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Engineering high-performance dielectric chiral shells with enhanced chiral fields for sensitive chiral biosensor

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Rare Metals 2024年第3期43卷 1197-1206页

作者： Yi-Fan Wang shan-shan Huang Zhen-Dong Dai Shi-Lin Xian Xuan-Nan wu Fu-Hua Gao Yi-Dong Hou College of Physics Sichuan UniversityChengdu610065China Graduate School of Sichuan University Sichuan UniversityChengdu610065China

Chiral metamaterials have been a topic of significant research interest in recent years due to their potential for various applications in nanophotonic devices and chiral ***,the intrinsic Ohmic loss in surface plasmonic resonance has limited their practical use,resulting in large light dissipation and weak chiroptical ***,we report on the development of high-performance dielectric chiral shells(DCS)through a two-step Si deposition process on a self-assembled microsphere *** form DCS sample completely oyercomes the cancelation effect originated from the disorder property of the micro-sphere monolayer in macroscale,and at a wavelength of approximately 710 nm,the measured optimal chiral signal(g-factor)and transmittance can reach up to 0.7 and 0.3,*** strong chiroptical effect comes from the asymmetric circular displacement currents(i.e.,magnetic modes)enabled by the specific shell *** chiral shell geometry,electromagnetic properties,sensor sensitivity of chiral molecules and figure of merit are systematically *** DCSs demonstrate highly sensitive detection of chiral biomolecules owing to their easily accessible geometry and enhanced uniform chiral field.

关键词： Dielectric chiral shells(DCS) Si deposition Magnetic resonance Highly sensitive sensor Chiral field

Photocatalytic vinyl radical-mediated multicomponent 1,4-/1,8-carboimination across alkynes and olefins/(hetero)arenes

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Science China Chemistry 2024年第2期67卷 558-567页

作者： shan-shan Li Yu-Shi Jiang Xue-Ling Luo Xuming Ran Yuqiang Li Dong wu Cheng-Xue Pan Peng-Ju Xia School of Chemistry and Pharmaceutical Sciences Guangxi Normal UniversityGuilin541004China shanghai Artificial Intelligence Laboratory Shanghai200433China The Institute for Advanced Studies Wuhan UniversityWuhan430064China

We developed a highly selective and efficient multicomponent transformation by utilizing alkynes and olefins/(hetero)arenes through photoinduced energy-transfer *** reaction involves the formation of three distinct chemical bonds,namely C(sp~3)–C(sp~2),C(sp~2)–C(sp~3),and C(sp~3)–N,in a single coordinated *** strategy used a vinyl radical-mediated radical relay approach under mild conditions,exhibiting a broad substrate scope(>70 examples),excellent functional-group tolerance,and remarkable regio-and *** the utilization of a combination of experimental techniques and density functional theory(DFT),we delved deeper into the mechanistic intricacies of this distinctive *** revealed that the selective radical addition to electron-deficient alkynes,rather than olefins,was governed by the inherent reactivity of alkyl *** discovery presented a highly effective approach for the synthesis of stereodefined multisubstituted alkenes.

关键词： alkyne-olefin coupling DFT studies regio-and anti-stereoselectivity multisubstituted alkenes

Oleuropein alleviates sepsis-induced acute lung injury via the AMPK/Nrf-2/HO-1 signaling

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Asian Pacific Journal of Tropical Biomedicine 2024年第5期14卷 187-198页

作者： shan-Hu Wang Yang-Yang wu Xiao-Jiao Xia Department of Pediatrics The Second Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325027China

Objective:To explore the effect of oleuropein on sepsis-induced acute lung injury(ALI)in vitro and in vivo and investigate the underlying ***:In an lipopolysaccharide(LPS)-mediated cell model of sepsis-induced ALI and a cecal ligation and puncture-induced mouse model of septic ALI,CCK-8 assay and flow cytometry analysis were used to detect cell activity and *** and relevant assay kits were used to measure the levels of inflammatory cytokines and oxidative stress,*** blot was applied to determine the expression of apoptosis-and AMP-activated protein kinase(AMPK)/nuclear factor erythroid 2-related factor-2(Nrf-2)/heme oxygenase-1(HO-1)signaling-associated ***-1 staining,adenosine triphosphate(ATP)assay kit,and MitoSOX Red assays were performed to detect mitochondrial membrane potential,ATP content,and mitochondrial ROS formation,***,lung injury was evaluated by measuring lung morphological alternations,lung wet-to-dry ratio,myeloperoxidase content,and total protein ***:Oleuropein reduced inflammatory reaction,oxidative damage,and apoptosis,and ameliorated mitochondrial dysfunction in LPS-exposed BEAS-2B cells and mice with septic ***,oleuropein activated the AMPK/Nrf-2/HO-1 signaling ***,these effects of oleuropein were abrogated by an AMPK inhibitor compound ***:Oleuropein can protect against sepsis-induced ALI in vitro and in vivo by activating the AMPK/Nrf-2/HO-1 signaling,which might be a potential therapeutic agent for the treatment of sepsis-induced ALI.

关键词： AMPK/Nrf-2/HO-1 signaling Inflammatory response Lung damage Mitochondrial dysfunction Oleuropein Oxidative stress Sepsis

Mitigation of Deane and Hamill phenomenon in gallium nitride high-voltage power supply for electric propulsion system application

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High Voltage 2024年第1期9卷 252-265页

作者： Minghai Dong Hui Li shan Yin Kye Yak See Yingzhe wu Xiong Xin School of Aeronautics&Astronautics University of Electronic Science and Technology of ChinaChengduChina School of Electrical&Electronic Engineering Nanyang Technological UniversitySingaporeSingapore School of Automation Engineering University of Electronic Science and Technology of ChinaChengduChina Innoscience(Shenzhen)Semiconductor Co.Ltd. ShenzhenChina

The step-up resonant converters are widely adopted to provide high voltage in kV-level for electric propulsion system due to their high efficiency,low mass,modularisation,and high-power *** bipolar Cockcroft-Walton voltage multiplier(BiCWVM)is a major circuit that steps up the voltage in the resonant ***,the diode nonlinearity in BiCWVM can introduce self-sustained quasi-periodic oscillations in the voltage and current waveforms,which is commonly known as the Deane and Hamill(DH)*** oscillation can lead to higher magnetic loss and control failure,and it is more likely to present in the gallium nitride-based converter due to the highfrequency *** authors aim to investigate and mitigate the DH phenomenon systematically so that proper mitigation can be *** facilitate the investigation,the circuit before the BiCWVM in the converter is derived and modelled as a voltage source v_(m)and a series inductor L_(sy).Also,the reverse recovery process of the diode in the BiCWVM can be represented by a piecewise-linear(PWL)model,with the simplified circuit and PWL model,the relationship between voltage and current under different operating conditions can be determined with *** relationship allows to understand the mechanism of diode reverse recovery in BiCWVM that leads to DH ***,a hybrid-/full-silicon carbide(SiC)design is proposed to mitigate the DH phenomenon,which is verified experimentally for a 300-kHz,5-W,20-V/1.5-kV GaN-based step-up resonant converter.

关键词： power resonant high

Numerical investigation of hydro-morphodynamic characteristics of a cascading failure of landslide dams

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Journal of Mountain Science 2024年第6期21卷 1868-1885页

作者： ZHONG Qiming CHEN Lingchun MEI Shengyao shan Yibo wu Hao ZHAO Kunpeng Department of Geotechnical Engineering Nanjing Hydraulic Research InstituteNanjing 210024China National Key Laboratory of Water Disaster Prevention Nanjing 210098China Key Laboratory of Reservoir and Dam Safety of the Ministry of Water Resources Nanjing 210029China

A cascading failure of landslide dams caused by strong earthquakes or torrential rains in mountainous river valleys can pose great threats to people’s lives,properties,and *** this study,based on the three-dimensional Reynoldsaveraged Navier-Stokes equations(RANS),the renormalization group(RNG)k-εturbulence model,suspended and bed load transport equations,and the instability discriminant formula of dam breach side slope,and the explicit finite volume method(FVM),a detailed numerical simulation model for calculating the hydro-morphodynamic characteristics of cascading dam breach process has been *** developed numerical model can simulate the breach hydrograph and the dam breach morphology evolution during the cascading failure process of landslide dams.A model test of the breaches of two cascading landslide dams has been used as the validation *** comparison of the calculated and measured results indicates that the breach hydrograph and the breach morphology evolution process of the upstream and downstream dams are generally consistent with each other,and the relative errors of the key breaching parameters,i.e.,the peak breach flow and the time to peak of each dam,are less than±5%.Further,the comparison of the breach hydrographs of the upstream and downstream dams shows that there is an amplification effect of the breach flood on the cascading landslide dam *** key parameters,i.e.,the distance between the upstream and the downstream dams,the river channel slope,and the downstream dam height,have been used to study the flood amplification *** parameter sensitivity analyses show that the peak breach flow at the downstream dam decreases with increasing distance between the upstream and the downstream dams,and the downstream dam ***,the peak breach flow at the downstream dam first increases and then decreases with steepening of the river channel *** the flood caused by the upstream dam failure flows to the

关键词： Cascading landslide dams Cascading dam failure process Detailed numerical simulation model Flood amplification effect Parameter sensitivity analyses

Towards a Theoretical Background for Strong-Scattering Inversion–Direct Envelope Inversion and Gel’fand-Levitan-Marchenko Theory

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Communications in Computational Physics 2020年第6期28卷 41-73页

作者： Ru-shan wu Modeling and Imaging Laboratory Earth and Planetary SciencesUniversity of CaliforniaSanta Cruz95060CAUSA

Strong-scattering inversion or the inverse problem for strong scattering has different physical-mathematical foundations from the weak-scattering *** inversion based on wave equation for strong scattering cannot be directly solved by Newton’s local optimization method which is based on weak-nonlinear *** I try to illustrate the connection between the Schr̈odinger inverse scattering(inverse problem for Schr̈odinger equation)by GLM(Gel’fand-Levitan-Marchenko)the-ory and the direct envelope inversion(DEI)using reflection *** difference between wave equation and Schr̈odinger equation is that the latter has a potential independent of frequency while the former has a frequency-square dependency in the potential.I also point out that the traditional GLM equation for potential inversion can only recover the high-wavenumber components of impedance profile.I propose to use the Schr̈odinger impedance equation for direct impedance inversion and introduce a singular impedance function which also corresponds to a singular potential for the reconstruction of impedance profile,including discontinuities and long-wavelength velocity structure.I will review the GLM theory and its application to impedance inversion including some numerical *** I analyze the recently developed multi-scale direct envelope inversion(MS-DEI)and its connection to the inverse Schr̈odinger *** is conceivable that the combination of strong-scattering inversion(inverse Schr̈odinger scattering)and weak-scattering inversion(local optimization based inversion)may create some inversion methods working for a whole range of inversion problems in geophysical exploration.

关键词： Strong-scattering strong nonlinear inversion GLM theory envelope inversion

Big Data Access Control Mechanism Based on Two-Layer Permission Decision Structure

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Computers, Materials & Continua 2024年第4期79卷 1705-1726页

作者： Aodi Liu Na Wang Xuehui Du Dibin shan Xiangyu wu Wenjuan Wang He’nan Province Key Laboratory of Information Security Information Engineering UniversityZhengzhou450000China

Big data resources are characterized by large scale, wide sources, and strong dynamics. Existing access controlmechanisms based on manual policy formulation by security experts suffer from drawbacks such as low policymanagement efficiency and difficulty in accurately describing the access control policy. To overcome theseproblems, this paper proposes a big data access control mechanism based on a two-layer permission decisionstructure. This mechanism extends the attribute-based access control (ABAC) model. Business attributes areintroduced in the ABAC model as business constraints between entities. The proposed mechanism implementsa two-layer permission decision structure composed of the inherent attributes of access control entities and thebusiness attributes, which constitute the general permission decision algorithm based on logical calculation andthe business permission decision algorithm based on a bi-directional long short-term memory (BiLSTM) neuralnetwork, respectively. The general permission decision algorithm is used to implement accurate policy decisions,while the business permission decision algorithm implements fuzzy decisions based on the business *** BiLSTM neural network is used to calculate the similarity of the business attributes to realize intelligent,adaptive, and efficient access control permission decisions. Through the two-layer permission decision structure,the complex and diverse big data access control management requirements can be satisfied by considering thesecurity and availability of resources. Experimental results show that the proposed mechanism is effective andreliable. In summary, it can efficiently support the secure sharing of big data resources.

关键词： Big data access control data security BiLSTM

超声引导下小剂量复方倍他米松注射对肩袖损伤患者肩关节功能的影响及危险因素分析

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中华全科医学 2024年第3期22卷 495-499页

作者：徐琼吴单杜信田涛涛张茂良杜奋飞东阳市人民医院康复科浙江东阳322100

目的探究超声引导下小剂量复方倍他米松注射对肩袖损伤患者肩关节功能的改善效果,并分析影响其疗效的因素,旨在为临床提升肩袖损伤患者治疗效果提供帮助。方法回顾性选择2022年1月—2023年3月于东阳市人民医院接受治疗的96例肩袖损伤... 详细信息

目的探究超声引导下小剂量复方倍他米松注射对肩袖损伤患者肩关节功能的改善效果,并分析影响其疗效的因素,旨在为临床提升肩袖损伤患者治疗效果提供帮助。方法回顾性选择2022年1月—2023年3月于东阳市人民医院接受治疗的96例肩袖损伤患者作为研究对象。患者均接受超声引导下注射小剂量复方倍他米松治疗。比较患者不同时点疼痛水平,治疗前及治疗1个月时肩关节功能、上肢运动能力、日常生活能力。根据治疗1个月时Neer肩关节功能评分评估患者临床疗效,根据评分分为优良组、中差组。统计患者基线资料,采用二元logistic回归分析影响肩袖损伤患者超声引导下小剂量复方倍他米松注射治疗后临床疗效的因素。结果治疗1个月时,经Neer评分评估,优良率为80.21%(77/96)。治疗1个月时患者Neer评分高于治疗前(P1,P<0.05)。结论超声引导下注射小剂量倍他米松能够有效改善肩袖损伤患者肩关节功能,提升患者上肢运动及日常生活能力,同时年龄、劳动强度、合并糖尿病与患者临床疗效密切相关。

关键词：肩袖损伤倍他米松超声引导肩关节功能危险因素

Theoretical study of superradiant masing with solid-state spins at room temperature

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Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 38-47页

作者： Qilong wu Yuan Zhang Hao wu Shi-Lei Su Kai-Kai Liu Mark Oxborrow Chong-Xin shan Klaus Mølmer Henan Key Laboratory of Diamond Optoelectronic Materials and Devices Key Laboratory of Material Physics Ministry of EducationSchool of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450052China Institute of Quantum Materials and Physics Henan Academy of SciencesZhengzhou 450046China Center for Quantum Technology Research and Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurements School of PhysicsBeijing Institute of TechnologyBeijing 100081China Beijing Academy of Quantum Information Sciences Beijing 100193China Department of Materials Imperial College LondonLondon SW72AZUK Niels Bohr Institute University of CopenhagenCopenhagen 2100Denmark

Steady-state superradiance and superradiant lasing attract significant attentions in the field of optical lattice clocks,but have not been achieved yet due to the technical challenges and atom loss *** this article,we propose that their counter-part may be observed in the microwave domain with solid-state spins,i.e.,nitrogen-vacancy center spins and pentacene molecular spins,coupled to microwave resonator at room temperature with realistic technical *** validate our proposal,we investigate systematically the system dynamics and steady-state by solving quantum master equations for the multi-level and multi-process dynamics of trillions of *** calculations show that the superradiant Rabi oscillations occur firstly due to transitions among different Dicke states,and the subsequent continuous-wave superradiant masing can achieve a linewidth well below *** work may guide further exploration of transient and steady-state superradiant masing with the mentioned and other solid-state spins *** ultra-narrow linewidth may find applications in deep-space communications,radio astronomy and high-precision metrology.

关键词： solid-state spins superradiance maser

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