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Antimicrobial hydrogel foam dressing with controlled release of gallium maltolate for infection control in chronic wounds

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Bioactive Materials 2024年第12期42卷 433-448页

作者： Ziyang Lan Leopold Guo Alan Fletcher Nicolai Ang Canaan Whitfield-Cargile Laura Bryan shannara welch Lauren Richardson Elizabeth Cosgriff-Hernandez Department of Biomedical Engineering the University of Texas at AustinAustinTX78712USA Department of Large Animal Medicine University of GeorgiaAthensGA30602USA Department of Pathobiology Texas A&M UniversityCollege StationTX77843USA Clinical Microbiology Lab Veterinary Teaching HospitalTexas A&M UniversityCollege StationTX77843USA

Effective treatment of infection in chronic wounds is critical to improve patient outcomes and prevent severe complications,including systemic infections,increased morbidity,and *** treatments,including antibiotic administration and antimicrobial dressings,are challenged by the increasing prevalence of antibiotic resistance and patients’sensitivity to the delivered *** studies have demonstrated the potential of a new antimicrobial agent,Gallium maltolate(GaM);however,the high burst release from the GaMloaded hydrogel gauze required frequent dressing *** address this need,we developed a hydrogel foambased wound dressing with GaM-loaded microspheres for sustained infection ***,the minimal inhibitory and bactericidal concentrations(MIC and MBC)of GaM against two Staphylococcus aureus strains isolated from chronic wounds were *** significant adverse effects of GaM on dermal fibroblasts were shown at the MIC,indicating an acceptable selectivity *** the sustained release of GaM,electrospraying was employed to fabricate microspheres with different release *** investigation of loading and microsphere size on release kinetics indicated that the larger microsphere size and lower GaM loading resulted in a sustained GaM release profile over the target 5 *** of the GaM-loaded hydrogel dressing demonstrated cytocompatibility and antibacterial activities with a zone of inhibition *** equine distal limb wound model was developed and utilized to demonstrate the efficacy of GaM-loaded hydrogel foam in *** antimicrobial hydrogel foam dressing displayed the potential to combat methicillin-resistant ***(MRSA)infection with controlled GaM release to improve chronic wound healing.

关键词： Chronic wounds Hydrogel foam Antimicrobials wound dressing Infection control Microsphere

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