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Uncertainty in illness and coping styles:Moderating and mediating effects of resilience in stroke patients

World Journal of Clinical Cases 2021年第30期9卷 8999-9010页

作者： Zi-Ting Han Hui-Min Zhang Yi-Ming Wang shan-shan zhu Dong-Yang Wang School of Nursing Xinxiang Medical UniversityXinxiang 453000Henan ProvinceChina School of International Education Xinxiang Medical UniversityXinxiang 453000Henan ProvinceChina Department of Nursing School of PharmacyChangzhou UniversityChangzhou 213000Jiangsu ProvinceChina Faculty of Nursing Mahidol UniversityNakhon Pathom 73170Thailand

BACKGROUND Stroke has a great influence on the patient’s mental health,and reasonable psychological adjustment and disease perception can promote the recovery of mental *** To explore the relationships among resilience,coping style,and uncertainty in illness of stroke *** A retrospective study was used to investigate 154 stroke patients who were diagnosed and treated at eight medical institutes in Henan province,China from October to December *** used the Mishel Uncertainty in Illness Scale,the Connor-Davidson Resilience Scale,and the Medical Coping Modes Questionnaire to test the uncertainty in illness,resilience,and coping style,*** Resilience had a significant moderating role in the correlation between coping style and unpredictability and information deficiency for uncertainty in illness(P<0.05).Further,the tenacity and strength dimensions of resilience mediated the correlation between the confrontation coping style and complexity,respectively(P<0.05).The strength dimension of resilience mediated the correlation between an avoidance coping style and the unpredictability of uncertainty in illness(P<0.05),as well as correlated with resignation,complexity,and unpredictability(P<0.05).CONCLUSION Resilience has moderating and mediating roles in the associations between coping style and uncertainty in illness,indicating that it is vital to improve resilience and consider positive coping styles for stroke patients in the prevention and control of uncertainty in illness.

关键词： Stroke Resilience,Psychological Coping styles Uncertainty in illness

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Photoinduced Merging with Copper-or Nickel-Catalyzed 1,4-Cyanoalkylarylation of 1,3-Enynes to Access Multiple Functionalizatized Allenes in Batch and Continuous Flow

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Chinese Journal of Chemistry 2022年第13期40卷 1537-1545页

作者： Qi Sun Xin-Peng Zhang Xiu Duan Long-Zhou Qin Xin Yuan Meng-Yu Wu Jie Liu shan-shan zhu Jiang-Kai Qiu Kai Gu Biotechnology and Pharmaceutical Engineering Nanjing Tech UniversityNanjingJiangsu 211816China State Key Laboratory of Materials-Oriented Chemical Engineering Nanjing Tech UniversityNanjingJiangsu 211800China

A three-component reaction of 1,3-enynes and cyclobutanone oxime esters in the presence of aryl boronic acids or organozinc reagents via the photoredox/copper or photoredox/nickel catalysis has been *** redox-neutral 1,4-cyanoalkylarylation reaction has demonstrated mild condition,high catalytic reactivity and wide functional group compatibility,allowing access to a variety of functionalized tetra-substituted allene derivatives with high chemo-and ***,using photocatalytic continuous flow technique to promote this process would result in increased yields(70%in flow vs.61%in batch),reduced reaction times(7 min in flow vs.6 h in batch),and easy scale-up(upgrade to gram scale),showcasing its potential as a synthetic platform.

关键词： Photochemistry 1,4-Cyanoalkylarylation Radical reaction 1,3-Enynes 1,4-Cyanoalkylarylation Tetra-substituted allenes Photocatalytic continuous flow technique

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Serum microRNA-221 as a biomarker for diabetic retinopathy in patients associated with type 2 diabetes

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International Journal of Ophthalmology(English edition) 2018年第12期11卷 1889-1894页

作者： He-Nan Liu Xun Li Na Wu Meng-Meng Tong Shuo Chen shan-shan zhu Wei Qian Xiao-Long Chen Department of Ophthalmology Shengjing Hospital China Medical University Department of Endocrinology Shengjing Hospital China Medical University Sino-Dutch Biomedical and Information Engineering School Northeastern University Department of Electrical and Computer Engineering College of Engineering University of Texas at El Paso

AIM: To investigate the candidate microRNA(miRNA), miR-221 as a novel biomarker for diabetic retinopathy(DR) in patients associated with type 2 diabetes(T2D).METHODS: The subjects involved were divided into four groups: healthy control(HC), no diabetic retinopathy(NDR), non-proliferative diabetic retinopathy(NPDR) and proliferative diabetic retinopathy(PDR) group. Serum miR-221 was validated by real-time quantitative reversetranscription polymerase chain reaction(qRT-PCR). Also, serum angiotensin II(Ang II) and vascular endothelial growth factor(VEGF) were examined by enzyme-linked immunosorbent assay. In addition, receiver operating characteristic(ROC) curve was performed to explore the diagnostic accuracy of miR-221, Ang Ⅱ and VEGF for DR in patients with T2D. Spearman’s rank correlation coefficient was executed to estimate the correlations of serum miR-221 with metabolic parameters and serum markers in patients with ***: Primarily, serum miR-221, Ang Ⅱ and VEGF were increased significantly in T2D patients compared to HC participant respectively, and progressive up-regulated in NDR, NPDR and PDR groups(P<0.001). Additionally, miR-221 in serum was remarkably positively correlatedwith metabolic parameters such as glycated hemoglobin(r=0.310, P=0.002) and homeostasis model assessment for insulin resistance(r=0.413, P<0.001), as well as serum markers for instance Ang Ⅱ(r=0.667, P<0.001) and VEGF(r=0.499, P<0.001). Furthermore, serum miR-221(AUC, 0.894; 95%CI, 0.833-0.955; P<0.001), Ang Ⅱ(AUC, 0.888; 95%CI, 0.828-0.949; P<0.001) and VEGF(AUC, 0.785; 95%CI, 0.695-0.875; P<0.001) had evidently diagnostic efficiency in DR, and miR-221 is the most effective among ***: Serum miR-221 as a potential biomarker could be related to not only occurrence but also progression for DR in patients with T2D. However, a prospective clinical trial is warranted.

关键词： microRNA-221 biomarker diabetic retinopathy type 2 diabetes

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Isoflurane preconditioning protects against ischemia-reperfusion injury partly by attenuating cytochrome c release from subsarcolemmal mitochondria in isolated rat hearts

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Acta Pharmacologica Sinica 2005年第7期26卷 813-820页

作者： Li-ping QIAN shan-shan zhu~2 Jun-li CAO Yin-ming ZENG Jiangsu Provincial Key Lab of Anesthesiology,Jiangsu Institute of Anesthesiology,Xuzhou Medical College,Xuzhou 221002,China Jiangsu Provincial Key Lab of Anesthesiology Jiangsu Institute of Anesthesiology Xuzhou Medical College Xuzhou 221002 China

Aim:To examine if isoflurane preconditioning can attenuate ischemia/reperfusioninjury by reducing cytochrome c release from inner mitochondrial ***:Isolated hearts of Sprague-Dawley rats were perfused on *** were randomly assigned to a non-treated group(CON group,n=12)or three isoflurane preconditioning groups(0.5% ISC group,1.0% ISC group,and 2.0% ISC group;n=12).In the latter three groups,isoflurane was given atconcentrations of 0.5%,1.0%,and 2.0% for 15 min with 15-rain washout before30-min *** mitochondria of the myocardium were isolatedafter 60-min *** of the each heart was recorded,infarctsize of the hearts and contents of cytosolic cytochrome or mitochondrial cyto-chrome c were measured at the end of *** of isolated mito-chondria in the four groups was evaluated,***:Compared withthe CON group,cytosolic cytochrome c in 0.5% ISC group,1.0% ISC group,and2.0% ISC group were significantly decreased along with a significant increase ofmitochondrial cytochrome *** size of the hearts in the four groups were56%±12%,41%±12%,32%±7% and 33 %±11%,*** values of thethree isoflurane preconditioning groups were significantly lower than that of theCON group(P<0.05).Isoflurane exposure before ischemia can attenuate the changeof morphology of mitochondria after *** effects of 2.0% isofluraneon reducing cytochrome c release were more remarkable than 0.5% and 1.0%concentrations of ***:Myocardioprotective effects ofisofluranc preconditioning were associated with attenuation of cytochrome c lossfrom the inner membrane of subsarcolemmal mitochondria.

关键词： isoflurane reperfusion injury cytochromec mitochondria

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Identification of risk factors and construction of a nomogram predictive model for post-stroke infection in patients with acute ischemic stroke

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World Journal of Clinical Cases 2024年第20期12卷 4048-4056页

作者： Xiao-Chen Liu Xiao-Jie Chang Si-Ren Zhao shan-shan zhu Yan-Yan Tian Jing Zhang Xin-Yue Li Department of Neurosurgery Shandong Provincial Third HospitalJinan 250031Shandong ProvinceChina Department of Neurology Shandong Provincial Third HospitalJinan 250031Shandong ProvinceChina

BACKGROUND Post-stroke infection is the most common complication of stroke and poses a huge threat to *** addition to prolonging the hospitalization time and increasing the medical burden,post-stroke infection also significantly increases the risk of disease and *** the risk factors for post-stroke infection in patients with acute ischemic stroke(AIS)is of great *** can guide clinical practice to perform corresponding prevention and control work early,minimizing the risk of stroke-related infections and ensuring favorable disease *** To explore the risk factors for post-stroke infection in patients with AIS and to construct a nomogram predictive *** The clinical data of 206 patients with AIS admitted to our hospital between April 2020 and April 2023 were retrospectively *** data and post-stroke infection status of all study subjects were assessed,and the risk factors for poststroke infection in patients with AIS were *** Totally,48 patients with AIS developed stroke,with an infection rate of 23.3%.Age,diabetes,disturbance of consciousness,high National Institutes of Health Stroke Scale(NIHSS)score at admission,invasive operation,and chronic obstructive pulmonary disease(COPD)were risk factors for post-stroke infection in patients with AIS(P<0.05).A nomogram prediction model was constructed with a C-index of 0.891,reflecting the good potential clinical efficacy of the nomogram prediction *** calibration curve also showed good consistency between the actual observations and nomogram *** area under the receiver operating characteristic curve was 0.891(95%confidence interval:0.839–0.942),showing predictive value for post-stroke *** the optimal cutoff value was selected,the sensitivity and specificity were 87.5%and 79.7%,*** Age,diabetes,disturbance of consciousness,NIHSS score at admission,invasive surgery,and COPD are risk factors for post-st

关键词： Acute ischemic stroke Infection Risk factors Nomogram prediction model Chronic obstructive pulmonary disease

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大型运输机推力不对称补偿控制律设计

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飞行力学 2017年第5期35卷 36-39页

作者：张珊珊薛源朱妍中航工业西安飞机设计研究所飞行控制与液压设计研究所陕西西安710089

为了补偿推力不对称对大型飞机造成的影响,基于推力不对称对飞机姿态及运动的影响分析,提出了引入侧滑角反馈的横航向控制律补偿方案,并进行了仿真验证。仿真结果表明,补偿后的控制律能够减小侧向偏离、侧滑角及滚转角,保持航向和飞行姿... 详细信息

为了补偿推力不对称对大型飞机造成的影响,基于推力不对称对飞机姿态及运动的影响分析,提出了引入侧滑角反馈的横航向控制律补偿方案,并进行了仿真验证。仿真结果表明,补偿后的控制律能够减小侧向偏离、侧滑角及滚转角,保持航向和飞行姿态,从而减轻了飞行员负担,保证了飞行安全。

关键词：推力不对称动态特性补偿控制

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基于网络舆情的企业财务危机动态预警

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北京邮电大学学报（社会科学版） 2016年第6期18卷 31-38,73页

作者：段珊珊朱建明中央财经大学信息学院北京100081

当前我国企业面临的危机呈现复杂化与多样化的特点,财务信息披露质量问题导致基于财务指标的危机预警模型频频失准,而引入的非财务指标依赖于特定样本无法适应新危机的特性。为获取全面而客观的企业信息,提出基于自媒体中60家上市公司... 详细信息

当前我国企业面临的危机呈现复杂化与多样化的特点,财务信息披露质量问题导致基于财务指标的危机预警模型频频失准,而引入的非财务指标依赖于特定样本无法适应新危机的特性。为获取全面而客观的企业信息,提出基于自媒体中60家上市公司的相关评论,获取网民评论纵向数据流,通过情感分析处理形成网络舆情流指标,在此基础上结合财务指标,调节模型时间窗口宽度以连贯地动态反映企业财务状况,建立基于网络舆情的财务危机动态预警模型。实证表明:引入网络舆情指标的财务预警动态模型可获取最佳时间窗口宽度,预测效果显著优于仅包括财务指标的静态预警模型,具有更好的适应性。

关键词：网络舆情情感分析财务危机预警时间窗口

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The Interaction between Cytokinin and Auxin Controls Stem-Cell Specification during In Vitro Shoot Induction in Arabidopsis

The Interaction between Cytokinin and Auxin Controls Stem-Ce...

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2009中国植物学会植物细胞生物学学术年会

作者： Zhi Juan Cheng,shan shan zhu,Ying Hua Su,Xiang Yu Zhao,Xin Qi Gao,Xian Sheng Zhang~* State Key Laboratory of Crop Biology,College of Life Sciences,shandong Agricultural University,Taian,shandong 271018,China

Shoot regeneration is an important way for plant propagation in *** cells are critical for the formation of shoot apical meristem and must be induced within the cal lus during shoot *** is understood however about the... 详细信息

关键词： Arabidopsis stem cell specification auxin cytokinin in vitro organogenesis

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碳酸司维拉姆治疗慢性肾脏病矿物质、骨代谢异常的研究进展

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世界临床药物 2018年第3期39卷 I0002-I0006页

作者：郭姗姗王玉柱北京市海淀医院北京大学第三医院海淀院区肾脏内科北京100080

随着透析质量的提高,透析龄的延长,透析慢性并发症引起关注。慢性肾脏病矿物质、骨代谢异常(CKD-MBD)是长期透析患者的严重并发症之一,影响透析患者的生活质量,更增加透析患者的死亡风险。高磷血症是CKD-MBD的始动因素,新型降磷药物碳... 详细信息

随着透析质量的提高,透析龄的延长,透析慢性并发症引起关注。慢性肾脏病矿物质、骨代谢异常(CKD-MBD)是长期透析患者的严重并发症之一,影响透析患者的生活质量,更增加透析患者的死亡风险。高磷血症是CKD-MBD的始动因素,新型降磷药物碳酸司维拉姆,可有效控制血磷水平,提高透析患者的生存质量,不良反应较少,并有降血磷之外的益处,本文综述碳酸司维拉姆治疗CKD-MBD患者的临床应用研究进展。

关键词：碳酸司维拉姆高磷血症透析

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基于UPLC指纹图谱及化学识别模式的防暑清热饮质量评价

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中国药师 2023年第11期26卷 204-212页

作者：李杰杨育儒祝珊珊秦飞厦门医学院药学系福建厦门361023 厦门大学附属东南医院药剂科福建漳州363000

目的建立防暑清热饮指纹图谱,结合化学识别模式评价其质量。方法以3,5-O-二咖啡酰奎宁酸为参照峰,采用《中药色谱指纹图谱相似度评价系统》(2012版)建立10批次防暑清热饮的超高效液相色谱(UPLC)指纹图谱,指认共有峰并进行相似度评价,... 详细信息

目的建立防暑清热饮指纹图谱,结合化学识别模式评价其质量。方法以3,5-O-二咖啡酰奎宁酸为参照峰,采用《中药色谱指纹图谱相似度评价系统》(2012版)建立10批次防暑清热饮的超高效液相色谱(UPLC)指纹图谱,指认共有峰并进行相似度评价,确定每个共有峰的药材归属;运用化学模式识别法中的聚类分析(CA)、主成分分析(PCA)和正交偏最小二乘法-判别分析(OPLS-DA)确定影响制剂质量的差异性成分。结果 10批次防暑清热饮指纹图谱共有31个共有峰,相似度为0.975~0.996,指认6个共有峰,分别为9号峰(绿原酸)、19号峰(木犀草素-7-O-β-D-葡萄糖苷)、21号峰(3,5-O-二咖啡酰奎宁酸)、23号峰(橙皮苷)、29号峰(蒙花苷)和31号峰(广藿香酮);CA和PCA将10批次防暑清热饮分为3类;PCA结果显示,主成分1~6的累计方差贡献率为95.947%;OPLS-DA结果显示,共有13个峰变量重要性投影值大于1,为差异性成分。结论该方法简便、灵敏、快速,可用于防暑清热饮的质量评价。

关键词：防暑清热饮超高效液相色谱法指纹图谱化学模式识别质量评价

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