Antimicrobial hydrogel foam dressing with controlled release of gallium maltolate for infection control in chronic wounds

作     者：Ziyang Lan Leopold Guo Alan Fletcher Nicolai Ang Canaan Whitfield-Cargile Laura Bryan Shannara Welch Lauren Richardson Elizabeth Cosgriff-Hernandez 

作者机构：Department of Biomedical Engineeringthe University of Texas at AustinAustinTX78712USA Department of Large Animal MedicineUniversity of GeorgiaAthensGA30602USA Department of PathobiologyTexas A&M UniversityCollege StationTX77843USA Clinical Microbiology LabVeterinary Teaching HospitalTexas A&M UniversityCollege StationTX77843USA 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2024年第42卷第12期

页      面：433-448页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 

基　　金：supported by National Institutes of Health(Grant No.R21 AR076107) 

主　　题：Chronic wounds Hydrogel foam Antimicrobials wound dressing Infection control Microsphere 

摘      要：Effective treatment of infection in chronic wounds is critical to improve patient outcomes and prevent severe complications,including systemic infections,increased morbidity,and *** treatments,including antibiotic administration and antimicrobial dressings,are challenged by the increasing prevalence of antibiotic resistance and patients’sensitivity to the delivered *** studies have demonstrated the potential of a new antimicrobial agent,Gallium maltolate(GaM);however,the high burst release from the GaMloaded hydrogel gauze required frequent dressing *** address this need,we developed a hydrogel foambased wound dressing with GaM-loaded microspheres for sustained infection ***,the minimal inhibitory and bactericidal concentrations(MIC and MBC)of GaM against two Staphylococcus aureus strains isolated from chronic wounds were *** significant adverse effects of GaM on dermal fibroblasts were shown at the MIC,indicating an acceptable selectivity *** the sustained release of GaM,electrospraying was employed to fabricate microspheres with different release *** investigation of loading and microsphere size on release kinetics indicated that the larger microsphere size and lower GaM loading resulted in a sustained GaM release profile over the target 5 *** of the GaM-loaded hydrogel dressing demonstrated cytocompatibility and antibacterial activities with a zone of inhibition *** equine distal limb wound model was developed and utilized to demonstrate the efficacy of GaM-loaded hydrogel foam in *** antimicrobial hydrogel foam dressing displayed the potential to combat methicillin-resistant ***(MRSA)infection with controlled GaM release to improve chronic wound healing.