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Metallic nanoparticle based colorimetric assay for enzyme detection and inhibitor screening

2011年全国药物化学学术会议——药物的源头创新

作者： bengang xing,shao qing,yanmei yang division of chemistry and biological chemistry,school of physical and mathematical sciences,nanyang technological university,637371,singapore

＜正＞In general,the specificity observed in biological system is always mediated by the accurate and selective control of gene expression in response to intrinsic development programs and extrinsic *** possibility to better understand the regulation of gene expression and the specificity of biological pathways is to apply an assay with high sensitivity and fidelity that reports

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Metallic nanoparticle based colorimetric assay for enzyme de...

Nanoformulation of metal complexes： Intelligent stimuli- responsive platforms for precision therapeutics

中国化学会第27届学术年会

作者： Rongrong Liu, yanmei yang, bengang xing* division of chemistry and biological chemistry, school of physical and mathematical sciences, nanyang technological university, 637371, singapore

＜正＞Since the antibacterial properties of penicillin were first discovered in the last century, β-lactam based antibiotics have been widely utilized as miracle drugs in the treatment of bacterial infectious disease... 详细信息

关键词： Metallic nanoparticles bacterial enzyme colorimetric assay enzyme inhibition

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Nano Research 2018年第10期11卷 5474-5498页

作者： Ming Hu Xiangzhao Ai Zhimin Wang Zhijun Zhang Haolun Cheong Wenmin Zhang Jun Lin Juan Li Huanghao yang bengang xing division of chemistry & biological chemistry School of Physical & Mathematical Sciences Nanyang Technological University Singapore 637371 Singapore College of chemistry Fuzhou University Fuzhou 350116 China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China

Precision medicine is a potential effective therapeutic for various human diseases. Currently, metal complex-based drugs are being successfully used in clinical applications owing to diverse properties such as multiple redox states, photo-induced ligand exchange, and preferential ligand and coordination numbers, which facilitate drug design and development. However, drawbacks such as toxicity, lack of specificity, and severe side effects have hampered their therapeutic outcome. Therefore, innovative strategies for improving the specificity and pharmacokinetics of conventional metal complex-based therapeutic agents are required. Recently, nanotechnology, which provides a unique toolbox for developing effective and safer medicine, has attracted considerable attention, mainly because of their ability to reduce side effects and enhance drug loading efficiency and pharmacokinetics. Considering the promising chemical and physical properties of diverse nanostructures, nanoformulation of metal complexes can be used to effectively address the problems associated with current metallodrug complexes, especially those based on stimuli-responsive therapeutic strategies, with excellent spatial, temporal, and dosage control. In this review, we have mainly focused on the specificity and environment-responsiveness of metallodrug nanoformulations as therapeutics, and summarized the recent strategies being used for developing metal complex-functionalized intelligent nanoplatforms, which respond to various types of stimuli, including endogenous signals （pH, redox condition,s, and enzyme activities） or external triggers （light irradiation and magnetic field manipulations）. In addition, we have also discussed the potential challenges associated with use of metallodrugs and their nanoformulations as effective precision therapy with improved specificity and minimal side effects.

关键词： precision therapeutics metal drug complex multifunctionalnanomaterials stimuli-responsive

Five-dimensional tracking of single nanoparticles in living cells

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Light(Science & Applications) 2018年第1期7卷 911-912页

作者： Xiangzhao Ai bengang xing division of chemistry and biological chemistry School of Physical&Mathematical SciencesNanyang Technological UniversitySingapore 637371Singapore

An innovative approach to achieve dynamic fivedimensional tracking of single nanoparticles under simple microscopic inspection by human eyes was presented;this approach provided an effective means to investigate the c... 详细信息

关键词： dimensional innovative inspection

pH-sensitive and biodegradable charge-transfer nanocomplex for second near-infrared photoacoustic tumor imaging

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Nano Research 2019年第1期12卷 49-55页

作者： Zhimin Wang Paul Kumar Upputuri Xu Zhen Ruochong Zhang Yuyan Jiang Xiangzhao Ai Zhijun Zhang Ming Hu Zhenyu Meng Yunpeng Lu Yuanjing Zheng Kanyi Pu Manojit Pramanik bengang xing division of chemistry and biological chemistry School of Physical&Mathematical SciencesNanyang Technological UniversitySingapore 637371Singapore school of Chemical and Biomedical Engineering Nanyang Technological University70 Nanyang DriveSingapore 637459Singapore school of Electrical and Electronic Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore

The emerging technique of photoacoustic imaging,especially in the near infra-red(NIR)window,permits high resolution,deep-penetration,clinically reliable ***,few contrast agents are available that can specifically respond to intricate biological environments,and which are biodegradable and ***,we in troduce a new class of pH-sensitive orga nic photoacoustic con trast age nt that operates in the second NIR window(NIR-II,960-1,700 nm),which is derived from the self-assembled charge-transfer nanocomplex(CTN)by 3,3',5,5'-tetramethylbenzidine(TMB)and its dication structure(TMB++).The unique NIR-ll-responsive CTN can specifically respond to pH change in the physiological range and allows noninvasive and sensitive visualization of the tumor acidic microenvironment(*** pH5)in mice with higher signal-to-noise *** CTN is biodegradable under physiological conditions(*** 7.4),which alleviates the biosafety concern of nan oparticle accumulati on in *** results clearly show the pote ntial of the TMB/TMB++-based CTN as a promisi ng pH-activated and biodegradable molecular probe for specific tumor photoacoustic imaging in the NIR-II region.

关键词： charge-transfer nanocomplex second near-infrared window photoacoustic imaging pH-sensitive biodegradable tumor acidic microenvironment

Development of porphyrin and titanium dioxide sonosensitizers for sonodynamic cancer therapy

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Biomaterials Translational 2021年第1期2卷 72-85页

作者： Xiangyu Deng Zengwu shao Yanli Zhao Department of Orthopaedic Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina division of chemistry and biological chemistry School of Physical and Mathematical SciencesNanyang Technological UniversitySingapore

Sonodynamic therapy for malignant tumours has gained much attention for its deep penetration effect and efficient tumour killing *** design,modification,and utilization of sonosensitizers are important aspects of sonodynamic *** an essential factor in this process,highly effective sonosensitizers should be developed to facilitate the clinical applications of sonodynamic *** review takes porphyrin-and titanium dioxide(TiO_(2))-based systems as representative organic and inorganic sonosensitizers respectively,and summarizes their characteristics and biological effects as sonodynamic *** discovery of novel sonosensitizers,sonodynamic therapy becomes an efficient means of adjuvant therapy for the treatment of malignant tumours.

关键词： cancer treatment porphyrins sonodynamic therapy sonosensitizers TiO_(2)

Alumina-coated Ag nanocrystal monolayers as surfaceenhanced Raman spectroscopy platforms for the direct spectroscopic detection of water splitting reaction intermediates

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Nano Research 2014年第1期7卷 132-143页

作者： xing Yi Ling Ruoxue Yan Sylvia Lo Dat Tien Hoang Chong Liu Melissa A. Fardy Sher Bahadar Khan Abdullah M. Asiri Salem M. Bawaked Peidong yang Department of chemistry University of California Berkeley CA 94720-1460 USA Center of Excellence for Advanced Materials Research (CEAMR) King Abdulaziz University Jeddah 21589 P.O. Box 80203 Saudi Arabia division of chemistry and biological chemistry School of Physical and Mathematical Sciences Nanyang Technological University Singapore Department of Chemical and Environmental Engineering. university of California Riverside CA 9252 1 USA These authors contributed equally to this work.

A novel Ag-alumina hybrid surface-enhanced Raman spectroscopy （SERS） platform has been designed for the spectroscopic detection of surface reactions in the steady state. Single crystalline and faceted silver （Ag） nanoparticles with strong light scattering were prepared in large quantity, which enables their reproducible self-assembly into large scale monolayers of Raman sensor arrays by the Langrnuir-Blodgett technique. The close packed sensor film contains high density of sub-nm gaps between sharp edges of Ag nanoparticles, which created large local electromagnetic fields that serve as ＂hot spots＂ for SERS enhancement. The SERS substrate was then coated with a thin layer of alumina by atomic layer deposition to prevent charge transfer between Ag and the reaction system. The photocatalytic water splitting reaction on a monolayer of anatase TiO2 nanoplates decorated with Pt co-catalyst nanoparticles was employed as a model reaction system. Reaction intermediates of water photooxidation were observed at the TiO2/solution interface under UV irradiation. The surface-enhanced Raman vibrations corresponding to peroxo, hydroperoxo and hydroxo surface intermediate species were observed on the TiO2 surface, suggesting that the photo-oxidation of water on these anatase TiO2 nanosheets may be initiated by a nucleophilic attack mechanism.

关键词： surface-enhanced Ramanspectroscopy water splitting reaction reaction intermediates Ag nanocrystals

近红外上转换纳米转换器在光遗传学调控中的应用

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无机化学学报 2020年第6期36卷 969-982页

作者：王志敏胡明邢本刚新加坡南洋理工大学数理与科学学院化学与生物化学系新加坡637371

光遗传学作为一种新兴的生物技术,能够在时间和空间上精准调控生理功能。尤其是在基于视紫红质离子通道蛋白来操控神经兴奋性及钙信号通路激活等方面,近年来该技术吸引了广泛的关注。然而,目前该技术所使用的光遗传学工具只能被可见光激... 详细信息

光遗传学作为一种新兴的生物技术,能够在时间和空间上精准调控生理功能。尤其是在基于视紫红质离子通道蛋白来操控神经兴奋性及钙信号通路激活等方面,近年来该技术吸引了广泛的关注。然而,目前该技术所使用的光遗传学工具只能被可见光激发,难以穿透深层组织并实现无创地光学调控。为了解决这个问题,最近一些研究通过使用稀土掺杂上转换纳米粒子作为光转换器,将组织可穿透的近红外光转化为可见光发射,从而使复杂活体条件下的光遗传学调控成为可能。我们对近年来上转换纳米粒子介导的光遗传学技术的开发和应用进展做了详细的总结。另外,关于未来如何进一步推进该技术可用于临床研究提出了建议和展望。

关键词：光遗传学上转换纳米粒子近红外光转换器光调控离子通道生理活动