检索结果-南通市图书馆

Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： shan ping yu Emily Choi Michael QJiang Ling Wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

DPP-4 Inhibitor Linagliptin is Neuroprotective in Hyperglycemic Mice with Stroke via the AKT/mTOR Pathway and Anti-apoptotic Effects

引用

Neuroscience Bulletin 2020年第4期36卷 407-418页

作者： Gang Zhang Samuel Kim Xiaohuan Gu shan ping yu Ling Wei Department of Anesthesiology Emory University School of MedicineAtlantaGA 30322USA Department of Neurology Children's Hospital of Nanjing Medical UniversityNanjing 210000China Department of Neurology Emory University School of MedicineAtlantaGA 30322USA

Dipeptidyl peptidase 4 (DPP-4) inhibitors have been shown to have neuroprotective effects in diabetic patients suffering from stroke, but less research has focused on patients with mild hyperglycemia below the threshold for a diagnosis of diabetes. In this investigation, a hyperglycemic mouse model was generated by intraperitoneal injection of streptozotocin and then subjected to focal cerebral ischemia. We demonstrated that the DPP-4 inhibitor linagliptin significantly decreased the infarct volume, reduced neuronal cell death, decreased inflammation, and improved neurological deficit compared with control mice. Linagliptin up-regulated the expression of p-Akt and p-m TOR and regulated the apoptosis factors Bcl-2, Bax, and caspase 9. Taken together, these results suggest that linagliptin exerts a neuroprotective action likely through activation of the Akt/m TOR pathway along with anti-apoptotic and anti-inflammatory ***, linagliptin may be considered as a therapeutic treatment for stroke patients with mild hyperglycemia.

关键词： Cerebral ischemia Hyperglycemia DPP-4 inhibitor Linagliptin Neuroprotection

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Neonatal Maternal Deprivation Followed by Adult Stress Enhances Adrenergic Signaling to Advance Visceral Hypersensitivity

引用

Neuroscience Bulletin 2019年第1期35卷 4-14页

作者： Wan-Jie Du Shufen Hu Xin Li ping-An Zhang Xinghong Jiang shan-ping yu Guang-Yin Xu Laboratory for Translational Pain Medicine Institute of NeuroscienceSoochow UniversitySuzhou 215123China Center for Translational Medicine The Zhangjiagang Affiliated Hospital of Soochow UniversityZhangjiagang 215600China Department of Anesthesiology Emory University School of MedicineAtlantaGA 30307USA

The pathophysiology of visceral pain in patients with irritable bowel syndrome remains largely *** previous study showed that neonatal maternal deprivation(NMD) does not induce visceral hypersensitivity at the age of 6 weeks in rats. The aim of this study was to determine whether NMD followed by adult stress at the age of 6 weeks induces visceral pain in rats and to investigate the roles of adrenergic signaling in visceral pain. Here we showed that NMD rats exhibited visceral hypersensitivity 6 h and 24 h after the termination of adult multiple stressors(AMSs). The plasma level of norepinephrine was significantly increased in NMD rats after AMSs. Whole-cell patch-clamp recording showed that the excitability of dorsal root ganglion(DRG) neurons from NMD rats with AMSs was remarkably increased. The expression of β_2 adrenergic receptors at the protein and mRNA levels was markedly higher in NMD rats with AMSs than in rats with NMD alone. Inhibition of β_2 adrenergic receptors with propranolol or butoxamine enhanced the colorectal distention threshold and application of butoxamine also reversed the enhanced hypersensitivity of DRG neurons. Overall,our data demonstrate that AMS induces visceral hypersensitivity in NMD rats, in part due to enhanced NE-β_2 adrenergic signaling in DRGs.

关键词： Irritable bowel syndrome Dorsal root ganglion Norepinephrine Visceral pain Stress

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Measurement of soluble solids content in watermelon by Vis/NIR diffuse transmittance technique

引用

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第2期8卷 105-110页

作者： TIAN Hai-qing YING Yi-bin LU Hui-shan FU Xia-ping yu Hai-yan School of Biosystems Engineering and Food Science Zhefiang University Hangzhou 310029 China

Watermelon is a popular fruit in the world with soluble solids content （SSC） being one of the major characteristics used for assessing its quality. This study was aimed at obtaining a method for nondestructive SSC detection of watermelons by means of visible/near infrared （Vis/NIR） diffuse transmittance technique. Vis/NIR transmittance spectra of intact watermelons were acquired using a low-cost commercially available spectrometer operating over the range 350-1000 nm. Spectra data were analyzed by two multivariate calibration techniques： partial least squares （PLS） and principal component regression （PCR） methods. Two experiments were designed for two varieties of watermelons [Qilin （QL）, Zaochunhongyu （ZC）], which have different skin thickness range and shape dimensions. The influences of different data preprocessing and spectra treatments were also investigated. Performance of different models was assessed in terms of root mean square errors of calibration （RMSEC）, root mean square errors of prediction （RMSEP） and correlation coefficient （r） between the predicted and measured parameter values. Results showed that spectra data preprocessing influenced the performance of the calibration models. The first derivative spectra showed the best results with high correlation coefficient of determination [r=0.918 （QL）; r=0.954 （ZC）], low RMSEP [0.65 °Brix （QL）; 0.58 °Brix （ZC）], low RMSEC [0.48 °Brix （QL）; 0.34°Brix （ZC）] and small difference between the＇RMSEP and the RMSEC by PLS method. The nondestructive Vis/NIR measurements provided good estimates of SSC index of watermelon, and the predicted values were highly correlated with destructively measured values for SSC. The models based on smoothing spectra （Savitzky-Golay filter smoothing method） did not enhance the performance of calibration models obviously. The results indicated the feasibility of Vis/NIR diffuse transmittance spectral analysis for predicting watermelon SSC in a nondestructive way.

关键词： Diffuse transmittance Visible/near infrared Nondestructive detection Soluble solids content Watermelon

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A New Definition and Calculation Model for Evolutionary Multi-Objective Optimization

引用

Wuhan University Journal of Natural Sciences 2003年第S1期8卷 189-194页

作者： Zhou Ai-min, Kang Li-shan, Chen yu-ping, Huang yu-zhenState Key Laboratory of Software Engineering, Wuhan University, Wuhan 430072, Hubei, China Wuhan University State Key Laboratory of Software Engineering Wuhan Hubei China (GRID:grid.49470.3e) (ISNI:***)

We present a new definition (Evolving Solutions) for Multi-objective Optimization Problem (MOP) to answer the basic question (what's multi-objective optimal solution?) and advance an asynchronous evolutionary model (MINT Model) to solve MOPs. The new theory is based on our understanding of the natural evolution and the analysis of the difference between natural evolution and MOP, thus it is not only different from the Converting Optimization but also different from Pareto Optimization. Some tests prove that our new theory may conquer disadvantages of the upper two methods to some extent.

关键词： evolving equilibrium evolving solutions MINT model multi-objective optimization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Neuroprotective mechanisms and translational potential of therapeutic hypothermia in the treatment of ischemic stroke

引用

Neural Regeneration Research 2017年第3期12卷 341-350页

作者： Jin Hwan Lee James Zhang shan ping yu Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Veteran's Affair Medical Center Center for Visual and Neurocognitive RehabilitationAtlantaGAUSA

Stroke is a leading cause of disability and death,yet effective treatments for acute stroke has been very *** far,tissue plasminogen activator has been the only FDA-approved drug for thrombolytic treatment of ischemic stroke patients,yet its application is only applicable to less than 4–5% of stroke patients due to the narrow therapeutic window（〈 4.5 hours after the onset of stroke） and the high risk of hemorrhagic *** evidence from basic and clinical studies has shown that therapeutic hypothermia,also known as targeted temperature management,can be a promising therapy for patients with different types of ***,the success in animal models using pharmacologically induced hypothermia（PIH） has gained increasing momentum for clinical translation of hypothermic *** review provides an updated overview of the mechanisms and protective effects of therapeutic hypothermia,as well as the recent development and findings behind PIH *** is expected that a safe and effective hypothermic therapy has a high translational potential for clinical treatment of patients with stroke and other CNS injuries.

关键词： stroke therapeutic hypothermia drug-induced hypothermia ischemia cell death inflammation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Some Massively Parallel Algorithms from Nature

引用

Wuhan University Journal of Natural Sciences 2002年第1期7卷 37-46页

作者： Li Yan, Kang Li-shan, Chen yu-ping, Liu Pu, Cao Hong-qing, Pan Zheng-jun The State Key Laboratory of Software Engineering, Wuhan University, Wuhan 430072, Hubei, China Wuhan University The State Key Laboratory of Software Engineering Wuhan Hubei China (GRID:grid.49470.3e) (ISNI:***)

We introduced the work on parallel problem solvers from physics and biology being developed by the research team at the State Key Laboratory of Software Engineering, Wuhan University. Results on parallel solvers include the following areas: Evolutionary algorithms based on imitating the evolution processes of nature for parallel problem solving, especially for parallel optimization and model-building; Asynchronous parallel algorithms based on domain decomposition which are inspired by physical analogies such as elastic relaxation process and annealing process, for scientific computations, especially for solving nonlinear mathematical physics problems. All these algorithms have the following common characteristics: inherent parallelism, self-adaptation and self-organization, because the basic ideas of these solvers are from imitating the natural evolutionary processes.

关键词： evolutionary computation parallel algorithm imitating nature domain decomposition knowledge discovery in databases

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

氨基酸铜在猪生产中的研究与应用

引用

中国畜牧兽医 2011年第4期38卷 20-22页

作者：单玉萍单安山东北农业大学动物营养研究所黑龙江哈尔滨150030

高铜日粮在养猪生产中应用普遍,近些年来对于其危害的报道也比比皆是,氨基酸铜(主要包括复合氨基酸螯合铜、蛋氨酸铜、赖氨酸铜、甘氨酸铜)作为一种有机铜源,其生物利用率高、毒副作用小等特点已经受到国内外越来越多的学者的关注,并进... 详细信息

高铜日粮在养猪生产中应用普遍,近些年来对于其危害的报道也比比皆是,氨基酸铜(主要包括复合氨基酸螯合铜、蛋氨酸铜、赖氨酸铜、甘氨酸铜)作为一种有机铜源,其生物利用率高、毒副作用小等特点已经受到国内外越来越多的学者的关注,并进行了大量的试验研究。作者主要综述了氨基酸铜的理化特性,生物学功能及作为一种无机铜的替代产品在养猪生产中的研究与应用。

关键词：铜氨基酸铜猪

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Priming of the Cells： Hypoxic Preconditioning for Stem Cell Therapy

引用

Chinese Medical Journal 2017年第19期130卷 2361-2374页

作者： Zheng Z Wei Yan-Bing Zhu James Y Zhang Myles R McCrary Song Wang Yong-Bo Zhang shan-ping yu Ling Wei Department of Neurology Beijing Friendship Hospital Capital Medical University Beijing 100050 China Experimental and Translational Research Center Beijing Friendship Hospital Capital Medical University Beijing 100050 China Department of Anesthesiology Emory University School of Medicine Atlanta Georgia 30322 USA

Objective： Stem cell-based therapies are promising in regenerative medicine for protecting and repairing damaged brain tissues after injury or in the context of chronic diseases. Hypoxia can induce physiological and pathological responses. A hypoxic insult might act as a double-edged sword, it induces cell death and brain damage, but on the other hand, sublethal hypoxia can trigger an adaptation response called hypoxic preconditioning or hypoxic tolerance that is of immense importance for the survival of cells and tissues. Data Sources： This review was based on articles published in PubMed databases up to August 16, 2017, with the following keywords：＂stem cells,＂＂hypoxic preconditioning,＂＂ischemic preconditioning,＂ and ＂cell transplantation.＂Study Selection： Original articles and critical reviews on the topics were selected. Results： Hypoxic preconditioning has been investigated as a primary endogenous protective mechanism and possible treatment against ischemic injuries. Many cellular and molecular mechanisms underlying the protective effects of hypoxic preconditioning have been identified. Conclusions： In cell transplantation therapy, hypoxic pretreatment of stem cells and neural progenitors markedly increases the survival and regenerative capabilities of these cells in the host environment, leading to enhanced therapeutic effects in various disease models. Regenerative treatments can mobilize endogenous stem cells for neurogenesis and angiogenesis in the adult brain. Furthermore, transplantation of stem cells/neural progenitors achieves therapeutic benefits via cell replacement and/or increased trophic support. Combinatorial approaches of cell-based therapy with additional strategies such as neuroprotective protocols, anti-inflammatory treatment, and rehabilitation therapy can significantly improve therapeutic benefits. In this review, we will discuss the recent progress regarding cell types and applications in regenerative medicine as well as future applicatio

关键词： Angiogenesis Factor Cell Transplantation Endogenous Stem Cells Genome Editing Hypoxia Hypoxic Preconditioning Induced Pluripotent Stem Cells Neurological Disorders Tumor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

女贞子超临界CO_2萃取物遗传和亚急性毒性评价

引用

中国公共卫生 2011年第11期27卷 1424-1426页

作者：董茜单安山单玉萍东北农业大学动物科技学院黑龙江哈尔滨150030

目的从遗传毒性和亚急性毒性角度对女贞子超临界CO2萃取物进行毒理学评价。方法采用测定小鼠骨髓微核率和大鼠30 d饲养试验对受试动物进行体重、血液学指标、血清生化指标和脏器病理检测。结果在骨髓微核试验中,添加女贞子超临界CO2萃... 详细信息

目的从遗传毒性和亚急性毒性角度对女贞子超临界CO2萃取物进行毒理学评价。方法采用测定小鼠骨髓微核率和大鼠30 d饲养试验对受试动物进行体重、血液学指标、血清生化指标和脏器病理检测。结果在骨髓微核试验中,添加女贞子超临界CO2萃取物各剂量组的骨髓微核率与阴性对照组比较,差异均无统计学意义(P>0.05),但与阳性对照组比较,差异均有统计学意义(P<0.01);在30 d饲养试验中,添加女贞子超临界CO2萃取物的各剂量组动物在给药期均存活,且采食量、体重、行为活动性状等均正常;血液学检测结果,白细胞数9.3×1012～1012/L、红细胞数8.23×109～8.89×109/L、血红蛋白136.4～140.9 g/L和血小板312.3～330.9×109/L,血液生化指标检测结果,谷丙转氨酶41.8～45.8μ/L,谷草转氨酶150.3～153.0μ/L,尿素氮4.8～5.1 mmol/L,肌酐104.5～109.5μmol/L,血糖5.0～5.49 mmol/L,血清白蛋白38.87～40.8 g/L,总蛋白84.3～89.1 g/L,总胆固醇1.4～1.5 mmol/L和甘油三酯0.81～0.87 mmol/L,主要脏器重量和脏器系数均在正常范围内。结论女贞子超临界CO2萃取物不能引起小鼠遗传突变和大鼠亚慢性中毒。

关键词：女贞子超临界CO2萃取物微核率 30d饲养试验

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：