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The Carriage of Escherichia coli Resistant to Antibiotics in Healthy Populations in shanghai

Biomedical and Environmental Sciences 1998年第4期11卷 314-320页

作者： ZHANG XIAO-LIN WANG FU ZHU DE-MEI WU SHI WU PEI-CHENG CHEN YOU-DI WANG YU-QIAN AND ZHOU LE(Institute of Antibiotics, Huashan Hopital, shanghai Medical University, shanghai 200040, China) Institute of Antibiotics Huashan Hospital Shanghai Medical University China.

Healthy populations represent the largest reservoir of bacteria resistant to *** investigated the resistance of Escherichta coli to 12 antibiotics in fecal samples from untreated healthy populations in shanghai, China by using Kirby-Bauer (K-B) method. The results showed that: (i) All subjects carried resistant strains of Escherichta coli. (ii) The carriage rates of Escherichta coli resistant to various antibiotics were different, less than 10 % to amikacin and 30 % to 100% to others. (iii) In the elder children group aged 10-11 years, the percentages of stralns resistant to gentamicin, streptomycin, chloramphenicol, tetracycline, trimethoprim, and sulfamethoxazole were significantly lower than those in the younger group aged 5-6 years. In the adult group, the percentages of strains resistant to ampicillin, piperacillin, arnikacin, streptomycin, chloramphenicol, tetracycline, trimethoprim, and sulfamethoxarole were significantly lower than those in the elder children group. (iv) The number of strains resistant to five or more antibiotics accounted for 31. 8 % in the younger children group, 23. 7 % in the elder children group,and 12. 1 % in the adult group. These findings suggest that all healthy people in Shanghal carry resistant strains of Escherichta coli in the intestine. The younger the populations, the higher the level of resistance of fecal Escherichta coli to antibiotics. Improvement of health behaviors and environmental sanitation and rational use of antibiotics could remarkedly decrease the resistant level of bacteria

关键词： coli The Carriage of Escherichia coli Resistant to Antibiotics in Healthy Populations in shanghai

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Comparative studies of D_2 receptors and brain perfusion inhemi-parkinsonism rats

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Nuclear Science and Techniques 2000年第4期11卷 228-233页

作者： LIN Yan-Song, LIN Xiang-Tong (Huashan hospital, shanghai Medical University, shanghai 200040) Huashan Hospital Shanghai Medical University Shanghai 200040 China

The relationship between dopamine D2 receptors and brain perfusion in hemi-parkinsonism rats was studied. Hemi-parkinsonism rats were made by stereotaxic 6-hydroxy dopamine (6-OH-DA) lesions in substantia nigra(SN) and ventral tegmental area(VTA), apomorphine (Apo) which could induced the successful model rat rotates toward the intact side was used to select the rats, 125I-IBZM ex-vivo autoradiography analysis and 99mTc-HM-PAO regional cerebral biodistribution were used to evaluate D2 receptors and cerebral blood flow. The HPLC-ECD were used to measure striatum DA and its metabolites content. The lesioned side striatum DA and its metabolites HVA DOPAC reduced significantly than that of the intact side and seudo-operated group, striatum/cerebellum 125I-IBZM uptake ratio was 8.04+-0.71 in lesioned side of hemi-parkinsonism rats, significantly increased compared with the intact side and the seudo-operated group(p 0.05). These results indicated that in the 6- OH-DA lesioned side DA content decreased significantly and an up-regulation of striatum D2 receptor binding sites was induced in hemi-parkinsonism rats, which showed good correlation with rotation behavior induced by Apo. Comparing with cerebral blood flow, D2 receptor reflected by IBZM seems to be more specific and earlier to detect the cerebral functional impairment in experimental bend-parkinsonism.

关键词： ^125I-IBZM ^99mTc-HM-PAO 碘125 锝99 放射性核素药物自动放射化学疗法多巴胺D2受体脑灌注显像脑部疾病

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Clinical usefulness of ^(99m)Tc-HIgG scintigraphy for the abdominal inflammation

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Nuclear Science and Techniques 2000年第4期11卷 218-222页

作者： HE Wei, JIANG Mao-Song (shanghai Hua-Dong Hospital, shanghai 200040) 上海市华东医院上海 200040

This study was designed to evaluate the efficacy and safety of 99mTc labeled human IgG as the tracer for detection of focal inflammatory lesion in abdomen. 61 inpatients with 20 documented cases of pelvicellulitis, 41 cases of inflammatory bowel diseases were studied. All their diagnosis were based upon clinical signs and various types of laboratory data and other imaging modalities. 370-740MBq/mg of 99mTc-HIgG was injected intravenously. The whole body scan (Ant and Post views) were obtained 1, 2, 4, 6, 24 hours after injection, delayed imaging were repeated if necessary. Wherever abnormal areas, multiple spot views were added.99mTc-HIgG was avidly taken up by acute pelvis inflammation lesions and performed less well in 2 chronic cases, so the positive rate was 90%. 21 out of the 22 ulcerative colitis were positive, the positive rate was 93%. 17 out of the 19 Crohn’s were positive, the positive rate was 89%. All the negative cases were not active ones. With respect to the activity of the disease, the positive rate of 99mTc-HIgG scan in ulcerative colitis was 100% equal to that of endoscopy. In Crohn’s disease the positive rate was 100%, while endoscopy and X-ray were 30% and 94% respectively. If both diseases were in their relief stage,the scans were normal. Thus 99mTc-HIgG is proved to be effective in detecting the focal site of inflammation in the abdomen. Providing clinically useful assessment of disease activity and patient’s response to therapy,99mTc-HIgG scintigraphy is safe, convenient with no side effects. Physiological accumulation in some organs such as the liver makes it difficult to localize.

关键词： ^99mTc-HIgG 锝99 放射性核素标记 SPECT 临床应用放射性成像克罗恩氏病放射性治疗药物溃疡性结肠炎

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Drug brain distribution following intranasal administration of Huperzine A in situ gel in rats

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Acta Pharmacologica Sinica 2007年第2期28卷 273-278页

作者： Yan ZHAO Peng YUE Tao TAO~2 Qing-hua CHEN shanghai Institute of Pharmaceutical Industry,shanghai 200040,China shanghai Institute of Pharmaceutical Industry Shanghai China

Aim:To determine the uptake extent of Huperzine A(Hup A)into the brain afterintranasal administration of Hup A in situ gel to rats,and to compare the pharma-cokinetic parameters between intranasal administration and iv and ***:Hup A was administered to male Sprague-Dawley rats via nasal,iv and oral routesat the dose of 166.7,166.7,and 500 μg/kg,*** and brain tissuesamples including the cerebrum,hippocampus,cerebellum and olfactory bulbwere collected,and the concentrations of Hup A in the samples were assayed *** area under the concentration-time curve(AUC0→6 h)and the ratio ofthe AUCbrain to the AUCplasma(drug targeting efficiency,DTE)were calculated toevaluate the brain targeting efficiency of the drug via 3 administration ***:The AUC0→6 h of the drug in the cerebrum,hippocampus,cerebellum,left olfactory bulb and right olfactory bulb after intranasal administration of theHup A in situ gel were 1.5,1.3,1.0,1.2,and 1.0 times of those after iv administrationof the injection,and 2.7,2.2,1.9,3.1,and 2.6 times of those after administration ofthe oral *** AUCbrain0→6 h/AUCplasma0→6 h of HupAin the cerebrum,hippocampus and left olfactory bulb following the intranasal administration dosewere significantly higher(P<0.05)than the iv ***:Intranasal deliv-ery showed a viable,non-invasive strategy for delivering the drug into brain.

关键词： Huperzine A in situ gel brain distribution intranasal administration

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Image fusion using MIM software via picture archiving and communication system

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Nuclear Science and Techniques 2001年第4期12卷 241-246页

作者： GU Zhao-Xiang, JIANG Mao-Song Medicine and pharmaceuticals (Huadong Hospital, shanghai 200040) 上海市华东医院上海 200040

The preliminary studies of the multimodality image registration and fusion were performed using an image fusion software and a picture archiving and communication system (PACS) to explore the methodology. Original image voluminal data were acquired with a CT scanner, MR and dual-head coincidence SPECT, respectively. The data sets from all imaging devices were queried, retrieved, transferred and accessed via DICOM PACS. The image fusion was performed at the SPECT ICON work-station, where the MIM (Medical Image Merge) fusion software was installed. The images were created by reslicing original volume on the fly. The image volumes were aligned by translation and rotation of these view ports with respect to the original volume orientation. The transparency factor and contrast were adjusted in order that both volumes can be visualized in the merged images. The image volume data of CT, MR and nuclear medicine were transferred, accessed and loaded via PACS successfully. The perfect fused images of chest CT/18F-FDG and brain MR/SPECT were obtained. These results showed that image fusion technique using PACS was feasible and practical. Further experimentation and larger validation studies were needed to explore the full potential of the clinical use.

关键词：放射性医学图象融合软件开发

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Stereoselective Synthesis and Anticancer Activities of New Podophyllotoxin Derivatives:4-β-Cyano-4-Deoxy-4'-Demethylepipodophyllotoxin and 4-β-Carboxyl-4-Deoxy-4'-Demethylepipodophyllotoxin

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Chinese Chemical Letters 2000年第6期11卷 505-508页

作者： Zai Xin CHEN Wei Yong MA Chun Nian ZHANG(Department of Medicinal Chemistry shanghai Institute of Pharmaceutical Industry,shanghai 200040) Department of Medicinal Chemistry Shanghai Inst. Pharmaceutical I. Shanghai 200040 China

4-β-Cyano-4-deoxy-4'-demethylepipodophyllotoxin 4 was synthesized from 4'-de -methylepipodophyllotoxin and Me3SiCN in the presence of BF3· Et2O. 4-β-Carboxyl-4-deoxy-4'-demethylepipodophyllotoxin 5 was obtained by... 详细信息

关键词： Podophyllotoxin derivative anticancer activities

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Production of transgenic mice carrying green fluorescence protein gene by a lentiviral vector-mediated approach

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Progress in Natural Science:Materials International 2006年第8期16卷 827-832页

作者： ZHANG Jingzhi, GUO Xinbing, XIE Shuyang, ZHU Yiwen, HUANG Ying, WANG Shu and REN Zhaorui (shanghai Institute of Medical Genetics, shanghai JiaoTong University, shanghai 200040, China) shanghai Institute of Medical Genetics Shanghai JiaoTong University Shanghai 200040 China

A pseudo-lentivirus, which carries green fluorescence protein (GFP) expressing cassette, was injected into the periv itelline space of murine fertilized oocytes before transplanting into the oviducts of the foster mothers. The GFP transgenic pups were then obtained. By PCR amplification, fluorescent microscopy and flow assisted cytometry sorting analysis, we found that the integration rate of the transgene was estimated at above 40% . Real-time PCR analysis indicated that the copy number of the integrated GFP cassette was around 40. Fluorescent in situ hybridization analysis demonstrated that the integration pattern was random but inheritable. The transgenic mice with multi-integration sites and various expression levels possessed a great value in practice as well as research. The approach reported herein provides an efficient way to generate and screen the transgenic mouse strains.

关键词： lentiviral vector transgene mouse integration GFP.

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NUMERICAL SIMULATIONS OF WAVE-INDUCED SHIP MOTIONS IN TIME DOMAIN BY A RANKINE PANEL METHOD

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Journal of Hydrodynamics 2010年第3期22卷 373-380页

作者： CHEN Jing-pu ZHU De-xiang China Ship Scientific Research Center Shanghai 214082 China shanghai Institute of Computing Technology Shanghai 200040 China

A time domain prediction of wave-induced ship motions by a Rankine panel method is investigated. Linear boundary conditions on free surface and mean wetted body surface are adopted, while the numerical damping method is used for the radiation conditions. The motions of two ships in regular head waves are computed by the present method. The related numerical results are compared with the experiment data and those from linear strip theory. The comparison shows satisfactory agreements for pitch and heave transfer functions.

关键词： Rankine source panel method time domain ship motion forward speed

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Clinical value of dipyridamole brain perfusion imaging in the diagnosis of ischemic cerebrovascular disease

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Nuclear Science and Techniques 2002年第3期13卷 182-186页

作者： ZHANG Rong, WEI Wen-Shi, TANG Xi,GU Zhao-Xiang, JIANG Mao-Song(Huadong Hospital, shanghai 200040) Huadong Hospital 200040 Huadong Hospital

Using dipyridamole stress test to evaluate cerebral blood flow reserve in cerebrovascular disease (CVD). Dipyridamole stress tests were performed first, the baseline SPECT images were obtained under similar conditions 2-5 days later. By visual and semiquantitative analysis, the responses of cerebral blood flow to dipyridamole were divided into the following four patterns: A: The dipyridamole SPECT showed an expanded area of hypoperfusion, Asymmetry Index(AI) and Uptake Rate(UR) were all decreased; B: Rest images was normal but new hypoperfused areas appeared on stress test with decreased Al and UR; C: Hypoperfused areas were decreased in size or disappeared after stress test with increased Al and UR; D: No changes showed in cerebral perfusion imaging patterns, and in Al and UR between stress and rest studies. Dipyridarnole brain perfusion imaging may be helpful to the diagnosis of CVD, to the decision the therapeutic plan, and to predicting the therapeutic effect.

关键词：头部造影层析X射线摄影法临床诊断

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End-to-End QoS Solution in Multidomain Environment for UMTS IP Multimedia Subsystem

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China Communications 2007年第2期4卷 26-34页

作者： Wei Zhuang Deputy Chief Engineer,shanghai Telecommunication Co.Ltd. 7/F,No.1465 Beijing(W.) Road,shanghai,200040,P.R.China shanghai Telecommun Co Ltd Shanghai 200040 Peoples R China

The third-generation mobile system,or Universal Mobile Telecommunication System(UMTS),offers IP-based multimedia applications and services with end-to -end QoS *** support end-to-end QoS,the UMTS IP Multimedia Subsystem(IMS) network should be scalable,reliable and flexible for interconnection with other UMTS IMS ***-to-end QoS requirements have prompted operators and the 3 GPP group to consider QoS provision in a multi-domain *** this tutorial,two scenarios are discussed for UE-UE connection via interconnected IMS *** first involves the transit of control and user traffic through the same intermediate network. The transit of control and user traffic through different intermediate networks shall be described in the second scenario.

关键词： QoS UMTS IMS

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