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Are bowel symptoms and psychosocial features different in irritable bowel syndrome patients with abdominal discomfort compared to abdominal pain?

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World Journal of Gastroenterology 2022年第33期28卷 4861-4874页

作者： Xiu-Cai Fang Wen-Juan Fan Douglas D Drossman shao-mei han mei-Yun Ke Department of Gastroenterology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Gastroenterology Tongji HospitalTongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430030Hubei ProvinceChina Center of Functional GI and Motility Disorders University of North CarolinaChapel HillNC 27517United States Center for Education and Practice of Biopsychosocial Care Drossman GastroenterologyDurhamNC 27713United States Rome Foundation Rome FoundationRaleighNC 27614United States Department of Epidemiology and Statistics Institute of Basic Medical SciencesChinese Academy of Medical Sciences&School of Basic MedicinePeking Union Medical CollegeBeijing 100005China

BACKGROUND The Rome IV criteria eliminated abdominal discomfort for irritable bowel syndrome(IBS), which was previously included in Rome III. There are questions as to whether IBS patients with abdominal discomfort(seen in Rome III but not Rome IV) are different from those with abdominal pain(Rome IV).AIM To compare bowel symptoms and psychosocial features in IBS patients diagnosed with Rome III criteria with abdominal discomfort, abdominal pain, and pain &*** We studied IBS patients meeting Rome III criteria. We administered the IBS symptom questionnaire, psychological status, and IBS quality of life. Patients were classified according to the predominant abdominal symptom associated with defecation into an only pain group, only discomfort group, and pain & discomfort group. We compared bowel symptoms, extraintestinal symptoms, IBS quality of life, psychological status and healthcare-seeking behaviors, and efficacy among the three groups. Finally, we tested risk factors for symptom reporting in IBS *** Of the 367 Rome III IBS patients enrolled, 33.8%(124 cases) failed to meet Rome IV criteria for an IBS diagnosis. There were no meaningful differences between the pain group(n = 233) and the discomfort group(n = 83) for the following:(1) Frequency of defecatory abdominal pain or discomfort;(2) Bowel habits;(3) Coexisting extragastrointestinal pain;(4) Comorbid anxiety and depression;and(5) IBS quality of life scores except more patients in the discomfort group reported mild symptom than the pain group(22.9% vs 9.0%). There is a significant tendency for patients to report their defecatory and non-defecatory abdominal symptom as pain alone, or discomfort alone, or pain & discomfort(all P < 0.001).CONCLUSION IBS patients with abdominal discomfort have similar bowel symptoms and psychosocial features to those with abdominal pain. IBS symptoms manifesting abdominal pain or discomfort may primarily be due to different sensation and reporting expe

关键词： Irritable bowel syndrome Abdominal pain Abdominal discomfort Diagnosis Psychosocial distress Quality of life

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Prevalence and Factors Associated with Female Sexual Dysfunction in Beijing, China

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Chinese Medical Journal 2017年第12期130卷 1389-1394页

作者： Wen-Jia Lou Bo Chen Lan Zhu shao-mei han Tao Xu Jing-He Lang Lei Zhang Department of Obstetrics and Gynecology Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing 100730 China Department of Clinical Medicine Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100005 China Department of Epidemiology and Statistics Institute of Basic Medical Sciences Peking Union Medical College Chinese Academy of Medical Sciences and School of Basic Medicine Beijing 100005 China

Background： Female sexual dysfunction （FSD） is a highly prevalent and often underestimated problem. However, large-scale, population-based epidemiological surveys of FSD are scarce in China. The present study was conducted to evaluate the prevalence and the potential risk factors of FSD across a selection of social groups in Beijing, China, based on the Female Sexual Function Index （FSFI）. Methods： A cross-sectional study based on the multiple-stage cluster sampling was performed with adult women throughout the Dongcbeng and Shunyi districts of Beijing. The Chinese version of FSFI was used, as well as questions on demographic characteristics, the disease-related context, and social relationships. Results： A total of 6000 consecutive women entered this study, with an actual response from 5024 women, corresponding to a response rate of 83.7%. A total of 4697 （78.3%） questionnaires were effective. The prevalence of adult FSD in Beijing was 2973 （63.3%） using a score of 26.55 as the boundary value, whereas the total mean FSFI score was 23.92 ~ 6.37. However, 1423 （30.3%） women did not seek help. By multivariate logistic regression analysis, the possible potential risk factors included age （odds ratio [OR] = 1.051 ）, dissatisfaction with the spouse＇s sexual ability （OR = 3.520）, poor marital affection （OR = 2.087）, spouse sexual difficulties （OR = 1.720）, dissatisfaction with married life （OR = 1.476）, living in a rural area （OR = 1.292）, chronic pelvic pain （OR = 1.261）, chronic disease （OR = 1.534）, previous pelvic surgery （OR = 1.605）, vaginal delivery （OR = 2.285）, lower education （OR = 3.449） and postmenopausal （OR = 3.183）. Conclusions： As suggested by the FSFI scores, female sexual problems are highly prevalent in Beijing. Dissatisfaction with the spouse＇s sexual ability, poor marital affection, sexual difficulties of the spouse, dissatisfaction with the marriage, rural life, CPP, and postmenopausal were conceivable risk factors for FSD in Beijing women.

关键词： Beijing, Female Sexual Dysfunction Female Sexual Function Index Potential Risk Factors Prevalence

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Microstructural evolution during the progressive transformation-induced plasticity effect in a Fe-0.1C-5Mnmedium manganese steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 369-379页

作者： mei Zhang Wenhao Li Yangfei Chen Yang Jiang Xiaofei Guo han Dong School of Materials Science and Engineering Shanghai UniversityShanghai 200444China State Key Laboratory of Advanced Special Steel Shanghai UniversityShanghai 200444China

The microstructural evolution of a cold-rolled and intercritical annealed medium-Mn steel(Fe-0.10C-5Mn)was investigated during uniaxial tensile ***-situ observations under scanning electron microscopy,transmission electron microscopy,and X-ray diffraction analysis were conducted to characterize the progressive transformation-induced plasticity process and associated fracture initiation *** findings were discussed with the local strain measurements via digital image *** results indicated that Lüders band formation in the steel was limited to 1.5%strain,which was mainly due to the early-stage martensitic phase transformation of a very small amount of the less stable large-sized retained austenite(RA),which led to localized stress concentrations and strain hardening and further retardation of *** small-sized RA exhibited high stability and progressively transformed into martensite and contributed to a stably extended Portevin-Le Chatelier *** volume fraction of RA gradually decreased from 26.8%to 8.2%prior to *** the late deformation stage,fracture initiation primarily occurred at the austenite/martensite and ferrite/martensite interfaces and the ferrite phase.

关键词： medium-Mn steel retained austenite progressive transformation-induced plasticity effect local strain fracture initiation

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Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man han Deyang Zeng Wei Tan Xingxing Chen Shuyuan Bai Qiong Wu Yushan Chen Zhen Wei Yufei mei Yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

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己内酰胺生产技术及产业发展的现状与趋势

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化工设计通讯 2019年第9期45卷 139-140页

作者：邵寒梅王辉熊勇湖南百利工程科技股份有限公司

介绍了国内外己内酰胺的生产和消费情况,阐述了己内酰胺的主流生产技术路线,并对其技术路线中包含的环己酮、环己酮肟和己内酰胺精制等生产工艺技术进行简要综述,总结了各工艺技术的优缺点和应用趋势;研究结果表明:我国己内酰胺生产将... 详细信息

介绍了国内外己内酰胺的生产和消费情况,阐述了己内酰胺的主流生产技术路线,并对其技术路线中包含的环己酮、环己酮肟和己内酰胺精制等生产工艺技术进行简要综述,总结了各工艺技术的优缺点和应用趋势;研究结果表明:我国己内酰胺生产将逐渐向规模扩大化,上下游配套一体化、以及全项目多装置物料与能量耦合化的趋势发展。

关键词：己内酰胺工艺技术一体化

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复合导电橡胶的制备及性能

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武汉理工大学学报 2008年第10期30卷 1-4页

作者：王一龙官建国章桥新邵寒梅武汉理工大学材料复合新技术国家重点实验室武汉430070 武汉理工大学理学院武汉430070

以自制的银包玻璃微珠核壳复合粒子作为导电填料,丁腈橡胶为基胶,采用橡胶加工技术制备出一种复合导电橡胶材料。确定了该导电橡胶材料的配方,并优化了其加工工艺。研究了导电填料的填料量对该材料的电性能、力学性能和屏蔽效能等的影... 详细信息

以自制的银包玻璃微珠核壳复合粒子作为导电填料,丁腈橡胶为基胶,采用橡胶加工技术制备出一种复合导电橡胶材料。确定了该导电橡胶材料的配方,并优化了其加工工艺。研究了导电填料的填料量对该材料的电性能、力学性能和屏蔽效能等的影响规律。结果表明:该复合导电橡胶具有轻质的特点和优异的环境适应性;随着导电填料用量的增加,该材料的电性能和屏蔽效能均增加,但力学性能呈现下降趋势。当填料的体积分数达40%时,该橡胶材料的体积电阻率达7.41×10-3Ω.cm,具有较好的力学性能和屏蔽性能。

关键词：银包玻璃微珠核壳复合粒子丁腈橡胶导电橡胶屏蔽效能

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基于多元回归的色彩人格定量化研究

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四川大学学报（自然科学版） 2016年第6期53卷 1255-1260页

作者：吴芝明伍少梅韩春燕陈渝林涛四川大学计算机学院成都610065 四川民族学院康定626001

色彩是视觉感知的重要组成,它不仅具有美学价值,还能激起对人格特质的联想,即色彩人格.然而,目前仍缺乏对色彩与其激起的人格特质联想之间关系的定量化描述.本研究首次对色彩属性与人格联想间的定量化关系进行研究,采用语义差分法获取... 详细信息

色彩是视觉感知的重要组成,它不仅具有美学价值,还能激起对人格特质的联想,即色彩人格.然而,目前仍缺乏对色彩与其激起的人格特质联想之间关系的定量化描述.本研究首次对色彩属性与人格联想间的定量化关系进行研究,采用语义差分法获取了色彩激起的人格联想,基于多元回归建立了色彩人格模型.结果表明,色彩的明度,浓度和色相对人格特质的感知都具有影响;而且,色彩的属性及其激起人格联想之间的关系能够较好地被多元回归模型定量化.该结果为虚拟角色的色彩人格设计提供了依据.

关键词：色彩感知色彩情感人格感知角色设计

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一种己内酰胺生产过程中的降耗减排工艺

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化工设计通讯 2019年第9期45卷 235-235,243页

作者：王辉邵寒梅黄敏炎湖南百利工程科技股份有限公司

己内酰胺生产过程中的无机杂质——硫酸铵对离子交换工序影响较大,本工艺设置低投资的碱洗系统预先对粗己内酰胺水溶液进行碱洗,使其中大多数的无机杂质提前去除,离子交换运行周期得到有效延长,减少了脱盐水及再生剂的消耗,降低了废水... 详细信息

己内酰胺生产过程中的无机杂质——硫酸铵对离子交换工序影响较大,本工艺设置低投资的碱洗系统预先对粗己内酰胺水溶液进行碱洗,使其中大多数的无机杂质提前去除,离子交换运行周期得到有效延长,减少了脱盐水及再生剂的消耗,降低了废水排放量,达到降耗减排的目的。

关键词：己内酰胺精制无机杂质硫酸铵降耗减排

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肝动脉化疗灌注治疗晚期肝癌患者的护理

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国际护理学杂志 2008年第4期27卷 406-407页

作者：陈美琴邵寒梅吴东霞广东省江门市中心医院肝胆外科 529000

经皮导管肝动脉灌注化疗（介入治疗）晚期肝癌病者的护理。使用seldinger技术，经皮穿刺插管，将导管置于肝总动脉，注入化疗药物，使肝癌细胞坏死、缩小或消失。临床护士除了掌握专科护理知识外，还要掌握介入治疗和护理的新发展，从... 详细信息

经皮导管肝动脉灌注化疗（介入治疗）晚期肝癌病者的护理。使用seldinger技术，经皮穿刺插管，将导管置于肝总动脉，注入化疗药物，使肝癌细胞坏死、缩小或消失。临床护士除了掌握专科护理知识外，还要掌握介入治疗和护理的新发展，从而达到满意的护理效果。

关键词：介入治疗晚期肝癌护理

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腹腔双套管在肝胆术后患者中的应用和护理

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国际医药卫生导报 2008年第9期14卷 87-88页

作者：余林欢杜惠梅邵寒梅林艳霞江门市中心医院肝胆外科广东江门529070

目的探讨肝胆病人术后应用腹腔双套管的观察和护理。方法对159例肝胆术后病人使用腹腔双套管接中心负压吸引进行引流。结果本组病人中有2例术后2小时双套管引出鲜红色不凝血液达到300ml，需再次手术探查止血。有3例病人引出混浊样液体... 详细信息

目的探讨肝胆病人术后应用腹腔双套管的观察和护理。方法对159例肝胆术后病人使用腹腔双套管接中心负压吸引进行引流。结果本组病人中有2例术后2小时双套管引出鲜红色不凝血液达到300ml，需再次手术探查止血。有3例病人引出混浊样液体，经冲洗、抗感染等伤口愈合。有15例引流液引出黄褐色胆汁样液体，经充分引流、延长引流时间，伤口也慢慢愈合。无1例病人因护理不当而造成双套管脱出。结论肝胆病人术后使用腹腔双套管进行腹腔引流，可以保持有效的引流，防止管道的堵塞，及时观察患者有无术后出血、胆瘘等并发症的发生有积极的意义。

关键词：腹腔双套管负压引流

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