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Photonic crystal fibers, devices, and applications

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Frontiers of Optoelectronics 2013年第1期6卷 3-24页

作者： Wei JIN Jian ju hoi Lut ho Yeuk Lai hoO Ailing ZHANG Department of Electrical Engineering The Hong Kong Polytechnic University Hong Kong China

This paper reviews different types of air-silica photonic crystal fibers (PCFs), discusses their novel properties, and reports recent advances in PCF components and sensors as well as techniques for splicing PCFs to s... 详细信息

关键词： photonic crystal fibers (PCFs) microstructured optical fibers hollow-core photonic bandgap fibers (HC PBFs) optical fiber devices optical fiber sensors

Two new neolignans from Manglietia insignis

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Natural Products and Bioprospecting 2012年第5期2卷 227-230页

作者： shan-Zhai shanG ju-Ming YAN Hai-Bo ZHANG Yi-Ming SHI Zhong-Hua GAO Xue DU Yan LI Wei-Lie XIAO Han-Dong SUN State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina University of Chinese Academy of Sciences Beijing 100049China

Two new neolignans,manneoinsigins A(1)and B(2),together with four known lignans,were isolated from the leaves and stems of Manglietia *** new compounds were established on the basis of extensive spectroscopic *** compounds except 2 were tested for their cytotoxic *** 3 showed weak cytotoxic activity against the HL-60 human tumor cell line with the IC50 value of 23.5μM.

关键词： Magnoliaceae Manglietia insignis neolignan cytotoxic activity

Downregulation of alpha-fetoprotein siRNA inhibits proliferation of SMMC-7721 cells

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World Journal of Gastroenterology 2005年第38期11卷 6053-6055页

作者： Yun-shan Wang Xiao-Li Ma Tong-Gang Qi Xiang-Dong Liu Yue-Sheng Meng Guang-ju Guan Central Laboratory Jinan Central Hospital Clinical Medical College of Shandong University Jinan 250013 Shandong Province China Laboratory of Clinical Molecular Biology The Second Hospital of ShandongUniversity Jinan 250015 Shandong Province China shandong Provincial hospital Jinan 250020Shandong Province China

AIM: To study the function of α-fetoprotein (AFP) in SMMC-7721 hepatoma ***: A hairpin siRNA expressing plasmid pSilencer3.0-H1-afp was constructed and transfected into SMMC-7721 cells with Lipofectamine 2000. The expression of AFP was monitored by real-time RT-PCR and immunoassays, its effect on SMMC-7721 cell proliferation and cell death was detected by MTT and fluorescenceactivated cell sorter (FACS).RESULTS: The AFP-siRNA expressing plasmid downregulated the expression of AFP obviously (about 34%), and inhibited SMMC-7721 cell proliferation, but did not induce ***: Downregulation of AFP siRNA inhibits proliferation of SMMC-7721 cells, but cannot cause apoptosis.

关键词： siRNAs AFP SMMC-7721 cell Proliferation Apoptosis

Computed tomography findings for predicting severe acute hepatitis with prolonged cholestasis

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World Journal of Gastroenterology 2013年第16期19卷 2543-2549页

作者： Sang jung Park Jin Dong Kim Yeon Seok Seo Beom Jin Park Min ju Kim Soon ho Um Chang Ha Kim Hyung Joon Yim Soon Koo Baik Jin Yong jung Bora Keum Yoon Tae Jeen hong Sik Lee hoon Jai Chun Chang Duck Kim ho Sang Ryu Department of Internal Medicine College of Medicine Korea University Department of Internal Medicine Cheju Halla General Hospital Department of Radiology College of Medicine Korea University Department of Internal Medicine Yonsei University Wonju College of Medicine Wonju Christian Hospital

AIM: To evaluate the significance of computed tomography (CT) findings in relation to liver chemistry and the clinical course of acute hepatitis. METhoDS: Four hundred and twelve patients with acute hepatitis who underwent enhanced CT scanning were enrolled retrospectively. Imaging findings were analyzed for the following variables: gallbladder wall thickness (GWT), arterial heterogeneity, periportal tracking, number and maximum size of lymph nodes, presence of ascites, and size of spleen. The serum levels of alanine aminotransferase, alkaline phosphatase, bilirubin, albumin, and prothrombin time were measured on the day of admission and CT scan, and laboratory data were evaluated every 2-4 d for all subjects during hospitalization. RESULTS: The mean age of patients was 34.4 years, and the most common cause of hepatitis was hepatitis A virus (77.4%). The mean GWT was 5.2 mm. The number of patients who had findings of arterial heterogeneity, periportal tracking, lymph node enlargement > 7 mm, and ascites was 294 (80.1%), 348 (84.7%), 346 (84.5%), and 56 (13.6%), respectively. On multivariate logistic regression, male gender [odds ratio (OR) = 2.569, 95%CI: 1.477-4.469, P = 0.001], toxic hepatitis (OR = 3.531, 95%CI: 1.444-8.635, P = 0.006), level of albumin (OR = 2.154, 95%CI: 1.279-3.629, P = 0.004), and GWT (OR = 1.061, 95%CI: 1.015-1.110, P = 0.009) were independent predictive factors for severe hepatitis. The level of bilirubin (OR = 1.628, 95%CI: 1.331-1.991, P holestasis in multivariate analysis. CONCLUSION: In patients with acute hepatitis, GWT on CT scan was an independent predictor of severe hepatitis and prolonged cholestasis.

关键词： Acute hepatitis Cholestasis Computed tomography Prognosis Gallbladder

Efficiency enhancement of fluorescent blue organic light-emitting diodes using doped hole transport and emissive layers

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Chinese Optics Letters 2016年第4期14卷 86-90页

作者： Nam ho Kim You-Hyun Kim ju-An Yoon Seung Ⅱ Yoo Kok Wai Cheah Furong Zhu Woo Young Kim Department of Green Energy & Semiconductor Engineering Hoseo University 513-3 2nd Engineering Building 20 Hoeo-ro beon-gil baebang-eup Asan-si Chungcheongnam-do 31499 South Korea Department of Engineering Physics McMaster University 1280 Main St W Hamilton L8S 4L8 Canada Department of Physics Hong Kong Baptist University Hong Kong Kowloon Tong Waterloo Road 224 China

The electroluminescent characteristics of blue organic light-emitting diodes （BOLEDs） fabricated with doped charge carrier transport layers are analyzed. The fluorescent blue dopant BCzVBi is doped in an emissive layer, hole transport layer （HTL） and electron transport layer （ETL）, respectively, to optimize the probability of ex- citon generation in the BOLEDs. The luminance and luminous efficiency of BOLEDs made with BCzVBi-doped HTL and ETL increase by 22% and 17% from 11,683 cd/m2 at 8.5 V and 6.08 cd/A at 4.0 V to 14,264 cd/m2 at 8.5 V and 7.13 cd/A at 4.0 V while CIE coordinates of （0.15, 0.15） of both types of BOLEDs remained unchanged. The electron mobility of BCzVBi is estimated to be 1.02 × 10-5 cm2/Vs by TOF.

关键词： Carrier transport Doping (additives) Efficiency Electron transport properties Fluorescence hole mobility Light emission Light emitting diodes

Impact of statin intensity on adverse cardiac and cerebrovascular events in older adult patients with myocardial infarction

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Journal of Geriatric Cardiology 2021年第8期18卷 609-622页

作者： In Tae Moon Si-Hyuck Kang Wonjae Lee Youngjin Cho Jin Joo Park Yeonyee EYoon Il-Young Oh Chang-Hwan Yoon jung-Won Suh Tae-Jin Youn In-ho Chae Dong-ju Choi Young-Seok Cho Uijeongbu Eulji Medical Center Eulji University School of MedicineUijeongbuSouth Korea Seoul National University Bundang hospital SeongnamSouth Korea Department of Cardiology Incheon Sejong HospitalIncheonSouth Korea

BACKGROUND There is insufficient evidence regarding the effect of high-intensity statin therapy in older *** study aimed to investigate the effects of high-intensity statin treatment on the clinical outcomes in older adults with myocardial infarc-tion(MI).METhoDS Consecutive patients with MI aged at least 75 years were analyzed *** primary endpoint was major adverse cardiac and cerebrovascular events(MACCE),defined as a composite of all-cause death,MI,rehospitalization due to un-stable angina,repeat revascularization,and ischemic *** high-intensity group was compared to the low-to-moderate in-tensity group in the propensity score-matched *** Average age of total 546 patients was 81 *** them,84%of patients underwent percutaneous coronary *** unadjusted seven-year MACCE rate differed by statin intensity(high-intensity statin group:38%,moderate-intensity statin group:42%,low-intensity statin group:56%,and no-statin group:61%,P=0.004).however,among these groups,many baseline characteristics were significantly *** the 74 propensity score-matched pairs,which lacked any significant differences in all baseline characteristics,the high-intensity group had a significantly lower rate of MACCE than the low-to-moderate intensity group(37%vs.53%,P=0.047).Follow-up low-density lipoprotein cholesterol levels were significantly lower in the high-intensity group than that in the low-to-moderate intensity group(69.4±16.0 mg/dL vs.77.9±25.9 mg/dL,P=0.026).CONCLUSIONS In older adult patients with MI,the use of high-intensity statin caused significantly less occurrence of MACCE in comparison to that in low-to-moderate intensity for up to seven years of follow-up.

关键词： patients cardiac intensity

Mechanisms of treatment of cancer pain with a topical Chinese herbal formula in rats

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Chinese Medical Journal 2009年第17期122卷 2027-2031页

作者： YU shan PENG Hai-dong ju Da-wei WEI Pin-kang XU Ling LAO Li-xing LI jun Department of Chinese Medicine Shanghai ChangzhengHospital Second Military Medical University Shanghai 200003China

Background Pain has a substantial impact on patients＇ activities and overall quality of life, but current conventional drugs have debilitating side effects, including gastrointestinal disorders. Thus there is a pressing need for new therapies with fewer side effects to alleviate cancer pain. We recently developed a topical herbal formula Xiaotan Tongluo analgesic gel （X＇I-IL gel） based on the principles of traditional Chinese herbalism, and we have received positive feedback from bone cancer pain patients. The aim of this study was to determine the analgesic effects and explore the mechanisms of XTI-L gel in a rat model of bone cancer pain. Methods The rat model of bone cancer pain was established by inoculating Walker-256 rat carcinoma cells directly into the right tibial medullary cavity of Wistar rats. The rats were randomly assigned to three groups （n=-10 per group）：（1） sham bone cancer control （sham group）： vehicle （PBS） inoculation without carcinoma cells plus topical administration of blank gel; （2） Sham treatment control （vehicle group）： Walker-256 cell inoculation plus topical administration of blank gel; （3） XTTL gel treatment （treatment group）： Walker-256 cell inoculation plus topical administration of XTTL gel. XTTL gel treatments were applied daily for 7 days starting on day 14 following inoculation. Outcomes were assessed 21 days after inoculation by mechanical allodynia, histological staining, and by measuring concentrations of type I collagen carboxy-terminal telopeptide （ICTP） and bone-specific alkaline phosphatase （BAP） in serum. Results Fourteen days after cancer cell incubation, significant mechanical allodynia in the ipsilateral hind paw and tumor growth in proximal end of the tibia were observed in the vehicle and treatment groups but not in the sham group. At day 21, mechanical withdrawal thresholds in treatment group rats were significantly higher （（4.8557±0.8336） g） compared with those of the vehicle group （（1.8630±1.4369） g, P 〈0.05）. ICTP

关键词： bone cancer pain topical Chinese herbal medicine type I collagen carboxy-terminal telopeptide bone-specific alkaline phosphatase

原发肛管杯状细胞腺癌伴肛周Paget病的组织学及分子病理学研究

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诊断病理学杂志 2024年第6期31卷 503-507页

作者：董香香程波刘珊许琳刘凯华赵欢刘晋红丁姗姗权兰菊孙锁柱河北北方学院基础医学院河北张家口0075000 河北北方学院火箭军特色医学中心研究生培养基地北京100088 火箭军特色医学中心病理科北京100088 南京世和基因生物技术有限公司南京210061

目的探讨原发肛管杯状细胞腺癌(GCA)伴肛周Paget病的组织学及分子病理特征。方法选取2例原发肛管GCA伴肛周Paget病患者作为研究对象,对其临床资料进行回顾性分析,并采用HE染色、免疫组化、二代测序研究其原发病灶、肛周Paget病、淋巴结... 详细信息

目的探讨原发肛管杯状细胞腺癌(GCA)伴肛周Paget病的组织学及分子病理特征。方法选取2例原发肛管GCA伴肛周Paget病患者作为研究对象,对其临床资料进行回顾性分析,并采用HE染色、免疫组化、二代测序研究其原发病灶、肛周Paget病、淋巴结转移灶的组织学和分子病理特征。结果2例患者均为肛周肿物渐进性增大入院,显微镜下具有GCA的典型组织学和免疫组化特征。其中肛管原发GCA多呈条索状和实性片巢状排列,肿瘤细胞巢周围可见大量“黏液湖”样结构,似经典黏液癌;可见单纯或复杂腺管样结构,似经典结直肠管状腺癌;部分细胞核偏位、细胞浆富含黏液样物质的肿瘤细胞呈单个散在浸润性生长,似经典“印戒细胞癌”。肛管GCA继发肛周Paget病可见大量细胞核偏位、细胞浆富含黏液的“印戒样”细胞在复层鳞状上皮内原位浸润性生长伴局灶鳞状上皮乳头瘤样增生和Pinkus纤维上皮瘤样增生。淋巴结转移癌与肛管原发病灶组织学类型相似,组织形态相对单一,肿瘤细胞间异质性较低。病例1、2各部位肿瘤组织均检出ErbB3基因突变,未检出Kras、Nras、braf基因突变,未检出肿瘤组织微卫星不稳定现象(MSI)。结论肛管GCA在组织形态、免疫表型和分子病理等方面与阑尾多发的同类肿瘤相似,具有与经典管状腺癌、黏液癌、印戒细胞癌相似的组织学结构,同时伴有神经内分泌肿瘤的组织形态及免疫表型特征。

关键词：原发肛管杯状细胞腺癌肛周Paget病淋巴结转移癌组织学分子病理

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新一代航空发动机燃烧室

工程热物理学报 2022年第2期43卷 543-552页

作者：金如山党进刘富强美国加利福尼亚州AIAA Associate Follow 美国加利福尼亚州Fossil Energy Research Corp. 中国科学院工程热物理研究所轻型动力实验室北京100190 中国科学院大学北京100049

针对新一代高油气比(0.051及以上)航空发动机燃烧室,本文提出头部采用化学恰当比直接混合燃烧设计方案。对于新一代高压比(70及以上)低排放民用航空发动机燃烧室,由于其自着火延迟时间极短,因此采用贫油直接混合燃烧,而不能采用预混合... 详细信息

针对新一代高油气比(0.051及以上)航空发动机燃烧室,本文提出头部采用化学恰当比直接混合燃烧设计方案。对于新一代高压比(70及以上)低排放民用航空发动机燃烧室,由于其自着火延迟时间极短,因此采用贫油直接混合燃烧,而不能采用预混合预蒸发燃烧。本文提出了一种贫油直接混合低排放燃烧室方案,其燃油空气模由简单的压力雾化喷嘴和轴向旋流器组成,结合燃油分级技术降低污染物排放,该燃烧室具有较好的燃烧稳定性。这两类燃烧室的燃烧空气分数非常大,因此存在慢车贫油熄火问题。文中针对两类燃烧室分别提出了相应的解决方案,同时介绍了火焰筒外壁面及内壁面的冷却设计方案。本文研究成果可为下一代航空发动机燃烧室的发展提供指导作用。

关键词：低排放燃烧室高油气比燃烧室燃油空气模火焰筒冷却贫油直接混合燃烧慢车贫油熄火