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Exosomal miR-320e through wnt2targeted inhibition of the Wnt/β-catenin pathway allevisate cerebral small vessel disease and cognitive impairment

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世界精神病学杂志 2023年第9期13卷 630-644页

作者： Zheng Wang Xue-Ning Li shao-nan yang Yuan Wang Ke-Jin Gao Bin Han Ai-Jun Ma Department of Internal Medicine-Neurology Affiliated Hospital of Qingdao UniversityQingdao 266001Shandong ProvinceChina Department of Neurology The Affiliated Hospital of Qingdao UniversityQingdao 266001Shandong ProvinceChina

BACKGROUND Exosomal miRNAs play crucial roles in many central nervous system *** small vessel disease(CVSD)is a small vessel disease that is affected by various *** study aimed to investigate the role of exosomal miR-320e in the Wnt/β-catenin pathway stimulated by oxidative stress and assess its clinical correlation with psychiatric symptoms in patients with *** To explore whether exosomal miR-320e could suppress the Wnt/β-catenin pathway and play a protective role in CVSD progression,as well as examine its potential correlation with cognitive impairment and depression in patients with *** Differentially expressed exosomal miRNAs were filtered by sequencing plasma exosomes from patients with CVSD and healthy *** and dual luciferase analyses were used to confirm the binding of miR-320e to Wnt2,and the mRNA and protein levels of downstream components in the Wnt/β-catenin pathway were evaluated when overexpressed or with knockdown of miR-320e under H2O2-induced oxidative *** addition,Wnt2-targeting siRNA was used to confirm the role of miR-320e in the Wnt2-mediated inhibition of the Wnt/β-catenin pathway.A retrospective analysis was conducted among patients with CVSD to confirm the correlation between miR-320e expression and the severity of cognitive impairment and depression,which were quantified using the Montreal Cognitive Assessment(MoCA)/Executive Function Assessment(EFA),and the Hamilton Depression Scale(HAMD)/Beck Depression Inventory(BDI),*** High-throughput sequencing revealed that exosomal miR-320e was downregulated in patients with *** analysis and dual-luciferase reporter gene experiments showed that exosomal miR-320e inhibited the Wnt/β-catenin pathway in response to oxidative stress by targeting the 3'noncoding region of *** of exosomes carrying miR-320e into endothelial cells could also target Wnt2 and inhibit the Wnt2/β-catenin *** miR-32

关键词： Exosome Cerebral small vessel disease miRNA-320e Wnt2 Wnt/β-catenin pathway Depressed

Bending results of graphene origami reinforced doubly curved shell

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Defence Technology（防务技术） 2024年第5期35卷 198-210页

作者： nan yang Yunhe Zou Mohammad Arefi School of Architecture and Civil Engineering Qiqihar UniversityQiqihar 161006HeilongjiangChina School of Mechanical Engineering Inner Mongolia University of TechnologyHohhot 010051Inner MongoliaChina Inner Mongolia Key Laboratory of Special Service Intelligent Robotics Hohhot 010051Inner MongoliaChina Faculty of Mechanical Engineering Department of Solid MechanicsUniversity of KashanKashan87317-51167Iran

The present work investigates higher order stress,strain and deformation analyses of a shear deformable doubly curved shell manufactures by a Copper(Cu)core reinforced with graphene origami auxetic metamaterial subjected to mechanical and thermal *** effective material properties of the graphene origami auxetic reinforced Cu matrix are developed using micromechanical models cooperate both material properties of graphene and Cu in terms of temperature,volume fraction and folding *** principle of virtual work is used to derive governing equations with accounting thermal *** numerical results are analytically obtained using Navier's technique to investigate impact of significant parameters such as thermal loading,graphene amount,folding degree and directional coordinate on the stress,strain and deformation responses of the *** graphene origami materials may be used in aerospace vehicles and structures and defence technology because of their low weight and high stiffness.A verification study is presented for approving the formulation,solution methodology and numerical results.

关键词： Graphene origami Copper matrix Doubly curved Shear deformable Auxetic metamaterial

Moisture‑Electric–Moisture‑Sensitive Heterostructure Triggered Proton Hopping for Quality‑Enhancing Moist‑Electric Generator

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nano-Micro Letters 2024年第3期16卷 351-366页

作者： Ya’nan yang Jiaqi Wang Zhe Wang Changxiang shao Yuyang Han Ying Wang Xiaoting Liu Xiaotong Sun Liru Wang Yuanyuan Li Qiang Guo Wenpeng Wu nan Chen Liangti Qu Key Laboratory of Cluster Science Ministry of Education of ChinaKey Laboratory of Photoelectronic/Electrophotonic Conversion MaterialsSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081People’s Republic of China yangtze Delta Region Academy of Beijing Institute of Technology Jiaxing 314019People’s Republic of China Department of Chemistry Key Laboratory of Organic Optoelectronics&Molecular EngineeringMinistry of EducationTsinghua UniversityBeijing 100084People’s Republic of China

Moisture-enabled electricity(ME)is a method of converting the potential energy of water in the external environment into electrical energy through the interaction of functional materials with water molecules and can be directly applied to energy harvesting and signal ***,ME can be unreliable in numerous applications due to its sluggish response to moisture,thus sacrificing the value of fast energy harvesting and highly accurate information ***,by constructing a moisture-electric-moisture-sensitive(ME-MS)heterostructure,we develop an efficient ME generator with ultra-fast electric response to moisture achieved by triggering Grotthuss protons hopping in the sensitized ZnO,which modulates the heterostructure built-in interfacial potential,enables quick response(0.435 s),an unprecedented ultra-fast response rate of 972.4 mV s^(−1),and a durable electrical signal output for 8 h without any *** research provides an efficient way to generate electricity and important insight for a deeper understanding of the mechanisms of moisture-generated carrier migration in ME generator,which has a more comprehensive working scene and can serve as a typical model for human health monitoring and smart medical electronics design.

关键词： Moist-electric generators Grotthuss proton hopping Fast response Durable electrical output Personal health monitoring

Preparation of PrFe_(x)Co_(1-x)O_(3)/Mt catalyst and study on degradation of 2-hydroxybenzoic acid wastewater by catalytic wet peroxide oxidation

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Chinese Journal of Chemical Engineering 2024年第1期65卷 286-297页

作者： Binxia Zhao Yijia Gao Tiancheng Hun Xiaoxiao Fan nan shao Xiaoqian Chen School of Chemical Engineering Northwest UniversityXi'an 710069China

In this study,the perovskite nanocomposite PrFe_(x)Co_(1-x)O_(3)(Pr(S))was successfully synthesized by the sol-gel method;PrFe_(x)Co_(1-x)O_(3)/Al-pillared montmorillonite(Pr(S)/Mt)catalysts were prepared by impregnation(D)method and solid-melting(G)method,respectively,with Pr(S)as the active component and Al-pillared montmorillonite as the *** catalysts were applied to treat the 2-hydroxybenzoic acid(2-HA)-simulated wastewater by catalytic wet peroxide oxidation(CWPO)technique,and the chemical oxygen demand(COD)removal rate and the 2-HA degradation rate were used as indicators to evaluate the catalytic *** results of the experiment indicated that the solid-melting method was more conducive to preparing the catalyst when the Co/Fe molar ratio of 7:3 and the optimal structural properties of the catalysts were *** influence of operating parameters,including reaction temperature,catalyst dosage,H_(2)O_(2)dosage,pH,and initial 2-HA concentration,were optimized for the degradation of 2-HA by *** results showed that 97.64%of 2-HA degradation and 75.23%of COD removal rate were achieved under more suitable experimental *** addition,after the catalyst was used five times,the degradation rate of 2-HA could still reach 76.93%,which implied the high stability and reusability of the *** high catalytic activity of the catalyst was due to the doping of Co into PrFeO_(3),which could promote the generation of HO·,and the high stability could be attributed to the loading of Pr(S)onto Al-Mt,which reduced the leaching of reactive *** study of reaction mechanism and kinetics showed that the whole degradation process conformed to the pseudo-firstorder kinetic equation,and the Langmuir-Hinshelwood method was applied to demonstrate that catalysis was dominant in the degradation process.

关键词： Montmorillonite Perovskite Catalytic wet peroxide oxidation(CWPO) 2-Hydroxybenzoic acid

Molecular phylogenetic relationships based on mitochondrial genomes of novel deep-sea corals(Octocorallia:Alcyonacea):Insights into slow evolution and adaptation to extreme deep-sea environments

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Zoological Research 2024年第1期45卷 215-225页

作者： Zhan-Fei Wei Kai-Wen Ta nan-nan Zhang Shan-Shan Liu Liang Meng Kai-Qiang Liu Chong-yang Cai Xiao-Tong Peng Chang-Wei shao National Key Laboratory of Mariculture Biobreeding and Sustainable Goods Yellow Sea Fisheries Research InstituteChinese Academy of Fishery SciencesQingdaoShandong 266071China BGI-Qingdao BGI-ShenzhenQingdaoShandong 266555China Institute of Deep-Sea Science and Engineering Chinese Academy of SciencesSanyaHainan 572000China

A total of 10 specimens of Alcyonacea corals were collected at depths ranging from 905 m to 1633 m by the manned submersible Shenhai Yongshi during two cruises in the South China Sea(SCS).Based on mitochondrial genomic characteristics,morphological examination,and sclerite scanning electron microscopy,the samples were categorized into four suborders(Calcaxonia,Holaxonia,Scleraxonia,and Stolonifera),and identified as 9 possible new cold-water coral *** of GC-skew dissimilarity,phylogenetic distance,and average nucleotide identity(ANI)revealed a slow evolutionary rate for the octocoral mitochondrial *** nonsynonymous(Ka)to synonymous(Ks)substitution ratio(Ka/Ks)suggested that the 14 protein-coding genes(PCGs)were under purifying selection,likely due to specific deep-sea environmental *** analysis of the median Ka/Ks values of five gene families and environmental factors indicated that the genes encoding cytochrome b(cyt b)and DNA mismatch repair protein(mutS)may be influenced by environmental factors in the context of deep-sea species *** study highlights the slow evolutionary pace and adaptive mechanisms of deep-sea corals.

关键词： Mitochondrial genome Alcyonacea Ka/Ks evolution Environmental factors

PEGA:probabilistic environmental gradient-driven genetic algorithm considering epigenetic traits to balance global and local optimizations

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Frontiers of Information Technology & Electronic Engineering 2024年第6期25卷 839-855页

作者： Zhiyu DUAN Shunkun yang Qi shao Minghao yang School of Reliability and Systems Engineering Beihang UniversityBeijing 100191China

Epigenetics’flexibility in terms of finer manipulation of genes renders unprecedented levels of refined and diverse evolutionary mechanisms *** the epigenetic perspective,the main limitations to improving the stability and accuracy of genetic algorithms are as follows:(1)the unchangeable nature of the external environment,which leads to excessive disorders in the changed phenotype after mutation and crossover;(2)the premature convergence due to the limited types of epigenetic *** this paper,a probabilistic environmental gradientdriven genetic algorithm(PEGA)considering epigenetic traits is *** enhance the local convergence efficiency and acquire stable local search,a probabilistic environmental gradient(PEG)descent strategy together with a multi-dimensional heterogeneous exponential environmental vector tendentiously generates more offsprings along the gradient in the solution ***,to balance exploration and exploitation at different evolutionary stages,a variable nucleosome reorganization(VNR)operator is realized by dynamically adjusting the number of genes involved in mutation and *** on the above-mentioned operators,three epigenetic operators are further introduced to weaken the possible premature problem by enriching genetic *** experimental results on the open Congress on Evolutionary Computation-2017(CEC’17)benchmark over 10-,30-,50-,and 100-dimensional tests indicate that the proposed method outperforms 10 state-of-the-art evolutionary and swarm algorithms in terms of accuracy and stability on comprehensive *** ablation analysis demonstrates that for accuracy and stability,the fusion strategy of PEG and VNR are effective on 96.55%of the test functions and can improve the indicators by up to four orders of ***,the performance of PEGA on the real-world spacecraft trajectory optimization problem is the best in terms of quality of the solution.

关键词： Evolutionary algorithm Epigenetics Epigenetic algorithm Probabilistic environmental vector Variable nucleosome reorganization

Distributional and behavioral responses of the wintering Oriental Storks to drought in China’s largest freshwater lake

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Avian Research 2024年第2期15卷 187-195页

作者： Fucheng yang Mingqin shao Jianying Wang College of Life Science Jiangxi Normal UniversityNanchang330022China

Extreme droughts are increasing in frequency and severity globally as a result of climate *** understanding of species’responses to drought is crucial for their conservation,especially in regions experi-encing increased *** numerous studies have investigated birds’responses to drought,the emphasis has primarily been on *** can significantly alter the wetland environments that waterbirds inhabit,but the response of waterbirds to drought remains *** this study,we surveyed the distri-bution and behavior of Oriental Storks(Ciconia boyciana)in Poyang Lake,which is the largest freshwater lake in *** indicate that drought-induced catchment areas at the lowest water level limited the total popu-lation size of Oriental Storks in the ***-lakes with large catchment areas at the lowest water level demonstrated a capacity to support a larger population of wintering Oriental *** time,Oriental Storks exhibited a gradual concentration in Changhu Lake,characterized by larger catchments,after resource depletion in sub-lakes with smaller ***,the duration of Oriental Storks’vigilance and moving be-haviors decreased significantly compared with that observed before the *** the drought,Oriental Storks increased their foraging efforts,as evidenced by increased presence in deeper water and reaching their heads and necks into deeper water to forage,higher search rates,but lower foraging *** accordance with area-restricted search theory,reductions in habitat quality resulting from drought,including extensive fish die-offs,forced Oriental Storks to increase their foraging *** a specific water area in sub-lakes during droughts can preserve resource availability,which is crucial for the conservation of Oriental ***-menting measures such as water level control and micro-modification of lake bottoms in sub-lakes might mitigate the impact of drought on the pisc

关键词： Climate change Extreme drought Foraging behavior Oriental stork Poyang lake

High-efficiency prediction method for helicopter global/ground noise based on near-field acoustic holography

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Chinese Journal of Aeronautics 2024年第7期37卷 271-284页

作者： Mengxue shao yang LU Xice XU Jiaxin LU National Key Laboratory of Helicopter Aeromechanics Nanjing University of Aeronautics and AstronauticsNanjing 210016China

Noise reduction program design is an effective approach that relies on efficient noise prediction for reducing ground noise during *** existing noise prediction methods have the limitations of being computationally expensive or only applicable to *** this paper,a High-Efficiency Prediction Method(HEPM)for helicopter global/ground noise based on near-field acoustic holography is *** HEPM can predict the global noise based on acoustic modal analysis and has the advantages of high prediction accuracy and low time *** process is given as follows:firstly,the rotor noise on the holographic surface in the specified flight is obtained by simulations or ***,the global noise model,which maps time-domain noise to acoustic modes,is established based on near-field acoustic holography and Fourier acoustic analysis ***,combined with acoustic modal amplitude,the model established enables efficiently predicting the global/ground noise in the corresponding flight *** verify the accuracy of the prediction method,a simulation study is conducted in hovering and forward flight states using a model helicopter with a 2-meter rotor and Rotor Body Interaction(ROBIN)*** comparison of HEPM with numerical results shows that the average prediction errors of the global and ground noise are less than 0.3 dB and 0.2 dB,*** a region containing 100000 observers,the computation time of the HEPM is only one-fifth of that of the acoustic hemisphere method,demonstrating the rapidity of the proposed method.

关键词： Helicopter Rotor noise prediction Noise abatement procedure design Acoustic modal analysis Near-field acoustic holography

Crystalline-amorphous M@MN_x(M=Co,Fe,Ni)encapsulated in nitrogen-doped carbon for enhanced efficient and durable hydrogen evolution reaction

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Rare Metals 2024年第4期43卷 1547-1556页

作者： yang yang Xiao-Chuan Duan shao-Hui Guo Xian-Ming Zhang College of Materials Science and Engineering College of ChemistryKey Laboratory of Interface Science and Engineering in Advanced MaterialsTaiyuan University of TechnologyYuci030600China

Developing earth-abundant electrocatalysts for hydrogen evolution reaction(HER)is important for the sustainable energy ***,efficient and stable heterocatalysts consisting of crystalline-amorphous M@MN_(x)(M=Co,Fe,Ni)encapsulated in N-doped carbon layers supported with N-doped graphene sheets(denoted as M@MN_(x)@NC-NG)are synthesized by facile hydrothermal reaction and nitridation *** the nitriding process,metal ions in M(tzbc)_2(H_(2)O)_4(tzbc=4-(1H-1,2,4-triazol-1-yl)benzoic acid)complexes are reduced to crystalline M cores,accompanied by the formation of amorphous MN_(x)shells;the tzbc ligands are insitu carbonized to form outermost N-doped carbon(NC)layers that connect with inner MN_(x)via M-N-C motifs inherited from the complex precursors and inhibit the transition of MN_(x)from amorphous to crystalline *** Co@CoN_(x)@NC-NG catalyst exhibits excellent HER activity with small overpotentials of 45 and 64 mV at a cathode current density of 10 mA·cm^(-2)and low Tafel slopes of 40 and 85 mV·dec^(-1)in 0.5 mol·L^(-1)H_(2)SO_4 and1.0 mol·L^(-1)KOH electrolytes,*** Co@CoN_(x)@NC-NG retains 97%of the initial overpotential after 100,000 s in both acidic and alkaline *** outstanding HER performance originates from the crystalline-amorphous Co@CoN_(x)that redistributes electrons around the heterointerfaces,facilitating the conversion process of H^(+)/H_(2)O to hydrogen and thereby promoting HER *** outermost NC layers serve as the armor of Co@CoN_(x),and graphene nanosheets act as carriers of egg-like Co@CoN_(x)@NC and conduction paths for electron shuttles,ensuring stable and continuous electrocatalytic hydrogen production.

关键词： Hydrogen evolution reaction Electrocatalysts Iron group metals Heterojunction Crystalline-amorphous structure