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Malignant glaucoma treated by low-dose laser cycloplasty: a 1-year multicenter prospective noncomparative study

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1248-1254页

作者： Hai-Shuang Lin Xiao-Ping Xu Xuan-Li Zheng Ji-Bing Wang Su-Jie Fan Zuo-HongWu Su-Mian Cheng Li-Jun Zhao Qin-Hua Cai shao-dan zhang Shan-Shan Liu Ai-Guo Lyu Ying zhang Hong Chen dan-Ni Jiang Wu-Liang Li Nathan Congdon Clement C Tham Ming-Guang He Yuan-Bo Liang the Malignant Glaucoma TreatmentTrial Study(MGTT)Group Wenzhou Medical University Wenzhou 325027Zhejiang ProvinceChina Ningbo Eye Hospital Ningbo 315100Zhejiang ProvinceChina Weifang Eye Hospital Weifang 261000Shandong ProvinceChina Handan Eye Hospital Handan 056000Hebei ProvinceChina Aier Eye Hospital(Wuhan) Wuhan 430061Hubei ProvinceChina Hebei Eye Hospital Xingtai 054001Hebei ProvinceChina The Third People’s Hospital of Dalian Dalian 116033Liaoning ProvinceChina First Affiliated Hospital of Suzhou University Suzhou 215031Jiangsu ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Glaucoma Research Institute Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Centre for Public Health Queen’s University BelfastBelfast BT71NNUK Orbis International New YorkUSA Department of Ophthalmology and Visual Sciences the Chinese University of Hong KongHong Kong SAR 999077China Centre for Eye Research Australia University of MelbourneRoyal Victorian Eye and Ear HospitalEast Melbourne 3000VICAustralia 不详

AIM:To report a one-year clinical outcomes of low-dose laser cycloplasty(LCP)among malignant glaucoma ***:In this prospective,multicenter,noncomparative clinical study,participants with malignant glaucoma were recruited and underwent LCP at eight ophthalmic centers in *** were followed up at 1wk,1,3,6,and *** pressure(IOP),number of glaucoma medications,anterior chamber depth(ACD),and complications were *** success was defined as the reformation of the anterior chamber based on slit-lamp *** was defined by the presence of a shallow orﬂat anterior chamber after initial recovery from ***:A total of 34 eyes received *** IOP and medications decreased from 36.1±11.5 mm Hg with 3.3±1.5 glaucoma medications pre-treatment to 20.9±9.8 mm Hg(P<0.001)with 2.9±1.6 medications(P=0.046)at 1d,and 17.4±6.7 mm Hg(P<0.001)with 1.3±1.7 medications(P<0.001)at *** ACD increased from 1.1±0.8 mm at baseline to 1.7±1.0 mm and to 2.0±0.5 mm at 1d and 12mo,respectively.A total of 32(94.1%)eyes achieved initial anatomical *** follow-up,2(5.9%)eyes failed and 8(23.5%)eyes relapsed,yielding a 12-month anatomical success rate of 64.3%.Complications including anterior synechia(8.82%),choroidal/ciliary detachment(5.88%)and hypopyon(2.94%)were observed within ***:LCP is simple,safe,and effective in reforming the anterior chamber in malignant glaucoma.

关键词： anterior chamber reformation intraocular pressure low-dose laser cycloplasty malignant glaucoma anatomical success

SHMT1 C1420T polymorphism contributes to the risk of non-Hodgkin lymphoma:evidence from 7309 patients

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癌症 2015年第12期34卷 573-582页

作者： Yi-Wei Wang shao-dan zhang Wen-Ji Xue Mei-Ling Zhu Lei-Zhen Zheng Department of Oncology Xin Hua Hospital Affiliated To Shanghai Jiaotong University School of Medicine Department of Experimental Research State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer Center

Background:Serine hydroxymethyltransferase 1(SHMT1) is a key enzyme in the folate metabolic pathway that plays an important role in biosynthesis by providing one carbon ***1 C1420 T may lead to the abnormal biosynthesis involved in DNA synthesis and methylation,and it may eventually increase cancer *** epidemiologic studies have explored the association between C1420 T polymorphism and the risk of non-Hodgkin lymphoma(NHL),but the results have been ***,we performed this meta-analysis to evaluate the ***:The meta-analyses were conducted to evaluate the effect of SHMT1 C1420 T polymorphism on NHL *** ratios(ORs) and 95%confidence intervals(Cls) were calculated to measure the strength of the ***:Eight studies encompassing 3232 cases and 4077 controls were included.A statistically significant association was found between SHMT1 C1420 T polymorphism and NHL risk under the allelic comparison(T vs.C:OR = 1.09,95%CI 1.01-1.17);a borderline association was found between SHMT1 C1420 T polymorphism and NHL risk under the homozygote model(TT ***:OR = 1.18,95%CI 1.00-1.39) and the dominant model(CT+TT ***:OR = 1.10,95%CI 1.00-1.21).Conclusion:SHMT1 C1420 T polymorphism may be associated with NHL risk,which needs to be validated in large,prospective studies.

关键词： Serine hydroxymethyltransferase 1(SHMT1) Polymorphism Non-Hodgkin lymphoma Meta-analysis

Effect of Low-Temperature Thermal Oxidation on the Capillary Performance of Sintered Copper Powder Wicks

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Journal of Thermal Science 2024年第1期33卷 29-40页

作者： ZHU Minghan FANG Runquan HU Yanxin zhang Jiangyun shao dan HUANG Jin School of Material and Energy Guangdong University of TechnologyGuangzhou 510006China School of Electric Power Engineering Guangdong Polytechnic of Water Resources and Electric EngineeringGuangzhou 510006China Research into Artifacts Guangdong Key Laboratory of Battery SafetyGuangzhou Institute of Energy testingGuangzhou 511447China

In this study,a composite powder capillary wick is prepared,manufactured by sintering copper powder and surface treated by low-temperature thermal *** is used to improve the performance of the capillary *** forced flow method and infrared imaging method are used to test the permeability and capillary performance of the *** effects of different oxidation temperatures on the performance of capillary wick are *** experimental results show that the wetting performance of the oxidized samples is significantly *** the increase of oxidation temperature,the permeability *** capillary height and velocity of the thermally oxidized samples are significantly higher than those of the untreated capillary ***,the oxidation temperature needs to be adjusted to obtain the best capillary *** highest capillary performance is found at oxidation temperature of 300℃,with an increase of 46% compared to the untreated *** with other composite wicks show that the sample with an oxidation temperature of 300℃ has competitive capillary performance,making it a favorable alternative to two-phase heat transfer *** study shows that combining low-temperature thermal oxidation technology with powder sintering is a convenient and effective method to improve the capillary performance of powder wicks.

关键词： low-temperature thermal oxidation capillary performance copper powder permeability

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Nasopharyngeal brushing: a convenient and feasible sampling method for nucleic acid-based nasopharyngeal carcinoma research

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Cancer Communications 2018年第1期38卷 95-104页

作者： Pei-Fen zhang Xiao-Hui Zheng Xi-Zhao Li Tian Tian shao-dan zhang Ye-Zhu Hu Wei-Hua Jia Tumor Resource Bank State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer Center651 Dongfeng East RoadGuangzhou 510060Guang-dongP.R.China Affiliated Tumor Hospital of Xinjiang Medical University Ürümqi 830000XinjiangP.R.China

Background:Tissue specimens for nasopharyngeal carcinoma(NPC)research are scarce because of sampling *** studies have suggested non-invasive nasopharyngeal brushing as an effective sampling method for NPC *** present study aimed to evaluate the feasibility of nasopharyngeal brushing in the acquisition of NPC nucleic acids for ***:Nasopharyngeal brushing samples were acquired from 24 healthy individuals and 48 NPC *** from 48 NPC and 18 nasopharyngitis patients were collected by endoscopic *** expression levels of tumor suppressor genes(TSGs)and Epstein-Barr virus(EBV)-encoded microRNAs as well as EBV DNA copy number were measured by quantitative polymerase chain reaction in both types of ***:Among six TSGs examined,the expression levels of two genes were significantly decreased in nasopharyn-geal brushing and tissue samples from NPC patients as compared with those from healthy/nasopharyngitis *** EBV-encoded microRNAs,mir-bart1-5p,mir-bart5,mir-bart6-5p,and mir-bart17-5p,were significantly up-regulated in both NPC brushing and tissue samples compared with those from healthy/nasopharyngitis controls(P<0.001).EBV DNA was significantly increased in both nasopharyngeal brushing samples(P<0.001)and tissue sam-ples(P<0.001)from NPC patients in comparison with those from healthy ***:Nasopharyngeal brushing can obtain sufficient tumoral materials for the analysis of viral nucleic acid,including EBV-encoded microRNAs and EBV *** the detection of TSG expression,nasopharyngeal brushings was feasible but inferior to tissue *** study confirms nasopharyngeal brushing as an applicable sampling method that can aid in nucleic acid-based NPC research.

关键词： Nasopharyngeal brushing Tissue samples Nasopharyngeal carcinoma Nucleic acid Cancer research

Elevated urine formaldehyde in elderly patients with primary open angle glaucoma

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International Journal of Ophthalmology(English edition) 2016年第3期9卷 411-416页

作者： Ying Cui Tao Su shao-dan zhang Ping Huang Ying-Ge He Ying Liu Chun zhang Robert Ritch Rong-Qiao He Departrncnt of Ophthalmology Peking University Third Hospital Beijing 100191 China Key Laboratory of Vision Loss and Restoration Ministry of Education Beijing 100191 China State Key Laboratory of Brain and Cognitive Science Institute of Biophysics Chinese Academy of SciencesBeijing 100101 China Einhorn Clinical Research Center New York Eye and Ear Infirmary of Mount Sinai New York NY 10003 USA

AIM：To investigate the risk factor of primary open angle glaucoma（POAG）,which is the leading cause of irreversible blindness *** abnormally high level of endogenous formaldehyde（FA） has recently been found correlated with cell death and neurodegenerative disease,raising the possibility of a putative correlation of abnormal endogenous FA with POAG.· METHODS：Thirty-four elderly patients with POAG and sixteen healthy controls were *** visual defects were present at both the functional（visual field） and structural[retinal nerve fiber layer（RNFL）thickness]*** urine samples were obtained and were analyzed by high-performance liquid chromatography（HPLC） to detect the endogenous FA level in a double blind manner.· RESULTS：Patients with POAG（P 〈0.05） had significantly higher urine FA *** urine FA level of patients with severe visual field defects[mean deviation（MD）≥12 dB]was significantly（P〈0.001） greater than that of patients with mild to moderate defects（MD〈12 dB）.By optical coherence tomography（OCT）,the superior and inferior RNFL thickness of POAG group was significantly（P〈0.001） thinner than in ***,the superior and inferior thinning of the RNFL was correlated with the elevation of urine FA ***：Endogenous FA level is positively correlated with the neuronal defects of POAG.

关键词： primary open angle glaucoma urineformaldehyde Alzheimer's disease

Comparison of bevacizumab and ranibizumab in agerelated macular degeneration: a systematic review and meta-analysis

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International Journal of Ophthalmology(English edition) 2014年第2期7卷 355-364页

作者： Xiao-Yu zhang Xiao-Fan Guo shao-dan zhang Jing-Na He Cao-Yu Sun Yin Zou Han-Si Bi Yang Qu Department of Ophthalmology the Fourth People's Hospital of Shenyang Department of Cardiology the First Hospital of China Medical University

AIMTo compare the effectiveness and safety between bevacizumab and ranibizumab in the treatment of age-related macular degeneration (AMD) through a systematic review and meta-analysis.

关键词： age-related macular degeneration bevacizumab ranibizumab

Progress in research on metal-based materials in stabilized Zn anodes

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Rare Metals 2024年第1期43卷 20-40页

作者： Le Li shao-Feng Jia Ming-Hui Cao Yong-Qiang Ji Heng-Wei Qiu dan zhang Shaanxi Key Laboratory of Industrial Automation School of Mechanical EngineeringShaanxi University of TechnologyHanzhong 723001China School of Electronic and Information Engineering Qingdao UniversityQingdao 266071China State Key Laboratory for Artifcial Microstructure and Mesoscopic Physics School of PhysicsPeking UniversityBeijing 100871China Department of Chemistry Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical BiologyTsinghua UniversityBeijing 100084China Shaanxi Key Laboratory of Catalysis School of Chemistry and Environment ScienceShaanxi University of TechnologyHanzhong 723001China

Aqueous zinc-ion batteries(ZIBs) combine the benefits of metallic Zn anodes with those of aqueous electrolytes and are well suited for large-scale energy storage because of their inherent high safety, cost-effectiveness, and eco-friendliness. Currently, the practical application of such batteries is hindered by the poor cycling performance of Zn anodes due to uncontrolled dendrite formation and severe side reactions, although recent reports suggest that these problems can be mitigated through the modification of Zn anodes with metal-based *** that the mechanisms of improving Zn deposition and the structural evolution of metal-based materials have not been systematically reviewed, we herein systematically overview the metal-based materials used to stabilize Zn anodes, starting with a brief summary of the anode working mechanism and the challenges faced by stabilized Zn anodes. Subsequently, the design principles of Zn anodes stabilized by metal-based materials and the related recent progress are reviewed, and the key challenges and perspectives for the future development of such Zn anodes are proposed.

关键词： Zinc-ion batteries(ZIBs) Zn anode Metalbased materials Alloying metal Stabilized Zn anodes

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Plasma microRNA profiling in nasopharyngeal carcinoma patients reveals miR-548q and miR-483-5p as potential biomarkers

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Chinese Journal of Cancer 2014年第7期33卷 330-338页

作者： Xiao-Hui Zheng Cui Cui Hong-Lian Ruan Wen-Qiong Xue shao-dan zhang Ye-Zhu Hu Xin-Xi Zhou Wei-Hua Jia State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Department of Experimental Research Sun Yat-sen University Cancer Center

MicroRNAs(miRNAs), which play a role in tumorigenesis, may also serve as diagnostic or prognostic biomarkers. However, studies on human miRNA profiles in plasma from nasopharyngeal carcinoma(NPC) patients are in their infancy. Here, we used microarrays to perform systematic profiling of human miRNAs in plasma from NPC patients. We subsequently used real-time quantitative polymerase chain reaction(Q-PCR) to validate miRNAs with aberrant expression that could serve as potential biomarkers. By comparing the plasma miRNA profiles of 31 NPC patients and 19 controls, 39 of 887 human miRNAs were found to be aberrantly expressed. Considering the fold change and P value, miR-548q and miR-483-5p were validated in 132 samples from 82 NPC patients and 50 controls. Moreover, high expression of miR-548q and miR-483-5p was further found in 3 NPC cell lines and clinical biopsy tissues from 54 NPC patients and 22 controls. Our results revealed that miR-548q and miR-483-5p are potential biomarkers of NPC. Combining the receiver operating characteristic(ROC) analyses of these 2 miRNAs, an area under the ROC curve(AUC) of 0.737 with 67.1% sensitivity and 68.0% specificity were obtained, showing the preliminary diagnostic value of plasma miRNAs. Moreover, most NPC patients with a poor outcome exhibited high expression(> median) of miR-548q(70.6%) and miR-483-5p(64.7%) in tissue samples, indicating their prognostic value. The high expression levels of miR-548q and miR-483-5p in plasma, cell lines, and clinical tissues of NPC patients indicate that their roles in NPC should be explored in the future.

关键词：生物标志物 microRNA 鼻咽癌患者血浆 miRNA 全国人民代表大会聚合酶链反应

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Effect of low dose laser cycloplasty on deepening anterior chamber in chronic angle-closure glaucoma

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International Journal of Ophthalmology(English edition) 2023年第12期16卷 2011-2017页

作者： Xuan-Li Zheng Hai-Shuang Lin Xiao-Jie Wang Jia-Qian Li Yan-Qian Xie shao-dan zhang Yuan-Bo Liang Wenzhou Medical University Wenzhou 325027Zhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Glaucoma Research Institute Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To describe the outcome of using low-dose laser cycloplasty(LCP)in chronic angle-closure glaucoma(CACG).METHODS:A retrospective case *** charts of CACG patients who underwent LCP in the Eye Hospital of Wenzhou Medical University were *** main outcomes included intraocular pressure(IOP),the number of glaucoma medication,anterior segment parameters and surgery-related ***:A total of 7 eyes of 7 CACG patients(age 38.9±11.0y)underwent LCP with a mean follow-up of 27.1±13.7mo(range 16-48mo).Following LCP,mean IOP and glaucoma medications decreased from 26.1±6.1 mm Hg with 3.1±1.1 glaucoma medications pre-treatment to 14.9±3.1 mm Hg(P=0.027)with 0.4±1.1 glaucoma medications(P=0.001)at final *** anterior chamber depth(ACD),angle opening distance500 and trabecular-iris angle increased from 1.65±0.33 mm,0.05 mm(range 0-0.30 mm)and 5.1°(range,0-31.97°)at baseline to 1.98±0.43 mm(P=0.073),0.53 mm(range 0.42-0.91 mm,P=0.015),45.9°(range,40.2°-59.4°),(P=0.015)in the long-term follow-up,*** deepening of ACD and reopening of anterior chamber angle(ACA)was observed in 6 eyes(85.7%).CONCLUSION:LCP is a promising treatment option for patients with CACG via reducing IOP and glaucoma medication without serious *** addition,LCP can bring a significant deepening in ACD and reopening of ACA.

关键词： chronic angle-closure glaucoma low dose laser cycloplasty anterior chamber depth intraocular pressure