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Nasopharyngeal brushing: a convenient and feasible sampling method for nucleic acid-based nasopharyngeal carcinoma research

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Cancer Communications 2018年第1期38卷 95-104页

作者： Pei-Fen zhang Xiao-Hui Zheng Xi-Zhao Li Tian Tian shao-dan zhang Ye-Zhu Hu Wei-Hua Jia Tumor Resource Bank State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer Center651 Dongfeng East RoadGuangzhou 510060Guang-dongP.R.China Affiliated Tumor Hospital of Xinjiang Medical University Ürümqi 830000XinjiangP.R.China

Background:Tissue specimens for nasopharyngeal carcinoma(NPC)research are scarce because of sampling *** studies have suggested non-invasive nasopharyngeal brushing as an effective sampling method for NPC *** present study aimed to evaluate the feasibility of nasopharyngeal brushing in the acquisition of NPC nucleic acids for ***:Nasopharyngeal brushing samples were acquired from 24 healthy individuals and 48 NPC *** from 48 NPC and 18 nasopharyngitis patients were collected by endoscopic *** expression levels of tumor suppressor genes(TSGs)and Epstein-Barr virus(EBV)-encoded microRNAs as well as EBV DNA copy number were measured by quantitative polymerase chain reaction in both types of ***:Among six TSGs examined,the expression levels of two genes were significantly decreased in nasopharyn-geal brushing and tissue samples from NPC patients as compared with those from healthy/nasopharyngitis *** EBV-encoded microRNAs,mir-bart1-5p,mir-bart5,mir-bart6-5p,and mir-bart17-5p,were significantly up-regulated in both NPC brushing and tissue samples compared with those from healthy/nasopharyngitis controls(P<0.001).EBV DNA was significantly increased in both nasopharyngeal brushing samples(P<0.001)and tissue sam-ples(P<0.001)from NPC patients in comparison with those from healthy ***:Nasopharyngeal brushing can obtain sufficient tumoral materials for the analysis of viral nucleic acid,including EBV-encoded microRNAs and EBV *** the detection of TSG expression,nasopharyngeal brushings was feasible but inferior to tissue *** study confirms nasopharyngeal brushing as an applicable sampling method that can aid in nucleic acid-based NPC research.

关键词： Nasopharyngeal brushing Tissue samples Nasopharyngeal carcinoma Nucleic acid Cancer research

Patient satisfaction and follow-up adherence to glaucoma case management clinic in China

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 73-81页

作者： Hao Lin Hu-Jie Lu Wen-Zhe Zhou Shu-Shu Zuo Yan-Yan Chen shao-dan zhang National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina School of Ophthalmology and Optometry Biomedical EngineeringWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To assess glaucoma patient satisfaction and follow-up adherence in case management and identify associated predictors to improve healthcare quality and patient ***:In this cross-sectional study,a total of 119 patients completed a Patient Satisfaction Questionnaire-18 and a sociodemographic *** data was obtained from the case management ***-up adherence was defined as completing each follow-up within±30d of the scheduled time set by ophthalmologists during the study ***:Average satisfaction scored 78.65±7,with an average of 4.39±0.58 across the seven *** negatively correlated with satisfaction(P=0.008),whilst patients with follow-up duration of 2 or more years reported higher satisfaction(P=0.045).Multivariate logistics regression analysis revealed that longer follow-up durations were associated with lower follow-up adherence(OR=0.97,95%CI,0.95-1.00,P=0.044).Additionally,patients with suspected glaucoma(OR=2.72,95%CI,1.03-7.20,P=0.044)and those with an annual income over 100000 Chinese yuan demonstrated higher adherence(OR=5.57,95%CI,1.00-30.89,P=0.049).CONCLUSION:The case management model proves effective for glaucoma patients,with positive adherence *** implementation of this model can be optimized in the future based on the identified factors and extended to glaucoma patients in more hospitals.

关键词： glaucoma patient satisfaction follow-up adherence case management

Elevated urine formaldehyde in elderly patients with primary open angle glaucoma

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International Journal of Ophthalmology(English edition) 2016年第3期9卷 411-416页

作者： Ying Cui Tao Su shao-dan zhang Ping Huang Ying-Ge He Ying Liu Chun zhang Robert Ritch Rong-Qiao He Departrncnt of Ophthalmology Peking University Third Hospital Beijing 100191 China Key Laboratory of Vision Loss and Restoration Ministry of Education Beijing 100191 China State Key Laboratory of Brain and Cognitive Science Institute of Biophysics Chinese Academy of SciencesBeijing 100101 China Einhorn Clinical Research Center New York Eye and Ear Infirmary of Mount Sinai New York NY 10003 USA

AIM：To investigate the risk factor of primary open angle glaucoma（POAG）,which is the leading cause of irreversible blindness *** abnormally high level of endogenous formaldehyde（FA） has recently been found correlated with cell death and neurodegenerative disease,raising the possibility of a putative correlation of abnormal endogenous FA with POAG.· METHODS：Thirty-four elderly patients with POAG and sixteen healthy controls were *** visual defects were present at both the functional（visual field） and structural[retinal nerve fiber layer（RNFL）thickness]*** urine samples were obtained and were analyzed by high-performance liquid chromatography（HPLC） to detect the endogenous FA level in a double blind manner.· RESULTS：Patients with POAG（P 〈0.05） had significantly higher urine FA *** urine FA level of patients with severe visual field defects[mean deviation（MD）≥12 dB]was significantly（P〈0.001） greater than that of patients with mild to moderate defects（MD〈12 dB）.By optical coherence tomography（OCT）,the superior and inferior RNFL thickness of POAG group was significantly（P〈0.001） thinner than in ***,the superior and inferior thinning of the RNFL was correlated with the elevation of urine FA ***：Endogenous FA level is positively correlated with the neuronal defects of POAG.

关键词： primary open angle glaucoma urineformaldehyde Alzheimer's disease

Comparison of bevacizumab and ranibizumab in agerelated macular degeneration: a systematic review and meta-analysis

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International Journal of Ophthalmology(English edition) 2014年第2期7卷 355-364页

作者： Xiao-Yu zhang Xiao-Fan Guo shao-dan zhang Jing-Na He Cao-Yu Sun Yin Zou Han-Si Bi Yang Qu Department of Ophthalmology the Fourth People's Hospital of Shenyang Department of Cardiology the First Hospital of China Medical University

AIMTo compare the effectiveness and safety between bevacizumab and ranibizumab in the treatment of age-related macular degeneration (AMD) through a systematic review and meta-analysis.

关键词： age-related macular degeneration bevacizumab ranibizumab

Effect of low dose laser cycloplasty on deepening anterior chamber in chronic angle-closure glaucoma

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International Journal of Ophthalmology(English edition) 2023年第12期16卷 2011-2017页

作者： Xuan-Li Zheng Hai-Shuang Lin Xiao-Jie Wang Jia-Qian Li Yan-Qian Xie shao-dan zhang Yuan-Bo Liang Wenzhou Medical University Wenzhou 325027Zhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Glaucoma Research Institute Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To describe the outcome of using low-dose laser cycloplasty(LCP)in chronic angle-closure glaucoma(CACG).METHODS:A retrospective case *** charts of CACG patients who underwent LCP in the Eye Hospital of Wenzhou Medical University were *** main outcomes included intraocular pressure(IOP),the number of glaucoma medication,anterior segment parameters and surgery-related ***:A total of 7 eyes of 7 CACG patients(age 38.9±11.0y)underwent LCP with a mean follow-up of 27.1±13.7mo(range 16-48mo).Following LCP,mean IOP and glaucoma medications decreased from 26.1±6.1 mm Hg with 3.1±1.1 glaucoma medications pre-treatment to 14.9±3.1 mm Hg(P=0.027)with 0.4±1.1 glaucoma medications(P=0.001)at final *** anterior chamber depth(ACD),angle opening distance500 and trabecular-iris angle increased from 1.65±0.33 mm,0.05 mm(range 0-0.30 mm)and 5.1°(range,0-31.97°)at baseline to 1.98±0.43 mm(P=0.073),0.53 mm(range 0.42-0.91 mm,P=0.015),45.9°(range,40.2°-59.4°),(P=0.015)in the long-term follow-up,*** deepening of ACD and reopening of anterior chamber angle(ACA)was observed in 6 eyes(85.7%).CONCLUSION:LCP is a promising treatment option for patients with CACG via reducing IOP and glaucoma medication without serious *** addition,LCP can bring a significant deepening in ACD and reopening of ACA.

关键词： chronic angle-closure glaucoma low dose laser cycloplasty anterior chamber depth intraocular pressure

A new bleb-independent surgery namely penetrating canaloplasty for corticosteroid-induced glaucoma: a prospective case series

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International Journal of Ophthalmology(English edition) 2022年第7期15卷 1077-1081页

作者： Jing-Jing Hu Hai-Shuang Lin shao-dan zhang Wen-Qing Ye Juan Gu Yan-Qian Xie Yi-Hua Tang Yuan-Bo Liang The Eye Hospital School of Ophthalmology&OptometryWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Glaucoma Institute Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM: To report the outcomes of penetrating canaloplasty for corticosteroid-induced glaucoma in a case ***: Penetrating canaloplasty is a blebindependent filtering surger y unifying canaloplasty and trabeculectomy. In this study, the surger y was performed to restore the natural outflow through surgically expanded Schlemm’s canal and generated trabeculum ostium. A total of 10 eyes of 8 patients were treated with penetrating canaloplasty for corticosteroid-induced glaucoma. Intraocular pressure(IOP) and the number of glaucoma medications at postoperative 3, 6, 12, 18, 24,36, and 48mo were documented as primary *** after the surgery were recorded as secondary ***: Penetrating canaloplasty was accomplished successfully for all 10 eyes, with a mean follow-up of 20.4±13.0mo(range 6-48mo). The mean preoperative IOP and number of anti-glaucoma medications were 45.1±6.5 mm Hg and 3.3±0.5 respectively. The mean post-operative IOP at 3, 6, 12, 18, 24, 36, and 48mo were 15.8±6.0, 14.7±3.3,15.3±2.0, 15.6±2.6, 17.5±1.8, 16.5±4.9, and 14.0 mm *** number of anti-glaucoma medications at these time points were all 0. This surgery failed to control the IOP in 1 eye at 1mo after surgery. Hyphaema occurred in 3 eyes on the first day after surgery. Postoperative transient IOP increasing was encountered with in two eyes from 1wk to 1mo after surgery. Choroidal detachment developed in one eye but responded well to conservative ***: Penetrating canaloplasty is effective for corticosteroid-induced glaucoma without serious complications, making it a viable or preferred alternative option.

关键词： penetrating canaloplasty corticosteroid-induced glaucoma intraocular pressure bleb-independent filtering surgery

Trend of glaucoma internal filtration surgeries in a tertiary hospital in China

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International Journal of Ophthalmology(English edition) 2023年第2期16卷 251-259页

作者： Yang Cao Hai-Shuang Lin Hui-Yan Mao Yin Zhao Yan-Qian Xie shao-dan zhang Qi zhang Pei-Juan Wang Guo-Xing Li Ai-Wu Fang Yuan-Bo Liang The Eye Hospital School of Ophthalmology and OptometryWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Glaucoma Research Institute Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Wenzhou 325027Zhejiang ProvinceChina

AIM:To evaluate the trend of glaucoma internal filtration surgeries for inpatients between 2015 and 2021 at the Eye Hospital of Wenzhou Medical ***:A review of the medical records of inpatients who had been diagnosed with glaucoma and received antiglaucoma surgery between January 1,2015 and December 31,2021 was *** glaucoma diagnosis in this study included primary open angle glaucoma,primary angleclosure glaucoma,secondary glaucoma,and paediatric *** types of surgeries were categorised as internal filtration,external filtration,and cyclodestruction surgery based on the pathway of aqueous humor *** trend of these glaucoma surgeries in the sample of patients with different types of glaucoma was then ***:The number of patients hospitalised for glaucoma surgery increased yearly,from 752 in 2015 to 1373 in 2021,at the Eye Hospital of Wenzhou Medical *** the patients diagnosed with primary open angle glaucoma,internal filtration surgery increased from 27.40%of the sample to 54.40%of the sample,while external filtration surgery decreased from 71.50%to 44.20%between 2015 and *** paediatric glaucoma,internal filtration surgery increased from 37.50%in 2015 to 88.20%in *** different types of surgeries were performed on the sample of patients with secondary glaucoma,the proportion of internal filtration surgery also showed an increase from 18.20%in 2015 to 40.90%in ***,internal filtration surgery in the patient sample with primary angle-closure glaucoma already accounted for over 70.00%in 2015,and showed a small increase by ***:As surgical technology and surgical experience continue to elevate and improve,the range of glaucoma surgeries are correspondingly *** study find that internal filtration surgeries accounted for an increasing proportion of treatments in the surgical management of glaucoma between 2015 and 2021.

关键词： glaucoma internal filtration surgery inpatient trend

Treating epilepsy based on phlegm-turbidity syndrome

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TMR Integrative Medicine 2020年第7期4卷 1-5页

作者： Shu-Ning Liu Xin Ping shao-Kun Qin Ye Lu shao-dan zhang Lin Pei School of Chinese Medicine North China University of Science and TechnologyTangshan 063210China School of Chinese Medicine Hebei UniversityBaoding 071051China Hebei Academy of Traditional Chinese Medicine Shijiazhuang 050031China The Second Hospital of Hebei Medical University Shijiazhuang 050073China

Through expounding the theory of phlegm-turbidity and the development of epilepsy,this paper presents the new theoretical basis for the treatment of *** authors calculate that phlegm and turbidity are different in the formation and pathogenic ***,it is necessary to expound the formation of the phlegm and *** is also necessary to explain the pathogenesis of the phlegm and turbidity in the *** is caused by the invasion of external evil,emotional disorders,or Qi deficiency and decline,resulting in Qi and blood disorder in the body;the accumulation of phlegm and heat for a long time will lead to the accumulation of turbidity;further with the failure of Qi and fluid circulation,it will lead to brain damage and epileptic ***,the treatment needs to distinguish the severity of phlegm and turbidity,based on which,use different herbs for the treatment of epilepsy.

关键词： Epilepsy Phlegm-turbidity Pathogenesis Detoxification Traditional Chinese medical treatment

Malignant glaucoma treated by low-dose laser cycloplasty: a 1-year multicenter prospective noncomparative study

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1248-1254页

作者： Hai-Shuang Lin Xiao-Ping Xu Xuan-Li Zheng Ji-Bing Wang Su-Jie Fan Zuo-HongWu Su-Mian Cheng Li-Jun Zhao Qin-Hua Cai shao-dan zhang Shan-Shan Liu Ai-Guo Lyu Ying zhang Hong Chen dan-Ni Jiang Wu-Liang Li Nathan Congdon Clement C Tham Ming-Guang He Yuan-Bo Liang the Malignant Glaucoma TreatmentTrial Study(MGTT)Group Wenzhou Medical University Wenzhou 325027Zhejiang ProvinceChina Ningbo Eye Hospital Ningbo 315100Zhejiang ProvinceChina Weifang Eye Hospital Weifang 261000Shandong ProvinceChina Handan Eye Hospital Handan 056000Hebei ProvinceChina Aier Eye Hospital(Wuhan) Wuhan 430061Hubei ProvinceChina Hebei Eye Hospital Xingtai 054001Hebei ProvinceChina The Third People’s Hospital of Dalian Dalian 116033Liaoning ProvinceChina First Affiliated Hospital of Suzhou University Suzhou 215031Jiangsu ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Glaucoma Research Institute Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Centre for Public Health Queen’s University BelfastBelfast BT71NNUK Orbis International New YorkUSA Department of Ophthalmology and Visual Sciences the Chinese University of Hong KongHong Kong SAR 999077China Centre for Eye Research Australia University of MelbourneRoyal Victorian Eye and Ear HospitalEast Melbourne 3000VICAustralia 不详

AIM:To report a one-year clinical outcomes of low-dose laser cycloplasty(LCP)among malignant glaucoma ***:In this prospective,multicenter,noncomparative clinical study,participants with malignant glaucoma were recruited and underwent LCP at eight ophthalmic centers in *** were followed up at 1wk,1,3,6,and *** pressure(IOP),number of glaucoma medications,anterior chamber depth(ACD),and complications were *** success was defined as the reformation of the anterior chamber based on slit-lamp *** was defined by the presence of a shallow orﬂat anterior chamber after initial recovery from ***:A total of 34 eyes received *** IOP and medications decreased from 36.1±11.5 mm Hg with 3.3±1.5 glaucoma medications pre-treatment to 20.9±9.8 mm Hg(P<0.001)with 2.9±1.6 medications(P=0.046)at 1d,and 17.4±6.7 mm Hg(P<0.001)with 1.3±1.7 medications(P<0.001)at *** ACD increased from 1.1±0.8 mm at baseline to 1.7±1.0 mm and to 2.0±0.5 mm at 1d and 12mo,respectively.A total of 32(94.1%)eyes achieved initial anatomical *** follow-up,2(5.9%)eyes failed and 8(23.5%)eyes relapsed,yielding a 12-month anatomical success rate of 64.3%.Complications including anterior synechia(8.82%),choroidal/ciliary detachment(5.88%)and hypopyon(2.94%)were observed within ***:LCP is simple,safe,and effective in reforming the anterior chamber in malignant glaucoma.

关键词： anterior chamber reformation intraocular pressure low-dose laser cycloplasty malignant glaucoma anatomical success