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Anticoagulation therapy prevents portal-splenic vein thrombosis after splenectomy with gastroesophageal devascularization

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World Journal of Gastroenterology 2012年第26期18卷 3443-3450页

作者： Wei Lai Shi-Chun Lu Guan-Yin Li Chuan-Yun Li ju-shan Wu Qing-Liang Guo Meng-Long Wang Ning Li Depart-ment of Hepatobiliary Surgery and You-An Liver Transplanta-tion Center Beijing You-An HospitalCapital Medical Univer-sityBeijing 100069China

AIM:To compare the incidence of early portal or splenic vein thrombosis(PSVT) in patients treated with irregular and regular anticoagulantion after splenectomy with gastroesophageal ***:We retrospectively analyzed 301 patients who underwent splenectomy with gastroesophageal devascularization for portal hypertension due to cirrhosis between April 2004 and july *** were categorized into group A with irregular anticoagulation and group B with regular anticoagulation,*** A(153 patients) received anticoagulant monotherapy for an undesignated time period or with aspirin or warfarin without low-molecular-weight heparin(LMWH) *** B(148 patients) received subcutaneous injection of LMWH routinely within the first 5 d after surgery,followed by oral warfarin and aspirin for one month *** target prothrombin time/international normalized ratio(PT/INR) was *** and PT/INR were *** Doppler imaging was performed to monitor PSVT as well as the effectiveness of thrombolytic ***:The patients' data were collected and analyzed *** the patients,94 developed early postoperative mural PSVT,including 63 patients in group A(63/153,41.17%) and 31 patients in group B(31/148,20.94%).There were 50(32.67%) patients in group A and 27(18.24%) in group B with mural PSVT in the main trunk of portal *** the administration of thrombolytic,anticoagulant and antiaggregation therapy,complete or partial thrombus dissolution achieved in 50(79.37%) in group A and 26(83.87%) in group ***:Regular anticoagulation therapy can reduce the incidence of PSVT in patients who undergo splenectomy with gastroesophageal devascularization,and regular anticoagulant therapy is safer and more effective than irregular anticoagulant *** and timely thrombolytic therapy is imperative and feasible for the prevention of PSVT.

关键词： Portal vein hypertension Splenectomy withgastroesophageal devascularization Portal or splenicvein thrombosis Anticoagulation regimen Thrombo-lyric therapy

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Stimulation of melanogenesis by scoparone in B16 melanoma cells

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Acta Pharmacologica Sinica 2006年第11期27卷 1467-1473页

作者： Jeong-yeh YANG Jeung-hyunKOO Young-gilSONG Kang-beom KWON ju-hyung LEE Hee-sook SOHN Byung-hyun PARK Eun-chung JHEE Jin-woo PARK Department of Biochemistry Dental SchoolChonbuk National UniversityJeonju 561-756Korea Department of Biochemistry Medical School Chonbuk National UniversityJeonju 561-756Korea Department of Physiology School of Oriental MedicineWon-Kwang UniversityIksan 570-749Korea Department of Preventive Medicine Medical School Department of Food Science and Human Nutrition College of Home EconomyChonbuk National UniversityJeonju 561-756Korea Department of Biochemistry Medical SchoolChonbuk National UniversityJeonju 561-756Korea Institute for Healthcare Technology DevelopmentChonbuk National UniversityJeonju 561-756Korea Department of Biochemistry Medical SchoolChonbuk National UniversityJeonju 561-756Korea Institute for Healthcare Technology Development Chonbuk National UniversityJeonju 561-756Korea

Aim:The effect of coumarin derivatives on melanogenesis was investigated inB16 murine melanoma ***:Melanin content and tyrosinase activitywere analyzed *** expression of tyrosinase,tyrosinase-related protein-1(TRP-1)and tyrosinase-related protein-2(TRP-2)were measuredeither by reverse transcription-polymerase chain reaction(RT-PCR)or ***:Among the coumarin derivatives studied,scoparone(6,7-dimethoxycoumarin)was the most potent;the 6-or 7-methoxy group was found tobe essential for the stimulation of *** melanin content was greatlyincreased by scoparone in a dose-dependent manner;there was no cytotoxicity atthe effective *** increased enzyme activity as well asprotein and mRNA expression of *** addition,mRNA of TRP-1 andTRP-2 were also increased after treatment with scoparone.H-89,an inhibitor ofprotein kinase A(PKA),completely inhibited the scoparone-induced increase ofmelanogenesis and the tyrosinase ***:These results suggestthat scoparone-induced stimulation of melanogenesis is likely to occur at thetranscriptional level of melanogenesis-related enzymes through PKA signaling.

关键词： melanogenesis scoparone (6,7-dimethoxy-coumarin) tyrosinase tyrosinase-related proteins protein kinase A

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Ti-6Al-4V电弧熔丝增材辊轧复合制造的有限元模拟

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稀有金属材料与工程 2020年第3期49卷 878-882页

作者：鞠洪涛徐东生单飞虎杨锐中国科学院金属研究所辽宁沈阳110016 中国科学技术大学辽宁沈阳110016 中国航空制造技术研究院北京100024

增材制造过程中在凝固、冷却阶段因骤热骤冷而易于产生较大的残余应力,进而影响部件的成形和使用。在增材过程中引入辊轧工序,可望改变局部应力状态并降低宏观残余应力,进而改善部件宏观变形和微观组织形态。通过建立Ti-6Al-4V钛合金电... 详细信息

增材制造过程中在凝固、冷却阶段因骤热骤冷而易于产生较大的残余应力,进而影响部件的成形和使用。在增材过程中引入辊轧工序,可望改变局部应力状态并降低宏观残余应力,进而改善部件宏观变形和微观组织形态。通过建立Ti-6Al-4V钛合金电弧熔丝增材与层间辊轧复合成形过程的有限元模型,研究在圆柱形轧辊条件下,不同压下量对部件温度、应力、应变及残余应力分布的影响规律。结果表明,层间辊轧可显著降低沉积层金属中的残余应力;同时降低对基板的整体应力。采用圆柱形轧辊并增加压下量可显著降低残余应力,为复合增材工艺的优化指明了方向。

关键词：增材制造辊轧残余应力有限元模拟

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The development and application of the test system for the silicon pixel modules in HEPS-BPIX

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Radiation Detection Technology and Methods 2021年第1期5卷 53-60页

作者： Ye Ding Jie Zhang Wei Wei Zhen-jie Li Hang-xu Li Xiao-lu Ji Yan Zhang Xiao-shan Jiang Ke-jun Zhu Peng Liu Yuan-bo Chen Qiu-ju Li Wei-fan Sheng State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of Sciences(CAS)Beijing 100049China Institute of High Energy Physics Chinese Academy of Sciences19 B Yuquan RdShijingshan DistrictBeijingChina University of Chinese Academy of Sciences(UCAS) Beijing 100049China

Background HEPS-BPIX is a prototype of photon counting pixel detector developed for the High Energy Photon *** consists of 16 silicon pixel modules which should be tested individually to ensure the function and *** Due to various factors such as the non-uniformity of the processes and voltage drop,the response of each pixel in the silicon pixel module is not identical *** response difference of pixels can be minimized by the threshold *** system is developed for the quality test and calibration of the silicon pixel *** The system consists of a mother board,a control board and a data acquisition(DAQ)*** mother board provides necessary resources including power supplies and the fanout of calibration ***,it can be used to test the connectivity by monitoring the power *** control board reads data out and provides the clock,trigger and configuration data for the silicon pixel *** DAQ system sends the control commands and receives the readout data through an Ethernet *** Compared with the previous readout system,this designed system has a lower noise level and better scanning curves making the calibration more *** it has been successfully applied to the comparison experiments of the through silicon via and wire-bonding silicon pixel *** The results show that this test system can be used to the quality test and calibration of the silicon pixel *** addition,the system can be adapted to the measurement of different pixel array detector modules.

关键词： Hybrid silicon pixel module Test and calibration Power management Through silicon via and wire-bonding HEPS

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Geology and mineralization of the Duobaoshan supergiant porphyry Cu-Au-Mo-Ag deposit(2.36 Mt)in Heilongjiang Province,China:A review

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China Geology 2023年第1期6卷 100-136页

作者： Sen Zhang Nan ju Guo-bin Zhang Yuan-dong Zhao Yun-sheng Ren Bao-shan Liu Hui Wang Rong-rong Guo Qun Yang Zhen-ming Sun Feng-ming Xu Ke-yong Wang Yu-jie Hao Cores and Samples Centre of Natural Resources China Geological SurveyMinistry of Natural ResourcesLangfang 065200China Shenyang Center China Geological SurveyMinistry of Natural Resources(Northeast Geological S&T Innovation Center)Shenyang 110034China Mining College Liaoning Technical UniversityFuxin 123000China Mudanjiang Natural Resources Survey Center China Geological SurveyMinistry of Natural ResourcesMudanjiang 157021China Institute of Disaster Prevention Langfang 065200China College of Earth Sciences Jilin UniversityChangchun 130000China School of Earth Science and Resources Chang’an UniversityXi’an 710000China School of Resources and Civil Engineering Northeastern UniversityShenyang 110031China School of Prospecting&Surveying Engineering Changchun Institute of TechnologyChangchun 130000China

The reserves of the Duobaoshan porphyry Cu-Au-Mo-Ag deposit(also referred to as the Duobaoshan porphyry Cu deposit)ranks first among the copper deposits in China and 33rd among the porphyry copper deposits in the *** has proven resources of copper(Cu),molybdenum(Mo),gold(Au),and silver(Ag)of 2.28×10^(6)t,80×10^(3)t,73 t,and 1046 t,*** major characteristics of the Duobaoshan porphyry Cu deposit are as *** is located in a zone sandwiched by the Siberian,North China,and paleo-Pacific plates in an island arc tectonic setting and was formed by the Paleozoic mineralization and the Mesozoic mineralization induced by superposition and *** metallogenic porphyries are the Middle Hercynian granodiorite *** alterations of surrounding rocks are distributed in a ring *** silicified porphyries at the center,the alteration zones of K-feldspar,biotite,sericite,and propylite occur from inside to *** deposit is composed of 215 ore bodies(including 14 major ore bodies)in four mineralized *** body No.X in the No.3 mineralized zone has the largest resource reserves,accounting for more than 78%of the total reserves of the *** ore components include Cu,Mo,Au,Ag,Se,and Ga,which have an average content of 0.46%,0.015%,0.16 g/t,1.22 g/t,0.0003%,and 0.001%-0.003%,*** ore minerals of this deposit primarily include pyrite,chalcopyrite,bornite,and molybdenite,followed by magnetite,hematite,rutile,gelenite,and *** ore-forming fluids of this deposit were magmatic water in the early metallogenic stage and then the mixture of meteoric water and magmatic water at the late metallogenic *** ore-forming fluids experienced three *** ore-forming fluids of stageⅠhad a hydrochemical type of H_(2)O-CO_(2)-Na Cl,an ore-forming temperature of 375-650℃,and ore-forming pressure of 110-160 *** ore-forming fluids of stageⅡhad a hydrochemical type of H_(2)O-CO_(2)-Na Cl,an ore-forming temperatur

关键词： Cu-Au-Mo-Ag deposit Porphyry Mineralization Mineralization model Mineral exploration engineering Prospecting modle Duobaoshan Heilongjiang China

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基于PCA-RBF神经网络的航空飞行几何参数拟合

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地球物理学报 2016年第4期59卷 1498-1505页

作者：嵇艳鞠徐鹏赵雪娇朱宇关珊珊栾卉吉林大学仪器科学与电气工程学院长春130026 地球信息探测仪器教育部重点实验室长春130026

采用地面异常线圈对直升机时域航空电磁探测系统进行标定时,发射-接收线圈姿态的变化将导致实测数据产生误差,影响标定的精度.本文基于时间域航空电磁系统,计算了发射-接收线圈姿态任意变化时异常线圈的电磁响应,提出了主成分分析-径向... 详细信息

采用地面异常线圈对直升机时域航空电磁探测系统进行标定时,发射-接收线圈姿态的变化将导致实测数据产生误差,影响标定的精度.本文基于时间域航空电磁系统,计算了发射-接收线圈姿态任意变化时异常线圈的电磁响应,提出了主成分分析-径向基神经网络(PCA-RBF)的拟合算法,采用主成分分析法提取飞行几何参数的贡献率,利用径向基神经网络法对电磁响应进行了测线剖面的批量数据拟合,并对理论仿真和河南桐柏直升机飞行试验数据进行拟合分析,单一异常体理论数据的绝对误差平均值小于20nV·m-2,双异常体理论数据绝对误差平均值为160nV·m-2.野外实测数据在异常线圈中心位置的拟合相对误差小于1%,整条剖面测线的拟合相对误差小于±6%,平均值为2.5%.结果表明PCA-RBF拟合算法能够较好地实现航空电磁系统飞行参数的拟合,为航空电磁系统海量实测数据的快速处理提供了新方法.

关键词：时间域航空电磁直升机飞行权重系数主成分分析径向基神经网络参数拟合

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Evaluation Research of Travel Transfer Model in Conditions of Random Travel Factors

Evaluation Research of Travel Transfer Model in Conditions o...

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第十五届全国非线性振动暨第十二届全国非线性动力学和运动稳定性学术会议

作者：赵杰 AN Xin-lei ZHANG Jian-gang DU San-shan DU Wen-ju School of Mathematics and Physics Lanzhou Jiaotong University

With the rapid development of urban construction,the public transport has become the mainstream way for people to *** travel transport can be seen as a highly integrated and complex network system related to the management,mechanism,infrastructure,scheme,investment and other various *** choose a favorable travel route directly affect the daily work and life of urban resident travel,for example travel price factor,travel time factor and travel comfort degree factor affect the the whole public transport systems in the urban sustainable *** is necessary to design an effective travel transfer network *** this paper,a travel transfer network model is built with the research of complex *** set the nodes as the origin,destination and the stops in approach,while the edges as the transfer routes of public *** the evaluation model is built by this structure of travel transfer model.A travel transfer evaluation model influenced by the random demand factors of passengers is investigated on the basic of traffic travel transfer *** model can make scientific evaluation on travel route and plan out the optimal choice in the random conditions to make the passenger travel choice more *** choose the travel routes of Lanzhou as the case study.A local travel transfer evaluation model is made in the conditions of travel price factor,travel time factor and travel comfort degree factor to verify the availability and scientific nature of this *** aim of this article is that the weighted ratios of random selection chosen by passengers will provide them nicer travel routes and better travel *** scientific appraisal can increase the profit of the travel transport and provide more convenient service for urban *** it to practical application and trying to set a public machine to look up the travel choice route for passengers via Google *** passengers can choose random weighted ratios of the trav

关键词： traffic network travel transfer evaluation model comfort degree

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基于APP的大学英语翻转课堂教学改革探索

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黑龙江高教研究 2015年第5期33卷 162-167页

作者：窦菊花文珊广东科学技术职业学院广东珠海519090 华南农业大学外国语学院广东广州510642

文章在分析了信息时代大学英语教学所面临的困境基础上提出了基于APP的大学英语翻转课堂教学模式。该模式对传统大学英语教学模式进行了信息化改造与革新,教学实践数据显示该模式在激发学生学习兴趣、增强师生交流互动、深化知识理解方... 详细信息

文章在分析了信息时代大学英语教学所面临的困境基础上提出了基于APP的大学英语翻转课堂教学模式。该模式对传统大学英语教学模式进行了信息化改造与革新,教学实践数据显示该模式在激发学生学习兴趣、增强师生交流互动、深化知识理解方面较传统课堂教学模式更具优势。

关键词： APP 大学英语移动学习微课翻转课堂教学改革

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近代以来日本在海南岛的领事设置及领事活动

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海南大学学报(人文社会科学版) 2021年第6期39卷 21-31页

作者：王奋举金山南开大学日本研究院海南大学外国语学院

1871年中日签订《修好条规》,时属广东的"琼州口"(今属海南海口)成为第一批向日本开放的通商口岸之一。1873至1906年间琼州先后被日本驻香港、广东领事馆交替纳入管辖范围,1906年以后归后者管辖。1939年日本占领海南岛并设置海口总领事... 详细信息

1871年中日签订《修好条规》,时属广东的"琼州口"(今属海南海口)成为第一批向日本开放的通商口岸之一。1873至1906年间琼州先后被日本驻香港、广东领事馆交替纳入管辖范围,1906年以后归后者管辖。1939年日本占领海南岛并设置海口总领事馆,海南岛开始脱离广东成为独立的领事管辖区域。作为近代以来日本在海南岛设置的"正式"领事机构,海口总领事馆参与了岛内侨民管理、情报收集、殖民统治等相关工作,但在欲独占海南岛的日本海军势力排挤下,其领事活动基本被限定在海口、琼山等北部区域,活动内容也存在明显的局限性。尤其到占领后期,随着海军在岛内独占体制的形成,海口总领事馆基本上失去了其作为领事机构存在的实际意义,名副其实地成为了掩饰海军对海南岛领土野心的"形式机构"。

关键词：领事活动海口总领事馆海南海军特务部外务省

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近5年国内钻井液降黏剂研发进展

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油田化学 2007年第4期24卷 372-374页

作者：王善举杨小华中原石油勘探局钻井工程技术研究院河南濮阳457001

介绍了我国近5年来钻井液用降黏剂的研究与应用情况,包括改性天然材料类(改性木质素类、改性单宁类及其他)、合成聚合物类(含羧酸基团类、含磺酸基团类、含两性离子基团类及有机硅类)和以工业废料为原料的共三大类降黏剂。近年来对聚合... 详细信息

介绍了我国近5年来钻井液用降黏剂的研究与应用情况,包括改性天然材料类(改性木质素类、改性单宁类及其他)、合成聚合物类(含羧酸基团类、含磺酸基团类、含两性离子基团类及有机硅类)和以工业废料为原料的共三大类降黏剂。近年来对聚合物类降黏剂的研究较多。

关键词：钻井液处理剂降黏剂进展综述

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