Modulation of innate immune response to viruses including SARS-CoV-2 by progesterone

作     者：Shan Su Duo Hua Jin-Peng Li Xia-Nan Zhang Lei Bai Li-Bo Cao Yi Guo Ming Zhang Jia-Zhen Dong Xiao-Wei Liang Ke Lan Ming-Ming Hu Hong-Bing Shu 

作者机构：Department of Infectious DiseasesFrontier Science Center for Immunology and MetabolismMedical Research InstituteZhongnan Hospital of Wuhan UniversityWuhan UniversityWuhan 430071China Department of Thyroid and Breast SurgeryZhongnan Hospital of Wuhan UniversityWuhan 430071China State Key Laboratory of VirologyCollege of Life SciencesWuhan UniversityWuhan 430071China 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2022年第7卷第5期

页      面：1783-1796页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学] 

基　　金：This work was supported by grants from the State Key R&D Program of China(2017YFA0505800 and 2021YFA1302400) the National Natural Science Foundation of China(31922021,32170713,31830042,and 31771555) the CAMS Innovation Fund for Medical Sciences(2019-I2M-5-071) 

主　　题：progesterone metabolism stimulation 

摘      要：Whether and how innate antiviral response is regulated by humoral metabolism remains *** show that viral infection induces progesterone via the hypothalamic-pituitary-adrenal axis in *** induces downstream antiviral genes and promotes innate antiviral response in cells and mice,whereas knockout of the progesterone receptor PGR has opposite ***,stimulation of PGR by progesterone activates the tyrosine kinase SRC,which phosphorylates the transcriptional factor IRF3 at Y107.