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文学经济学批评范式的生成逻辑与方法论意义

河北学刊 2017年第1期37卷 79-86页

作者：龚举善中南民族大学文学与新闻传播学院湖北武汉430074

社会历史批评作为中国当代文学批评的主线,相继经历了政治学批评、经济学批评和身体美学批评三个阶段,并相应凝聚为三种批评范式。经济话语规模化进入当代文学批评场域,与马克思主义艺术生产理论的召唤、文学及其批评现场经济要素的参... 详细信息

社会历史批评作为中国当代文学批评的主线,相继经历了政治学批评、经济学批评和身体美学批评三个阶段,并相应凝聚为三种批评范式。经济话语规模化进入当代文学批评场域,与马克思主义艺术生产理论的召唤、文学及其批评现场经济要素的参与、市场经济规则的体制化运作等密不可分。文学经济学批评的动态生成,主要受制于三大机制:客体的经济生活是实现文学经济学批评的前提条件;创作与消费双重主体是达成文学经济学批评的内在动因;文学传播中的媒介因素成为文学经济学批评的运行中介。辩证地看,文学经济学批评既有积极的方法论价值,也存在自身局限。文学批评者既不能迷信"经济实用论",也不可盲从经济与文学间的"二元对立论",而应提倡并践行社会主义文学批评的多元发展观。

关键词：当代文学批评文学经济学主流范式生成逻辑方法论意义

Equivalent pipe algorithm for metal spiral casing and its application in hydraulic transient computation based on equiangular spiral model

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Journal of Hydrodynamics 2014年第1期26卷 137-143页

作者：彭小东杨朝晖刘善均鞠小明 State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan University Department of Water Resources of Guizhou Province

For the metal spiral casing of water turbines, a new equivalent pipe algorithm is developed based on the idea of equiangu-lar spiral. Prototype tests and computations are carried out to investigate the hydraulic transient characteristics. The computation re-sults by using the new model are in a good agreement with the prototype test data with respect to the maximum speed of the tur-bine-generator unit, the maximum water hammer pressure in the spiral casing and the maximum vacuum in the draft tube. The propo-sed method is a significant improvement over the conventional algorithm with the accuracy increased and the error reduced by about 3%.

关键词： equiangular spiral metal spiral casing equivalent pipe hydraulic transient

Natural ingredients from Chinese materia medica for pulmonary hypertension

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Chinese Journal of Natural Medicines 2021年第11期19卷 801-814页

作者： ZHANG Jia-Rui OUYANG Xuan HOU Chi YANG Qi-Feng Wu Yingjun LU Wen-ju LIU Chun-Li YANG Kai ZHONG Nan-shan WANG Jian CHEN Yu-Qin State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangdong Key Laboratory of Vascular DiseaseGuangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510000China Division of Pulmonary and Critical Care Medicine the People’s Hospital of Inner MongoliaHuhhot 010000China Department of Neurology Guangzhou Women and Children’s Medical CenterGuangzhou 510000China Section of Physiology Division of PulmonaryCritical Care and Sleep MedicineUniversity of CaliforniaSan Diego 92173USA The Second Affiliated Hospital of Guangzhou medical university 250 Changgangdong RdGuangzhou 51026China

Pulmonary hypertension(PH)is a severe pathophysiological condition characterized by pulmonary artery remodeling and continuous increases in pulmonary artery pressure,which may eventually develop to right heart failure and *** newly discovered and incredible treatment strategies in recent years have improved the prognosis of PH,limited types of effective and economical drugs for PH still makes it as a life-threatening *** drugs from Chinese materia medica(CMM)have been traditionally applied in the treatment of lung *** evidence suggests active pharmaceutical ingredients(APIs)derived from those medicines brings promising future for the prevention and treatment of *** this review,we summarized the pharmacological effects of APIs derived from CMM which are potent in treating PH,so as to provide new thoughts for initial drug discovery and identification of potential therapeutic strategies in alternative medicine for PH.

关键词： Pulmonary hypertension Active pharmaceutical ingredients Chinese materia medica

Cypripediquinone A, a new phenanthraquinone from Cypripedium macranthum (Orchidaceae)

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Chinese Chemical Letters 2000年第1期11卷 37-38页

作者： Jian Hua ju jun shan YANG Jin LI Pei Gen XIAO (Institute of Medicinal Plant Development. Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094) Chinese Acad Med Sci Inst Med Plant Dev Beijing 100094 Peoples R China Peking Union Med Coll Beijing 100094 Peoples R China

A new phenanthraquinone, cypripediquinone A, was isolated from the rhizome of Cypripedium macranthum ( Orchidaceae ) and its structure was established as 2,4,7-trimethoxy-9, 10- phenanthraquinone mainly by spectroscop... 详细信息

关键词： Cypripedium macranthum cypripediquinone A

Connecting the P300 to the diagnosis and prognosis of unconscious patients

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Neural Regeneration Research 2015年第3期10卷 473-480页

作者： Ran Li Wei-qun Song ju-bao Du Su Huo Gui-xiang shan Department of Rehabilitation Medicine Xuanwu HospitalCapital Medical University

The residual consciousness of unconscious patients can be detected by studying the P300, a wave among event-related potentials. Previous studies have applied tones, the subject＇s name and other names as stimuli. However, the results were not satisfactory. In this study, we changed the constituent order of subjects＇ two-character names to create derived names. The subject＇s derived names, together with tones and their own names, were used as auditory stimuli in event-related potential experiments. Healthy controls and unconscious patients were included in this study and made to listen to these auditory stimuli. In the two paradigms, a sine tone followed by the subject＇s own name and the subject＇s derived name followed by the subject＇s own name were used as standard and deviant stimuli, respectively. The results showed that all healthy controls had the P300 using both paradigms, and that the P300 in the second paradigm had a longer latency and two peaks. All minimally conscious state patients had the P300 in the first paradigm and the majority of them had the P300 in the second paradigm. Most vegetative state patients had no P300. Patients who showed the P300 in the two paradigms had more residual consciousness, and patients with the two-peak P300 had a higher probability of awakening within a short time. Our experimental findings suggest that the P300 event-related potential could reflect the conscious state of unconscious patients.

关键词： nerve regeneration brain injury cognitive neuroscience event-related potential P300 electrophysiology nutritional state minimally conscious state consciousness disorders of consciousness unconsciousness evaluation prognosis NSFC grants neural regeneration

Phytosphinganine Affects Plasmodesmata Permeability via Facilitating PDLP5-Stimulated Callose Accumulation in Arabidopsis

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Molecular Plant 2020年第1期13卷 128-143页

作者： Ning-Jing Liu Tao Zhang Zhao-Hui Liu Xin Chen Hui-shan Guo Bai-Hang ju Yuan-Yuan Zhang Guo-Zhu Li Qiang-Hui Zhou Yong-Mei Qin Yu-Xian Zhu State Key Laboratory of Protein and Plant Gene Research College of-Life SciencesPeking UniversityRoom 228Jinguang BuildingNo5 in Yi-He Yuan RoadBeijing 100871People's Republic of China State Key Laboratory of Plant Genomics Institute of MicrobiologyChinese Academy of SciencesBeijing 100101 People's Republic of China Institute for Advanced Studies Wuhan UniversityWuhan 430072People's Republic of China

Plant plasmodesmata (PDs) are specialized channels that enable communication between neighboring cells. The intercellular permeability of PDs, which affects plant development, defense, and responses to stimuli, must be tightly regulated. However, the lipid compositions of PD membrane and their impact on PD permeability remain elusive. Here, we report that the Arabidopsis sld1 sld2 double mutant, lacking sphingolipid long-chain base 8 desaturases 1 and 2, displayed decreased PD permeability due to a significant increase in callose accumulation. PD-located protein 5 (PDLP5) was significantly enriched in the leaf epidermal cells of sld1 sld2 and showed specific binding affinity to phytosphinganine (t18:0), suggesting that the enrichment of t18:0-based sphingolipids in sld1 sld2 PDs might facilitate the recruitment of PDLP5 proteins to PDs. The sld1 sld2 double mutant seedlings showed enhanced resistance to the fungal-wilt pathogen Verticillium dahlia and the bacterium Pseudomonas syringae pv. tomato DC3000, which could be fully rescued in sld1 sld2 pdlp5 triple mutant . Taken together, these results indicate that phytosphinganine might regulate PD functions and cell-to-cell communication by modifying the level of PDLP5 in PD membranes.

关键词： plasmodesmata phytosphinganine sphingolipid binding motif PDLP5

Insight from in situ microscopy into which precipitate morphology can enable high strength in magnesium alloys

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Journal of Materials Science & Technology 2018年第7期34卷 1061-1066页

作者： Bo-Yu Liu Nan Yang Jian Wang Matthew Barnett Yun-Chang Xin Di Wu Ren-Long Xin Bin Li R. Lakshmi Narayan Jian-Feng Nie ju Li Evan Ma Zhi-Wei shan Center for Advancing Materials Performance from the Nanoscale (CAMP-Nano) & Hysitron Applied Research Center in China (HARCC) State Key Laboratory for Mechanical Behavior of Materials Xi' an Jiaotong University Xi' an 710049. People's Republic of China Mechanical and Materials Engineering University of Nebraska-Lincoln Lincoln NE 68588 USA Institute for Frontier Materials Deakin University Geelong Victoria 3216 Australia College of Materials Science and Engineering Chongqing University Chongqing 400045 People's Republic of China Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 People's Republic of China Department of Chemical and Materials Engineering University of Nevada Reno USA Department of Materials Science and Engineering Carnegie Mellon University Pittsburgh PA 15213 USA Department of Materials Science and Engineering Monash University Melbourne Victoria 3800 Australia Department of Nuclear Science and Engineering and Department of Materials Science and Engineering Massachusetts Institute of Technology 77 Massachusetts Avenue Cambridge MA 02139 USA Department of Materials Science and Engineering Johns Hopkins University Baltimore MD 21218 USA

Magnesium alloys, while boasting light weight, suffer from a major drawback in their relatively low strength. Identifying the microstructural features that are most effective in strengthening is therefore a pressing challenge. Deformation twinning often mediates plastic yielding in magnesium alloys. Unfortunately, due to the complexity involved in the twinning mechanism and twin-precipitate interactions, the optimal precipitate morphology that can best impede twinning has yet to be singled out. Based on the understanding of twinning mechanism in magnesium alloys, here we propose that the lamellar precipitates or the network of plate-shaped precipitates are most effective in suppressing deformation twinning. This has been verified through quantitative in situ tests inside a transmission electron microscope on a series of magnesium alloys containing precipitates with different morphology. The insight gained is expected to have general implications for strengthening strategies and alloy design. 2018 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science ＆ Technology.

关键词： Precipitate selection criterionIn-situ TEM Mg alloy Mechanical property Deformation twinning

Carbide precipitation and microstructure refinement of Cr-Co-Mo-Ni bearing steel during hot deformation

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Journal of Central South University 2015年第9期22卷 3265-3274页

作者：袁晓虹郑善举杨卯生赵昆渝 Faculty of Material Science and Engineering Kunming University of Science and Technology Central Iron and Steel Research Institute New Metallurgy Hi-tech Group Co. Ltd. China Iron and Steel Research Institute Group

The dynamic recrystallization and carbides precipitation of the Cr-Co-Mo-Ni bearing steel were investigated by hot compression tests performed at temperatures ranging from 850 ℃to 1080 ℃ with strain rate of 1-20 s-1. The activation energy（Q） for the tested steel is calculated to be around 682.99 k J/mol at a deformation strain of 0.6. Microstructural analysis by SEM shows that the dynamic recrystallization（DRX） behavior is dependent sensitively on the deformation strain, temperature and strain rate, while an exponential relationship between DRX grain size and Z parameter is obtained from the computational formula. Moreover, the M6C-type carbides（〈1 μm） act as the main prohibitor of grain coarsening, and the polynomial regression relationship between them is worked out. With electron backscatter diffraction（EBSD） observation, DRX is the main nucleation mechanism responsible for the formation of new grains during hot compression. In conclusion, the interaction between DRX affected by hot deformation parameters and carbides precipitation determines the ultimate grain size refinement.

关键词： high-alloy steel Z parameter grain size refinement carbides dynamic recrystallization (DRX) mechanism

Effect of Cordyceps sinensis on the Treatment of Experimental Autoimmune Encephalomyelitis： A Pilot Study on Mice Model

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Chinese Medical Journal 2017年第19期130卷 2296-2301页

作者： shan-shan Zhong Ya-juan Xiang Pen-ju Liu Yang He Ting-Ting Yang Yang-YanpWang A Rong jun Zhang Guang-Zhi Liu Department of Neurology Peking University People's Hospital Beijing 1000441 China Department of Neurology The First Hospital of Tsinghua University Beijing 100016 China Deptartment of Neurology Beijing Anzhen Hospital Capital Medical University Beijing 100029 China Deptartment of Neurology Tsinghua Changgung Hospital Beijing 102218 China

Background： As a traditional Chinese medicine, Cordyceps sinensis （CS） possesses a variety of immunoregulatory properties. This study aimed to explore the therapeutic potential of CS in a mice model of multiple sclerosis （MS）-experimental autoimmune encephalomyelitis （EAE）. Methods： Female C57BL/6 mice were immunized with myelin oligodendrocyte glycoprotein35–55 to induce EAE, followed by an instant intragastric feeding with a low dosage of CS （low CS group, n = 5）, high dosage of CS （high-CS group, n = 5）, or the same volume of normal saline （control group, n = 5）.All the mice were observed for clinical assessment. Over the 30 days of CS treatment, flow cytometry was used to detect the frequency of helper T-cell （Th） subsets, Th1 and Th17, and CD4＋ CD25＋ regulatory T cells in the spleen and lymph nodes. Meanwhile, pathological changes in brain were determined using both hematoxylin-eosin and luxol fast blue staining. Data were analyzed using the one-way analysis of variance （ANOVA）. Results： Over the 15 and 30 days of CS treatment, the clinical assessment for EAE demonstrated that both high-CS group （2.51 ± 0.31 and 2.26 ± 0.39 scores, respectively） and low-CS group （2.99 ± 0.40 and 2.69 ± 0.46, respectively） had lower disease severity scores than those of control group （3.57 ± 0.53 and 3.29 ± 0.53, all P 〈 0.01, respectively）. Meanwhile, after 15 and 30 days, the high-CS group （19.18 ± 1.34 g and 20.41 ± 1.56 g, respectively） and low-CS group （18.07 ± 1.18 g and 19.48 ± 1.69 g, respectively） had a lower body weight, as compared with control group （16.85 ± 1.15 g and 18.22 ± 1.63 g, all P 〈 0.01, respectively）.At 30 days post-CS treatment, there was a lower Th1 frequency in the lymph nodes （2.85 ± 1.54% and 2.77 ± 1.07% vs. 5.35 ± 1.34%, respectively; P 〈 0.05） and spleens （3.96 ± 1.09% and 3.09 ± 0.84% vs. 5.07 ± 1.50%, respectively; P 〈 0.05） and less inflammatory infiltration and demyelination in the brain of CS-treated mice than that of control group. Conclusio

关键词： Autoimmune Cordyceps Encephalomyelitis Experimental Multiple Sclerosis