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Cancer Rehabilitation,A New Discipline Based upon Multidisciplinary Collaboration

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Journal of Advances in Medicine Science 2022年第2期5卷 14-21页

作者： shan su Cancer Rehabilitation Medicine(Clinical)Research Center Shanghai International Medical CenterShanghaiChina

Cancer Rehabilitation is a new discipline,a combination of tumor medication,immunology,psychology,nutritional science and exercise physiology etc..The core of cancer rehabilitation is the therapy of natural immunology,which aims at activating T-cells,and restoring the bone marrow function impaired during chemo-radiation therapy.Cancer rehabilitation seeks to achieve the gradual recovery of the immune system,which in turn hinders recurrence and metastasis.In addition,with the help of psychological consultation,nutritional and physical exercise guidance,cancer patients may have a better chance at managing the risk of recurrence and metastasis,extending life expectancy with an improved quality of life.

关键词： Cancer rehabilitation Therapy of natural immunology Immune activation Immune reconstruction Immune response management Cancer rehabilitation psychology Cancer rehabilitation nutritional science Cancer rehabilitation exercise physiology

A suspicious role of interferon in the pathogenesis of SARS-CoV-2 by enhancing expression of ACE2

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1822-1823页

作者： shan su Shibo Jiang Key Laboratory of Medical Molecular Virology(MOE/MOH/CAM) School of Basic Medical SciencesFudan University130 Dong An Rd.Xuhui DistrictShanghai 200032China

Based on a number of published and unpublished single-cell RNAsequencing(scRNA-seq)datasets,a recent study identified putative specific cell subtypes targeted by SARS-CoV-2(severe acute respiratory syndrome coronavirus 2)and a possible role of interferon(IFN)in its pathogenesis.The rapid spread of SARS-CoV-2,the causative pathogen of COVID-19,has had global public health and economic consequences.The molecular mechanism(s)underlying the high transmissibility of SARS-CoV-2 remain(s)elusive.Therefore,we must follow a pragmatic and stepwise path to determine the specific target cell subsets and factors that regulate SARS-CoV-2 infection to elucidate true targets for treatment.In a recent issue of Cell,Carly and co-workers1 identified the cell subsets targeted by SARS-CoV-2 in certain tissues.In addition,they found that IFN-αenhanced the expression of angiotensin-converting enzyme 2(ACE2),the receptor for SARS-CoV-2,in primary human upper airway basal cells.However,we know that IFN is cell-type-and host speciesspecific,indicating the need for more preclinical and clinical data to clarify the role of IFN in the pathogenesis of COVID-19.

关键词： ACE2 pathogenesis interferon

A highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases

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Acta Pharmaceutica Sinica B 2022年第4期12卷 1652-1661页

作者： Jie Zhou Wei Xu Zezhong Liu Chao Wang Shuai Xia Qiaoshuai Lan Yanxing Cai shan su Jing Pu Lixiao Xing Youhua Xie Lu Lu Shibo Jiang Qian Wang Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical Sciences and BSL-3 FacilityShanghai Institute of Infectious Diseases and BiosecurityFudan UniversityShanghai 200032China State Key Laboratory of Toxicology and Medical Countermeasures Beijing Institute of Pharmacology and ToxicologyBeijing 100850China

The development of broad-spectrum antivirals against human coronaviruses(HCoVs)is critical to combat the current coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and its variants,as well as future outbreaks of emerging CoVs.We have previously identified a polyethylene glycol-conjugated(PEGylated)lipopeptide,EK1C4,with potent pan-CoV fusion inhibitory activity.However,PEG linkers in peptide or protein drugs may reduce stability or induce anti-PEG antibodies in vivo.Therefore,we herein report the design and synthesis of a series of dePEGylated lipopeptide-based pan-CoV fusion inhibitors featuring the replacement of the PEG linker with amino acids in the heptad repeat 2 C-terminal fragment(HR2-CF)of HCoV-OC43.Among these lipopeptides,EKL1C showed the most potent inhibitory activity against infection by SARS-CoV-2 and its spike(S)mutants,as well as other HCoVs and some bat SARS-related coronaviruses(SARSr-CoVs)tested.The dePEGylated lipopeptide EKL1C exhibited significantly stronger resistance to proteolytic enzymes,better metabolic stability in mouse serum,higher thermostability than the PEGylated lipopeptide EK1C4,suggesting that EKL1C could be further developed as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases.

关键词： Coronavirus Lipopeptide SARS-CoV-2 Polyethylene glycol Fusion inhibitor

Pembrolizumab-Induced Steven-Johnson Syndrome in an NSCLC Patient: A Case Report

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Health 2022年第1期14卷 57-62页

作者： shan su Xinxing Hu Hongzhong Yang Graduate School of Hunan University of Traditional Chinese Medicine Changsha China Department of Respiratory and Critical Care Medicine Changsha Central Hospital Changsha China

Background: Immune checkpoints inhibitors (ICIs) are widely used in various therapy of tumors. With the increasing usage of them, immune-related adverse events (irAEs) have been known and become common events, especially in the dermatologic system. However, the rare and severe immune-related cutaneous adverse events (irCAEs) still lack enough knowledge. Case presentation: We described a rare case of Steven-Johnson syndrome (SJS) induced by pembrolizumab in an advanced squamous non-small cell lung cancer (NSCLC) patient. SJS is a rare irCAE that could happen at any time after immunotherapy while this case happened from the 3rd day. The patient had influence-like symptoms and several mucous lesions including oral, eye, and skin. With a gradually severer condition, a stoss therapy of intravenous immunoglobulin (IVIG) had a mild effect. It was a long process and failed to respond to usual dermatologic treatment. Conclusion: We share this case in order to enhance clinicians’ ability to early recognition and diagnosis in severe irCAEs. Early recognition and appropriate management are important to evade the termination of immunotherapy. such severe irCAE should be paid more attention to in clinical medicine when using ICIs.

关键词： Pembrolizumab Non-Small Cell Lung Cancer Immune-Related Cutaneous Adverse Event Steven-Johnson Syndrome

Modulation of innate immune response to viruses including SARS-CoV-2 by progesterone

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Signal Transduction and Targeted Therapy 2022年第5期7卷 1783-1796页

作者： shan su Duo Hua Jin-Peng Li Xia-Nan Zhang Lei Bai Li-Bo Cao Yi Guo Ming Zhang Jia-Zhen Dong Xiao-Wei Liang Ke Lan Ming-Ming Hu Hong-Bing Shu Department of Infectious Diseases Frontier Science Center for Immunology and MetabolismMedical Research InstituteZhongnan Hospital of Wuhan UniversityWuhan UniversityWuhan 430071China Department of Thyroid and Breast surgery Zhongnan Hospital of Wuhan UniversityWuhan 430071China State Key Laboratory of Virology College of Life SciencesWuhan UniversityWuhan 430071China

Whether and how innate antiviral response is regulated by humoral metabolism remains enigmatic.We show that viral infection induces progesterone via the hypothalamic-pituitary-adrenal axis in mice.Progesterone induces downstream antiviral genes and promotes innate antiviral response in cells and mice,whereas knockout of the progesterone receptor PGR has opposite effects.Mechanistically,stimulation of PGR by progesterone activates the tyrosine kinase SRC,which phosphorylates the transcriptional factor IRF3 at Y107.

关键词： progesterone metabolism stimulation

Embryonic Growth and Yolk Depletion during Incubation in the Chinese Skink, Plestiodon chinensis

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Asian Herpetological Research 2019年第1期10卷 56-61页

作者： Li MA Kun GUO shan su Xiang JI Jiangsu Key Laboratory for Biodiversity and Biotechnology College of Life Sciences Nanjing Normal University

We collected 24 gravid female Chinese skinks(Plestiodon chinensis) to study embryonic growth and yolk depletion during incubation. Females laid eggs between late May and mid-June. Eggs were incubated at 24(± 0.3) ℃. One egg from each clutch was dissected at 5-d intervals starting at laying. Embryonic stages at laying varied from Dufaure and Hubert's(1961) Stage 30-35, with a mean stage of 32.6. Incubation lengths at 24 ℃ varied from 35.1 to 48.3 d, with a mean of 41.5 d. Based on the derived functions describing instantaneous changes in embryo dry mass and yolk dry mass, we identified three phases of embryonic growth or yolk depletion in P. chinensis. Phase 1, from Day 0(at laying) to Day 15(～36% of the way through incubation), was one of minimal transfer of material from yolk to embryo. Phase 2, from Day 15 to Day 32-33(～77%-80% of the way through incubation), was characterized by increasingly rapid embryonic growth or yolk depletion. Phase 3, from Day 32-33 to hatching, was characterized by reduced embryonic growth or yolk depletion. The length of the last embryonic stage(Stage 40 = completely differentiated embryos) accounted for about 28% of incubation length, and the dry mass of the smallest embryos of Stage 40 accounted for only ～48% of the hatchling dry mass. Our study adds evidence to the idea that oviposition is not timed to coincide with the onset of rapid embryonic growth in oviparous reptiles, and is first to demonstrate that ～50% embryonic growth occurs in the last quarter of incubation in P. chinensis.

关键词： egg incubation embryonic growth embryonic stage Plestiodon chinensis scincid lizard yolk depletion

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车辆图像智能抓拍系统的设计与实现

移动信息 2024年第6期46卷 295-297页

作者：苏珊广西科技大学广西柳州545006

文中以车道图像智能抓拍系统为分析对象,研究了车辆智能抓拍系统的设计与实现。合理设计车道图像智能抓拍,能满足交通运行需求,使驾驶人员按照交通规则安全驾驶,提升交通安全系数,减少违章行为,避免给交通安全造成影响。

关键词：车道图像智能抓拍系统设计实现

基于转录组测序探究C-MET表达在非小细胞肺癌中的免疫调控机制

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实用医学杂志 2024年第1期40卷 7-12页

作者：徐越张言斌苏珊清远市人民医院广东清远511518 广州市红十字会医院广州510240 广州市胸科医院广州510095

目的通过转录组测序技术分析C-MET表达在非小细胞肺癌中的免疫调控机制。方法使用siRNA分子干扰技术将C-MET高表达肺腺癌细胞株(H1993)、肺鳞癌细胞株(EBC-1)的C-MET表达沉默,利用转录组测序技术检测C-MET沉默前后细胞差异表达的基因(DE... 详细信息

目的通过转录组测序技术分析C-MET表达在非小细胞肺癌中的免疫调控机制。方法使用siRNA分子干扰技术将C-MET高表达肺腺癌细胞株(H1993)、肺鳞癌细胞株(EBC-1)的C-MET表达沉默,利用转录组测序技术检测C-MET沉默前后细胞差异表达的基因(DEGs),通过生物信息学分析挖掘出C-MET可能参与调控的免疫微环境信号通路及相关基因。最后使用人免疫细胞与H1993、EBC-1共培养技术验证C-MET对免疫因子(INF-γ、INF-β、CXCL-10)的影响。结果通过转录组测序技术共检测到505个DEGs,其中H1993的C-MET调控前后表达差异组的表达差异基因共有38个,上调的差异表达基因有24个,下调的差异表达基因有14个。EBC-1的C-MET调控前后表达差异组的表达差异基因共有467个,上调的差异表达基因有347个,下调的差异表达基因121个。差异基因的KEGG分析表明,C-MET表达可能通过白细胞介素(IL-17)信号通路、白细胞分化、细胞因子受体活性、细胞周期、细胞因子-细胞因子受体相互作用参与免疫细胞调节因子的调控。使用肺癌细胞与人免疫细胞共同培养技术验证C-MET对免疫因子分泌的影响,Rt-qPCR检测结果提示:与C-MET高表达组共培养的PBMC中干扰素(INF-γ)的m RNA转录水平是低表达组的77倍、CXCL-10的mRNA转录水平是低表达组的1.6倍,INF-β的mRNA转录水平是低表达组的2倍。结论C-MET表达可能通过IL-17信号通路、白细胞分化、细胞因子受体活性通路参与肿瘤周围免疫微环境调控。

关键词：非小细胞肺癌 C-MET 免疫微环境表达谱测序

基于图像识别的TBM隧道围岩条件与岩渣级配相关性研究

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隧道建设（中英文） 2024年第5期44卷 964-972页

作者：周振梁雷可李庆楼肖海晖苏珊北京交通大学城市地下工程教育部重点实验室北京100044 中铁十六局集团有限公司北京101499 新疆水利发展投资(集团)有限公司新疆乌鲁木齐830000

为了在TBM不停机的条件下根据岩渣特征提前判断掌子面围岩条件,建立TBM岩渣图像采集系统,对各类围岩条件下产生的渣片图像进行采集,借助二值化与分水岭分割方法对渣片图像进行处理,选取曲率系数、不均匀系数、最大粒径和粗糙度指数作为... 详细信息

为了在TBM不停机的条件下根据岩渣特征提前判断掌子面围岩条件,建立TBM岩渣图像采集系统,对各类围岩条件下产生的渣片图像进行采集,借助二值化与分水岭分割方法对渣片图像进行处理,选取曲率系数、不均匀系数、最大粒径和粗糙度指数作为岩渣的级配特征指标,分别采用线性、对数、逆、二次、幂、复合、S曲线和增长共8种模型建立岩渣级配参数与围岩类别、岩石单轴抗压强度、岩石完整性系数之间的关系。结果表明:1)随着围岩条件变差,岩渣的曲率系数逐渐减小,不均匀系数、最大粒径、粗糙度指数逐渐增大;2)随着岩石单轴抗压强度增大,岩渣的曲率系数呈增大趋势,不均匀系数、最大粒径、粗糙度指数呈减小趋势;3)随岩石完整性系数增加,岩渣曲率系数呈增大趋势,不均匀系数、最大粒径、粗糙度指数呈减小趋势。

关键词： TBM 渣片识别图像采集系统图像处理级配特征参数