检索结果-南通市图书馆

Staging liver fibrosis with various diffusion-weighted magnetic resonance imaging models

World Journal of Gastroenterology 2024年第9期30卷 1164-1176页

作者： Yan-Li Jiang Juan Li Peng-Fei Zhang Feng-Xian Fan Jie Zou Pin Yang Peng-Fei wang shao-yu wang Jing Zhang Department of Magnetic Resonance Imaging The Second Hospital&Clinical Medical SchoolLanzhou UniversityLanzhou 730030Gansu ProvinceChina Second Clinical School Lanzhou UniversityLanzhou 730030Gansu ProvinceChina Gansu Province Clinical Research Center for Functional and Molecular Imaging The Second Hospital&Clinical Medical SchoolLanzhou UniversityLanzhou 730030Gansu ProvinceChina Department of Hepatology The Second Hospital&Clinical Medical SchoolLanzhou UniversityLanzhou 730030Gansu ProvinceChina MR Scientific Marketing Siemens HealthineersXi’an 710065Shaanxi ProvinceChina

BACKGROUND Diffusion-weighted imaging(DWI)has been developed to stage liver ***,its diagnostic performance is inconsistent among ***,it is worth studying the diagnostic value of various diffusion models for liver fibrosis in one *** To evaluate the clinical potential of six diffusion-weighted models in liver fibrosis staging and compare their diagnostic *** This prospective study enrolled 59 patients suspected of liver disease and scheduled for liver biopsy and 17 healthy *** participants underwent multi-b value *** main DWI-derived parameters included Mono-apparent diffusion coefficient(ADC)from mono-exponential DWI,intravoxel incoherent motion model-derived true diffusion coefficient(IVIM-D),diffusion kurtosis imaging-derived apparent diffusivity(DKI-MD),stretched exponential model-derived distributed diffusion coefficient(SEM-DDC),fractional order calculus(FROC)model-derived diffusion coefficient(FROC-D)and FROC model-derived microstructural quantity(FROC-μ),and continuous-time random-walk(CTRW)model-derived anomalous diffusion coefficient(CTRW-D)and CTRW model-derived temporal diffusion heterogeneity index(CTRW-α).The correlations between DWI-derived parameters and fibrosis stages and the parameters’diagnostic efficacy in detecting significant fibrosis(SF)were assessed and *** CTRW-D(r=-0.356),CTRW-α(r=-0.297),DKI-MD(r=-0.297),FROC-D(r=-0.350),FROC-μ(r=-0.321),IVIM-D(r=-0.251),Mono-ADC(r=-0.362),and SEM-DDC(r=-0.263)were significantly correlated with fibrosis *** areas under the ROC curves(AUCs)of the combined index of the six models for distinguishing SF(0.697-0.747)were higher than each of the parameters alone(0.524-0.719).The DWI models’ability to detect SF was *** combined index of CTRW model parameters had the highest AUC(0.747).CONCLUSION The DWI models were similarly valuable in distinguishing SF in patients with liver *** combined index of CTRW paramet

关键词： Liver fibrosis Magnetic resonance imaging Diffusion-weighted magnetic resonance Liver biopsy Significant fibrosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of Hot Environment on Strength and Heat Transfer Coefficient of Nano-Clay Concrete Paper Title

引用

Journal of Materials Science and Chemical Engineering 2016年第7期4卷 45-52页

作者： Wei-Chien wang shao-yu wang Cheng-Hsun Lin Department of Civil Engineering Chung Yuan Christian University Taiwan

This study selected water-cement ratio 0.5 and slump 16 cm for ACI mix design, and used nano- clay to replace 0.1%, 0.3% and 0.5% of cement by weight to make cylinder and angle column specimens. The effects of different high temperatures on the compressive strength and heat transfer coefficient were tested, and the ignition loss of nano-clay cement paste was measured. The results showed that an appropriate replacement of nano-clay for 0.3% - 0.5% of cement can enhance the strength and heat transfer coefficient of concrete, especially 0.3% replacement. The 0.1% nano- clay replacement for cement reduces the strength and heat transfer coefficient of concrete. When the ambient temperature exceeds 300?C, the nano-clay concrete strength begins to decline, and the heat transfer coefficient decreases greatly, the effect of hot environment on the strength trend of nano-clay concrete is similar to that on normal concrete. When the nano-clay replaces cement by 0% - 0.5%, the ignition loss is approximately in exponential and logarithmic relationships to the compressive strength respectively when the ignition loss is smaller than and greater than 6%.

关键词： Nano-Clay Cement Paste Concrete Ignition Loss

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protective effects of carbenoxolone are associated with attenuation of oxidative stress in ischemic brain injury

引用

Neuroscience Bulletin 2013年第3期29卷 311-320页

作者： Lang Zhang yu-Min Li yu-Hong Jing shao-yu wang Yan-Feng Song Jie Yin Institute of Anatomy Histology and Embryology School of Basic Medical Sciences Lanzhou University Key Laboratory of Digestive System Tumors of Gansu Province The Second Hospital of Lanzhou University Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical SciencesLanzhou University Division of Radiology Tumor Hospital of Gansu

Accumulating evidence has suggested that the gap junction plays an important role in the determination of cerebral ischemia, but the underlying mechanisms remain to be elucidated. In this study, we assessed the effect of a gap-junction blocker, carbenoxolone （CBX）, on ischemia/reperfusion-induced brain injury and the possible mechanisms. By using the transient cerebral ischemia model induced by occlusion of the middle cerebral artery for 30 min followed by reperfusion for 24 h, we found that pre-administration of CBX （25 mg/kg, intracerebroventricular injection, 30 min before cerebral ischemic surgery） diminished the infarction size in rats. And this was associated with a decrease of reactive oxygen species generation and inhibition of the activation of astrocytes and microglia. In PC12 cells, H202 treatment induced more coupling and apoptosis, while CBX partly inhibited the opening of gap junctions and improved the cell viability. These results suggest that cerebral ischemia enhances the opening of gap junctions. Blocking the gap junction with CBX may attenuate the brain injury after cerebral ischemia/reperfusion by partially contributing to amelioration of the oxidative stress and apoptosis.

关键词： gap junction communication cerebralischemia reactive oxygen species

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Constraints on holographic QCD phase transitions from PTA observations

引用

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： Song He Li Li Sai wang shao-Jiang wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

基于动态模式分解的离心压缩机动态流场分析

引用

热能动力工程 2018年第5期33卷 55-62页

作者：邵昱昌王彤上海交通大学机械与动力工程学院

动静流道相互作用引起的非定常流动是离心式压缩机内流的主要特征,借助模态分解方法可以有效提取出该流场中相干结构,进而可以说明该动静干涉流场的主要特征。本文将动态模式分解（Dynamic Mode Decomposition,DMD）方法应用于带无叶扩... 详细信息

动静流道相互作用引起的非定常流动是离心式压缩机内流的主要特征,借助模态分解方法可以有效提取出该流场中相干结构,进而可以说明该动静干涉流场的主要特征。本文将动态模式分解（Dynamic Mode Decomposition,DMD）方法应用于带无叶扩压器通道的离心式压缩机流场分析中,通过对动静干涉速度场和压力场的模态提取和分析,直观揭示出动静流道中的流体运动特征。在设计流量工况下,叶轮出口叶顶间隙的流体流动和动静流道干涉效应影响了叶轮出口的速度参数和压力参数的分布。在叶轮和扩压器流道中分别出现了频率1 715和725Hz的湍流相干结构,两频率和叶轮通过频率有关。动静干涉流道中压力沿叶高方向动态规律相似,而速度场沿叶高方向波动规律存在一定的差异。该特征可以为压缩机流场测试提供参考。

关键词：离心式压缩机动静干涉流动动态模式分解

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

试论中国外贸增长方式的转变

引用

国际经贸探索 2006年第5期22卷 4-8页

作者：邵望予上海对外贸易学院WTO研究中心上海200031

入世以来,我国对外贸易快速增长,但以劳动密集型产品的粗放型出口方式为主,产品缺乏专有技术和自主品牌,相互低价竞争,招致频繁的贸易摩擦。为使我国对外贸易持续发展,应转变增长方式,加强知识产权保护,以激励自主创新,大力发展服务贸易... 详细信息

入世以来,我国对外贸易快速增长,但以劳动密集型产品的粗放型出口方式为主,产品缺乏专有技术和自主品牌,相互低价竞争,招致频繁的贸易摩擦。为使我国对外贸易持续发展,应转变增长方式,加强知识产权保护,以激励自主创新,大力发展服务贸易,加强区域经济合作,使国际市场多元化;提高利用外资质量,鼓励有条件的企业“走出去”;扩大内需,争取保持进出口基本平衡。

关键词：自主创新贸易摩擦 FTA 扩大内需

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

论中国纺织贸易摩擦与对策

引用

国际经贸探索 2006年第2期22卷 4-8页

作者：邵望予上海对外贸易学院上海200031

为使我国纺织业能持续发展,纺织企业应促进产品结构优化升级,注重创新,实施品牌和市场多元化战略,在经营上还应国内外市场并重,有条件的企业可到境外去投资设厂。同时,政府在宏观政策上,应加强对纺织业的监督管理,完善相关的法律法规,... 详细信息

为使我国纺织业能持续发展,纺织企业应促进产品结构优化升级,注重创新,实施品牌和市场多元化战略,在经营上还应国内外市场并重,有条件的企业可到境外去投资设厂。同时,政府在宏观政策上,应加强对纺织业的监督管理,完善相关的法律法规,引导企业有序经营,大力制止恶性竞争;并加快政府职能转变,积极支持行业商协会强化自律机制,以充分发挥行业的协调和咨询作用。

关键词：后配额时代贸易摩擦 ATC

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Computed tomography enterography-based radiomics for assessing mucosal healing in patients with small bowel Crohn's disease

引用

World Journal of Gastroenterology 2025年第3期31卷 62-72页

作者： Hao Ding yuan-yuan Fang Wen-Jie Fan Chen-yu Zhang shao-Fei wang Jing Hu Wei Han Qiao Mei Department of Gastroenterology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Radiation Oncology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Gastroenterology Suzhou First People's HospitalSuzhou 234099Anhui ProvinceChina

BACKGROUND Mucosal healing(MH)is the major therapeutic target for Crohn's disease(CD).As the most commonly involved intestinal segment,small bowel(SB)assessment is crucial for CD ***,it poses a significant challenge due to its limited accessibility through conventional endoscopic *** To establish a noninvasive radiomic model based on computed tomography enterography(CTE)for MH assessment in SBCD *** Seventy-three patients diagnosed with SBCD were included and divided into a training cohort(n=55)and a test cohort(n=18).Radiomic features were obtained from CTE images to establish a radiomic *** demographics were analysed to establish a clinical model.A radiomic-clinical nomogram was constructed by combining significant clinical and radiomic *** diagnostic efficacy and clinical benefit were evaluated via receiver operating characteristic(ROC)curve analysis and decision curve analysis(DCA),*** Of the 73 patients enrolled,25 patients achieved *** radiomic-clinical nomogram had an area under the ROC curve of 0.961(95%confidence interval:0.886-1.000)in the training cohort and 0.958(0.877-1.000)in the test cohort and provided superior clinical benefit to either the clinical or radiomic models alone,as demonstrated by *** These results indicate that the CTE-based radiomic-clinical nomogram is a promising imaging biomarker for MH and serves as a potential noninvasive alternative to enteroscopy for MH assessment in SBCD patients.

关键词： Crohn’s disease Computed tomography enterography Mucosal healing Nomogram Radiomics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Relationship between cytokines gene polymorphism and susceptibility to hepatitis B virus intrauterine infection

引用

Chinese Medical Journal 2005年第19期118卷 1604-1609页

作者： ZHU Qi-rong GE Yan-ling GU shao-qing yu Hui wang Jian-she GU Xin-huan FEI Lin-e DONG Zuo-quan Department of Infection Disease Children＇s Hospital FudanUniversity Shanghai 200032 China

Background The influences of genomic background are confirmed in more diseases. Immunologic tolerance after intrauterine infection of hepatitis B virus is considered to occur in T cells. Cytokines work effectively in eliminating virus by immune system after hepatitis B virus infection. To explore the relationship between cytokines （tumor necrosis factor-α, interferon-γ, interleukin-4 and interleukin-10）, which expressed abnormal quantity in the peripheral blood to intrauterine hepatitis B virus infectious children, gene single nucleotide polymorphism （SNP） and susceptibility to hepatitis B virus intrauterine infection. Methods This is a cross sectional study of molecular clinical epidemiology. The subjects in this study were selected from outpatients of hepatitis B vaccine follow-up special clinics of our hospital in the period. According to intrant criteria, the high risk children of hepatitis B virus （HBV） intrauterine infection were divided into immune failure group （group Ⅰ） ; and immune effective group （group Ⅱ） and non high risk children belonged to the control group. Four gene SNP sites of TNF-α -238, IFN-γ ＋874, IL-4 -590 and IL-10 -1082 were determined by real-time quantitative fluorescent polymerase chain reaction （PCR）. Results The significant differences of TNF-α- 238 A allele frequency were found between group Ⅰand group Ⅱ（X^2 =6. 797, P 〈 0.05 ） and between group Ⅰ and the control group （ X^2 = 9. 513, P 〈 0.05 ）. No evident differences of TNF-α- 238 A were found between group Ⅱand control group （ X^2 = 0. 047, P 〉 0. 05 ） ; the significant differences of IFN-γ ＋ 874 A allele frequency were found between group Ⅰand group Ⅱ（ X^2 = 7. 238, P〈0. 05）, and between group Ⅰand the control group （X^2 =5. 199,P 〈0. 05）. No evident differences were found between groupⅡ and the control group （ X^2 =0. 602 ,P 〉0. 05 ） ; the significant differences of IL-4 -590 C/T allele frequency were not found between groupⅠand group Ⅱ （ X^2 = 0. 632, P 〉 0. 05 ） , also group Ⅰ

关键词： cytokine gene polymorphism hepatitis B virus infection uterus susceptibility

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Relationship between cytokines gene polymorphism and susceptibility to hepatitis B virus intrauterine infection

引用

中华医学杂志(英文版) 2005年第19期000卷 22-27页

作者： ZHU Qi-rong, GE Yan-ling, GU shao-qing, yu Hui, wang Jian-she, GU Xin-huan, FEI Lin-e and DONG Zuo-quan Department of Infection Disease, Children’s Hospital, Fudan University, Shanghai 200032, China Department of Infection Disease Children's Hospital Fudan University Shanghai 200032 China

One of the major reasons for high prevalence of hepatitis B virus (HBV) in China is the mother transmit the HBV to the infant during the intrauterine and perinatal period. There are 50% HBV carriers arising from the mother to infant transmission.~ 1-3 During the period of intrauterine or perinatal HBV infection, patients can be in long immunologic tolerance stage with high level of viremia (high load of HBV DNA) and high titer of HBeAg; alanine aminotransferase (ALT) and/or aspartate amino-transferase (AST) can be persistent normal or mild abnormally; liver histology will be normal or mild changing; being not sensitive to antiviral therapy.~ 4,5 So interruption of mother to infant transmission of HBV in intrauterine and perinatal period is an important part of prevention hepatitis B (HB) in our country.~ 6,7 The researches for immune tolerance of HBV intrauterine infection showed that T cell level and humoral immunity level of host decreased, due to the reduced secretion of T helper type 1 (Th1) and T helper type 2 (Th2) cytokines and lacking of effective modulation.~ 8,9 In recent years, people have recognized that many uncongenial diseases have genetic background. This contributes to explaining the difference of susceptibility, course, effect on therapy and prognosis of some diseases in different persons and masses.

关键词： cytokine · gene polymorphism · hepatitis B virus · infection uterus · susceptibility

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：