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Post-dilatation improves stent apposition in patients with ST-segment elevation myocardial infarction receiving primary percutaneous intervention: A multicenter, randomized controlled trial using optical coherence tomography

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World Journal of Emergency Medicine 2020年第2期11卷 87-92页

作者： Jun Jiang Nai-liang Tian Han-bin Cui Chang-ling Li Xian-bao Liu liang Dong Yong Sun Xiao-min chen shao-liang chen Bo Xu Jian-an Wang Department of Cardiology the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhouChina Department of Cardiology Nanjing First HospitalNanjingChina Department of Cardiology Ningbo First HospitalNingboChina Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesBeijingChina

BACKGROUND: Stent failure is more likely in the lipid rich and thrombus laden culprit lesions underlying ST-segment elevation myocardial infarction(STEMI).This study assessed the effectiveness of post-dilatation in primary percutaneous coronary intervention(pPCI) for acute ***: The multi-center POST-STEMI trial enrolled 41 consecutive STEMI patients with symptom onset 16 atm *** apposition and coverage were evaluated by optical coherence tomography(OCT) after intracoronary verapamil administration via thrombus aspiration catheter, post pPCI and at 7-month *** primary endpoint was rate of incomplete strut apposition(ISA) at 7 months after ***: There were similar baseline characteristics except for stent length(21.9 [SD 6.5] mm vs.26.0 [SD 5.8] mm, respectively, P=0.03).In post-dilatation *** group, ISA rate was lower(2.5% vs.4.5%, P=0.04) immediately after pPCI without affecting final TIMI flow 3 rate(95.2% vs.95.0%, P>0.05) or corrected TIMI frame counts(22.6±9.4 vs.22.0±9.7, P>0.05); and at 7-month follow-up(0.7% vs.1.8%, P<0.0001), the primary study endpoint, with similar strut coverage(98.5% vs.98.4%, P=0.63) and 1-year rate of major adverse cardiovascular events(MACE).CONCLUSION: In STEMI patients, post-dilatation after stent implantation and thrombus aspiration improved strut apposition up to 7 months without affecting coronary blood flow or 1-year MACE *** and longer term studies are warranted to further assess safety(Clinical *** identifier: NCT02121223).

关键词： ST-segment elevation myocardial infarction Post-dilatation Incomplete strut apposition Optical coherence tomography

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Clinical Relevance of Coronary Fractional Flow Reserve： Art-of-state

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Chinese Medical Journal 2015年第10期128卷 1399-1406页

作者： Yohanes Adiputra shao-liang chen Department of Cardiology Nanjing First Hospital of Nanjing Medical University Nanjing Jiangsu 210006 China

Objective：The objective was to delineate the current knowledge of fractional flow reserve （FFR） in terms of definition,features,clinical applications,and pitfalls of measurement of *** Sources：We searched database for primary studies published in *** database of National Library of Medicine （NLM）,MEDLINE,and PubMed up to July 2014 was used to conduct a search using the keyword term ＂FFR＂.Study Selection：The articles about the definition,features,clinical application,and pitfalls of measurement of FFR were identified,retrieved,and ***：Coronary pressure-derived FFR rapidly assesses the hemodynamic significance of individual coronary artery lesions and can readily be performed in the catheterization *** use of FFR has been shown to effectively guide coronary revascularization procedures leading to improved patient ***：FFR is a valuable tool to determine the functional significance of coronary *** combines physiological and anatomical information,and can be followed immediately by percutaneous coronary intervention （PCI） if *** technique of FFR measurement can be performed easily,rapidly,and safely in the catheterization *** systematic use of FFR in dubious stenosis and multi-vessel disease,PCI can be made an even more effective and better treatment than it is *** current clinical evidence for FFR should encourage cardiologists to use this tool in the catheterization laboratory.

关键词： Clinical Application Features: Fractional Flow Reserve Limitation

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Risks of incident heart failure with preserved ejection fraction in Chinese patients hospitalized for cardiovascular diseases

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Journal of Geriatric Cardiology 2019年第12期16卷 885-893页

作者： Jun-Xia ZHANG Yi-Xian LIU Chun-Lei XIA Peng CHU Xin-liang QU Lin-Lin ZHU shao-liang chen Department of Cardiology Nanjing First Hospital Nanjing Medical University

Background Endogenous aldehyde damages DNA and potentiates an ageing phenotype. The aldehyde dehydrogenase 2(ALDH2) rs671 polymorphism has a prevalence of 30%–50% in Asian populations. In this study, we aimed to analyze risk factors contributing to the development of heart failure with preserved ejection fraction(HFpEF) along with the genetic exposure in Chinese patients hospitalized with cardiovascular diseases(CVD). Methods From July 2017 to October 2018, a total of 770 consecutive Chinese patients with normal left ventricular ejection fractions(LVEF) and established CVD(hypertension, coronary heart diseases, or diabetes) were enrolled in this prospective cross-sectional study. HFpEF was defined by the presence of at least one of symptom(dyspnoea and fatigue) or sign(rales and ankle swelling) related to heart failure;N-terminal pro-B-Type natriuretic peptide(NT pro-BNP ≥ 280 pg/mL);LVEF ≥ 50%;and at least one criterion related to elevated ventricular filling pressure or diastolic dysfunction(left atrial diameter > 40 mm, E/E’ ≥ 13, E’/A’ < 1 or concurrent atrial fibrillation). Logistic regression was performed to yield adjusted odds ratios(ORs) for HFp EF incidence associated with traditional and/or genetic exposures. Results Finally, among 770 patients with CVD, 92(11.9%) patients were classified into the HFpEF group according to the diagnostic criteria. The mean age of the participants was 67 ± 12 years, and 278(36.1%) patients were females. A total of 303(39.4%) patients were ALDH2*2 variant carriers. In the univariate analysis, eight exposures were found to be associated with HFpEF: atrial fibrillation, ALDH2*2 variants, hypertension, age, anaemia, smoking, alcohol consumption and sex. Multivariable logistic regression showed that 4 ‘A’ variables(atrial fibrillation, ALDH2*2 variants, age and anaemia) were significantly associated with an increased risk of HFpEF. Atrial fibrillation was associated with a 3.8-fold increased HFpEF risk(95% CI: 2.21–6.61, P < 0.0

关键词： Aldehyde dehydrogenase 2 Cardiovascular diseases Diastolic dysfunction Heart failure with preserved ejection fraction Riskfactor

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Over-transcription of genes in a parathion-resistant strain of mosquito Culex pipiens quinquefasciatus

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Insect Science 2015年第1期22卷 150-156页

作者： Wei Wang Si-Lu Liu Yang-Yang Liu Chuan-Ling Qiao shao-liang chen Feng Cui College of Biological Sciences and Technology Beijing Forestry University Beijing State Key Laboratory of Integrated Managementof Pest Insects and Rodents Institute of Zoology Chinese Academy of Sciences Beijing China

Insecticide resistance is an evolutionary adaptation that develops quite quickly in mosquitoes because of the high selection pressure of chemical insecticides, rapid generation time and large population size. Identification of genes associated with insecticide resistance is fundamental to understand the complex processes responsible for resistance. We compared the gene transcriptional profiles of parathion-resistant and -susceptible Culex pipiens quinquefasciatus using a combination of suppression subtractive hybridization and complementary DNA （cDNA） microarray techniques. A total of 278 colonies were selected from the resistant-susceptible mosquito subtractive library, 38 of which showed more than two fold stronger immunoblotting signals in the resistant strain than in the susceptible strain using cDNA microarray selection. The sequencing results showed that the 38 colonies can be matched to 12 genes of C. p. quinquefasciatus. Eight genes were confirmed to be overexpressed by more than two fold in the resistant strain. These genes encode chymotrypsin-1, theta glutathione S-transferase, lipase 3, larval serum protein 1β chain, cytochrome b, mitochondrial ribosomal large subunit, 28S rRNA, and a protein with unknown function. This study serves as a preliminary attempt to identify new genes associated with organophosphate resistance in this mosquito species and provides insights into the complicated physiological phenomenon of insecticide resistance.

关键词： cDNA microarray chymotrypsin gene up-regulation insecticide resistance suppression subtractive hybridization theta glutathione S-transferase

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Association of glutathione peroxidase-1 （GPx-1） rs1050450 Pro198Leu and Pro197Leu polymorphisms with cardiovascular risk：a meta-analysis of ob-servational studies

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Journal of Geriatric Cardiology 2014年第2期11卷 141-150页

作者： Jun-Xia ZHANG Zhi-Mei WANG Jun-Jie ZHANG Lin-Lin ZHU Xiao-Fei GAO shao-liang chen Department of Cardiology Nanjing First Hospital Affiliated to Nanjing Medical University Nanjing Jiangsu Province 210006 China

Objective To clarify the association between rs1050450 polymorphism in Glutathione peroxidase-1 （GPx-1） and the risk of cardi-ovascular diseases （CVD） by performing a meta-analysis of published studies. There is growing evidence from different study types for an association of the GPx-1 polymorphism and cardiovascular outcomes, but observational studies have so far shown inconsistent results. Me-thods Relevant publications were searched through PubMed, Embase database databases and the Cochrane Library. We used odds ratios （ORs） with 95%confidence intervals （CIs） to assess the strength of association under the best genetic model. Both Q statistic and the I2 were used to check heterogeneity. Meta-regression analysis was performed to explore heterogeneity source. Sensitivity analysis, cumulative me-ta-analysis analysis and publication bias were used to test the reliability of the results. Results Data were available from two cohort studies and 8 case-control studies involving 1,430 cases and 3,767 controls. The pooled ORs for overall CVD risk was 1.36 with 95%CI：1.08-1.70 under a co-dominant model, and that for East Asian subgroup was 1.84 （95%CI：1.39-2.43）. Substantial heterogeneity for ORs were de-tected among all the included studies, mainly caused by ethnic differences between East Asian and non-East Asian populations. Although Egger＇s regression test suggested no statistical significant publication bias, Begg＇s funnel plot exhibited obvious asymmetry. The statistical significance disappeared after adjusting for potential publication bias in the overall studies. However, no substantial publication bias was found in the East Asian subgroup. Conclusions GPx-1 gene Pro198Leu and Pro197Leu polymorphisms considerably increased the risk of CVD in the East Asian population. Large-scale investigations are needed to confirm the results in different ethnicities.

关键词： Glutathione peroxidase-1 Cardiovascular diseases Polymorphism Meta-analysis

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Comparison of the safety and efficacy of two types of drug-eluting balloons （RESTORE DEB and SeQuent Please） in the treatment of coronary in-stent restenosis： study protocol for a randomized controlled trial （RESTORE ISR China）

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Journal of Geriatric Cardiology 2018年第2期15卷 117-122页

作者： Lei GAO Qin QIN shao-liang chen Hui chen Le-Feng WANG Ze-Ning JIN Hui LI Jun ZHANG Jian-An WANG Yang ZHENG Guo-Sheng FU Yun-Dai chen Department of Cardiology Chinese PLA General Hospital Beijing China Department of Cardiology Tianjin Chest Hospital Tianjin China Department of Cardiology Nanjing First Hospital Nanjing China Department of Cardiology Beijing Friendship Hospital Capital Medical University Beijing China Department of Cardiology Beijing Chao-yang Hospital Capital Medical University Beijing China Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing China Department of Cardiology Daqing Oilfield General Hospital Daqing China Department of Cardiology Cangzhou Central Hospital Cangzhou China Department of Cardiology the Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou China Department of Cardiology the First Hospital of Jilin University Changchun China Department of Cardiology Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou China

1 Introduction In-stent restenosis （ISR）, characterized by neointimal proliferation and/or neoatherosclerosis in the vessel of the stent, can cause a reduction in lumen diameter after stent implantation, which can directly induce the recurrence of angina symptoms or an acute coronary syndrome in patients and is usually life-threatening.

关键词： Drug-eluting balloons In-stent restenosis Percutaneous coronary interventions

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Left atrial diameter and atrial fibrillation,but not elevated NT-proBNP,predict the development of pulmonary hypertension in patients with HFpEF

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Journal of Geriatric Cardiology 2020年第7期17卷 400-409页

作者： Yi-Xian LIU Hui LI Yi-Yuan XIA Chun-Lei XIA Xin-liang QU Peng CHU Wen-Yin ZHOU Lin-Lin ZHU Li LI shao-liang chen Jun-Xia ZHANG Department of Cardiology Nanjing First HospitalNanjing Medical UniversityNanjingChina Laboratory of Cardiovascular Diseases Nanjing Heart CentreNanjingChina Department of Cardiology Guangzhou Red Cross HospitalJinan UniversityGuangzhouChina Department of Cardiology Nanjing First HospitalNanjing Medical UniversityNo.68 Changle RoadNanjing 210006China

Background The determinants of pulmonary hypertension(PH)due to heart failure with preserved ejection fraction(HFpEF)have been poorly investigated in patients with cardiovascular diseases(CVD).Methods From July 12017 to March 312019,a total of 149 consecutive HFp EF patients hospitalized with CVD were enrolled in this prospective cross-sectional study.A systolic pulmonary artery pressure(PASP)>35 mm Hg estimated by echocardiography was defined as PH-HFp *** regression was performed to establish predictors of PH in HFpEF *** Overall,the mean age of participants was 72±11 years,and 74(49.7%)patients were females.A total of 59(39.6%)patients were diagnosed with PH-HFpEF by *** left atrial diameter(LAD)was related to the ratio of the transmitral flow velocities/mitral annulus tissue velocities in early diastole(E/E’)and the left ventricular diameter in systole(LVDs).N-Terminal pro B-type natriuretic peptide(NT-proBNP)was not found to be associated with LAD and impaired diastolic or systolic function of the left *** logistic regression showed that atrial fibrillation(AF)increased the risk of PH-HFpEF incidence 3.46-fold with a 95%confidence interval(CI)of 1.44–8.32,P=***,LAD≥45 mm resulted in a 3.43-fold increased risk,95%CI:1.51–7.75,P=***,the significance levels of NT-proBNP,age and LVEF were underpowered in the regression *** variables,AF and LAD≥45 mm,predicted the PH-HFpEF incidence(C-statistic=0.773,95%CI:0.695–0.852,P<0.001).Conclusions Two parameters associated with electrical and anatomical remodelling of the left atrium were related to the incidence of PH in HFpEF patients with CVD.

关键词： Atrial fibrillation Ejection fraction Heart failure Left atrial diameter Pulmonary hypertension

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Growth, Gas Exchange, Abscisic Acid, and Calmodulin Response to Salt Stress in Three Poplars

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Journal of Integrative Plant Biology 2006年第3期48卷 286-293页

作者： Yu Chang shao-liang chen Wei-Lun Yin Rui-Gang Wang Yan-Feng Liu Yong Shi Yuan-Yuan Shen Yue Li Jie Jiang Yue Liu College of Biological Science and Technology Beijing Forestry University Beijing 100083 China

In the present study, we Investigated the effects of Increaslng sallnlty on growth, gas exchange, absclslc acld （ABA）, calmodulln （CAM）, and the relevance to salt tolerance In seedllngs of Populus euphratlca Ollv. and cutUngs of P. ＂pupularls 35-44＂（P. popularls） and P. x euramerlcana cv. 1-214 （P. cv. Itallca）. The relatlve growth rates of shoot helght （RGR,） for P. cv. Itallca and P. popularls were severely reduced by Increaslng salt stress, whereas the growth reductlon was relatlvely less in P. euphratica. Slmllarly, P. euphratlca malntalned hlgher net photosynthetlc rates （Pn） and unlt transplration rotes （TRN） than P. cv. Itallca and P. popularls under condltlons of hlgher sallnlty. Sallnity caused a slgnlficant increase In leaf ABA and CaM In the three genotypes after the onset of stress, but NaCl-induced ABA and CaM accumulatlon was more pronounced In P. euphratlca, suggeeUng that P. euphratlca plants are more sensitlve in sensing soil salinlty than the other two poplars. Furthermore, P. euphratica maintained relatively higher ABA and CaM concentrations under conditions of high salinity. The higher capacity to synthesize stress signals, namely ABA and CaM, In P. euphratica and the contrlbuUon of this to the salt resistance of P. euphratica are discussed.

关键词： abscisic acid calmodulin gas exchange growth NaCl Populus euphratica.

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Expression analysis of two novel cotton 14-3-3 genes in root development and in response to salt stress

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Progress in Natural Science:Materials International 2009年第2期19卷 173-178页

作者： Xinzheng Wei1,Zeting Zhang1,Yang Li,Xiulan Wang,Suqiang shao,liang chen,Xuebao Li Hubei Key Laboratory of Genetic Regulation and Integrative Biology,College of Life Sciences,Huazhong Normal University,Wuhan 430079,China [a]Hubei Key Laboratory of Genetic Regulation and Integrative Biology College of Life Sciences Huazhong Normal University Wuhan 430079 China

14-3-3 proteins are phosphoserine-binding proteins that regulate the activities of a wide array of targets via direct protein-protein interactions,and may play an important role in response to biotic and abiotic stresses. In this study,two cDNAs (designated as Gh14-3-3b and Gh14-3-3c) encoding putative 14-3-3 proteins were isolated from cotton cDNA libraries. Gh14-3-3b gene encodes a pro-tein of 268 amino acids,while Gh14-3-3c gene encodes a protein of 261 amino acids. Real-time RT-PCR analysis revealed that both the Gh14-3-3b and Gh14-3-3c genes were preferentially expressed in roots. The transcript levels of both the genes were the highest in 3-day-old roots,and then dramatically decreased to relatively low levels in parallel with root development. In addition,the expression of these Gh14-3-3 genes in roots was significantly up regulated by salt treatments,suggesting that they may be involved in the signaling pathways in response to salt stress in cotton.

关键词： Cotton (Gossypium hirsutum) 14-3-3 genes Gene expression Root development Salt stress

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Low Shear Stress Regulating Autophagy Mediated by the p38 Mitogen Activated Protein Kinase and p53 Pathways in Human Umbilical Vein Endothelial Cells

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Chinese Medical Journal 2018年第9期131卷 1132-1133页

作者： Hui-Zhen Liu Li Li shao-liang chen Jian-Rui Wei Jun-Xia Zhang Jia Liu Jie-Wen Guo Xin-liang Qu Peng Chu Department of Cardiology Guangzhou Red Cross Hospital Jinan University affiliated Guangzhou Red Cross Hospital Guangzhou Guangdong 510000 China Department of Cardiology Nanjing First Hospital Nanjing Medical University Nanjing Jiangsu China

To the Editor：Autophagy is reported to play a critical role in low shear stress （LSS）-induced endothelial cell injury and the formation of atherosclerotic plaques.[1] However,the corresponding mechanisms remain unclear.[2-8] This study was to investigate the changes and mechanism of LSS-induced autophagy in human umbilical vein endothelial cells （HUVECs）.HUVECs were treated with LSS of 5 dyn/cm2 for 0,5,15,30,and 60 min in a parallel plate flow chamber *** chain （LC） Ⅱ,LC3 Ⅰ,and p62,p38 mitogen-activated protein kinase （MAPK） and their protein of phosphorylation of p38 （p-p38） were detected with Western blot *** protein levels of p-p53 （ser15） and their distribution were detected by immunofluorescence （IF）.

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