检索结果-南通市图书馆

振幅整合脑电图评估孕妇产前糖皮质激素治疗对早产儿脑发育的影响

在线全文

学校读者我要写书评

暂无评论

中国当代儿科杂志 2024年第3期26卷 244-249页

作者：吴迪鞠俊常贺生首都医科大学附属北京朝阳医院儿科北京100020

目的通过振幅整合脑电图(amplitude-integrated electroencephalography,aEEG)探讨孕妇产前糖皮质激素(antenatal corticosteroid,ACS)治疗对早产儿脑发育的影响。方法回顾性纳入胎龄28^(+0)~34^(+6)周早产儿211例,根据产前是否使用地塞米松进行促胎肺成熟治疗分为ACS组(131例)和对照组(80例)。在生后24 h内进行首次aEEG监测(记为aEEG1),生后5~7 d进行第2次aEEG监测(记为aEEG2),对aEEG结果进行分析比较。结果胎龄28^(+0)~31^(+6)周早产儿中,ACS组相较于对照组,aEEG1周期性更成熟、振幅下边界更高(P<0.05);胎龄32^(+0)~33^(+6)周及胎龄34^(+0)~34^(+6)周早产儿中,ACS组相较于对照组,连续模式比例更高、周期性更成熟且Burdjalov评分更高(P<0.05)。胎龄32^(+0)~33^(+6)周及胎龄34^(+0)~34^(+6)周早产儿中,ACS组相较于对照组,aEEG2连续模式比例更高、周期性更成熟、振幅下边界更高、波谱带宽更窄且Burdjalov评分更高(P<0.05)。结论ACS治疗早产儿比未行ACS早产儿aEEG图形更成熟,ACS对早产儿脑发育有一定促进作用。

关键词：脑发育产前糖皮质激素振幅整合脑电图早产儿

Rapid identification of full-length genome and tracing variations of monkeypox virus in clinical specimens based on mNGS and amplicon sequencing

在线全文

学校读者我要写书评

暂无评论

Virologica Sinica 2024年第1期39卷 134-143页

作者： Changcheng Wu Ruhan A sheng Ye Fei Ye Weibang Huo Roujian Lu Yue Tang Jianwei Yang Xuehong Meng Yun Tang Shuang Chen Li Zhao Baoying Huang Zhongxian Zhang Yuda Chen Dongfang Li Wenling Wang Ke-jia shan Jian Lu Wenjie Tan NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing100052China Chongqing Municipal Key Laboratory for High Pathogenic Microbes Chongqing Center for Disease Control and PreventionChongqing400042China MGI BGI-ShenzhenShenzhen518083China Thermo Fisher Scientific Beijing100013China School of Public Health Baotou Medical CollegeBaotou014030China BGI PathoGenesis Pharmaceutical Technology Shenzhen518000China State Key Laboratory of Protein and Plant Gene Research Center for BioinformaticsSchool of Life SciencesPeking UniversityBeijing100871China College of Life Sciences University of Chinese Academy of SciencesBeijing100049China

The monkeypox virus(MPXV)has triggered a current outbreak *** sequencing of MPXV and rapid tracing of genetic variants will benefit disease diagnosis and *** is a significant challenge but necessary to optimize the strategy and application of rapid full-length genome identification and to track variations of MPXV in clinical specimens with low viral loads,as it is one of the DNA viruses with the largest genome and the most AT-biased,and has a significant number of tandem *** we evaluated the performance of metagenomic and amplicon sequencing techniques,and three sequencing platforms in MPXV genome sequencing based on multiple clinical specimens of five mpox cases in Chinese *** rapidly identified the full-length genome of MPXV with the assembly of accurate tandem repeats in multiple clinical *** sequencing enables cost-effective and rapid sequencing of clinical specimens to obtain high-quality MPXV ***-generation sequencing facilitates the assembly of the terminal tandem repeat regions in the monkeypox virus genome and corrects a common misassembly in published ***,several intra-host single nucleotide variations were identified in the first imported mpox *** study offers an evaluation of various strategies aimed at identifying the complete genome of MPXV in clinical *** findings of this study will significantly enhance the surveillance of MPXV.

关键词： Monkeypox virus(MPXV) Metagenomic Next generation sequencing Amplicon Third-generation sequencing

Gastric cancer liver metastasis will reduce the efficacy of immunotherapy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2024年第9期16卷 2760-2764页

作者： Liang Wang shan-shan Liu sheng-Mei Zhang Xiao-Qian Chen Tao Huang Rong Tian Ya-Qi Zhao Zhou Chen Cai-Rang Xianba Department of Gastrointestinal Oncology Surgery The Affiliated Hospital of Qinghai University&Affiliated Cancer Hospital of Qinghai UniversityXining 810000Qinghai ProvinceChina Intensive Care Unit The Affiliated Hospital of Qinghai University&Affiliated Cancer Hospital of Qinghai UniversityXining 810000Qinghai ProvinceChina Department of Ultrasound The Affiliated Hospital of Qinghai University&Affiliated Cancer Hospital of Qinghai UniversityXining 810000Qinghai ProvinceChina Department of General Surgery Hainan State People's Hospital of Qinghai ProvinceHainan Tibetan Autonomous Prefecture 813000Qinghai ProvinceChina

Immune checkpoint inhibitors augment the antitumor activity of T cells by inhibiting the negative regulatory pathway of T cells,leading to notable efficacy in patients with non-small cell lung cancer,melanoma,and other malignancies through immunotherapy ***,secondary malignant liver tumors not only lower the liver's sensitivity to immunotherapy but also trigger systemic immune suppression,resulting in reduced overall effectiveness of immune *** receiving immunotherapy for non-small cell lung cancer and melanoma experience reduced response rates,progression-free survival,and overall survival when secondary malignant tumors develop in the *** Liu's retrospective analysis,valuable insights are provided for the future clinical management of these ***,in patients with gastric cancer(GC),the occurrence of liver metastasis might be indicative of reduced efficacy of *** liver immune tolerance mechanisms and their negative impacts allows for the potential benefits of immunotherapy in patients with GC and liver *** Gastric cancer(GC)ranks among the prevalent malignancies affecting the digestive system *** on the latest epidemiological data[1,2],it holds the fifth position for incidence and the fourth position for mortality among all malignant *** cases and fatalities in China make up roughly half of the worldwide *** investigations[3]have demonstrated that the median overall survival(mOS)among advanced GC patients left untreated typically ranges from 3 to 4 *** chemotherapy recipients often experience a mOS of around one year,accompanied by a marked improvement in the quality of life among patients with advanced *** mainstay of treatment for advanced GC patients involves chemotherapeutic medications such as fluoropyrimidines,platinum compounds,and ***,their efficacy in tumor control is constrained by acquired resistance and pr

关键词： Immune checkpoint inhibitors Gastric cancer Gastric cancer with liver metastasis Immunotherapy Liver immune tolerance

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

《大浴女》器物叙事的范型、机制与功效

北方民族大学学报（哲学社会科学版） 2024年第3期 150-160页

作者：刘仁丽龚举善中南民族大学文学与新闻传播学院湖北武汉430074

置身于“物转向”的当代语境之下,具有诗性气质的器物书写在文学叙事中绽放着独特的艺术光彩。作为当代文学器物叙事的典范之作,铁凝的《大浴女》通过生活型器物、身份型器物和仪式型器物的分型连类书写,显示了相应社会阶层在特定历史... 详细信息

置身于“物转向”的当代语境之下,具有诗性气质的器物书写在文学叙事中绽放着独特的艺术光彩。作为当代文学器物叙事的典范之作,铁凝的《大浴女》通过生活型器物、身份型器物和仪式型器物的分型连类书写,显示了相应社会阶层在特定历史时期个体性、亲历性的创伤记忆与情感体验。细究该作器物叙事的系统生成,外因性社会情境、内因性主体选择以及活态性文本呈现堪称三大发动机制。器物的本原性和生成性特征,使之享有调控叙事节奏、隐喻作品意旨、增显“家国同构”的艺术功效。经由器物叙事话语分析以抵达生命美学的诗意追求,对中国当代小说器物叙事的“宽窄逻辑”建构不乏启示意义。

关键词：《大浴女》器物叙事范型机制功效

Chromosome-level genome assembly of Oncomelania hupensis: the intermediate snail host of Schistosoma japonicum

在线全文

学校读者我要写书评

暂无评论

Infectious Diseases of Poverty 2024年第1期13卷 16-26页

作者： Qin Liu Lei Duan Yun-Hai Guo Li-Min Yang Yi Zhang Shi-Zhu Li shan Lv Wei Hu Nan-sheng Chen Xiao-Nong Zhou National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention(Chinese Centerfor Tropical Diseases Research) NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Centre for Tropical DiseasesNational Center for International Research on Tropical DiseasesNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious DiseasesShanghai 200025People's Republic of China School of Global Health Chinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghai 200025People's Republic of China School of Life Science Fudan UniversityShanghai 200438People's Republic of China CAS Key Laboratory of Marine Ecology and Environmental Sciences Institute of OceanologyChinese Academy of SciencesQingdaoShandong 266071People'sRepublicofChina

Background Schistosoma japonicum is a parasitic flatworm that causes human schistosomiasis, which is a significant cause of morbidity in China, the Philippines and *** hupensis (Gastropoda: Pomatiopsidae) is the unique intermediate host ofS. japonicum. A complete genome sequence ofO. hupensis will enable the fundamental understanding of snail biology as well as its co-evolution with theS. japonicum parasite. Assembling a high-quality reference genome ofO. hupehensis will provide data for further research on the snail biology and controlling the spread ofS. *** The draft genome was de novo assembly using the long-read sequencing technology (PacBio Sequel II) and corrected with Illumina sequencing data. Then, using Hi-C sequencing data, the genome was assembled at the chromosomal level. CAFE was used to do analysis of contraction and expansion of the gene family and CodeML module in PAML was used for positive selection analysis in protein coding *** A total length of 1.46 Gb high-qualityO. hupensis genome with 17 unique full-length chromosomes (2n = 34) of the individual including a contig N50 of 1.35 Mb and a scaffold N50 of 75.08 Mb. Additionally, 95.03% of these contig sequences were anchored in 17 chromosomes. After scanning the assembled genome, a total of 30,604 protein-coding genes were predicted. Among them, 86.67% were functionally annotated. Further phylogenetic analysis revealed thatO. hupensis was separated from a common ancestor ofPomacea canaliculata andBellamya purificata approximately 170 million years ago. Comparing the genome ofO. hupensis with its most recent common ancestor, it showed 266 significantly expanded and 58 significantly contracted gene families (P < 0.05). Functional enrichment of the expanded gene families indicated that they were mainly involved with intracellular, DNA-mediated transposition, DNA integration and transposase *** Integrated use of multiple sequencing technol

关键词： Schistosomiasis Schistosoma japonicum Oncomelania hupensis Chromosome-level genome

在线全文

学校读者我要写书评

暂无评论

地方高校参与高质量乡村振兴的多案例研究

北京社会科学 2024年第4期 76-89页

作者：黄巨臣霍胜君兰州大学高等教育研究院

基于组织社会学视域,构建“组织—环境”分析框架,以典型个案为例,并将它们做类型化划分,进而探究不同区域地方高校参与乡村振兴的样态。研究发现,在特定情况下,以文化开发型参与为主的高校受到历史传统环境制约,生态建设型易被环境保... 详细信息

基于组织社会学视域,构建“组织—环境”分析框架,以典型个案为例,并将它们做类型化划分,进而探究不同区域地方高校参与乡村振兴的样态。研究发现,在特定情况下,以文化开发型参与为主的高校受到历史传统环境制约,生态建设型易被环境保护与开发政策牵引,而产业发展型则依赖于利用信息技术环境;拥有厚重的历史传统底蕴、良好的自然风光环境和规模化的农业生产分别是文化开发型、生态建设型与产业发展型适用推广的前提条件;三种类型的地方高校参与模式虽体现出了不同任务导向和组织优势条件下的差异化策略及其效果,但它们却一致遵循“通过发展促进农民增收”的共同富裕逻辑。

关键词：地方高校乡村振兴高质量发展组织社会学共同富裕

维普期刊数据库博看期刊

在线全文

学校读者我要写书评

暂无评论

电动公交车队置换与充电设施布局协同优化

中国公路学报 2024年第4期37卷 72-83页

作者：王玉生罗欣欣单香琦南京信息工程大学管理工程学院江苏南京210044

城市公交电动化可以有效缓解燃油车带来的空气污染和对化石能源的依赖,是公交行业发展的必然趋势。为此,将电动公交车队置换与充电设施布局进行统筹优化,以公交车队全生命周期成本和充电设施布局成本之和最小化为目标,基于时间和空间维... 详细信息

城市公交电动化可以有效缓解燃油车带来的空气污染和对化石能源的依赖,是公交行业发展的必然趋势。为此,将电动公交车队置换与充电设施布局进行统筹优化,以公交车队全生命周期成本和充电设施布局成本之和最小化为目标,基于时间和空间维度,构建电动公交车队置换与充电设施布局协同优化模型。根据模型特点,通过等价线性变换,将协同优化模型转换为混合整数线性规划模型。为验证协同优化模型的有效性,以江苏省江阴市公交网络为例,设计不同参数值情形下的数值试验。研究结果表明:在本案例参数设置下,协同优化决策获得的公交车队置换方案和充电设施布局方案比单独优化方案的总成本减少467 044.3元,具有较好的成本效益。在预算有限且排放限制要求不严格的情况下,公交运营商通常会购买更有价格优势的燃油公交车。随着电池技术的进步,电动公交车的采购价格有望下降,公交运营商会逐渐减少燃油车和混合动力车的购买,转而选择更环保的电动公交车。此外,公交车队的电动化进程需要与充电设施的建设相协调匹配,确保充电设施能够满足电动公交车的充电需求。政府可以通过增加CO_(2)的社会成本,促使运营商加速公交车队的电动化进程。研究成果为城市公交车队运营管理和充电基础设施建设提供了决策支持,为推进城市公交电动化进程提供了政策建议。

关键词：交通工程公交电动化协同优化模型公交车队置换充电设施布局

A Comparative Study of Numerical Models for Wave Propagation and Setup on Steep Coral Reefs

在线全文

学校读者我要写书评

暂无评论

China Ocean Engineering 2019年第4期33卷 424-435页

作者： ZHANG shan-ju ZHU Liang-sheng ZOU Kai South China University of Technology School of Civil Engineering and Transportation

Complex factors including steep slopes, intense wave breaking, large bottom friction and remarkable wave setup should be considered while studying wave propagation over coral reefs, and how to simulate wave propagation and setup on coral reefs efficiently has become a primary focus. Several wave models can be used on coral reefs as have been published, but further testing and comparison of the reliability and applicability of these models are needed. A comparative study of four numerical wave models (i.e., FUNWAVE-TVD, Coulwave, NHWAVE and ZZL18) is carried out in this paper. These models’ governing equations and numerical methods are compared and analyzed firstly to obtain their differences and connections;then the simulation effects of the four wave models are tested in four representative laboratory experiments. The results show that all four models can reasonably predict the spectrum transformation. Coulwave, NHWAVE and ZZL18 can predict the wave height variation more accurately;Coulwave and FUNWAVE-TVD tend to underestimate wave setup on the reef top induced by spilling breaker, while NHWAVE and ZZL18 can predict wave setup relatively accurately for all types of breakers;NHWAVE and ZZL18 can predict wave reflection by steep reef slope more accurately. This study can provide evidence for choosing suitable models for practical engineering or establishing new models.

关键词： coral reefs steep slope Boussinesq equations wave propagation and setup wave breaking numerical simulation comparative study

数字经济对黄河流域城市外向型经济韧性的影响研究——兼论要素升级的中介效应

在线全文

学校读者我要写书评

暂无评论

管理学刊 2024年第3期37卷 112-127页

作者：生延超陈昕徐珊李倩湖南工商大学公共管理与人文地理学院湖南长沙410205 湖南工商大学经济与贸易学院湖南长沙410205

数字经济是增强城市外向型经济韧性的重要动力,厘清其作用机制对落实黄河流域生态保护和高质量发展战略具有重要意义。理论探究发现,数字经济通过促进劳动力、资本和技术等要素升级强化城市外向型经济韧性。文章选取2008—2020年黄河流... 详细信息

数字经济是增强城市外向型经济韧性的重要动力,厘清其作用机制对落实黄河流域生态保护和高质量发展战略具有重要意义。理论探究发现,数字经济通过促进劳动力、资本和技术等要素升级强化城市外向型经济韧性。文章选取2008—2020年黄河流域81个地级市的面板数据,采用核心变量法测算黄河流域城市外向型经济韧性,并构建双重固定效应模型实证检验数字经济对黄河流域城市外向型经济韧性的影响及作用机制。实证结果表明:第一,数字经济显著增强黄河流域城市外向型经济韧性,该结论在经过一系列稳健性检验后依旧成立。第二,数字经济通过促进劳动力要素质量升级、资本要素质量升级和技术升级等机制增强黄河流域城市外向型经济韧性,且技术升级机制较劳动力与资本要素质量升级机制效用更明显。第三,地理区域位置、是否“一带一路”途经城市及区域资源禀赋会影响数字经济对黄河流域城市外向型经济韧性的提升作用。在上中游地区,数字经济对城市外向型经济韧性的提升作用显著,而下游不显著;数字经济对非“一带一路”途经城市外向型经济韧性促进作用显著,而“一带一路”途经城市不显著;数字经济对资源型城市促进作用显著,而非资源型城市外向型经济韧性不显著。为更好地应对外部环境的复杂变化,促进我国外向型经济稳健发展,应大力发展数字经济,增强数字经济的发动机作用。

关键词：外向型经济韧性数字经济黄河流域要素升级