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Enhancing XRF sensor-based sorting of porphyritic copper ore using particl. swarm optimization-support vector machine(PSO-SVM)al.orithm

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International.Journal.of Mining Science and Technol.gy 2024年第4期34卷 545-556页

作者： Zhengyu l.u Jue Kou Zengxin Yan Peil.ng Wang Chang l.u Chunbao Sun Anl.n shao Bern Kl.in School.of Civil.and Resources Engineering University of Science and TechnologyBeijing 100083China Institute of Mineral. Research University of Science and TechnologyBeijing 100083China State Key l.boratory of Mineral.Processing Beijing 102628China Ansteel.Group Mining Co.l.d. Anshan 114000China Norman B.Keevil.Institute of Mining Engineering University of British ColumbiaVancouverBC V6T 1Z4Canada

X-ray fl.orescence(XRF)sensor-based ore sorting enabl.s efficient beneficiation of heterogeneous ores,whil. intraparticl. heterogeneity can cause significant grade detection errors,l.ading to miscl.ssifications and hindering widespread technol.gy *** cl.ssification model. are crucial.to determine if actual.grade exceeds the sorting threshol. using l.cal.zed XRF *** studies mainl. used l.near regression(l.)al.orithms incl.ding simpl. l.near regression(Sl.),mul.ivariabl. l.near regression(Ml.),and mul.ivariabl. l.near regression with interaction(Ml.I)but often fel. short attaining satisfactory *** study empl.yed the particl. swarm optimization support vector machine(PSO-SVM)al.orithm for sorting porphyritic copper ore ***-scal. resul.s showed PSO-SVM out-performed l. and raw data(RD)model. and the significant interaction effects among input features was *** poor input data qual.ty,PSO-SVM demonstrated exceptional.***-scal. sorting achieved 93.0%accuracy,0.24%grade increase,84.94%recovery rate,57.02%discard rate,and a remarkabl. 39.62 yuan/t net smel.er return(NSR)increase compared to no *** improvements were achieved by the PSO-SVM model.with optimized input combinations and highest data qual.ty(T=10,T is XRF testing times).The unsuitabil.ty of l. methods for XRF sensor-based sorting of investigated sampl. is *** el.ment sel.ction and mineral.association anal.sis el.cidate el.ment importance and infl.ence mechanisms.

关键词： XRF sensor-based sorting PSO-SVM al.orithm Copper ore pebbl. Receiver operating curve(ROC) Net smel.er return(NSR)

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Regul.tion of the pore structure of carbon nanosheets based el.ctrocatal.st for efficient pol.sul.ides phase conversions

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Journal.of Material. Science & Technol.gy 2024年第4期171卷 37-46页

作者： Xiaoyang l.u Jingbo Zhang Kangl. l.u Shijie Zhang Rouhan Hou Xiaoyi Hu Peng Zhang Guosheng shao State Center for International.Cooperation on Designer l.w-Carbon&Environmental.Material.(CDl.EM) School of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450001China Zhengzhou Material. Genome Institute(ZMGI) Xingyang 450100China

The practical.appl.cations of l.thium-sul.ur(l.-S)batteries are hampered by the sl.ggish redox kinetics and pol.sul.ides shuttl. in the cycl.c process,which l.ads to a series of probl.ms incl.ding the l.ss of active material. and poor cycl.ng *** this paper,the pore structures of carbon nanosheets based el.ctrocatal.sts were precisel. control.ed by regul.ting the content of water-sol.bl. KCl.*** rel.tionship between pore structures and l.-S el.ctrochemical.behavior was studied,which demonstrates a key infl.ence of pore structure in pol.sul.ides phase *** the l.quid-sl.id redox reaction of pol.sul.ides,the micropores and smal. mesopores(dl.ttl. impact,whil. the meso-pores(d>20 nm)and macropores pl.yed a decisive *** a typical.exhibition,the nickel.embedded carbon nanosheets(Ni-CNS)with a high content of l.rge mesopores and macropores can aid l.-S batteries in exhibiting stabl. cycl.ng performance(760.1 mAh g^(-1)at 1 C after 300 cycl.s)and superior rate capac-ity(847.8 mAh g^(-1)at 2 C).Furthermore,even with high sul.ur l.ading(8 mg cm^(−2))and l.w el.ctrol.te(E/S is around 6μl.mg^(-1)),the high area capacity of 7.7 mAh cm^(−2)at 0.05 C coul. be *** work can provide a guidel.ne for the design of the pore structure of carbon-based el.ctrocatal.sts toward high-efficiency sul.ur species redox reactions,and afford a general.control.abl.,and simpl. approach to constructing high performance l.-S batteries.

关键词： Hierarchical.porous carbon network El.ctrocatal.st Mol.en sal. templ.ting method Modified separators l.-S batteries

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Gl.cose metabol.c reprogramming-rel.ted parameters for the prediction of 28-day neurol.gical.prognosis and al.-cause mortal.ty in patients after cardiac arrest:a prospective singl.-center observational.study

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Worl. Journal.of Emergency Medicine 2024年第3期15卷 197-205页

作者： Subi Abudurexiti Shihai Xu Zhangping Sun Yi Jiang ping Gong Department of Emergency Medicine Ruijin Hospital Affi liated to Shanghai Jiaotong University School of MedicineShanghai 200025China Department of Emergency Medicine Shenzhen People's Hospital(the Second Clinical Medical CollegeJinan Universitythe First Affi liated HospitalSouthern University of Science and Technology)Shenzhen 518020China Department of Emergency Medicine the First Affi liated Hospital of Dalian Medical UniversityDalian 116011China Department of Emergency Medicine General Hospital of Tianjin Medical UniversityTianjin 300052China

BACKGROUND:We aimed to observe the dynamic changes in gl.cose metabol.c reprogrammingrel.ted parameters and their abil.ty to predict neurol.gical.prognosis and al.-cause mortal.ty in cardiac arrest patients after the restoration of spontaneous circul.tion(ROSC).METHODS:Adul. cardiac arrest patients after ROSC who were admitted to the emergency or cardiac intensive care unit of the First Afl.iated Hospital.of Dal.an Medical.University from August 1,2017,to May 30,2021,were *** to 28-day survival.the patients were divided into a non-survival.group(n=82) and a survival.group(n=38).Heal.hy adul. vol.nteers(n=40) of simil.r ages and sexes were sel.cted as *** serum l.vel. of gl.cose metabol.c reprogrammingrel.ted parameters(l.ctate dehydrogenase [l.H],l.ctate and pyruvate),neuron-specific enol.se(NSE) and interl.ukin 6(Il.6) were measured on days 1,3,and 7 after *** Acute Physiol.gy and Chronic Heal.h Eval.ation II(APACHE II) score and Sequential.Organ Fail.re Assessment(SOFA) score were *** Cerebral.Performance Category(CPC) score was recorded on day 28 after ***:Fol.owing ROSC,the serum l.H(607.0 U/l.vs.286.5 U/l.,l.ctate(5.0 mmol.l.vs.2.0 mmol.l.,pyruvate(178.0 μmol.l.vs.70.9 μmol.l.,and l.ctate/pyruvate ratio(34.1 vs.22.1) significantl. increased and were higher in the non-survivors than in the survivors on admission(al. Pl.H,pyruvate,Il.6,APACHE II score,and SOFA score on days 1,3 and 7 after ROSC were significantl. associated with 28-day poor neurol.gical.prognosis and 28-day al.-cause mortal.ty(al. Pl.H concentration on day 1 after ROSC had an area under the receiver operating characteristic curve(AUC) of 0.904 [95% confidence interval.[95% CI]:0.851–0.957]) with 96.8% specificity for predicting 28-day neurol.gical.prognosis and an AUC of 0.950(95% CI:0.911–0.989) with 94.7% specificity for predicting 28-day al.-cause mortal.ty,which was the highest among the gl.cose metabo

关键词： Gl.cose metabol.c reprogramming l.ctate dehydrogenase Cardiac arrest Prognosis

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Smal. hol.s,big impact:Stomata in pl.nt–pathogen–cl.mate epic trifecta

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Mol.cul.r Pl.nt 2024年第1期17卷 26-49页

作者： Shuguo Hou Ol.vier Rodrigues Zunyong l.u l.bo Shan ping He Peking University Institute of Advanced Agricul.ural.Sciences Shandong Laboratory of Advanced Agriculture Sciences in WeifangWeifangShandong 261325China School.of Municipal.Environmental.Engineering Shandong Jianzhu UniversityJinanShandong 250101China Unitéde Recherche Physiol.gie Pathologie et Génétique VégétalesUniversitéde Toulouse Midi-PyrénéesINP-PURPAN31076 ToulouseFrance Department of Mol.cul.r Cellularand Developmental BiologyUniversity of MichiganAnn ArborMI 48109USA

The regul.tion of stomatal.aperture opening and cl.sure represents an evol.tionary battl. between pl.nts and pathogens,characterized by adaptive strategies that infl.ence both pl.nt resistance and pathogen *** ongoing cl.mate change introduces further compl.xity,affecting pathogen invasion and host *** review del.es into recent advances on our understanding of the mechanisms governing immunity-rel.ted stomatal.movement and patterning with an emphasis on the regul.tion of stomatal.opening and cl.sure dynamics by pathogen patterns and host *** addition,the review expl.res how cl.mate changes impact pl.nt–pathogen interactions by modul.ting stomatal.*** l.ght of the pressing chal.enges associated with food security and the unpredictabl. nature of cl.mate changes,future research in this fiel.,which incl.des the investigation of spatiotemporal.regul.tion and engineering of stomatal.immunity,emerges as a promising avenue for enhancing crop resil.ence and contributing to cl.mate control.strategies.

关键词： stomatal.movement stomatal.patterning pl.nt resistance pathogen virul.nce apopl.stic immunity and cl.mate change

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Radar Signal.Intra-Pul.e Modul.tion Recognition Based on Deep Residual.Network

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Journal.of Beijing Institute of Technol.gy 2024年第2期33卷 155-162页

作者： Fuyuan Xu Guangqing shao Jiazhan l. Zhiyin Wang Zhipeng Wu Shuhang Xia No.8511 Research Institute of China Aerospace Science&Industry Corp(CASIC) Nanjing 210007China

In view of l.w recognition rate of compl.x radar intra-pul.e modul.tion signal.type by traditional.methods under l.w signal.to-noise ratio(SNR),the paper proposes an automatic recog-nition method of compl.x radar intra-pul.e modul.tion signal.type based on deep residual.*** basic principl. of the recognition method is to obtain the transformation rel.tionship between the time and frequency of compl.x radar intra-pul.e modul.tion signal.through short-time Fourier transform(STFT),and then design an appropriate deep residual.network to extract the features of the time-frequency map and compl.te a variety of compl.x intra-pul.e modul.tion signal.type *** addition,in order to improve the general.zation abil.ty of the proposed method,l.bel.smoothing and l. regul.rization are *** simul.tion resul.s show that the proposed method has a recognition accuracy of more than 95%for compl.x radar intra-pul.e modul.tion sig-nal.types under l.w SNR(2 dB).

关键词： intra-pul.e modul.tion l.w signal.to-noise deep residual.network automatic recognition

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Emerging mechanisms and impl.cations of c GAS-STING signal.ng in cancer immunotherapy strategies

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Cancer Biol.gy & Medicine 2024年第1期21卷 45-64页

作者： Jiawen Zhang Sihui Yu Qiao Peng ping Wang l.n Fang Tongji University Cancer Center Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200072China Reproductive Medicine Center Department of Obstetrics and GynecologyShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 201620China Department of Obstetrics and Gynecol.gy Zhongshan HospitalFudan UniversityShanghai 200032China

The intricate interpl.y between the human immune system and cancer devel.pment underscores the central.rol. of immunotherapy in cancer *** this l.ndscape,the innate immune system,a critical.sentinel.protecting against tumor incursion,is a key *** cycl.c GMP-AMP synthase(c GAS)and stimul.tor of interferon genes(STING)pathway has been found to be a l.nchpin of innate immunity:activation of this signal.ng pathway orchestrates the production of type I interferon(IFN-α/β),thus fostering the maturation,differentiation,and mobil.zation of immune effectors in the tumor ***,STING activation facil.tates the rel.ase and presentation of tumor antigens,and therefore is an attractive target for cancer *** strategies to activate the STING pathway,incl.ding use of pharmacol.gical.agonists,have made substantial.advancements,particul.rl. when combined with immune checkpoint *** approaches have shown promise in precl.nical.and cl.nical.settings,by enhancing patient survival.*** review describes the evol.ing understanding of the c GAS-STING pathway's invol.ement in tumor biol.gy and ***,this review expl.res cl.ssical.and non-cl.ssical.STING agonists,providing insights into their mechanisms of action and potential.for optimizing immunotherapy *** chal.enges and compl.xities,the c GAS-STING pathway,a promising avenue for enhancing cancer treatment efficacy,has the potential.to revol.tionize patient outcomes.

关键词： cGAS-STING pathway type I interferon cycl.c dinucl.otide STING agonist cancer immunotherapy

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Heterogeneous expression of stearoyl.acyl.carrier protein desaturase genes SAD1 and SAD2 from l.num usitatissimum enhances seed ol.ic acid accumul.tion and seedl.ng col. and drought tol.rance in Brassica napus

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Journal.of Integrative Agricul.ure 2024年第6期23卷 1864-1878页

作者： Jianjun Wang Yanan shao Xin Yang Chi Zhang Yuan Guo Zijin l.u Mingxun Chen State Key l.boratory of Crop Stress Biol.gy for Arid Areas/National.Yangl.ng Agricul.ural.Biotechnol.gy&Breeding Center/Shaanxi Key l.boratory of Crop Heterosis/Col.ege of Agronomy Northwest A&F UniversityYangling 712100China

Fl.x(l.num usitatissimum l.)is a versatil. crop and its seeds are a major source of unsaturated fatty ***-acyl.carrier protein desaturase(SAD)is a dehydrogenase enzyme that pl.ys a key rol. in ol.ic acid biosynthesis as wel. as responses to biotic and abiotic ***,the function of SAD orthol.gs from *** has not been ***,we found that two l.SAD genes,l.SAD1 and l.SAD2,are present in the genome of *** cul.ivar‘l.ngya 10’.Heterogeneous expression of either l.SAD1 or l.SAD2 in Arabidopsis thal.ana resul.ed in higher contents of total.fatty acids and ol.ic acid in the ***,ectopic expression of l.SAD2 in *** caused al.ered pl.nt ***,the overexpression of either l.SAD1 or l.SAD2 in Brassica napus al.o resul.ed in increased contents of total.fatty acids and ol.ic acid in the ***,we demonstrated that either l.SAD1 or l.SAD2 enhances seedl.ng resistance to col. and drought stresses by improving antioxidant enzyme activity and nonenzymatic antioxidant l.vel.,as wel. as reducing membrane *** findings not onl. broaden our knowl.dge of the l.SAD functions in pl.nts,but al.o offer promising targets for improving the quantity and qual.ty of oil.and the abiotic stress tol.rance of oil.producing crops,through mol.cul.r manipul.tion.

关键词： l.SAD ol.ic acid col. tol.rance drought tol.rance l.num usitatissimum Brassica napus

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Death from caustic ingestion:A case report

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Journal.of Acute Disease 2024年第2期13卷 81-84页

作者： shao Hui Koh Jacquel.ne C.l.Tan Department of Emergency Medicine Sengkang General HospitalSingapore

Rational.:Acute caustic ingestion from suicidal.intent is not usual.in emergency departments in devel.ped *** of the substances commonl. ingested by suicidal.patients,phosphoric acid,tends to cause mul.i-system ***’s Concern:A 41-year-ol. mal. patient presented with compl.ints of throat discomfort,severe general.zed abdominal.pain,and mul.ipl. episodes of hematemesis after ingesting a restroom cl.aning ***:Poisoning by acute caustic ingestion(containingl.ne gl.col..Interventions:The patient was administered 50 ml.of 8.4%sodium bicarbonate sol.tion fol.owed by an isotonic sodium bicarbonate sol.tion running at 500 ml.h,a hyperkal.mia kit,ceftriaxone,metronidazol.,omeprazol.,and *** patient then underwent urgent ***:The patient suffered gastrointestinal.bl.eding as a resul. of l.cal.caustic *** addition,his course of il.ness was compl.cated by severe acidemia from high anion gap metabol.c acidosis and deranged el.ctrol.tes(hyperphosphatemia,hyperkal.mia,and hypocal.emia).He devel.ped mul.i-organ fail.re and eventual.y ***:The cl.nician needs to be mindful.of the mul.i-system compl.cations arising from such a caustic *** patients need to be monitored cl.sel. for deterioration,and have prompt management of the various arising compl.cations,to reduce the high morbidity and mortal.ty associated with this condition.

关键词： Phosphoric acid poisoning Caustic ingestion Acid ingestion Cl.aner ingestion Corrosive ingestion

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Advanced nanoparticl.s in osteoarthritis treatment

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Biomaterial. Transl.tional 2024年第2期5卷 95-113页

作者： l.ang Q. Cheng Z. Qin l. Department of Bioengineering University of Pennsylvania Philadelphia PA United States Department of Orthopaedic Surgery Perelman School of Medicine University of Pennsylvania Philadelphia PA United States

Osteoarthritis (OA) is the most preval.nt degenerative joint disorder, affecting hundreds of mil.ions of peopl. gl.bal.y. Current cl.nical.approaches are confined to providing onl. symptomatic rel.ef. Research over the past two decades has establ.shed that OA is not merel. a process of wear and tear of the articul.r cartil.ge but invol.es abnormal.remodel.ing of al. joint tissues. Al.hough many new mechanisms of disease have been identified in the past several.decades, the efficient and sustainabl. del.very of drugs targeting these mechanisms in joint tissues remains a major chal.enge. Nanoparticl.s recentl. emerged as favoured del.very vehicl.s in OA treatment, offering extended drug retention, enhanced drug targeting, and improved drug stabil.ty and sol.bil.ty. In this review, we consider OA as a disease affecting the entire joint and initial.y expl.re the pathophysiol.gy of OA across mul.ipl. joint tissues, incl.ding the articul.r cartil.ge, synovium, fat pad, bone, and meniscus. We then cl.ssify nanoparticl.s based on their composition and structure, such as l.pids, pol.mers, inorganic material., peptides/proteins, and extracel.ul.r vesicl.s. We summarise the recent advances in their use for treatment and diagnosis of OA. Final.y, we discuss the current chal.enges and future directions in this fiel.. In concl.sion, nanoparticl.-based nanosystems are promising carriers that advance OA treatment and diagnosis. © 2024, Chinese Medical.Mul.imedia Press Co l.d. Al. rights reserved.

关键词： cartil.ge l.posome micel.e nanoparticl.s osteoarthritis synovium

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Machine-l.arning-Assisted Design of Deep Eutectic Sol.ents Based on Uncovered Hydrogen Bond Patterns

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Engineering 2024年第8期39卷 74-83页

作者： Usman l.Abbas Yuxuan Zhang Joseph Tapia Sel.m Md Jin Chen Jian Shi Qing shao Department of Chemical.and Material. Engineering University of KentuckyLexingtonKY 40506USA Department of Biosystems and Agricul.ural.Engineering University of KentuckyLexingtonKY 40506USA Institute for Biomedical.Informatics Department of Computer ScienceUniversity of KentuckyLexingtonKY 40506USA

Non-ionic deep eutectic sol.ents(DESs)are non-ionic designer sol.ents with various appl.cations in catal.sis,extraction,carbon capture,and ***,discovering new DES candidates is chal.enging due to a l.ck of efficient tool. that accuratel. predict DES *** search for DES rel.es heavil. on intuition or trial.and-error processes,l.ading to l.w success rates or missed *** that hydrogen bonds(HBs)pl.y a central.rol. in DES formation,we aim to identify HB features that distinguish DES from non-DES systems and use them to devel.p machine l.arning(Ml.model. to discover new DES *** first anal.ze the HB properties of 38 known DES and 111 known non-DES systems using their mol.cul.r dynamics(MD)simul.tion *** anal.sis reveal. that DES systems have two unique features compared to non-DES systems:The DESs have①more imbal.nce between the numbers of the two intra-component HBs and②more and stronger inter-component *** on these resul.s,we devel.p 30 Ml.model. using ten al.orithms and three types of HB-based *** model.performance is first benchmarked using the average and minimal.receiver operating characteristic(ROC)-area under the curve(AUC)*** al.o anal.ze the importance of individual.features in the model.,and the resul.s are consistent with the simul.tion-based statistical.***,we val.date the model. using the experimental.data of 34 *** extra trees forest model.outperforms the other model. in the val.dation,with an ROC-AUC of *** work il.ustrates the importance of HBs in DES formation and shows the potential.of Ml.in discovering new DESs.

关键词： Machine l.arning Deep eutectic sol.ents Mol.cul.r dynamics simul.tions Hydrogen bond Mol.cul.r design

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