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Experimental investigation of shale imbibition capacity and the factors influencing loss of hydraulic fracturing fluids

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Petroleum Science 2015年第4期12卷 636-650页

作者： Hong-Kui Ge Liu Yang Ying-Hao Shen Kai Ren Fan-Bao Meng Wen-Ming Ji shan wu State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum

Spontaneous imbibition of water-based frac- turing fluids into the shale matrix is considered to be the main mechanism responsible for the high volume of water loss during the flowback period. Understanding the matrix imbibition capacity and rate helps to determine the frac- turing fluid volume, optimize the flowback design, and to analyze the influences on the production of shale gas. Imbibition experiments were conducted on shale samples from the Sichuan Basin, and some tight sandstone samples from the Ordos Basin. Tight volcanic samples from the Songliao Basin were also investigated for comparison. The effects of porosity, clay minerals, surfactants, and KC1 solutions on the matrix imbibition capacity and rate were systematically investigated. The results show that the imbibition characteristic of tight rocks can be characterized by the imbibition curve shape, the imbibition capacity, the imbibition rate, and the diffusion rate. The driving forces of water imbibition are the capillary pressure and the clay absorption force. For the tight rocks with low clay contents, the imbibition capacity and rate are positively correlated with the porosity. For tight rocks with high clay content, the type and content of clay minerals are the most impor- tant factors affecting the imbibition capacity. The imbibed water volume normalized by the porosity increases with an increasing total clay content. Smectite and illite/smectite tend to greatly enhance the water imbibition capacity. Furthermore, clay-rich tight rocks can imbibe a volume of water greater than their measured pore volume. The aver- age ratio of the imbibed water volume to the pore volume is approximately 1.1 in the Niutitang shale, 1.9 in the Lujiaping shale, 2.8 in the Longmaxi shale, and 4.0 in the Yingcheng volcanic rock, and this ratio can be regarded as a parameter that indicates the influence of clay. In addition, surfactants can change the imbibition capacity due to alteration of the capillary pressure and

关键词： Imbibition . Shale Fracturing fluid Capillary pressure Clay

Network meta-analysis of combination strategies in metastatic hormone-sensitive prostate cancer

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Asian Journal of Andrology 2024年第4期26卷 402-408页

作者： shan-shan Wang Xiao-Jie Bian Jun-Long wu Bei-He Wang Sheng Zhang Ding-Wei Ye Department of Urology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Department of Medical Oncology Fudan University Shanghai Cancer CenterShanghai 200032China.

This study compared different doublet and triplet therapies for efficacy and safety in metastatic hormone-sensitive prostate cancer(mHSPC).PubMed,EMBASE,and the Cochrane Library were comprehensively searched for eligible randomized controlled trials(RCTs)published from inception to October *** included abiraterone,apalutamide,enzalutamide,docetaxel,darolutamide,and androgen deprivation therapy(ADT),either as doublet or triplet *** outcomes examined were overall survival(OS),progression-free survival(PFS),castration-resistant prostate cancer(CRPC)-free survival,time to symptomatic skeletal event(SSE),and *** surface under the cumulative ranking curve(SUCRA)was determined to identify the preferred *** RCTs were *** combination of darolutamide,docetaxel,and ADT had the highest SUCRA of 84.3 for OS,followed by combined abiraterone,docetaxel,and ADT(SUCRA=71.6).The highest SUCRAs for PFS were observed for triplet therapies(abiraterone,docetaxel,and ADT[SUCRA=74.9],followed by enzalutamide,docetaxel,and ADT[SUCRA=74.3])and other androgen receptor axis-targeted therapy-based doublet therapies(SUCRAs:26.5–59.3).Darolutamide,docetaxel,and ADT had the highest SUCRAs,i.e.,80.8 and 84.0 regarding CRPC-free survival and time to SSE,*** Grade>3 adverse events(AEs),the SUCRAs of triplet therapies(SUCRAs:14.8–31.5)were similar to that of docetaxel and ADT(SUCRA=39.5).Three studies had a low risk of bias in all categories;the remaining studies had at least an unclear risk of bias in at least one *** therapy demonstrated potentially enhanced effectiveness than doublet therapy in mHSPC,with acceptable safety *** might be the optimal option for triplet therapy in combination with docetaxel and ADT.

关键词： androgen antagonist androgen receptor antagonist docetaxel meta-analysis prostatic neoplasm

Fast Approximate Geodesic Paths on Triangle Mesh

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International Journal of Automation and computing 2007年第1期4卷 8-13页

作者： Jie Tang Gang-shan wu Fu-Yan Zhang Ming-Min Zhang State Key Laboratory for Novel Software Technology Nanjing University Nanjiag 210093 PRC School of Computer Science Zhejiang University Hangzhou 310027 PRC

We present a new algorithm to compute a geodesic path over a triangle mesh. Based on Novotni＇s propagating wavefront method which is similar to the well known Dijkstra algorithm, we made some improvements which Novotni had missed and we also gave the method to find out the geodesic path which Novotni had not. It can handle both convex and non-convex surfaces or even with boundaries. Experiment results show that our method works very well both in efficiency and precision.

关键词： Triangle mesh geodesic path virtual reality.

A One-pot Procedure to Prepare Ethynylferrocene and Iodoethynylferrocene

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Chinese Chemical Letters 2001年第5期12卷 387-390页

作者： Ji shan wu Chun Yan CHI Xian Hong WANG Xiao Jiang ZHAO Ji LI Fo Song WANG State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022

Ethynylferrocene and iodoethynylferrocene were prepared in high yield as 88-90% through a one-pot procedure. 1, 1'-diiodoferrocenylene was in-situ prepared from reaction of CHI3 PPh3, t-BuOK and ferrocenecarboxaldehyd... 详细信息

关键词： Ferrocene derivatives Wittig-type reaction.

Ripening and rot:How ripening processes influence disease susceptibility in fleshy fruits

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Journal of Integrative Plant Biology 2024年第9期66卷 1831-1863页

作者： shan Li Yu Zhao Pan wu Donald Grierson Lei Gao State Key Laboratory of Plant Diversity and Specialty Crops Wuhan Botanical GardenChinese Academy of SciencesWuhan 430074China University of Chinese Academy of Sciences Beijing 100049China Plant and Crop Sciences Division School of BiosciencesUniversity of NottinghamSutton Bonington CampusLoughboroughLE125RDUK Hubei Hongshan Laboratory Wuhan 430070China

Fleshy fruits become more susceptible to pathogen infection when they ripen;for example,changes in cell wall properties related to softening make it easier for pathogens to infect *** need for high-quality fruit has driven extensive research on improving pathogen resistance in important fruit crops such as tomato(Solanum lycopersicum).In this review,we summarize current progress in understanding how changes in fruit properties during ripening affect infection by *** changes affect physical barriers that limit pathogen entry,such as the fruit epidermis and its cuticle,along with other defenses that limit pathogen growth,such as preformed and induced defense *** plant immune system also protects ripening fruit by recognizing pathogens and initiating defense responses involving reactive oxygen species production,mitogen-activated protein kinase signaling cascades,and jasmonic acid,salicylic acid,ethylene,and abscisic acid *** phytohormones regulate an intricate web of transcription factors(TFs)that activate resistance mechanisms,including the expression of pathogenesis-related *** tomato,ripening regulators,such as RIPENING INHIBITOR and NON_RIPENING,not only regulate ripening but also influence fruit defenses against ***,members of the ETHYLENE RESPONSE FACTOR(ERF)family play pivotal and distinct roles in ripening and defense,with different members being regulated by different *** also discuss the interaction of ripening-related and defense-related TFs with the Mediator transcription *** the ripening processes in climacteric and non-climacteric fruits share many similarities,these processes have broad applications across fruiting *** research on the individual contributions of ERFs and other TFs will inform efforts to diminish disease susceptibility in ripe fruit,satisfy the growing demand for high-quality fruit and decrease food waste and related economic losses.

关键词： fleshy fruit pathogen phytohormones ripening transcription factors

Engineering high-performance dielectric chiral shells with enhanced chiral fields for sensitive chiral biosensor

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Rare Metals 2024年第3期43卷 1197-1206页

作者： Yi-Fan Wang shan-shan Huang Zhen-Dong Dai Shi-Lin Xian Xuan-Nan wu Fu-Hua Gao Yi-Dong Hou College of Physics Sichuan UniversityChengdu610065China Graduate School of Sichuan University Sichuan UniversityChengdu610065China

Chiral metamaterials have been a topic of significant research interest in recent years due to their potential for various applications in nanophotonic devices and chiral ***,the intrinsic Ohmic loss in surface plasmonic resonance has limited their practical use,resulting in large light dissipation and weak chiroptical ***,we report on the development of high-performance dielectric chiral shells(DCS)through a two-step Si deposition process on a self-assembled microsphere *** form DCS sample completely oyercomes the cancelation effect originated from the disorder property of the micro-sphere monolayer in macroscale,and at a wavelength of approximately 710 nm,the measured optimal chiral signal(g-factor)and transmittance can reach up to 0.7 and 0.3,*** strong chiroptical effect comes from the asymmetric circular displacement currents(i.e.,magnetic modes)enabled by the specific shell *** chiral shell geometry,electromagnetic properties,sensor sensitivity of chiral molecules and figure of merit are systematically *** DCSs demonstrate highly sensitive detection of chiral biomolecules owing to their easily accessible geometry and enhanced uniform chiral field.

关键词： Dielectric chiral shells(DCS) Si deposition Magnetic resonance Highly sensitive sensor Chiral field

Photocatalytic vinyl radical-mediated multicomponent 1,4-/1,8-carboimination across alkynes and olefins/(hetero)arenes

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Science China Chemistry 2024年第2期67卷 558-567页

作者： shan-shan Li Yu-Shi Jiang Xue-Ling Luo Xuming Ran Yuqiang Li Dong wu Cheng-Xue Pan Peng-Ju Xia School of Chemistry and Pharmaceutical Sciences Guangxi Normal UniversityGuilin541004China shanghai Artificial Intelligence Laboratory Shanghai200433China The Institute for Advanced Studies Wuhan UniversityWuhan430064China

We developed a highly selective and efficient multicomponent transformation by utilizing alkynes and olefins/(hetero)arenes through photoinduced energy-transfer *** reaction involves the formation of three distinct chemical bonds,namely C(sp~3)–C(sp~2),C(sp~2)–C(sp~3),and C(sp~3)–N,in a single coordinated *** strategy used a vinyl radical-mediated radical relay approach under mild conditions,exhibiting a broad substrate scope(>70 examples),excellent functional-group tolerance,and remarkable regio-and *** the utilization of a combination of experimental techniques and density functional theory(DFT),we delved deeper into the mechanistic intricacies of this distinctive *** revealed that the selective radical addition to electron-deficient alkynes,rather than olefins,was governed by the inherent reactivity of alkyl *** discovery presented a highly effective approach for the synthesis of stereodefined multisubstituted alkenes.

关键词： alkyne-olefin coupling DFT studies regio-and anti-stereoselectivity multisubstituted alkenes

Oleuropein alleviates sepsis-induced acute lung injury via the AMPK/Nrf-2/HO-1 signaling

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Asian Pacific Journal of Tropical Biomedicine 2024年第5期14卷 187-198页

作者： shan-Hu Wang Yang-Yang wu Xiao-Jiao Xia Department of Pediatrics The Second Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325027China

Objective:To explore the effect of oleuropein on sepsis-induced acute lung injury(ALI)in vitro and in vivo and investigate the underlying ***:In an lipopolysaccharide(LPS)-mediated cell model of sepsis-induced ALI and a cecal ligation and puncture-induced mouse model of septic ALI,CCK-8 assay and flow cytometry analysis were used to detect cell activity and *** and relevant assay kits were used to measure the levels of inflammatory cytokines and oxidative stress,*** blot was applied to determine the expression of apoptosis-and AMP-activated protein kinase(AMPK)/nuclear factor erythroid 2-related factor-2(Nrf-2)/heme oxygenase-1(HO-1)signaling-associated ***-1 staining,adenosine triphosphate(ATP)assay kit,and MitoSOX Red assays were performed to detect mitochondrial membrane potential,ATP content,and mitochondrial ROS formation,***,lung injury was evaluated by measuring lung morphological alternations,lung wet-to-dry ratio,myeloperoxidase content,and total protein ***:Oleuropein reduced inflammatory reaction,oxidative damage,and apoptosis,and ameliorated mitochondrial dysfunction in LPS-exposed BEAS-2B cells and mice with septic ***,oleuropein activated the AMPK/Nrf-2/HO-1 signaling ***,these effects of oleuropein were abrogated by an AMPK inhibitor compound ***:Oleuropein can protect against sepsis-induced ALI in vitro and in vivo by activating the AMPK/Nrf-2/HO-1 signaling,which might be a potential therapeutic agent for the treatment of sepsis-induced ALI.

关键词： AMPK/Nrf-2/HO-1 signaling Inflammatory response Lung damage Mitochondrial dysfunction Oleuropein Oxidative stress Sepsis

Science Letters:Proteomic analysis of differentially expressed proteins in mice with concanavalin A-induced hepatitis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第3期11卷 221-226页

作者： Xu-fei TAN Feng CHEN shan-shan wu Yu SHI Dong-cheng LIU Zhi CHEN State Key Laboratory for Diagnosis and Treatment of lnfectious Diseases the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Objective： To find new protein biomarkers for the detection and evaluation of liver injury and to analyze the relationship between such proteins and disease progression in concanavalin A （Con A）-induced hepatitis. Methods： Twenty-five mice were randomly divided into five groups： an untreated group, a control group injected with phosphate buffered saline （PBS）, and groups with Con A-induced hepatitis evaluated at 1, 3 and 6 h. Two-dimensional gel electrophoresis （2-DE） and mass spectrometry （MS） were used to identify differences in protein expression among groups. Quantitative real-time polymerase chain reaction （qRT-PCR） was performed to verify the results. Results： In mice with Con A-induced hepatitis, expression levels of four proteins were increased： RIKEN, fructose bisphosphatase 1 （fbp1）, ketohexokinase （khk）, and Chain A of class pi glutathione S-transferase. Changes in fbpl and khk were confirmed by qRT-PCR. Conclusion： Levels of two proteins, fbp1 and khk, are clearly up-regulated in mice with Con A-induced hepatitis.

关键词： Concanavalin A (Con A) Liver injury Protein Two-dimensional electrophoresis (2-DE)