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Journal of Materials Science & Technology 2017年第12期33卷 1582-1595页

作者： shao-shi rui Yi-Bo Shang Wenhui Qiu Li-Sha Niu Hui-Ji shi Shunsaku Matsumoto Yasuharu Chuman Applied Mechanics Laboratory School of Aerospace EngineeringTsinghua UniversityBeijing 100084China Residential Air Conditioning Division MIDEAFoshan528311China Strength Research Department Research&Innovation CenterMitsubishi Heavy IndustriesLtd.Nagasaki 851-0392Japan

The fracture modes of low alloy steels and cast irons under tensile and fatigue conditions were identified by electron back-scattered diffraction（EBSD） misorientation analysis in this research. The curves of grain reference orientation deviation（GROD） distribution perpendicular to the fracture surface were obtained by EBSD observation, and the characteristics of each fracture mode were identified. The GROD value of the specimen fractured in tension decreases to a constant related to the elongation of corresponding specimen in the far field（farther than 5 mm away from the fracture surface）. The peak exhibits in GROD curves of two smooth specimens and a notched specimen near the fracture surface（within 5 mm away from the fracture surface）, and the formation mechanisms were discussed in detail based on the influences of specimen geometries（smooth or notched） and material toughness. The GROD value of fatigue fractured specimen is close to that at undeformed condition in the whole field, except the small area near the crack path. The loading conditions（constant stress amplitude loading or constant stress intensity factor range K loading） and the EBSD striation formation during fatigue crack propagation were also studied by EBSD observation parallel to the crack path.

关键词： Fracture mode identification Low alloy steels Cast irons Electron back-scattered diffraction (EBSD) Misorientation

Oxidation damage and interfacial failure of dissimilar metal welds containing ferritic heat resistant steels

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Journal of Iron and Steel Research International 2021年第11期28卷 1439-1450页

作者： Xiao-gang Li Zhi-peng Cai Xin Chen Shu-qing Dong Wen-he Cai Yu Zhang Shan-lin Li Ke-jian Li shao-shi rui Ji-luan Pan Department of Mechanical Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Ministry of EducationBeijing 100084China State Key Laboratory of Tribology Tsinghua UniversityBeijing 100084China Collaborative Innovation Center of Advanced Nuclear Energy Technology Tsinghua UniversityBeijing 100084China China Datang Corporation Science and Technological Research Institute Thermal Power Technology Research InstituteBeijing 100040China

The ex-service steam tubes containing dissimilar metal weld(DMW)between high Cr ferritic steel T91 and austenitic stainless steel TP347H and the ex-service steam tubes containing DMW between low Cr ferritic steel G102 and austenitic stainless steel TP347H were obtained from coal-fired thermal power plants in China,and their microstructures at the nickel-based weld metal(WM)/ferritic steel interfaces and oxidation characteristics were *** operating for 15,000 h at steam temperature of 541 C and steam pressure of 17.5 MPa,a G102/TP347H DMW failed along the WM/G102 steel interface,which was a dangerous premature failure mode without obvious plastic *** interfacial failure was attributed to the interaction between oxidation and cracking along the interface,where fracture appeared to be related with the strain concentration at the *** notch along the WM/G102 steel interface was the precursor of premature interfacial failure of DMW involving *** the DMW involving high Cr ferritic steel T91,ferritic steel side could form a Cr-rich passive film during service and thus would not be further oxidized after operating for 67,000 h at steam temperature of 541 C and steam pressure of 3.5 *** was concluded that oxidation played a more important role in failure of these DMWs,and retarding the development of oxidation and avoiding the interfacial oxide notch would dramatically improve the service performance of steam tubes containing DMWs.

关键词： Dissimilar metal weld Ferritic heat resistant steel Nickel-based weld metal Oxidation Interfacial failure High-temperature service

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一种新型Ku波段龙伯透镜反射器

微波学报 2015年第5期31卷 73-76页

作者：史绍蕊吴昱明于浩杨帅吴群哈尔滨工业大学电子与信息工程学院哈尔滨150001 北京理工大学北京毫米波与太赫兹技术重点实验室北京100000

与传统制造工艺相比,3D打印技术制造龙伯透镜加工简单,精度更高,成本更低。提出一种采用超材料单元构成的新型结构的龙伯透镜反射器。通过改变单元结构的尺寸,设置梯度折射率趋于连续变化,借助电磁场三维仿真软件CST对单元结构进行仿真... 详细信息

与传统制造工艺相比,3D打印技术制造龙伯透镜加工简单,精度更高,成本更低。提出一种采用超材料单元构成的新型结构的龙伯透镜反射器。通过改变单元结构的尺寸,设置梯度折射率趋于连续变化,借助电磁场三维仿真软件CST对单元结构进行仿真,利用等效媒质理论进行计算,从而得到单元结构的有效介电常数。仿真结果表明,透镜直径仅仅为75mm时的反射器就可实现-1.49d Bm2量级的RCS,并且具有宽角响应。

关键词：龙伯透镜反射器梯度折率人工电磁材料

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唾液皮质醇对库欣综合征的诊断价值探讨

四川大学学报（医学版） 2009年第2期40卷 298-301页

作者：施绍瑞干伟邹茜婷熊中云安振梅四川大学华西医院实验医学科激素检测室成都610041

目的评价唾液皮质醇(SC)与血皮质醇(PTC)的相关性,探讨SC筛查库欣综合征的价值。方法以18例经病理证实的库欣综合征患者作为疾病组,13例单纯性肥胖患者作为疾病对照组,36例健康志愿者作为正常对照组,收集8∶00、16∶00、24∶00及1 mg地... 详细信息

目的评价唾液皮质醇(SC)与血皮质醇(PTC)的相关性,探讨SC筛查库欣综合征的价值。方法以18例经病理证实的库欣综合征患者作为疾病组,13例单纯性肥胖患者作为疾病对照组,36例健康志愿者作为正常对照组,收集8∶00、16∶00、24∶00及1 mg地塞米松过夜抑制试验(DST)后次日8∶00的血液和唾液,收集24 h尿液并记录尿量。用电化学发光法检测唾液、血液和尿游离皮质醇(24 h UFC)浓度。结果SC与PTC在4个时间点呈显著直线相关,相关系数r值依次为0.71、0.74、0.78、0.71,总的相关系数r=0.73,P均<0.05;SC与24 h UFC在4个时间点也呈显著正相关(r值分别为0.75、0.70、0.76和0.58),库欣综合征组的午夜SC均值明显高于正常对照组和单纯性肥胖组(P<0.001);8∶00 SC以6.21 nmol/L作为临界值,筛查库欣综合征的灵敏度为100%,特异性为84.0%;若以8.33 nmol/L作为临界值,筛查库欣综合征的灵敏度为62.5%,特异性为100%;午夜24∶00 SC以2.80 nmol/L作为临界值,筛查库欣综合征的灵敏度为100%,特异性为93.9%;若以4.56 nmol/L作为临界值,筛查库欣综合征的灵敏度为93.8%,特异性为100%。结论SC与PTC及24 h UFC具有较好的相关性,午夜24∶00 SC是一种简单方便且无创的库欣综合征筛查指标,具有较高的灵敏度和特异性。

关键词：唾液皮质醇库欣综合征电化学发光测定法

47,XXX综合征患者孕育正常胎儿的细胞遗传学探讨

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中国优生与遗传杂志 2018年第2期26卷 57-58,F0003页

作者：张林琳施绍瑞宜宾市第二人民医院检验科遗传室四川宜宾644000

目的探讨47,XXX综合征患者孕育正常胎儿的细胞遗传学机制。方法应用外周血淋巴细胞培养染色体核型分析技术确定患者的染色体核型,应用羊水细胞培养染色体核型分析技术确定患者胎儿的染色体核型。结果 47,XXX综合征患者孕育的胎儿染色体... 详细信息

目的探讨47,XXX综合征患者孕育正常胎儿的细胞遗传学机制。方法应用外周血淋巴细胞培养染色体核型分析技术确定患者的染色体核型,应用羊水细胞培养染色体核型分析技术确定患者胎儿的染色体核型。结果 47,XXX综合征患者孕育的胎儿染色体核型为46,XY。结论 47,XXX综合征患者可以孕育染色体核型正常的胎儿,但必须进行产前诊断。

关键词： 47,XXX综合征性染色体非整倍体细胞培养核型分析

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三倍体综合征的临床分析及产前诊断探讨

中国优生与遗传杂志 2018年第1期26卷 43-44,F0003页

作者：张林琳施绍瑞宜宾市第二人民医院检验科遗传室四川宜宾644000

目的了解三倍体综合征的临床特点,并探讨三倍体综合征的临床诊断。方法采用羊水细胞培养染色体核型分析技术确定孕妇胎儿的染色体核型。结果 1例孕中期彩超示多发畸形的胎儿羊水染色体核型分析结果为69,XXX。结论细胞遗传学染色体核型... 详细信息

目的了解三倍体综合征的临床特点,并探讨三倍体综合征的临床诊断。方法采用羊水细胞培养染色体核型分析技术确定孕妇胎儿的染色体核型。结果 1例孕中期彩超示多发畸形的胎儿羊水染色体核型分析结果为69,XXX。结论细胞遗传学染色体核型分析技术可确诊三倍体综合征。

关键词：三倍体综合征双雄受精双雌受精细胞遗传学产前诊断

电化学发光免疫分析法检测人胰岛素原方法的建立

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中华检验医学杂志 2009年第9期32卷 1015-1018页

作者：张玫施绍瑞张林熊中云黄明洁安振梅四川大学华西医院实验医学科激素检测室成都610041

目的建立一种快速、特异、灵敏的检测人胰岛素原（PI）电化学发光免疫分析法（ECLIA）。方法用链霉亲和素包被的微粒、生物素化的抗胰岛素单克隆抗体、钌标记的抗C肽单克隆抗体组成PIECLIA试剂盒，并对其准确性、灵敏度、特异性等效能... 详细信息

目的建立一种快速、特异、灵敏的检测人胰岛素原（PI）电化学发光免疫分析法（ECLIA）。方法用链霉亲和素包被的微粒、生物素化的抗胰岛素单克隆抗体、钌标记的抗C肽单克隆抗体组成PIECLIA试剂盒，并对其准确性、灵敏度、特异性等效能进行方法学评价，同时用所建方法与放射免疫分析法（mA）检测和对比分析44例2型糖尿病患者和60名健康志愿者PT水平。结果用自建ECLIA检测PI的平均回收率为103．8％。检测低限为0．38pmol／L，生物检测限在0．25—0．5pmol／L之间，功能灵敏度为0．5pmol／L，与500μU／ml胰岛素和450ng／ml C肽无交叉反应，总不精密度小于5．0％，分析测量范围为2．22—169．68pmol／L；与IliA比较，相关性好（r=0．967，P=0．000），自建ECLIA检测Pl的95％参考区间为1．07—15．54pmol／L，ECLIA检测人PI时间（18min）比RIA方法短（72h）。临床检测结果显示，2型糖尿病患者血清空腹PI[6．72（3．61～11．92）pmo]／L]高于健康对照组[5．72（2．65～8．74）pmol／L，Z=-2．023，P〈0．05]。结论自建ECLIA检测PI法特异性高，灵敏度好，检测速度快，无放射性污染，在诊断2型糖尿病中有较好的应用价值。

关键词：胰岛素原电化学发光免疫测定

Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

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两兄弟双侧男性乳房发育病例分析及病因探讨

中国优生与遗传杂志 2020年第10期28卷 1202-1204,1220页

作者：张林琳施绍瑞代云才宜宾市第二人民医院检验科遗传室四川宜宾644000

目的探讨临床表现相似的两兄弟双侧男性乳房发育的不同病因及其发病机制。方法乳腺彩超、性腺激素全套检查等可辅助诊断,可为鉴别诊断提供重要依据,而外周血淋巴细胞培养染色体核型分析技术可确定患者的染色体核型,可明确诊断。结果患... 详细信息

目的探讨临床表现相似的两兄弟双侧男性乳房发育的不同病因及其发病机制。方法乳腺彩超、性腺激素全套检查等可辅助诊断,可为鉴别诊断提供重要依据,而外周血淋巴细胞培养染色体核型分析技术可确定患者的染色体核型,可明确诊断。结果患者之一的哥哥,乳腺彩超检查异常,性激素水平异常,其外周血染色体核型分析结果为47,XXY;患者之一的弟弟,乳腺彩超检查异常,性激素水平异常,其外周血染色体核型分析结果为46,XY。结论哥哥可以明确诊断系克氏综合征导致的双侧男性乳房发育,而弟弟病因尚不明确,尚需进一步检查以明确诊断。

关键词：双侧男性乳房发育克氏综合征染色体核型分析乳腺彩超性激素检查

46,XY女性性反转综合征的细胞遗传学诊断

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中国优生与遗传杂志 2015年第11期23卷 60-61页

作者：张林琳代云才施绍瑞宜宾市第二人民医院检验科遗传室四川宜宾644000

目的探讨46,XY女性性反转综合征及人类的性别决定与性别分化的细胞遗传学诊断。方法外周血淋巴细胞培养染色体核型分析技术和荧光原位杂交(FISH)技术确定患者的染色体核型。结果 1名社会性别为女性的外周血染色体核型分析结果为:46,XY... 详细信息

目的探讨46,XY女性性反转综合征及人类的性别决定与性别分化的细胞遗传学诊断。方法外周血淋巴细胞培养染色体核型分析技术和荧光原位杂交(FISH)技术确定患者的染色体核型。结果 1名社会性别为女性的外周血染色体核型分析结果为:46,XY。结论细胞遗传学染色体核型分析技术和FISH技术均可确诊46,XY女性性反转综合征—染色体性别与性腺性别不相符。

关键词： 46,XY女性性反转综合征核型分析 FISH技术