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Correlation analysis of interstitial maturity and prognosis of colorectal cancer:Meta-analysis

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2816-2825页

作者： Zhen-jun Liu Xu-Wen Zhang Qi-Qi Liu shao-Zhao Wang Department of Gastrointestinal Surgery Feicheng People's HospitalFeicheng 271600Shandong ProvinceChina Department of Hepatobiliary Surgery Feicheng People's HospitalFeicheng 271600Shandong ProvinceChina Department of Gastrointestinal Surgery Peking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina Department of Anorectal Word Central Hospital Affiliated Shandong First Medical UniversityJinan 250013Shandong ProvinceChina

BACKGROUND To investigate the relationship between interstitial maturity and prognosis of colorectal *** To examine the correlation between interstitial maturity and the prognosis of colorectal *** The paper database PubMed,EMBASE,Cochranelibrary,Springerlink,CNKI,and Wanfang database were searched until December 2023."tumor stroma maturity""desmoplastic stroma reaction""desmoplastic reaction""stroma reaction""degree of stroma reaction""stroma classification""stroma density""colorectal cancer""colon cancer""rectal cancer""prognosis"were searched for the search *** system assessors independently screened the literature quality according to the inclusion exclusion criteria,Quality evaluation and data extraction were performed for the included literatures,and meta-analysis was performed for randomized control trials included at using Review Manager 5.2 *** Finally,data of 9849 patients with colorectal cancer from 19 cosets in 15 literatures were included,including 4339 patients with mature type(control group),3048 patients with intermediate type(intermediate group)and 2456 patients with immature type(immature group).The results of meta-analysis showed:Relapse-free survival[hazard ratio(HR)=2.66,95%confidence interval(CI):2.30-3.08;P<0.00001],disease-free survival(HR=3.68,95%CI:2.33-5.81;P<0.00001)and overall survival(HR=1.70,95%CI:1.53-1.87;P<0.00001)were significantly lower than those in mature group(control group);relapse-free survival(HR=1.36,95%CI:1.17-1.59;P<0.0001)and disease-free survival rate(HR=1.85,95%CI:1.53-2.24;P<0.0001)was significantly lower than the mature group(control group).CONCLUSION There is the correlation between tumor interstitial maturity and survival prognosis of colorectal cancer,and different degrees of tumor interstitial maturity have a certain impact on the quality of life of colorectal cancer patients.

关键词： Colorectal tumor Survival prognosis Tumor interstitial maturity Systematic review Meta-analysis

Multifunctional interfacial molecular bridge enabled by an aggregation-induced emission strategy for enhancing efficiency and UV stability of perovskite solar cells

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Journal of Energy Chemistry 2024年第8期95卷 588-595,I0013页

作者： Shuhang Bian Yuqi Wang Fancong Zeng Zhongqi Liu Bin Liu Yanjie Wu Long shao Yongzhi shao Huan Zhang Shuainan Liu Jin Liang Xue bai Lin Xu Donglei Zhou Biao Dong Hongwei Song State Key Laboratory on Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012JilinChina College of Science Shanghai UniversityShanghai 200444China

The interface defects between the electron transport layer(ETL)and the perovskite layer,as well as the low ultraviolet(UV)light utilization rate of the perovskite absorption layer,pose significant challenges for the commercialization of perovskite solar cells(PSCs).To address this issue,this paper proposes an innovative multifunctional interface modulation strategy by introducing aggregation-induced emission(AIE)molecule 5-[4-[1,2,2-tri[4-(3,5-dicarboxyphenyl)phenyl]ethylene]phenyl]benzene-1,3-dicarboxylic acid(H_(8)ETTB)at the SnO_(2)ETL/perovskite ***,the interaction of H_(8)ETTB with the SnO_(2)surface,facilitated by its carboxyl groups,is effective in passivating surface defects caused by noncoord inated Sn and O *** interaction enhances the conductivity of the SnO_(2)film and adjusts energy levels,leading to enhanced charge carrier ***,H_(8)ETTB can passivate noncoord inated Pb^(2+)ions at the perovskite interface,promoting perovskite crystallization and reducing the interface energy barrier,resulting in a perovskite film with low defects and high crystalline *** importantly,the H_(8)ETTB molecule,can convert UV light into light absorbable by the perovskite,thereby reducing damage caused by UV light and improving the device's utilization of ***,the champion PSC based on SnO_(2)-H_(8)ETTB achieves an impressing efficiency of 23.32%and significantly improved photostability compared with the control device after continuous exposure to intense UV *** addition,the Cs_(0.05)(FA_(0.95)MA_(0.05))_(0.95)Pb(I_(0.95)Br_(0.05))_(3)based device can achieve maximum efficiency of 24.01%,demonstrating the effectiveness and universality of this ***,this innovative interface bridging strategy effectively tackles interface defects and low UV light utilization in PSCs,presenting a promising approach for achieving highly efficient and stable PSCs.

关键词： Perovskite solar cells Aggregation-induced emission Defect passivation Efficiency UV stability

FPR1 Antagonist (BOC-MLF) Inhibits Amniotic Epithelial-mesenchymal Transition

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Current Medical Science 2024年第1期44卷 187-194页

作者： Xiao-mei HUANG E LIAO jun-qun LIAO Ya-ling LIU Yong shao Department of Obstetrics and Gynecology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Department of Obstetrics Maternal and Child Health Hospital of Hubei ProvinceWuhan 430070China Medical Laboratory Science The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Department of Obstetrics Yubei Maternity and Child Healthcare HospitalChongqing 400042China

Objective:Premature rupture of membranes(PROM)is a common pregnancy disorder that is closely associated with structural weakening of fetal *** have found that formyl peptide receptor 1(FPR1)activates inflammatory pathways and amniotic epithelial-mesenchymal transition(EMT),stimulates collagen degradation,and leads to membrane weakening and membrane *** purpose of this study was to investigate the anti-inflammatory and EMT inhibitory effects of FPR1 antagonist(BOC-MLF)to provide a basis for clinical prevention of ***:The relationship between PROM,FPR1,and EMT was analyzed in human fetal membrane tissue and plasma samples using Western blotting,PCR,Masson staining,and ELISA ***(LPS)was used to establish a fetal membrane inflammation model in pregnant rats,and BOC-MLF was used to treat the LPS rat *** detected interleukin(IL)-6 in blood from the rat hearts to determine whether the inflammatory model was successful and whether the anti-inflammatory treatment was *** used electron microscopy to analyze the structure and collagen expression of rat fetal ***:Western blotting,PCR and Masson staining indicated that the expression of FPR1 was significantly increased,the expression of collagen was decreased,and EMT appeared in *** rat model indicated that LPS caused the collapse of fetal membrane epithelial cells,increased intercellular gaps,and decreased ***-MLF promoted an increase in fetal membrane collagen,inhibited EMT,and reduced the weakening of fetal ***:The expression of FPR1 in the fetal membrane of PROM was significantly increased,and EMT of the amniotic membrane was ***-MLF can treat inflammation and inhibit amniotic EMT.

关键词： formyl peptide receptor 1 BOC-MLF epithelial-mesenchymal transition premature rupture of membranes

Advanced Materials for NH_(3)Capture:Interaction Sites and Transport Pathways

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Nano-Micro Letters 2024年第11期16卷 119-155页

作者： Hai‑Yan Jiang Zao‑Ming Wang Xue‑Qi Sun shao‑Juan Zeng Yang‑Yang Guo Lu bai Ming‑Shui Yao Xiang‑Ping Zhang Key Laboratory of Green Process and Engineering State Key Laboratory of Mesoscience and EngineeringBeijing Key Laboratory of Ionic Liquids Clean ProcessInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190People’s Republic of China School of Future Technology University of Chinese Academy of SciencesBeijing 100049People’s Republic of China China University of Petroleum Beijing 102249People’s Republic of China Institute for Integrated Cell‑Material Sciences(iCeMS) Kyoto UniversitySakyo‑KuYoshidaKyoto 606‑8501Japan

Ammonia(NH3)is a carbon-free,hydrogen-rich chemical related to global food safety,clean energy,and environmental *** an essential technology for meeting the requirements raised by such issues,NH3 capture has been intensively explored by researchers in both fundamental and applied *** four typical methods used are(1)solvent absorption by ionic liquids and their derivatives,(2)adsorption by porous solids,(3)abadsorption by porous liquids,and(4)membrane *** in the development of advanced materials for NH3 capture,we conducted a coherent review of the design of different materials,mainly in the past 5 years,their interactions with NH3 molecules and construction of transport pathways,as well as the structure–property relationship,with specific examples ***,the challenges in current research and future worthwhile directions for NH3 capture materials are proposed.

关键词： Ammonia capture Solvents Porous solids Porous liquids Membranes

Biological Evaluation of Lysionotin:a Novel Inhibitor of 5-Lipoxygenase for Anti-glioma

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Chinese Journal of Integrative Medicine 2024年第9期30卷 826-834页

作者： shao Xin-xin CHEN Cong LIU Jie LI Qing-jun HE Shan QI Xiang-hua FU Xian-jun WANG Zhen-guo The First Clinical College of Medicine Shandong University of Traditional Chinese MedicineJinan250355China Institute for Literature and Culture of Chinese Medicine Shandong University of Traditional Chinese MedicineJinan250355China Key Laboratory of Classical Theory of Traditional Chinese Medicine Ministry of EducationShandong University of Traditional Chinese MedicineJinan250355China College of Pharmacy Shandong University of Traditional Chinese MedicineJinan250355China Experimental Center Shandong University of Traditional Chinese MedicineJinan250355China Neurology Department Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan250014China Marine Traditional Chinese Medicine Research Center Qingdao Academy of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineQingdao266114Shandong ProvinceChina

Objective:To explore the potential mechanism of lysionotin in treating ***:First,target prediction based on Bernoulli Naïve Bayes profiling and pathway enrichment was used to predict the biological activity of *** binding between 5-lipoxygenase(5-LO)and lysionotin was detected by surface plasmon resonance(SPR)and molecular docking,and the inhibitory effects of lysionotin on 5-LO and proliferation of glioma were determined using enzyme inhibition assay in vitro and cell viability analysis,***,the pharmaceutical effect of lysionotin was explored by cell survival rate analysis and liquid chromatography with tandem mass spectrometry(LC-MS/MS).The protein expression,intracellular calcium ion concentration and cytoskeleton detection were revealed by Western blot,flow cytometry and fluorescence labeling,***:Target prediction and pathway enrichment revealed that lysionotin inhibited 5-LO,a key enzyme involved in the arachidonic acid metabolism pathway,to inhibit the proliferation of *** docking results demonstrated that 5-LO can be binding to lysionotin through hydrogen bonds,forming bonds with His600,Gln557,Asn554,and *** analysis further confirmed the interaction between 5-LO and ***,enzyme inhibition assay in vitro and cell survival rate analysis revealed that 50%inhibition concentration of lysionotin and the median effective concentration of lysionotin were 90 and 16.58µmol/L,respectively,and the results of LC-MS/MS showed that lysionotin inhibited the production of 5S-hydroperoxy-eicosatetraenoic acid(P<0.05),and moreover,the LC-MS/MS results indicated that lysionotin can enter glioma cells well(P<0.01)and inhibit their *** blot analysis demonstrated that lysionotin can inhibit the expression of 5-LO(P<0.05)and downstream leukotriene B4 receptor(P<0.01).In addition,the results showed that lysionotin affected intracellular calcium ion concentration by inh

关键词： 5-lipoxygenase inhibitor lysionotin 5-lipoxygenase leukotriene B4 calcium ion cytoskeleton

The Crystallization Behavior of L-Poly(lactic acid)/Polypropylene Blends:The Acceleration for Both L-Poly(lactic acid)and Polypropylene

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Chinese Journal of Polymer Science 2024年第6期42卷 775-786页

作者： Shuang-Cheng Li Wei-Jia Zhou Wen-Jie Wu jun shao Shui-Liang Chen Hao-Qing Hou Sheng Xiang College of Chemistry&Chemical Engineering and Nanofiber Engineering Center of Jiangxi Province Jiangxi Normal UniversityNanchang330022China National Engineering Research Center for Carbohydrate Synthesis/Key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education Jiangxi Normal UniversityNanchang330022China Wenzhou Institute University of Chinese Academy of SciencesWenzhou325001China

For a polymer/polymer dismissible blend with two crystallizable components,the crystallization behavior of different components and the reciprocal influences between different crystals are interesting and important,but did not investigate in *** this study,the L-poly(lactic acid)/polypropylene(PLLA/PP)blends with different weight ratios were prepared by melt mixing and the crystallization behavior of the blends were *** showed that the crystalline structures of PLLA and PP were not altered by the *** the crystallization of PLLA,both the diffusion of chain segments and crystallization rate were enhanced under the existence of PP *** the crystallization of PP,its crystallization rate was depressed under the existence of amorphous PLLA molecular *** the PP crystallized from the existence of PLLA crystals,although the diffusion rate of PP was reduced by PLLA crystals,the nucleation positions were obviously enhanced,which accelerated the formation of PP *** investigation would supply more basic data for the application of PLLA/PP blend.

关键词： L-poly(lactic acid) Polypropylene Blends Crystalization behavior Crystallization acceleration

Using vitamin C to improve both performance and stability of n-type organic semiconductors

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Science China Materials 2024年

作者： Sizhe Liu Xingxin shao jun Liu Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences School of Applied Chemistry and Engineering University of Science and Technology of China

Organic semiconductors (OSCs) have the great advantages of flexibility, light weight, low-cost and large-area processing [1].After intensively studied for several decades, OSCs are now considered to be the most promising candidate materials for next-generation electronic circuits. N-type OSCs are the vital component for the basic electronic element, such as p-n junctions, light-emitting diodes and complementary circuits [2].However, the limited reliability of n-type OSCs inhibits their practical applications [3]. This is due to the generation of organic radical anions during device operation, which are thermodynamically unstable and easily react with oxygen and water [4]. The anti-oxidation properties of n-type OSCs can be expected if the lowest unoccupied molecular orbital (LUMO)energy levels are downshifted to lower than-4.8 eV [5,6].However, the molecular design and synthesis of n-type OSCs with ultralow LUMO energy levels are very challenging.

关键词：

A compact route for efficient production of high-purity β-Ga2O3 powder

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Rare Metals 2024年第9期43卷 4573-4584页

作者： Xiao-Wei Zhou Gao-Jie Chen Liang Xu Zhi-jun shao Cheng Yang Yong-Pan Tian Zhuo Zhao School of Metallurgical Engineering Anhui University of Technology Low-Carbon Research Institute Anhui University of Technology

The present study has proposed a compact process for the production of high-purity β-Ga2O3powder by simply using gallium metal and water as the raw materials. The process basically consists of two essential steps including hydrothermal synthesis of Ga OOH and calcination of Ga OOH for the production of the target product of β-Ga2O3. Thermodynamic evaluation and systematic experiments were conducted for process parameter optimization. X-ray diffractometer（XRD）, scanning electron microscopy（SEM）, thermogravimetryDdifferential scanning calorimetry（TG-DSC） and X-ray photoelectron spectroscopy（XPS） were utilized to clarify the reaction mechanisms of the hydrothermal synthesis and transformation of Ga OOH to β-Ga2O3by calcination. Chemical analysis of the final product of β-Ga2O3obtained under the optimal conditions was carried out with inductively coupled plasma mass spectrometry（ICP-MS）, and the results showed that the contents of the representative impurities such as Ni, Cu, In, Mn, Co, Zn and Cr are obviously lower than the requirement of 5N β-Ga2O3standard, exhibiting excellent application prospect of the proposed process to produce high-purity β-Ga2O3.

关键词： Calcination Hydrothermal synthesis Purity Reaction mechanism β-Ga2O3

Predictive Value of High Mobility Group Box-1 and miR-146b in Septic Shock Patients

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Wuhan University Journal of Natural Sciences 2024年第1期29卷 85-94页

作者： FENG jun shao Shasha LIU junya PAN Yongjun YIN Huimei WANG junshuai Department of Emergency Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030HubeiChina Department of Critical Care Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030HubeiChina Department of Critical Care Medicine Southern University of Science and Technology HospitalShenzhen 518055GuangdongChina Department of Emergency Medicine People's Hospital of Bortala Mongol Autonomous PrefectureBole 833400XinjiangChina

In the face of the elevated incidence and mortality rate of septic shock in the ICU,this retrospective study seeks to investigate the indicative and predictive value of high-mobility group box 1(HMGB1)and miR-146b in patients with septic *** RTPCR was employed in this study to quantify the HMGB1 and miR-146b levels in plasma samples obtained from the patient group and healthy *** investigation involved the comparison between the two groups and tracking changes in the patient group over *** finding revealed that upon admission,the patient group exhibited markedly elevated relative expression levels of HMGB1,which subsequently decreased over ***,the patient group displayed significantly reduced relative expression levels of miR-146b upon admission,which subsequently increased over time compared to the control *** operating characteristic(ROC)curves showed good predictive value for HMGB1 and *** experimental results suggest that HMGB1 and miR-146b serve as valuable and convenient biomarkers for evaluating the severity of septic shock and predicting ***,it is proposed that serum miR-146b may be inducible and potentially exerts a negative regulatory effect on the expression of HMGB1.

关键词： septic shock feedback loop high mobility group box-1 miR-146b disease severity