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2015年中国药学大会暨第十五届中国药师周

作者： MU Fei DUAN Jia-lin BIAN Hai-xu YIN Ying ZHU Yan-rong WEI guo GUAN Yue WANG Yan-hua GUO Chao WEN Ai-dong xi Miao-miao department of Pharmacy Xijing Hospital Fourth Military Medical University

Aim: Salvia miltiorrhiza Bunge（SM） and lignum dalbergiae odoriferae（DO） are both traditional chinese medicine.that have cardioprotective effects. Here, we further examined the combined effects of SM and DO on rat myocardial ischemia/reperfusion injury. The possible mechanism of SM and DO also were elucidated. Material and Methods: DO was divided into aqueous extract of lignum dalbergiae odoriferae（DOW） and lignum dalbergiae odoriferae oil（DOO）. Sprague-Dawley rats were randomized to seven groups: sham group, model group, treatment groups including SM（10 g/kg）, DOW（5 g/kg）, DOO（0.5 ml/kg）, SM+DOW（10 g/kg+5 g/kg）, SM+DOO（10 g/kg+0.5 ml/kg）. Rats were pretreated with homologous drug for 7 days and then subjected to 30 min of ischemia followed by 180 min of reperfusion. Electrocardiogram（ECG） and heart rate were monitored and recorded continuously. At the end of reperfusion, blood samples were collected to determine the serum levels of creatine kinase-MB（CK-MB） and lactate dehydrogenase（lDH）. Hearts were harvested to assess heart-body rate, infarct size and histopathological changes as well. Maximum and minimum effective points were determined by measuring indicators associate with myocardial injury at different time-points of reperfusion（5 min, 15 min, 30 min, 45 min, 60 min, 120 min, 180 min）. The potential therapeutic mechanism of SM and SM+DOO were carried out by detecting superoxide dismutase（SOD）,malondialdehyde（MDA）, tumor necrosis factor-alpha（TNF-alpha） and interleukin 6（Il-6）. Results: The results showed SM and DO can ameliorate cardiac function respectively, and this cardioprotective effect was further strengthened by their combinations. Among all the combinations, SM+DOO showed predominant potential to improve ECG and heart rate, reduce heart-body rate（28.5% ±1.4%, P＜0.01 vs model）and myocardial infarct size（20.96%±1.61%,P＜0.01 vs model, P＜0.05 vs SM）, attenuate histopathological damage, decrease the levels of CK-MB and lDH（P＜0.01 vs model, P＜0.05 vs SM）. Th

关键词： myocardial ischemia/reperfusion injury Salvia miltiorrhiza Bunge lignum dalbergiae odoriferae the maximum and minimum effective points anti-oxidant anti-inflammatory

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Sex differences in the scored Patient-Generated Subjective Global Assessment in 19,528 cancer patients

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Journal of Nutritional Oncology 2023年第1期8卷 38-46页

作者： Wang Yan-li wu Tian-Tian Fu Zhen-Ming Guo Zeng-Qing lin Yuan Shi Ying-Ying Hu Wen Ba Yi li Su-Yi li Zeng-Ning Wang Kun-hua wu Jing He Ying Yang Jia-Jun xie Cong-hua Zhou Fu-xiang Song xin-xia Chen Gong-Yan Ma Wen-Jun luo Su-xia Chen Zi-hua Cong Ming-hua Ma Hu Zhou Chun-ling Wang Wei luo Qi Shi Yong-Mei Qi Yu-Mei Jiang Hai-Ping Guan Wen-xian Chen Jun-Qiang Chen Jia-xin Fang Yu Zhou lan Feng Yong-Dong Tan Rong-shao li Tao Ou Jun-Wen Zhao Qing-Chuan wu Jian-xiong lin xin Yang liu-Qing Zhang Qi Jia Ping-Ping li Wei Xu Hong-xia Shi Han-Ping Song Chun-hua The Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group chinese Society of Nutritional Oncology department of Epidemiology and Statistics College of Public HealthZhengzhou UniversityZhengzhouHenanChina Cancer Center Renmin Hospital of Wuhan UniversityWuhanHubeiChina department of medical Oncology Fujian Cancer HospitalFujian Medical University Cancer HospitalFuzhouFujianChina department of Gastrointestinal Surgery Affiliated Tumor Hospital of Guangxi Medical UniversityNanningGuangxiChina department of Surgery The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina department of Clinical Nutrition West China Hospital of Sichuan UniversityChengduSichuanChina department of Gastrointestinal Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin Key Laboratory of Cancer Prevention and TherapyTianjinChina department of Nutrition and Metabolism of Oncology Affiliated Provincial Hospital of Anhui Medical UniversityHefeiAnhuiChina department of Clinical Nutrition The First Hospital of Hebei Medical UniversityShijiazhuangHebeiChina department of Gastrointestinal Surgery Institute of GastroenterologyThe First Affiliated Hospital of Kunming Medical UniversityKunmingYunnanChina Zhongshan Chenxinghai hospital(Affiliated Zhongshan Chenxinghai hospital of Guangdong medical university. ZhongshanGuangdongChina department of Clinical Nutrition The First People's Hospital of KashiKashiXinjiangChina department of Clinical Nutrition Chongqing General HospitalChongqingChina department of Colorectal and Anal Surgery Huizhou Municipal Central HospitalHuizhouGuangdongChina department of Radiation and medical Oncology Zhongnan Hospital of Wuhan UniversityWuhanHubeiChina department of Oncology Xingtai People’s HospitalHebei Medical UniversityXingtaiHebeiChina The First department of the Tumor hospital of Harbin medical university HarbinHeilongjiangChina department of Nutrition Guangdong General HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdongChina department of Oncology Affiliated

Background:The scored Patient-Generated Subjective Global Assessment(PG-SGA)has been widely used to assess the nutritional status of cancer *** purpose of this study is to compare the differences in PG-SGA scores and the 7 domain scores of the PG-SGA in male and female cancer ***:This study was conducted at 72 hospitals from July 2013 to December 2018,a part of the Investigation on Nutritional Status and its Clinical Outcomes of Common *** PG-SGA was recorded to evaluate the nutritional status of patients.A total of 19,528 patients with 13 common malignancies were included in this *** t test and the χ^(2) test were applied to analyze the sex diferences in the 7 domain *** Cancer Genome Atlas(TCGA)database was used to analyze the expression levels of symptom-related ***:There were significant sex dfferences in the PG-SGA(P=0.032),notably in patients with gastric cancer(male vs female:9.09±4.86 vs 9.58±5.07,P=0.005)and esophageal cancer(9.64±4.90 vs 10.46±4.96,P=0.011)and the average total PG-SGA of female patients was slightly higher than that of male patients(7.64±4.98 vs 7.77±5.14).The differences were mainly related to the weight,eating,symptom,as well as activity and physical function scores in the stratified *** causes of the sex differences were the rates of nausea,vomiting,dry mouth,and other symptoms,in both gastric and esophageal cancer *** of the TCGA database suggested that most of the related genes were sex neutral,except for genes related to dysphagia in gastric cancer(VEGFC was higher in female patients,VEGFA and VEGFB higher in male patients).Conclusions:There are sex differences in the PG-SGA scores in patients with various tumor types(female patients generally had higher scores than male patients),with differences mainly in the weight,eating,symptom,as well as activity and physical function *** sex differences in PG-SGA scores might be due to the differences i

关键词： PG-SGA Sex differences Malnutrition Cancer patients TCGA database

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A double-blind,randomized,placebo-and positive-controlled phase III trial of 1% benvitimod cream in mild-to-moderate plaque psoriasis

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chinese medical Journal 2020年第24期133卷 2905-2909页

作者： lin Cai Gen-Hui Chen Qian-Jin lu Min Zheng Yu-Zhen li Jin Chen Jie Zheng Fu-Ren Zhang Jian-Bin Yu Sen Yang Fu-Qiu li Sheng-xiang xiao Qiu-Ning Sun Jin-hua Xu xing-hua Gao Hong Fang Tian-Wen Gao Fei Hao Quan-Zhong liu Ya-Ting Tu Ruo-Yu li Bao-xi Wang Dan-Qi Deng Qing-Shan Zheng Hong-xia liu Jian-Zhong Zhang department of Dermatology Peking University People’s HospitalBeijing 100044China Beijing Wenfeng Tianji Pharma ltd. Beijing 100044China department of Dermatology The Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China department of Dermatology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang 310009China department of Dermatology Harbin Medical University Second HospitalHarbinHeilongjiang 150001China department of Dermatology Sichuan Provincial People’s HospitalChengduSichuan 610072China department of Dermatology Shanghai JiaoTong University School of Medicine Ruijin HospitalShanghai 213002China Shandong Provinical Institute of Dermatology and Venereology JinanShandong 250022China department of Dermatology The First Affiliated HospitalZhengzhou UniversityZhengzhouHenan 450052China department of Dermatology The First Affiliated HospitalAnhui Medical UniversityHefeiAnhui 230022China department of Dermatology The Second Hospital of Jilin UniversityChangchunJilin 130041China department of Dermatology The Second Affiliated HospitalXi’an Jiaotong UniversityXi’anShaanxi 710004China department of Dermatology Peking Union Medical College HospitalBeijing 100730China department of Dermatology Fudan University Huashan HospitalShanghai 200041China department of Dermatology The First Hospital of China Medical UniversityShenyangLiaoning 110001China department of Dermatology The First Affiliated HospitalZhejiang UniversityHangzhouZhejiang 310006China department of Dermatology Xijing HospitalAir Force Medical University of People’s Liberation ArmyXi’anShaanxi 710032China department of Dermatology Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China department of Dermatology Tianjin Medical University General HospitalTianjin 300052China department of Dermatology Wuhan Union HospitalWuhanHubei 430022China department of Dermatology Peking University First HospitalBeijing

Background:Benvitimod cream,a novel synthetic small molecule,was effective in treating mild-to-moderate plaque *** conducted a phase III clinical trial to assess the efficacy and safety of benvitimod cream in patients with mild-to-moderate plaque ***:We randomly assigned 686 patients(2:1:1)to receive 1%benvitimod cream,0.005%calcipotriol ointment or placebo twice a day for 12 *** primary efficacy end points were the percentage of patients with a 75%or greater reduction from baseline in the psoriasis area and severity index(PASI 75)score and with a score of 0 or 1 in static physician’s global assessment(sPGA)at week ***:The results showed that 50.4%of patients in the benvitimod group achieved PASI 75,which was significantly higher than that in the calcipotriol(38.5%,Placebo(13.9%,P1 was 66.3%in the benvitimod group and 63.9%in the calcipotriol group,which were both significantly higher than that in the placebo group(34%,Plong-term follow-up study,50.8%of patients experienced *** retreatment with 1%benvitimod,73.3%of patients achieved an sPGA score of 0 or 1 again at week *** events included application site irritation,follicular papules,and contact *** systemic adverse reactions were ***:During this 12-week study,benvitimod cream was demonstrated with high effectiveness and safety in patients with mild-to-moderate plaque psoriasis.

关键词： Psoriasis Benvitimod Immune modulator Drug discovery 3,5-dihydroxy-4-isopropylstilbene

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Esomeprazole regimens for reflux symptoms in chinesepatients with chronic gastrit

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World Journal of Gastroenterology 2015年第22期21卷 6965-6973页

作者： Jing Sun, Yao-Zong Yuan, xiao-hua Hou, Duo-wu Zou, Bin lu, Min-Hu Chen, Fei liu, Kai-Chun wu, xiao-Ping Zou, Yan-Qing li,li-Ya Zhou Jing Sun Yao-Zong Yuan Department of Gastroenterology Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 China xiao-hua Hou Department of Gastroenterology Union Hospital Medical College Huazhong University of Science and Technology Wuhan 430074 Hubei Province China Duo-wu Zou Department of Gastroenterology Changhai Hospital The Second Military Medical University Shanghai 200433 China Bin lu Department of Gastroenterology Zhejiang Traditional Chinese Medicine Hospital Hangzhou 310006 Zhejiang Province China Min-Hu Chen Department of Gastroenterology The First Affiliated Hospital Sun Yat-sen University Guangzhou 510080 Guangdong Province China Fei liu Department of Gastroenterology Shanghai East Hospital Shanghai 200120 China Kai-Chun wu Department of Gastroenterology Xijing Hospital the Fourth Military Medical College Xi&#x02019 an 710032 Shaanxi Province China xiao-Ping Zou Department of Gastroenterology Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical School Nanjing 210093 Jiangsu Province China Yan-Qing li Department of Gastroenterology Qilu Hospital of Shandong University Jinan 250012 Shandong Province China li-Ya Zhou Department of Gastroenterology Peking University Third Hospital Beijing 100191 China

AIM To compare symptom control with esomeprazoleregimens for non-erosive reflux disease and chronicgastritis in patients with a negative ***： This randomized, open-label study wasdesigned in line with clinical practice in china. Patientswith typical reflux symptoms for ≥ 3 mo and a negativeendoscopy who had a Gastroesophageal Reflux DiseaseQuestionnaire score ≥ 8 were randomized to initialtreatment with esomeprazole 20 mg once daily eitherfor 8 wk or for 2 wk. Patients with symptom reliefcould enter another 24 wk of maintenance/on-demandtreatment, where further courses of esomeprazole 20mg once daily were given if symptoms recurred. Theprimary endpoint was the symptom control rate at week24 of the maintenance/on-demand treatment *** endpoints were symptom relief rate, successrate （defined as patients who had symptom reliefafter initial treatment and after 24 wk of maintenancetreatment）, time-to-first-relapse and satisfaction ***： Based on the data collected in the modifiedintention-to-treat population （MITT; patients in the ITTpopulation with symptom relief after initial esomeprazoletreatment, n = 262）, the symptom control rate showeda small but statistically significant difference in favorof the 8-wk regimen （94.9% vs 87.3%, P = 0.0473）.Among the secondary endpoints, based on the datacollected in the ITT population （n = 305）, the 8-wkgroup presented marginally better results in symptomrelief after initial esomeprazole treatment （88.3% vs83.4%, P = 0.2513） and success rate over the wholestudy （83.8% vs 72.8%, P = 0.0258）. The 8-wkregimen was found to provide a 46% reduction in riskof relapse vs the 2-wk regimen （HR = 0.543; 95%CI：0.388-0.761）. In addition, fewer unscheduled visits andhigher patient satisfaction supported the therapeuticbenefits of the 8-wk regimen over the 2-wk *** was comparable between the two groups, withboth regimens being well ***： chinese patients diagnosed withchronic gastritis a

关键词： Esomeprazole Non-erosive reflux diseaseregimen Chronic gastritis regimen Symptom controlrate

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Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients

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chinese medical Journal 2013年第12期126卷 2276-2280页

作者： ZHENG Ying CAI Guang-yan CHEN xiang-mei FU Ping CHEN Jiang-hua DING xiao-qiang YU Xue-qing lIN Hong-li lIU Jian xiE Ru-juan WANG li-ning NI Zhao-hui lIU Fu-you YIN Ai-ping xiNG Chang-ying WANG li SHI Wei lIU Jian-she HE Ya-ni DING Guo-hua lI Wen-ge wu Guang-li MIAO li-ning CHEN Nan SU Zhen MEI Chang-lin ZHAO Jiu-yang GU Yong BAI Yun-kai lUO Hui-min lIN Shan CHEN Meng-hua GONG li YANG Yi-bin YANG xiao-ping lI Ying WAN Jian-xin WANG Nian-song lI Hai-ying xi Chun-sheng HAO li XU Yan FANG Jing-ai lIU Bi-cheng lI Rong-shan WANG Rong ZHANG Jing-hong WANG Jian-qin lOU Tan-qi shao Feng-min MEI Feng lIU Zhi-hong YUAN Wei-jie SUN Shi-ren ZHANG ling ZHOU Chun-hua CHEN Qin-kai JIA Shun-lian GONG Zhi-feng GUAN Guang-ju xiA Tian ZHONG liang-bao department of Nephrology State key Laboratory of Kidney Disease Chinese PLA General Hospital Beijing 100853 China Nephrology Institute of the chinese People's liberation Army Chinese People's Liberation Army Key Laboratory of Nephrology Beijing 100853 China department of Nephrology West China Hospital of Sichuan University Chengdu Sichuan 610041 China department of Nephrology First Affiliated Hospital School of Medicine Zhejiang University Hangzhou Zhejiang 310003 China department of Nephrology Zhongshan Hospital Fudan University Shanghai 200032 China department of Nephrology First Affiiated Hospital of Sun Yat-sen University Guangzhou Guangdong 510080 China department of Nephrology First Affiliated Hospital of Dalian Medical University Dalian Liaoning 116011 China department of Nephrology First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang 830054 China department of Nephrology First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China department of Nephrology First Afftiated Hospital of China Medical University Shenyang Liaoning 110001 China department of Nephrology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200025 China department of Nephrology Second Xiangya Hospital Central South University Changsha Hunan 410000 China department of Nephrology First Affiliated Hospital of Medical College Xi'an Jiaotong University Xi'an Shaanxi 710061 China department of Nephrology First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital) Nanjing Jiangsu 210029 China department of Nephrology Sichuan Provincial People's Hospital Chengdu Sichuan 610072 China department of Nephrology Guangdong Provincial People's Hospital Guangzhou Guangdong 510030 China department of Nephrology Affliated Xiehe Hospital Tongji Medical College Huazhong Science and Technology University Wuhan Hubei 430022 China department of Nephrology Daping Hospital Third Military Medi

Background Data on the epidemiology of hypertension in chinese non-dialysis chronic kidney disease （CKD） patients are *** aim of the present study was to investigate the prevalence,awareness,treatment,and control of hypertension in the non-dialysis CKD patients through a nationwide,multicenter study in *** The survey was performed in 61 tertiary hospitals in 31 province.,municipalities,and autonomous regions in china （except Hong Kong,Macao,and Taiwan）.Trained physicians collected demographic and clinical data and measured blood pressure （BP） using a standardized *** was defned as systolic BP ≥140 mmHg and/or diastolic BP ≥90 mmHg,and/or use of antihypertensive *** 〈140/90 mmHg and 〈130/80 mmHg were used as the 2 thresholds of hypertension *** multivariate logistic regression with adjustment for sex and age,we analyzed the association between CKD stages and uncontrolled hypertension in non-dialysis CKD *** The analysis included 8927 non-dialysis CKD *** prevalence,awareness,and treatment of hypertension in non-dialysis CKD patients were 67.3%,85.8%,and 81.0%,*** hypertensive CKD patients,33.1% and 14.1% had controlled BP to 〈140/90 mmHg and 〈130/80 mmHg,*** successive CKD stages,the prevalence of hypertension in non-dialysis CKD patients increased,but the control of hypertension decreased （P〈0.001）.When the threshold of BP 〈130/80 mmHg was considered,the risk of uncontrolled hypertension in CKD 2,3a,3b,4,and 5 stages increased 1.3,1.4,1.4,2.5,and 4.0 times compared with CKD 1 stage,respectively （P〈0.05）.Using the threshold of 〈140/90 mmHg,the risk of uncontrolled hypertension increased in advanced stages （P〈0.05）.Conclusions The prevalence of hypertension chinese non-dialysis CKD patients was high,and the hypertension control was *** successive CKD stages,the risk of uncontrolled hypertension increased.

关键词： non-dialysis chronic kidney disease chronic kidney disease stages hypertension epidemiology

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Efficacy and safety of the long-acting fusion inhibitor albuvirtide in antiretroviral-experienced adults with human immunodeficiency virus-1:interim analysis of the randomized,controlled,phase 3,non-inferiority TAlENT study

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chinese medical Journal 2020年第24期133卷 2919-2927页

作者： Bin Su Cheng Yao Qing-xia Zhao Wei-Ping Cai Min Wang Hong-Zhou lu Yuan-Yuan Chen li liu Hui Wang Yun He Yu-huang Zheng ling-hua li Jin-Feng Chen Jian-hua Yu Biao Zhu Min Zhao Yong-Tao Sun Wen-Hui lun Wei xia li-Jun Sun li-li Dai Tai-Yi Jiang Mei-xia Wang Qing-Shan Zheng Hai-Yan Peng Yao Wang Rong-Jian lu Jian-hua Hu Hui xing Yi-Ming shao Dong xie Tong Zhang Fu-Jie Zhang Hao wu TAlENT Study Team Center for Infectious Diseases Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Frontier Biotechnologies Inc. NanjingJiangsu 211122China department of Infectious Diseases Infectious Disease Hospital of Henan ProvinceZhengzhouHenan 450061China Infectious Disease Center Guangzhou Eighth People’s HospitalGuangzhou Medical UniversityGuangzhouGuangdong 510060China Institute of HIV/AIDS The First Hospital of ChangshaChangshaHunan 410005China department of Infectious Diseases Shanghai Public Health Clinical CenterFudan UniversityShanghai 201508China department of Infectious Diseases National Clinical Center for Infectious DiseasesShenzhen Third People’s HospitalShenzhenGuangdong 518112China department of Infectious Diseases The Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China department of Infectious Diseases Xixi Hospital of HangzhouHangzhouZhejiang 310023China State Key laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesThe First Affiliated HospitalZhejiang UniversityHangzhouZhejiang 310003China National Clinical Research Center for Infectious Diseases the Fifth Medical Center of PLA General HospitalBeijing 100039China department of Infectious Diseases Tangdu HospitalThe Fourth Military Medical UniversityXi’anShaanxi 710038China Clinical and Research Center of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Center for Drug Clinical Research Shanghai University of Traditional Chinese MedicineShanghai 201203China Beijing Co-CRO medical Development Co. Ltd.Beijing 100711China State Key laboratory for Infectious Disease Prevention and Control National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China 不详

Background:Albuvirtide is a once-weekly injectable human immunodeficiency virus(HIV)-1 fusion *** present interim data for a phase 3 trial assessing the safety and efficacy of albuvirtide plus lopinavir-ritonavir in HIV-1-infected adults already treated with antiretroviral ***:We carried out a 48-week,randomized,controlled,open-label non-inferiority trial at 12 sites in *** on the World Health Organization(WHO)-recommended first-line treatment for>6 months with a plasma viral load>1000 copies/ml were enrolled and randomly assigned(1:1)to receive albuvirtide(once weekly)plus ritonavir-boosted lopinavir(ABT group)or the WHO-recommended second-line treatment(NRTI group).The primary endpoint was the proportion of patients with a plasma viral load below 50 copies/ml at 48 ***-inferiority was prespecified with a margin of 12%.Results:At the time of analysis,week 24 data were available for 83 and 92 patients,and week 48 data were available for 46 and 50 patients in the albuvirtide and NRTI groups,*** 48 weeks,80.4%of patients in the ABT group and 66.0%of those in the NRTI group had HIV-1 RNA levels below 50 copies/ml,meeting the criteria for *** the per-protocol population,the superiority of albuvirtide over NRTI was *** frequency of grade 3 to 4 adverse events was similar in the two groups;the most common adverse events were diarrhea,upper respiratory tract infections,and grade 3 to 4 increases in triglyceride *** function was significantly more impaired at 12 weeks in the patients of the NRTI group who received tenofovir disoproxil fumarate than in those of the ABT ***:The TAlENT study is the first phase 3 trial of an injectable long-acting HIV *** interim analysis indicates that once-weekly albuvirtide in combination with ritonavir-boosted lopinavir is well tolerated and non-inferior to the WHO-recommended second-line regimen in patients with first-line treatme

关键词： HIV Fusion inhibitor Albuvirtide lPV/r Phase 3 clinical trial

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Extension Protocol for the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in china(INSCOC)Study:2021 update

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Journal of Nutritional Oncology 2022年第2期7卷 64-74页

作者： Hong xia Xu Chun hua Song liang Yu Yin Chang Wang Zhen Ming Fu Zeng Qing Guo Yuan lin Ying Ying Shi Wen Hu Yi Ba Su Yi li Zeng Ning li Kun hua Wang Jing wu Ying He Jia Jun Yang Cong hua xie Fu xiang Zhou xin xia Song Gong Yan Chen Wen Jun Ma Su xia luo Zi hua Chen Zhi Kang Chen Ming hua Cong Hu Ma Chun ling Zhou Wei Wang Qi luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen xian Guan Jun Qiang Chen xiang hua wu Jia xin Chen Yu Fang lan Zhou Yong Dong Feng Rong shao Tan Tao li Jun Wen Ou Qing Chuan Zhao Jian xiong wu Min Weng Qing hua Yao Ya Yin Yu Quan Jun lyu Hong Qiu Ming liu Wei li Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group department of Nutrition Daping HospitalArmy Medical University(Third Military Medical University)Chongqing 400042China department of Epidemiology College of Public HealthZhengzhou UniversityZhengzhou 450001HenanChina Cancer Center of the First hospital of Jilin university Changchun 130021Jilin China Cancer Center Renmin Hospital of Wuhan UniversityWuhan 430060HubeiChina department of medical Oncology Fujian Cancer HospitalFujian Medical University Cancer HospitalFuzhou 350014FujianChina department of Gastrointestinal Surgery Affiliated Tumor Hospital of Guangxi Medical UniversityNanning 530021GuangxiChina department of Surgery The First Affiliated Hospital of SunYat-Sen UniversityGuangzhou 510080GuangdongChina department of Clinical Nutrition West China Hospital of Sichuan UniversityChengdu 610041SichuanChina department of Gastrointestinal Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin Key Laboratory of Cancer Prevention and TherapyTianjin 300060China department of Nutrition and Metabolism of Oncology The First Affiliated Hospital of University of Science and Technology of ChinaAnhui Provincial Cancer HospitalHefei 230031AnhuiChina department of Clinical Nutrition The First Hospital of Hebei Medical UniversityShijiazhuang 050031HebeiChina department of Gastrointestinal Surgery Institute of GastroenterologyThe First Affiliated Hospital of Kunming Medical UniversityKunming 650032YunnanChina department of Clinical Nutrition The First Affiliated Hospital of Zhejiang Chinese Medical UniversityZhejiang Provincial Hospital of Traditional Chinese MedicineHangzhou 310006ZhejiangChina department of Clinical Nutrition Chongqing General HospitalChongqing 400014China department of Colorectal and Anal Surgery Huizhou Municipal Central HospitalHuizhou 516001GuangdongChina department of Radiation and medical Oncology Zhongnan Hospital of Wuhan UniversityWuhan 430071HubeiChina department of Oncology Xingtai Peo

Background Malnutrition is common in patients with cancer,and this adversely affects the survival and quality of life of *** Society for Nutritional Oncology issued a multi-center,large-scale,long-term follow-up prospective study,the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in china(INSCOC study)since *** is an extension to the previous 2013-2020 study *** study still sought to:①address the prognostic impact of nutritional factors and quality of life on cancer patient survival;②describe the overall and cancer-specific incidence and/or distribution of malnutrition and different measurements of patient quality of *** and study design This is an observational,multi-centered,hospital-based prospective cohort *** collection will be performed at baseline(within 48 hours after patient admission),during the hospital stay and 30 days after hospital ***-up will be conducted for 1-20 years after *** primary outcome will be the all-cause mortality/overall survival,and secondary outcomes will be the length of hospital stay and costs of *** factors will include demographic characteristics,tumor characteristics,information about chronic diseases,hematological measurements(e.g.,red blood cell count,total lymphocyte counts,hemoglobin,albumin,prealbumin,creatinine,C-reactive protein,Il-6),anthropometric measurements(e.g.,height,weight,arm circumference,arm muscle circumference,triceps skinfold thickness,and waist circumference),body composition parameters,PG-SGA scores,quality of life(as indicated by the QlQ-C30 questionnaire),muscle mass(as indicated by the calf circumference),muscle strength(as indicated by the handgrip strength),muscle function(as indicated by the six-meter walking speed test)and physical status assessments(as indicated by the Karnofsky Performance Status scores).This clinical study protocol was approved by local Ethics Committees of

关键词： Cancer Malnutrition Nutritional status Nutritional assessment Survival Patient-Generated Subjective Global Assessment

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Consensus on Treatment of Acne Scars in china(2021)

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International Journal of Dermatology and Venereology 2022年第3期5卷 121-131页

作者：无 Sen Yang Zhong lu Tong lin Guo-Yu Zhou Min Yao Yi liu Rong-Ya Yang Zhi-Fei liu Yuan-Hong li Dong-Ni li xiao-Dong Chen Shu-xian Yan lin Gao Qiu-Ning Sun Hong Cai Yan-hua liang Rong xiao xiao-Ming Jia Jin Chen Jing-long Cai Cai-xia Tu laser Cosmetology Group Medical Aesthetics and Cosmetology Branch of Chinese Medical Association Cosmetic laser Group Chinese Society of Dermatology laser Group Cosmetic and Plastic Surgeon Branch of Chinese Medical Doctor Association department of Dermatology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China department of Dermatology Huashan HospitalFudan UniversityShanghai 200040China department of Cosmetic laser Surgery Hospital of DermatologyChinese Academy of Medical SciencesNanjingJiangsu 210042China department of Oral and Maxillofacial-Head Neck Oncology Department of Laser and Aesthetic MedicineShanghai Ninth People's HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghai 200011China department of Plastic Surgery Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Institute of Dermatology Chinese Academy of Medical SciencesNanjingJiangsu 210042China department of Dermatology The Seventh Medical Center of PLA General Hospital(PLA Army General Hospital)Beijing 100700China department of Plastic Surgery Peking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China department of Dermatology The First Affiliated Hospital of China Medical UniversityShenyangLiaoning 110002China department of Plastic and Reconstructive Surgery Guangdong Second Provincial General HospitalGuangzhouGuangdong 510317China department of Dermatology Affiliated Hospital of Nantong UniversityNantongJiangsu 226006China department of Dermatology Xijing HospitalThe Fourth Military Medical UniversityXi’anShaanxi 710032China department of Dermatology Peking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China department of Dermatology The Air Force General Hospital of PLABeijing 100142China department of Dermatology Cosmetology and VenereologyShenzhen HospitalSouther

Acne scars are caused by inflammatory reactions,infections,and improper handling of acne *** scars have a high incidence and are difficult to *** are many methods currently used to treat acne scars,including medications,photoelectric technology,surgery,filling,chemical peeling,traditional chinese medicine.biotherapy,and microneedle therapy,and many new methods are constantly ***,there are still many issues,such as the lack of high-quality clinical studies,non-uniform treatment methods,and unsatisfactory therapeutic *** selection of appropriate methods for the comprehensive treatment of different types of acne scars at different stages in clinical practice remains challenging and is a research topic of great *** the perspective of evidence-based medicine.this consensus aims to provide a reference for the treatment of acne scars in clinical practice.

关键词： acne vulgaris cicatrix practice guideline therapy

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Malnutrition and Quality of life in chinese Cancer Patients: a Clinical Study of 23,994 Subjects

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Journal of Nutritional Oncology 2021年第1期6卷 16-32页

作者： Hong xia Xu Chun hua Song Zhen Ming Fu Chang Wang Zeng Qing Guo Yuan lin Ying Ying Shi Wen Hu Yi Ba Su Yi li Zeng Ning li Kun hua Wang Jing wu Ying He Jia Jun Yang Cong hua xie Fu xiang Zhou xin xia Song Gong Yan Chen Wen Jun Ma Su xia luo Zi hua Chen Ming hua Cong Hu Ma Chun ling Zhou Wei Wang Qi luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen xian Guan Jun Qiang Chen Jia xin Chen Yu Fang lan Zhou Yong Dong Feng Rong shao Tan Tao li Jun Wen Ou Qing Chuan Zhao Jian xiong wu Min Weng Qing hua Yao Jiu Wei Cui Wei li Han Ping Shi the Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group department of Nutrition Daping Hospital&Research Institute of SurgeryThird Military Medical UniversityChongqing 400042China department of Epidemiology College of Public HealthZhengzhou UniversityZhengzhou 450001HenanChina Cancer Center Renmin Hospital of Wuhan UniversityWuhan 430060HubeiChina Cancer Center of the First hospital of Jilin university Changchun 130021JilinChina department of medical Oncology Fujian Cancer HospitalFujian Medical University Cancer HospitalFuzhou 350014FujianChina department of Gastrointestinal Surgery Cancer Hospital Affiliated to Guangxi Medical UniversityNanning 530021GuangxiChina department of Surgery The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080GuangdongChina department of Clinical Nutrition West China Hospital of Sichuan UniversityChengdu 610041SichuanChina department of Gastrointestinal Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin Key Laboratory of Cancer Prevention and TherapyTianjin 300060China department of Nutrition and Metabolism of Oncology Affiliated Provincial Hospital of Anhui Medical UniversityHefei 230031AnhuiChina department of Clinical Nutrition the First Hospital of Hebei Medical UniversityShijiazhuang 050031HebeiChina department of Gastrointestinal Surgery Institute of Gastroenterologythe First Affiliated Hospital of Kunming Medical University 650032KunmingYunnanChina department of Clinical Nutrition the First People's Hospital of KashiKashi 844000XinjiangChina department of Clinical Nutrition Chongqing General HospitalChongqing 400014China department of Colorectal and Anal Surgery Huizhou Municipal Central HospitalHuizhou 516001GuangdongChina department of Radiation and medical Oncology Zhongnan Hospital of Wuhan UniversityWuhan 430071HubeiChina department of Oncology Xingtai People’s HospitalHebei Medical UniversityXingtai 054031HebeiChina Harbin medical university.Cancer hospital Harbin 150085HeilongjiangChina

Background Malnutrition is common in patients with cancer,and can negatively impact their quality of life(Qol)and even ***,there is currently no large data available on the prevalence of malnutrition in chinese cancer *** study evaluated the prevalence of malnutrition and the Qol of chinese patients with locoregional,recurrent or metastatic *** We conducted a nationwide observational,multi-center,hospital-based cross-sectional study within the chinese Society of Nutritional Oncology(CSNO)*** of the patients were diagnosed with one of the following 18 different types of malignant tumors:lung cancer,gastric cancer,liver cancer,colorectal cancer,breast cancer,esophageal cancer,cervical cancer,endometrial cancer,nasopharyngeal carcinoma,malignant lymphoma,leukemia,pancreatic cancer,ovarian cancer,prostate cancer,bladder cancer,brain cancer,biliary tract malignant tumors or gastrointestinal stromal *** patients were enrolled from 72 hospitals located in different regions of *** patients’nutritional status was evaluated based on the body mass index(BMI),loss of bodyweight,laboratory measurements and patient generated-subjective global assessment(PG-SGA)*** cancer patients’physical status and Qol were assessed by the Karnofsky Performance Status(KPS)questionnaire and the European Organization for Research and Treatment of Cancer(EORTC)QlQ-C30 questionnaire,*** From December 2013 to April 2016,23,994 patients hospitalized for cancer treatment(such as surgery,chemotherapy or radiotherapy)were enrolled in the *** patients included 12,494(52.9%)males and 11,124(47.1%)*** mean age was 55.8±13.7 *** proportions of patients in cancer stagesⅠ,Ⅱ,Ⅲ,Ⅳand uncertain were 11.5%,20.3%,27.5%,30.2%and 10.5%,*** the 23,994 inpatients,the proportions of patients who were underweight(BMI18.5 kg/m2),normal(18.5 kg/m2

关键词： Nutritional status Nutritional assessment Malnutrition Patient generated subjective global assessment Body mass index Body weight loss Karnofsky Performance Status score Quality of life

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Validity of the chinese Version of the Patient-Generated Subjective Global Assessment (PG-SGA) in Gastric Cancer Patients

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Journal of Nutritional Oncology 2018年第4期3卷 182-188页

作者： Zhen Ming Fu Hong xia Xu Chun hua Song Wei li Zeng Qing Guo Yuan lin Ying Ying Shi Wen Hu Yi Ba Su Yi li Zeng Ning li Kun hua Wang Jing wu Ying He Jia Jun Yang Cong hua xie xin xia Song Gong Yan Chen Wen Jun Ma Su xia luo Zi hua Chen Ming hua Cong Hu Ma Chun ling Zhou Wei Wang Qi luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen xian Guan Jun Qiang Chen Jia xin Chen Yu Fang lan Zhou Yong Dong Feng Rong shao Tan Tao li Jun Wen Ou Qing Chuan Zhao Jian xiong wu Chang Wang Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) Group Cancer Center Renmin Hospital of Wuhan University Wuhan Hubei 430060 China department of Nutrition and Metabolism of Oncology Affiliated Provincial Hospital of Anhui Medical University Hefei Anhui 230031 China department of Clinical Nutrition The First Hospital of Hebei Medical University Shijiazhuang Hebei 050031 China department of Gastrointestinal Surgery Institute of Gastroenterology The First Affiliated Hospital of Kunming Medical University Kunming Yunnan 650032 China department of Clinical Nutrition The First People's Hospital of Kashi Xinjiang 844000 China department of Clinical Nutrition Chongqing General Hospital Chongqing 400014 China department of Colorectal and Anal Surgery Huizhou Municipal Central Hospital Huizhou Guangdong 516001 China department of Radiation and medical Oncology Zhongnan Hospital of Wuhan University Wuhan Hubei 430071 China department of Oncology Xingtai People’s Hospital Hebei Medical University Xingtai Hebei 054031 China The First department of the Tumor hospital of Harbin medical university Harbin Heilongjiang 150085 China department of Nutrition Guangdong General Hospital Guangdong Academy of Medical Sciences Guangzhou Guangdong 510080 China department of Nutrition Daping Hospital & Research Institute of Surgery Third Military Medical University Chongqing 400042 China department of Oncology Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital Zhengzhou Henan 450008 China department of General Surgery Xiangya Hospital Central South University Changsha Hunan 410008 China Comprehensive Oncology department Cancer Hospital Chinese Academy of Medical Sciences Beijing 100021 China department of Oncology Affiliated Hospital of Zunyi Medical University Zunyi Guizhou 563000 China The fourth Affiliated hospital Harbin Medical University Harbin Heilongjiang 150001 China Cancer center The First People's Hospital of Foshan Foshan Guangdong 528000 China department of Gastrointestinal Tumor Surge

Purpose Malnutrition is severe among gastric cancer patients in china. While the Patient-Generated Subjective Global Assessment (PG-SGA) is a widely used nutritional assessment tool, the validation for chinese patients with gastric cancer has not been performed yet. The aim of this research is to validate the chinese version of the PGSGA in chinese gastric cancer patients by conducting analyses of nutrition screening and assessment data. Methods Two thousand consecutive adult patients with gastric cancer were included in this observational, cross-sectional study in several tertiary hospitals in china. A survey was made among those patients, which included several questionnaires and some anthropometric parameters. We calculated the parameters to validate the use of PG-SGA categorizing the nutritional status of gastric cancer patients. Then we performed statistical analysis to evaluate the internal consistency, external consistency, and construct validity. Results This study verified the ability of the PG-SGA to differentiate gastric cancer patients into different nutritional groups. The confirmatory factor analysis verified the original four-factor structure of the PG-SGA. The internal and external consistency was measured by a concordance analysis which showed an intraclass correlation coefficients (ICC) of 0.987. The correlations of the Box 4 score with the Karnofsky performance status score demonstrated alternative form validity with good external consistency (Pearson, r = 0.643, P ll three anthropometric dimensions of the PG-SGA were supported by principal component analysis. Spearman correlations (P lusion The chinese version of the PG-SGA is a valid tool to access the patients’ nutritional status for chinese gastric patients.

关键词： Validation Nutrition status chinese version Cancer

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