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Highly responsive biosensors based on organic field-effect transistors under light irradiation

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Chinese Chemical Letters 2021年第11期32卷 3364-3367页

作者： Xiaoqian Jiang Chenfang Sun Congcong Zhang shanshan cheng Department of Chemistry Tianjin Key Laboratory of Molecular Optoelectronic Sciences School of ScienceTianjin UniversityTianjin 300072China Institute for Advanced Interdisciplinary Research University of JinanJi'nan 250011China

High responsivity and sensitivity play essential roles in the development of organic field-effect transistors(OFETs)-based biosensors with regard to biological detections,particularly for disease ***,how to design a biosensor which improves these two outstanding properties while achieving low cost,easy processing,and time saving is a daunting ***,a novel biosensor based on OFET with copolymer thin film,whose surface is illuminated with a suitable light beam is *** film can be used as both an organic semiconductor material and as a photoelectric active *** to amplification of signals as a result of the film’s strong response to light,the biosensor possesses higher responsivity and sensitivity compared to dark condition and even realizes a maximum responsivity of up to 10^(3)for alpha-fetoprotein(AFP)*** simple combination of light and transistor builds a bridge between photoelectric effect and biological *** addition,the emergence of more excellent photoelectric active materials is expected to pave a way for ultrasensitive bio-chemical diagnostic tools.

关键词： Organic field-effect transistors Photoelectric active materials Photo response Biosensors Disease diagnosis

Graphene Nanostructure-Based Tactile Sensors for Electronic Skin Applications

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Nano-Micro Letters 2019年第4期11卷 239-275页

作者： Pei Miao Jian Wang Congcong Zhang Mingyuan Sun shanshan cheng Hong Liu Institute for Advanced Interdisciplinary Research Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of ShandongUniversity of Jinan336 Nanxinzhuang West RoadJinan 250011People’s Republic of China Department of Chemistry School of Chemistry and Chemical EngineeringUniversity of Jinan336 Nanxinzhuang West RoadJinan 250011People’s Republic of China Department of Chemistry Tianjin Key Laboratory of Molecular Optoelectronic SciencesSchool of ScienceTianjin University92 Weijin RoadTianjin 300072People’s Republic of China Center of Bio and Micro/Nano Functional Materials State Key Laboratory of Crystal MaterialsShandong University27 Shanda South RoadJinan 250100People’s Republic of China

Skin is the largest organ of the human body and can perceive and respond to complex environmental ***,the development of electronic skin(E-skin)for the mimicry of the human sensory system has drawn great attention due to its potential applications in wearable human health monitoring and care systems,advanced robotics,artificial intelligence,and human-machine *** sense is one of the most important senses of human skin that has attracted special *** ability to obtain unique functions using diverse assembly processible methods has rapidly advanced the use of graphene,the most celebrated two-dimensional material,in electronic tactile sensing *** a special emphasis on the works achieved since 2016,this review begins with the assembly and modification of graphene materials and then critically and comprehensively summarizes the most advanced material assembly methods,device construction technologies and signal characterization approaches in pressure and strain detection based on graphene and its derivative *** review emphasizes on:(1)the underlying working principles of these types of sensors and the unique roles and advantages of graphene materials;(2)state-of-the-art protocols recently developed for high-performance tactile sensing,including representative examples;and(3)perspectives and current challenges for graphene-based tactile sensors in E-skin applications.A summary of these cutting-edge developments intends to provide readers with a deep understanding of the future design of high-quality tactile sensing devices and paves a path for their future commercial applications in the field of E-skin.

关键词： Graphene derivatives Tactile sensor Electronic skin Assembly

Phenanthrene derivatives combined charge transport properties and strong solid-state emission

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Science China Chemistry 2019年第7期62卷 916-920页

作者： Jinfeng Li chenguang Li Lingjie Sun Xiaotao Zhang shanshan cheng Wenping Hu Tianjin Key Laboratory of Molecular Optoelectronic Sciences Department of Chemistry School of Science Tianjin University & Collaborative Innovation Centre of Chemical Science and Engineering (Tianjin)

As bifunctional materials, phenanthrene derivatives 2,7-diphenylphenanthrene and 2,7-di(styryl)phenanthrene(DPPa and DSPa) were designed and studied. Both materials show charge transport properties and strong solid-state emission. The hole mobility was measured to be 1.6 and 0.4 cm^2 V-1 s^-1 for DPPa and DSPa, respectively. While the photoluminescence quantum yield of DPPa and DSPa was as high as 37.13% and 62.36%, respectively.

关键词： phenanthrene derivatives OFET strong solid-state emission

The role of autophagy in regulating metabolism in the tumor microenvironment

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Genes & Diseases 2023年第2期10卷 447-456页

作者： Panpan Zhang shanshan cheng Xiaonan Sheng Huijuan Dai Kang He Yueyao Du Department of Liver Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Department of Gynecology and Obstetrics Shanghai Key Laboratory of Gynecology OncologyRenji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Breast Surgery Renji HospitalSchool of MedicineShanghai Jiaotong UniversityNo. 1630 Dongfang RoadShanghai 200127China

Autophagy,as a special programmed cell death,is a critical degradative process that eliminates intracellular abnormal proteins or damage organelles to balance cell energy and favor cell metabolism with autophagy-related(ATG)*** activation is being increasingly recognized as an essential hallmark in tumorigenesis through influencing the metabolism of stromal cells in the tumor microenvironment(TME)which comprises of tumor cells,cancer-associated fibroblasts(CAFs),cancer-associated endothelial cells(CAEs),immune cells and *** cells can reuse autophagy-involved recycling to maintain mitochondrial function and energy supply to meet the metabolic demand of their growth and ***,the mechanism through which autophagy can promote a crosstalk between tumor and stroma cells is not *** metabolism is one of the main characteristics of TME leading to higher adaptability of tumor cells with diverse *** activation of autophagy has expanded our understanding on the interaction between tumor metabolism and *** aim of this review is to report recent advances on the metabolic cross-talk between stromal cells and solid tumor cells induced by autophagy in TME and revealed potential therapeutic targets.

关键词： Autophagy Metabolism Therapeutic targets Tumor Tumor microenvironment

Low-Frequency Oscillation Analysis of Grid-Connected VSG System Considering Multi-Parameter Coupling

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Computer Modeling in Engineering & Sciences 2023年第6期135卷 2373-2386页

作者： Shengyang Lu Tong Wang Yuanqing Liang shanshan cheng Yupeng Cai Haixin Wang Junyou Yang Yuqiu Sui Luyu Yang Shenyang University of Technology Shenyang110870China Electric Power Research Institute of State Grid Liaoning Electric Power Supply Co. Ltd.Shenyang110006China State Grid Liaoning Electric Power Supply Co. Ltd.Shenyang110006China

With the increasing integration of new energy generation into the power system and the massive withdrawal of traditional fossil fuel generation,the power system is faced with a large number of stability *** phenomenon of low-frequency oscillation caused by lack of damping and moment of inertia is worth *** recent years,virtual synchronous generator(VSG)technique has been developed rapidly because it can provide considerable damping and moment of *** improving the stability of the system,it also inevitably causes the problem of active power oscillation,especially the low mutual damping between the VSG and the power grid will make the oscillation more *** traditional time-domain state-space method cannot reflect the interaction among state variables and study the interaction between different nodes and branches of the power *** this paper,a frequency-domain method for analyzing low-frequency oscillations considering VSG parameter coupling is ***,based on the rotor motion equation of the synchronous generator(SG),a secondorder VSG model and linearized power-frequency control loop model are ***,the differences and connections between the coupling of key VSG parameters and low-frequency oscillation characteristics are studied through frequency domain *** path and influencemechanism of a VSG during low-frequency power grid oscillations are ***,the correctness of the theoretical analysis model is verified by simulation.

关键词： Inverter power supply low-frequency oscillation virtual synchronous generator rotor motor equation

Ultrasensitive and stable all graphene field-effect transistor-based Hg^(2+)sensor constructed by using different covalently bonded RGO films assembled by different conjugate linking molecules

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SmartMat 2021年第2期2卷 213-225页

作者： Mingyuan Sun Congcong Zhang Duo Chen Jian Wang Yanchen Ji Na Liang Haoyang Gao shanshan cheng Hong Liu Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of Shandong Institute for Advanced Interdisciplinary Research(iAIR)University of JinanJinanChina International School for Optoelectronic Engineering Qilu University of Technology(Shandong Academy of Science)JinanChina Department of Physics School of Physical Science and TechnologyUniversity of JinanJinanChina Department of Chemistry School of ScienceUniversity of TianjinTianjinChina State Key Laboratory of Crystal Materials Shandong UniversityJinanChina

As"molecular bridge,"coupling agents can not only realize the covalent connection of composites,but also affect their properties,thus affecting the properties of devices based on ***,leveraging differences in charge conduction properties of the(3-aminopropyl)trimethoxysilane and 5,10,15,20-tetrakis(4-aminophenyl)-21H,23H-porphine caused by conjugacy structural differences,two kinds of layerby-layer assembled smart carbon materials with different electrical properties are obtained at the same reduction *** two graphene ultrathin films are then“planted”on Si/SiO2 substrates,respectively,as semiconductor layer and source/drain electrodes to fabricate an ultra-stable all-graphene field effect transistor(AG-FET).Enabled by the covalent functionalized configuration and the functionally diverse of coupling agents,the AG-FET obtained by this simple method won the high electrical characteristics,the hole,electron mobility,and the shelflife could reach 3.79 cm2/(V·s),3.78 cm2/(V·s),and 18months,*** addition,good material stability and excellent device structure endow the device exceptional stability,electrical stability,and solvent resistance,improving its application prospect in solution phase sensing/*** characteristics could be used to sense,transduce,and respond to external stimuli,especially in solution phase to monitor the important analytes,such as Hg^(2+)in a flowing sewage *** believe that such easy-to-manufacture AG-FETs with ultrahigh performance and ultrahigh stability could also show great application prospects in other significant fields.

关键词： coupling agent covalent bond field effect transistors Hg^(2+)detection ultra-stable

Identification of susceptibility loci and relevant cell type for IgA nephropathy in Han Chinese by integrative genome-wide analysis

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Frontiers of Medicine 2024年第5期18卷 862-877页

作者： Ming Li Xingjie Hao Dianchun Shi shanshan cheng Zhong Zhong Lu Cai Minghui Jiang Lin Ding Lanbo Ding Chaolong Wang Xueqing Yu Department of Nephrology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of Nephrology The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Guangdong-Hong Kong Joint Laboratory on Immunological and Genetic Kidney Diseases Guangzhou 510080China Department of Epidemiology and Biostatistics Ministry of Education Key Laboratory of Environment and HealthSchool of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China NHC Key Laboratory of Nephrology(Sun Yat-sen University) and Guangdong Provincial Key Laboratory of NephrologyGuangzhou 510080China

Although many susceptibility loci for IgA nephropathy(IgAN)have been identified,they only account for 11.0%of the overall IgAN *** performed a large genome-wide meta-analysis of IgAN in Han Chinese with 3616 cases and 10417 controls to identify additional genetic loci of *** that inflammatory bowel disease(IBD)and asthma might share an etiology of dysregulated mucosal immunity with IgAN,we performed cross-trait integrative analysis by leveraging functional annotations of relevant cell type and the pleiotropic information from IBD and *** 8669456 imputed variants,we identified a novel locus at 4p14 containing the long noncoding RNA *** type enrichment analysis based on annotations suggested that PMA-I-stimulated CD4+CD25–IL17+Th17 cell was the most relevant cell type for IgAN,which highlights the essential role of Th17 pathway in the pathogenesis of ***,we identified six more novel loci associated with IgAN,which included three loci showing pleiotropic effects with IBD or asthma(2q35/PNKD,6q25.2/SCAF8,and 22q11.21/UBE2L3)and three loci specific to IgAN(14q32.32/TRAF3,16q22.2/TXNL4B,and 21q21.3/LINC00113)in the pleiotropic *** findings support the involvement of mucosal immunity,especially T cell immune response and IL-17 signal pathway,in the development of IgAN and shed light on further investigation of IgAN.

关键词： IgA nephropathy(IgAN) genome-wide association study(GWAS) relevant cell types integrative analysis pleiotropy

The Practice of Planning and Design of Characteristic Rural Areas in Jiangsu Province: A Case Study of Shiye Town, Zhenjiang City

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Journal of Landscape Research 2020年第1期12卷 49-57页

作者： GONG Yaxi ZHANG Yuan cheng shanshan School of Mechanics and Civil Engineering China University of Mining and TechnologyXuzhouJiangsu 221116China School of Architecture&Design China University of Mining and TechnologyXuzhouJiangsu 221116China School of Architecture and Urban Planning Suzhou University of Science and TechnologySuzhouJiangsu 215011China

Based on the theory of three living spaces,taking the characteristic rural areas of Shiye Town in Zhenjiang City as the research object,the study analyzed its constituent elements in production,life and ecological space (three living spaces) and put forward the strategy of space *** overall optimization design of the village is made according to the problems by combining with the current situation of pilot villages such as Yongmaowei,Huanqingzhou and group 1 of Xianfeng *** addition,special reconstruction measures were formulated for the existing problems of agricultural houses and public spaces in various typical villages.

关键词： Three living spaces Characteristic rural areas Planning and design Zhenjiang City

Structural Analysis of Green Infrastructure in Suzhou Dushu Lake Higher Education District

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Journal of Landscape Research 2019年第5期11卷 59-61,69页

作者： ZHANG Yuan cheng shanshan JI Xiang School of Architecture & Design China University of Mining and TechnologyXuzhouJiangsu 221116China School of Architecture and Urban Planning Suzhou University of Science and TechnologySuzhouJiangsu 215011China Jiangsu Cooperative Innovation Center of Building Energy Conservation and Building Technology XuzhouJiangsu 221116China

Green infrastructure (GI) is ecological supporting system for the sustainable development of urban construction,and plays an important role in promoting the urban ecological economic and social *** this paper,Suzhou Dushu Lake Higher Education District is taken as an example,and landscape ecological resources in Dushu Lake Higher Education District are analyzed on the basis of field *** with the relevant theory of green infrastructure,structure of GI in Suzhou Dushu Lake Higher Education District is analyzed and evaluated from hubs,links and sites,and the corresponding optimization strategy is put forward.

关键词： Dushu Lake Higher Education District Green infrastructure Hubs Links Sites