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Tumor therapy by fast moving magnetic nanoparticle under low-frequency alternating magnetic field

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Journal of Innovative Optical Health Sciences 2015年第2期8卷 52-60页

作者： Yangyang Liu Zhiyu qian Jianhua yin Xiao Wang Department of Biomedical Engineering Nanjing University of Aeronautics and Astronautics Nanjing P.R.China

Magnetic nanoparticle plays an important role in biomedical engineering,especially in tumor *** this paper,a new technique has been developed by using the rapid moving magnetic nanoparticle under a low-fequency alternating magnetic field(LFAMF)to kill tumor *** LFAMF system which was used to drive magnetic nanoparticles(MNPs)was setup with the magnetic field frequency and power range at心10-100Hz and~10-200 mT,*** the experiment,the LFAMF was adjusted at different frequencies and power *** exper-imental results show that the liver tumnor cells(HepG2)mixed with MNPs(10 pug/mL)becamne partial fragments when exposed in the LFAMF with different frequencies(~10-100Hz)and power(~10200 mT),and the higher the frequency or the power,the more the tumor cells were killed at the same magnetic nanoparticle ***:Tumor oells were effectively damaged by MNPs under LFAMF,which suggests that they had great potential to be applied in tumor therapy.

关键词： Different frequency cells power cancer

Breakthrough Innovation Evolution Model Based on Chaos Theory

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Wuhan University Journal of Natural Sciences 2020年第1期25卷 19-26页

作者： yin Junjie shao Yunfei WANG Simeng Civil Aviation Flight University of China Guanghan 618307SichuanChina School of Management and Economics University of Electronic Science and Technology of ChinaChengdu 611731SichuanChina

Breakthrough innovation is seen as a leading technology and industrial development direction, by which enterprises obtain the key for winning sustainable competitive advantage. In this paper, a chaos model is developed to examine how the breakthrough innovation evolves with the changed external environment ability and internal power. Numerical simulations based on chaos theory illustrate that the breakthrough innovation leads to chaos through the period-doubling bifurcation, and the chaos is the result of nonlinear interaction which is a qualitative change in the process between internal dynamics and external factors. The general conditions in which the breakthrough innovation comes to chaos instead of being in good order are gotten. The results show that the breakthrough innovation has chaotic characteristics and has a very sensitive dependence on the initial conditions in the process of running. The chaotic evolution can reflect the nonlinear character of the breakthrough innovation development and it can provide theoretical guidance for the application of chaos and chaotic control of innovation management.

关键词： breakthrough innovation chaos theory evolution model

Numerical Study of Parachute-Payload Land Site Distribution with Randomize Wind Gust Model

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Transactions of Nanjing University of Aeronautics and Astronautics 2018年第2期35卷 383-394页

作者： Tang Jianhua qian Linfang yin qiang Jiang Li School of Mechanical Engineering Wuyi UniversityJiangmen 529020 P. R. China School of Mechanical Engineering Nanjing University of Science and Technology Nanjing 210094 P.R. China

A parachute-payload model with randomize wind gust is developed to study the landing accuracy of the parachute decelerator system,which can be exactly described by the landing site *** research focuses on the steady descent phase of the parachute descent process,so the parachute and the payload suspension formulation during the phase are mainly *** addition,since the wind effects have a significant impact on the land site distribution of the passive decelerator system and it is difficult to obtain the exact wind profile in practice,major features of parachute-payload system are studied via the randomized wind gust *** the randomized wind gust formulation is adopted,the wind effect can be considered without the exact wind gust profile and the parachute aerodynamic simulation can be fulfilled with ***,the model is validated and discussed,and the parachute land site distributions with different wind randomize profiles are presented for *** results show that when parachute is less stable,the land site tends to have a larger variance.

关键词： parachute decelerator system wind profile Monte Carlo land site distribution

Highly ordered arrangement of meso-tetrakis(4-aminophenyl)porphyrin in self-assembled nanoaggregates via hydrogen bonding

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Chinese Chemical Letters 2014年第5期25卷 752-756页

作者： Qing-Yun Liu Qing-Yan Jia Ji-Qin Zhu qian shao Jun-Feng Fan Dong-Mei Wang Yan-Sheng yin College of Chemistry and Chemical Engineering Ocean University of China College of Chemical and Environmental Engineering Shandong University of Science and Technology Institute of Marine Materials Science and Engineering Shanghai Maritime University

meso-Tetrakis（4-aminophenyl）porphyrin（TAPP） can self-assemble into nanostructures with different morphologies by a phase-transfer *** morphologies（nanospheres,nanorods and nanothorns）of porphyrin nanoaggregates could be easily tuned just by changing the concentration of porphyrin in a proper solvent at room *** images revealed the formation of highly ordered supramolecular arrays of TAPP,i.e. superlattice of TAPP molecules in nanoaggregates,which agreed well with the size of one molecule of ***–vis absorption spectra showed an obvious red shift of the Soret band of TAPP,indicating the formation of J-aggregates of TAPP in nanoaggregates.

关键词： Porphyrin Self-assembly Nanoaggregates Highly ordered Hydrogen bonding

Experiment on a Double-Foot Stepping Piezoelectric Linear Motor

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Transactions of Nanjing University of Aeronautics and Astronautics 2018年第3期35卷 423-431页

作者： Sun Mengxin Huang Weiqing Wang yin Lu qian State Key Laboratory of Mechanics and Control of Mechanical Structures College of Aerospace EngineeringNanjing University of Aeronautics and Astronautics School of Mechanical and Electric Engineering Guangzhou University Center for Precision Measurement Technologies and Instruments Huaqiao University

A novel double-foot piezoelectric linear motor is *** kinematic model of the motor under stepping motion is *** motor mainly consists of a stator with four piezoelectric stacks,a mover,a holding mechanism,and a preloading mechanism to achieve large stroke with high *** element simulations are carried out to analyze the motion characteristics of the motor.A prototype is fabricated and a serial experiments are conducted to validate the feasibility of the motor *** results indicate that the motor can move at a speed of 670.22μm/s with a driving frequency of 120 Hz and a voltage of 120 *** resolution of the proposed motor is 3.6μm while the resolution of the single-step motion is 0.1μm.

关键词： piezoelectric linear motor piezoelectric stack performance test

On the Physical Processes in Contact Binary Systems

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Chinese Journal of Astronomy and Astrophysics 2007年第2期7卷 235-244页

作者： Run-qian Huang Han-Feng Song shao-Lan Bi National Astronomical Observatories/Yunnan Observatory Chinese Academy of Sciences Kunming 650011 Graduate University of Chinese Academy of Sciences Beijing 100049

Three important physical processes occurring in contact binary systems are studied. The first one is the effect of spin, orbital rotation and tide on the structure of the components, which includes also the effect of meridian circulation on the mixing of the chemical elements in the components. The second one is the mass and energy exchange between the components. To describe the energy exchange, a new approach is introduced based on the understanding that the exchange is due to the release of the potential, kinetic and thermal energy of the exchanged mass. The third is the loss of mass and angular momentum through the outer Lagrangian point. The rate of mass loss and the angular momentum carded away by the lost mass are discussed. To show the effects of these processes, we follow the evolution of a binary system consisting of a 12M⊙ and a 5M⊙ star with mass exchange between the components and mass loss via the outer Lagrangian point, both with and without considering the effects of rotation and tide. The result shows that the effect of rotation and tide advances the start of the semi-detached and the contact phases, and delays the end of the hydrogen-burning phase of the primary. Furthermore, it can change not only the occurrence of mass and angular momentum loss via the outer Lagrangian point, but also the contact or semi-contact status of the system. Thus, this effect can result in the special phenomenon of short-term variations occurring over a slow increase of the orbital period. The occurrence of mass and angular momentum loss via the outer Lagrangian point can affect the orbital period of the system significantly, but this process can be influenced, even suppressed out by the effect of rotation and tide. The mass and energy exchange occurs in the common envelope. The net result of the mass exchange process is a mass transfer from the primary to the secondary during the whole contact phase.

关键词： stars binaries general - stars mass-loss - stars evolution

High-concentration sevoflurane exposure in mid-gestation induces apoptosis of neural stem cells in rat offspring

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Neural Regeneration Research 2018年第9期13卷 1575-1584页

作者： Yuan Wang shao-Wei yin Nan Zhang Ping Zhao Department of Anesthesiology Shengjing Hospital of China Medical University Department of Obstetrics Shengjing Hospital of China Medical University Department of Neuroendocrine Pharmacology School of PharmacyChina Medical University

Sevoflurane is the most commonly used volatile anesthetic during *** viability of neural stem cells directly affects the development of the ***,it is unknown whether the use of sevoflurane during the second trimester affects the survival of fetal neural stem ***,in this study,we investigated whether exposure to sevoflurane in mid-gestation induces apoptosis of neural stem cells and behavioral *** gestational day 14,pregnant rats were anesthetized with 2% or 3.5% sevoflurane for 2 *** offspring were weaned at 28 days and subjected to the Morris water maze *** brains were harvested to examine neural stem cell apoptosis by immunofluorescence and to measure Nestin and SOX-2 levels by western blot assay at 6,24 and 48 hours after anesthesia as well as on postnatal day（P） 0,14 and *** endothelial growth factor（VEGF） and phosphoinositide 3-kinase（PI3 K）/AKT pathway protein levels in fetal brain at 6 hours after anesthesia were assessed by western blot *** to high-concentration（3.5%） sevoflurane during mid-gestation increased escape latency and path length to the platform,and it reduced the average duration spent in the target quadrant and platform crossing *** 6,24 and 48 hours after anesthesia and at P0,P14 and P28,the percentage of Nestin/terminal deoxynucleotidyl transferase d UTP nick end labeling（TUNEL）-positive cells was increased,but Nestin and SOX-2 protein levels were decreased in the hippocampus of the *** 6 hours after anesthesia,VEGF,PI3 K and phospho-AKT（p-AKT） levels were decreased in the fetal *** changes were not observed in animals given low-concentration（2%） sevoflurane ***,our findings indicate that exposure to a high concentration of sevoflurane（3.5%） in mid-gestation decreases VEGF,PI3 K and p-AKT protein levels and induces neural stem cell apoptosis,thereby causing learning and memory dysfunction in the offspring.

关键词： nerve regeneration sevoflurane neural stem cells apoptosis vascular endothelial growth factor PI3K p-AKT anesthesia learning memory developmental neurobiology neural regeneration

Structure-based design,synthesis of novel probes for cytochrome P450 OleT

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Chinese Chemical Letters 2021年第4期32卷 1466-1469页

作者： Dumei Ma Libo Zhang yingwu yin qian Wang Department of Chemical and Biochemical Engineering College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Department of Chemistry and Biochemistry University of South CarolinaColumbiaSC 29208United States

Cytochrome P450 OleT_(SA),a new cytochrome P450 enzyme from Staphylococcus aureus,catalyzes the oxidative decarboxylation and hydroxylation of fatty acids to generate terminal alkenes and fatty *** mechanism of this bifurcative chemistry remains largely ***,a class of derivatized fatty acids were synthesized as probes to investigate the effects of substrate structure on the product type of P450 OleT_(SA).The results demonstrate that the fine-tuned structure of substrates,even in a remote distance from the carboxyl group,significantly regulates OleT catalyzed decarboxylation/hydroxylation *** docking analysis indicated the potential interactions between the carboxylate groups of different probes and the enzyme active center which was attributed to the bifurcative chemistry.

关键词： Substrate engineering Cytochrome P450 OleT Decarboxylation Hydroxylation Fatty acid derivatives

Signaling pathways in the regulation of cytokine release syndrome in human diseases and intervention therapy

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Signal Transduction and Targeted Therapy 2021年第11期6卷 3230-3245页

作者： Xia Li Mi shao Xiangjun Zeng Pengxu qian He Huang Bone Marrow Transplantation Center The First Affiliated HospitalZhejiang University School of MedicineHangzhouPeople’s Republic of China Liangzhu Laboratory Zhejiang University Medical Center1369 West Wenyi RoadHangzhou311121People’s Republic of China Institute of Hematology Zhejiang UniversityHangzhouZhejiangPeople’s Republic of China Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy HangzhouZhejiangPeople’s Republic of China Center of Stem Cell and Regenerative Medicine Zhejiang University School of MedicineHangzhouPeople’s Republic of China

Cytokine release syndrome(CRS)embodies a mixture of clinical manifestations,including elevated circulating cytokine levels,acute systemic inflammatory symptoms and secondary organ dysfunction,which was first described in the context of acute graft-versus-host disease after allogeneic hematopoietic stem-cell transplantation and was later observed in pandemics of influenza,SARS-CoV and COVID-19,immunotherapy of tumor,after chimeric antigen receptor T(CAR-T)therapy,and in monogenic disorders and autoimmune ***,severe CRS is a very significant and life-threatening complication,which is clinically characterized by persistent high fever,hyperinflammation,and severe organ ***,CRS is a double-edged sword,which may be both helpful in controlling tumors/viruses/infections and harmful to the *** a high incidence and high levels of cytokines are features of CRS,the detailed kinetics and specific mechanisms of CRS in human diseases and intervention therapy remain *** the present review,we have summarized the most recent advances related to the clinical features and management of CRS as well as cutting-edge technologies to elucidate the mechanisms of *** that CRS is the major adverse event in human diseases and intervention therapy,our review delineates the characteristics,kinetics,signaling pathways,and potential mechanisms of CRS,which shows its clinical relevance for achieving both favorable efficacy and low toxicity.

关键词： cytokine release kinetics