoxia Dental Follicle (DF) Stem Cells Proliferation Gene Expression

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Detection of pancreatic cancer by indocyanine green-assisted fluorescence imaging in the first and second near-infrared windows

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Cancer Communications 2021年第12期41卷 1431-1434页

作者： Zhongqiang Li Zheng Li Alexandra Ramos J.Philip Boudreaux Ramcharan Thiagarajan Yvette Bren Mattison Michael E.Dunham Andrew J McWhorter Qing Chen Jian Zhang Ji-Ming Feng Yanping Li shaomian yao Jian Xu Division of Electrical and Computer Engineering College of EngineeringLouisiana State UniversityBaton RougeLA 70803USA Department of Comparative Biomedical Science School of Veterinary MedicineLouisiana State UniversityBaton RougeLA 70803USA Department of Surgery School of MedicineLouisiana State University Health Science CenterNew OrleansLA 70112USA Department of Otolaryngology School of MedicineLouisiana State University Health Science CenterNew OrleansLA 70112USA Division of Computer Science&Engineering College of EngineeringLouisiana State UniversityBaton RougeLA 70803USA School of Environment and Sustainability University of SaskatchewanSaskatoonSK S7N 5C9Canada

Dear Editor,In the United States,pancreatic cancer is considered the fourth most common reason for cancer-related deaths;over 53%of patients are diagnosed at end-stage with a 5-year survival rate of less than 3%[1].Incomplete removal of all cancerous cells generally leads to local recurrence of pancreatic cancer[2].Thus,the detection of tumor margin status plays an essential role in the complete resection of pancreatic *** of the existing imaging modalities,like computed tomography and magnetic resonance imaging,are primarily used for preoperative planning;these modalities also have issues of bulky equipment,radiation concerns,and slow imaging speed[2].Thus,these modalities can neither provide an intraoperative diagnosis of cancer with high sensitivity and specificity nor be used to define tumor margins[3].

关键词： diagnosis specificity neither

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