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Simulation of the Earth' s gravitational field recovery from GRACE using the energy balance approach

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Progress in Natural Science:Materials International 2005年第7期15卷 596-601页

作者： ZHENG Wei, LU Xiaolei, HSU Houtse, shao Chenggang, luo jun and WANG Nengchao ( Department of Physics, Huazhong University of Science and Technology, Wuhan 430074, China Institute of Geodesy and Geophysics, Chinese Academy of Sciences, Wuhan 430077, China Department of Mathematics, Huazhong University of Science and Technology, Wuhan 430074, China) Department of Physics Huazhong University of Science and Technology Wuhan 430074 China. Department of Mathematics Huazhong University of Science and Technology Wuhan 430074 China. Institute of Geodesy and Geophysics Chinese Academy of Sciences Wuhan 430077 China

Based on the measurement principles of GRACE satellites, the observation equations are set up using the energy balance approach. The Earth's gravitational field complete up to degree and order 120 is recovered applying the preconditioning conjugate gradient iterative approach by numerical simulation. Assuming an accuracy of 1 μm/s in range-rate measurements of the K-band microwave ranging system, the matching relationships of accuracies of K-band microwave ranging system, SuperSTAR Accelerometer, position vector and velocity vector measurements are investigated.

关键词： the Earth’s gravitational field GRACE satellites energy balance approach preconditioning conjugate gradient method.

Effects of antisense oligonucleotides of PKC-α on proliferation and apoptosis of HepG₂ in vitro

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Hepatobiliary & Pancreatic Diseases International 2005年第1期4卷 75-79页

作者： Bao-Hua Zhu Zhen-Xiang Yao shao-jun luo Li-Ming Jiang Jiang-Wei Xiao Sheng-Chun Liu Jin-Biao Liu Jian-Ming Sun Zhi-Yuan Pei Department of Hepatobiliary Surgery First Affiliated Hospital Chongqing University of Medical Sciences Chongqing 400016 China. baohuazhu@***

BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most common malignancies in China. The long-term survival rate of patients with HCC after prevention and management remains unsatisfactory. In order to provide a novel strategy to cure HCC, we investigated the effects of antisense oligonucleotides of PKC-alpha on proliferation and apoptosis of human hepatoma cell line HepG2 in vitro.METHODS: The human hepatocellular carcinoma cell line HepG2 was cultured and subcultured in RPMI1640 medium in vitro. PKC-alpha antisense oligonucleotides(asODN) of different concentrations with a random sequence as a control were transfected into HepG2 cells by lipofectin(LP). The cell growth index (GI) and the clone formation rate of HepG2 were detected by MTT colorimetric assay and soft agar assay, respectively. The apoptosis rate of HepG2 treated with PKC-alpha asODN was assayed by flow cytometry(FCM). The results were analyzed by SPSS 10.0 software.RESULTS: The GI of HepG2 transfected by PKC-alpha asODN with concentrations ranging from 0.10 micromol to 1.00 micromol were lower significantly than those of control groups (P<0.05). The clone formation rates of HepG2 transfected by PKC-alpha asODN from 0.05 micromol to 1.00 micromol were lower significantly than those of the control groups (P<0.01), and there was a dose-dependent relationship among them. The apoptosis rates of HepG2 treated with PKC-alpha asODN from 0.50 micromol to 1.00 micromol were significantly higher than those of the control groups.CONCLUSION: PKC-alpha asODN could inhibit the growth and proliferation of HepG2 and induce its apoptosis by blocking the cell signal transduction related to PKC-alpha in vitro, and may be potentially used in the prevention and management of recurrent and metastatic HCC.

关键词： hepatocellular carcinoma HepG2 PKC-α asODN

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金融法制定中的基本范畴与体系结构研究

新疆师范大学学报（哲学社会科学版） 2025年第2期46卷 17-29,F0002页

作者：刘少军中国政法大学民商经济法学院北京102249 中国政法大学金融法研究中心北京102249

党的十八届三中全会以来,党和政府高度重视金融立法和修法工作。全国人大常委会立法工作计划的预备审议项目要求研究包括金融监管制度在内的金融方面的综合性法律,党的二十届三中全会提出制定金融法,是落实党的二十大报告和2023年中央... 详细信息

党的十八届三中全会以来,党和政府高度重视金融立法和修法工作。全国人大常委会立法工作计划的预备审议项目要求研究包括金融监管制度在内的金融方面的综合性法律,党的二十届三中全会提出制定金融法,是落实党的二十大报告和2023年中央金融工作会议精神、实现建设金融强国目标的重要步骤。制定金融法的核心工作是对现行金融法规进行全面整合,实现金融规范和金融监管的全面覆盖。这就需要对金融法的基本范畴进行研究阐释,对其调整的范围,即金融、金融业及其机构、工具、市场、业务、行为等进行严格界定;必须构建逻辑清晰、结构严谨的金融法体系结构,明晰其目标与原则、要素法体系、行业法体系、体例与结构等问题。

关键词：金融的界定金融业界定目标与原则要素法体系行业法体系体例与结构

LBL-PBL-TBL模式在环境专业课程教学中的应用探讨

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山东化工 2018年第10期47卷 172-172,175页

作者：邵俊罗望张清唐山学院环境与化学工程系河北唐山063000

以环境化学课程为例,提出了在环境工程专业课程教学中建立LBL-PBL-TBL教学模式。该教学模式以学生为中心,以"任务"为驱动,以团队为基础,配套多元化考评体系,以期实现"教-学"角色互换,提升学生的思辨能力、自主学习能和团队协作能力。

关键词： LBL-PBL-TBL 环境化学教学模式

Stable copper boron–imidazolate cage as Cu-riched enzyme for highly efficient electrocatalytic CO2 reduction to ethylene

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Science China Chemistry 2025年

作者： jun-Qiang Chen Qiao-Hong Li Qin-Long Hong Ping shao Hai-Xia Zhang Jian Zhang State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences

Single-atom catalyst has garnered widespread attention to mimic mature enzymes due to its well-defined atomic structure and coordination environments. However, since the carbon–carbon（C–C） coupling reactions require synergistic catalysis of multiple sites, single-atom catalysts suffer from insufficient active sites and unclear reaction mechanisms. Controlling the reaction intermediates in a precisely targeted pocket through careful metal–organic cage design is therefore crucial. Here, we prepare a tetrahedral [Cu6L4]-type boron–imidazolate cage integrating highly active Cu sites and optimized cavity, which exhibits enzyme like specific catalytic performance in electrochemical CO2reduction reaction（CO2RR） to enhance the selectivity of *** analyses and computational calculations suggest that the single Cu site together with neighboring boron–imidazolate ligands provides suitably synergistic effects that enable the energetically favorable formation of an *COCHO intermediate, a key step determining selectivity. As a result, the [Cu6L4]-type cage of BIC-145 achieves a Faradaic efficiency of 28% for C2H4maintaining an average current density of -3.54 mA cm-2over a 5-hour electrolysis period. This work represents the first example for studying single-metal site catalysts with ultra-low coordination numbers through the rational design of metal–organic cages.

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Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

Primary parenchymal squamous cell carcinoma of the kidney:A case report

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World Journal of Clinical Cases 2025年第4期13卷 34-40页

作者： Zhi-Hui Zheng Bo shao Chao-Min Xu Ke Wang Jia-Zhu Wen Li-Kang luo Jia-Cheng Guan Department of Ultrasound The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Radiology Shulan(Quzhou)HospitalQuzhou 324000Zhejiang ProvinceChina Department of Radiology The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Pathology The Second people’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases *** SUMMARY This study reports a 51-year-old man with primary SCC of the renal *** patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross *** antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated *** patient underwent laparoscopic unilateral nephrectomy and lymph node *** pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and *** pathological stage was *** months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena *** patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease *** We report a case of primary SCC of the renal parenchyma,a rare renal *** clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis *** to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.

关键词： Renal tumor Renal parenchyma Squamous cell carcinoma Renal calculi Computed tomography Case report

Casimir Effect for Dielectric Plates

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Communications in Theoretical Physics 2006年第3期45卷 499-504页

作者： shao Cheng-Gang TONG Ai-Hong luo jun Department of Physics Huazhong University of Science and Technology Wuhan 430074 China

We generalize Kupisewska method to the three-dimensional system and another derivation of the Casimir effect between two dielectric plates is presented based on the explicit quantization of the electromagnetic field in the presence of dielectricsl where the physical meaning of ＂evanescent mode＂ is discussed. The Lifshitz＇s formula is rederived using all the vacuum mode functions, which include the contribution of the ＇evanescent modes＇. Only in the case of the perfect, metallic plates will the evanescent modes become unimportant.

关键词： Casimir effect electromagnetic field quantization evanescent mode

Revolutionizing breast cancer detection:Advances in fluorescent probe technology

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Nano Research 2025年第1期18卷 653-674页

作者： Qian Gao Lin Tang jun Zhan Yiyuan Xue Feng luo State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan UniversityChengdu 610041China Emergency Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Prosthodontics West China School of StomatologySichuan UniversityChengdu 610041China

With the increasing incidence of breast cancer globally,there is an urgent demand for enhanced diagnostic and therapeutic *** comprehensive review explores advancements in fluorescent probe technology for breast cancer imaging and early *** probes offer unparalleled sensitivity and specificity in detecting cancer biomarkers,enabling early diagnosis and delineation of tumor margins during *** categorize these probes into molecular,nano,ratiometric,the second near-infrared window(NIR-II),and multifunctional varieties,each with unique capabilities for targeting specific cancer *** review highlights recent innovations in probe design,emphasizing their applications in pathogenesis studies,drug development,precision medicine,and fluorescence-guided *** their promising clinical potential,challenges such as safety,biomarker targeting accuracy,system compatibility,and clinical translation *** these hurdles is crucial for the integration of fluorescent probes into standard cancer care,aiming to improve treatment outcomes and patient quality of life.

关键词： breast cancer fluorescent probes imaging early diagnosis biomarker