Transition-metal free trifluoromethylimination of alkenes enabled by direct activation of N-unprotected ketimines

作     者：Boqiang Wang Yongzhuo Xu Jiajia Wang Muyang Yang Guo-Jun Deng Wen Shao 

作者机构：Key Laboratory for Green Organic Synthesis and Application of Hunan ProvinceKey Laboratory of Environmentally Friendly Chemistry and Application of Ministry of EducationCollege of ChemistryXiangtan UniversityXiangtan 411105China Department School of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiang 453007China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2024年第35卷第9期

页      面：155-159页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：Financial support from the National Natural Science Foundation of China(Nos.22201239,22205192 and 22271244) the Hunan Provincial Natural Science Foundation of China(No.2022JJ40429) the Scientific Research Fund of Hunan Provincial Education Department(No.21B0130) the Open Research Fund of School of Chemistry and Chemical Engineering,Henan Normal University(No.2022C02) the Process Intensification&Green Chemical Engineering Innovation Team Project of Hunan Province 

主　　题：Transition-metal free Alkenes difunctionalization Amination Trifluoromethylation Single-electron transfer 

摘      要：A highly site-selective intermolecular trifluoromethylimination of activated and unactivated olefins was reported under transition-metal-and photosensitizer-free *** newly developed strategy provides straightforward and efficient access to diverse value-added vicinal trifluoromethyl amines without resorting to the pre-functionalized *** experiments demonstrate that the approach proceeded through CF_(3)and iminyl two-radicals process,which were generated directly from commercially available benzophenone imine in a novel electron-donor mode via a SET process activated by the bifunctional hypervalent iodine *** synthetic potential of the protocols was further showcased via the condensation/amination sequential cascade,and transformations to accessβ-CF_(3)primary amines.