检索结果-南通市图书馆

2种生物杀菌剂及其助剂对葡萄灰霉病菌室内抑制效果评价

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

南方园艺 2024年第1期35卷 23-27页

作者：赵荣华宋雅琴余扣花娄兵海何建军李善菊新疆维吾尔自治区葡萄瓜果研究所新疆鄯善838200 广西桂北特色经济作物种质创新与利用重点实验室/广西特色作物研究院广西桂林541004

[目的]为达到降低农药抗性及减少农药用量的目的,筛选防治葡萄灰霉病的有效生物杀菌剂及增效的农药助剂。[方法]研究采用菌丝生长速率法测定不同浓度的多抗霉素和小檗碱单剂使用及分别与加倍强、有机硅2种助剂复配对葡萄灰霉病病菌的室... 详细信息

[目的]为达到降低农药抗性及减少农药用量的目的,筛选防治葡萄灰霉病的有效生物杀菌剂及增效的农药助剂。[方法]研究采用菌丝生长速率法测定不同浓度的多抗霉素和小檗碱单剂使用及分别与加倍强、有机硅2种助剂复配对葡萄灰霉病病菌的室内毒力。[结果]生物杀菌剂多抗霉素抑菌效果较好,在有效浓度是8 mg/L时抑菌率最高,达(86.67±1.11)%;小檗碱的抑菌效果相对较差,最高抑菌率仅(35.93±1.28)%。结果还表明:2种助剂均能起到较好的增效作用,其中加倍强的增效作用更明显;有效浓度为4 mg/L的多抗霉素复配助剂加倍强5000倍液时,抑菌率可达到100%;小檗碱复配加倍强5000倍液后,抑菌率均在85%以上,比单剂抑菌增效60%以上,其中有效浓度为0.8 mg/L的小檗碱复配加倍强5000倍液抑菌效果最佳,达(97.04±2.57)%。[结论]生产中可直接选择10%多抗霉素1000倍液防治葡萄灰霉病;也可选用添加农药助剂加倍强的小檗碱250倍液防控葡萄灰霉病。

关键词：农药助剂生物杀菌剂葡萄灰霉病抑菌毒力测定

维普期刊数据库博看期刊

Effect of Cordyceps sinensis on the Treatment of Experimental Autoimmune Encephalomyelitis： A Pilot Study on Mice Model

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2017年第19期130卷 2296-2301页

作者： shan-shan Zhong Ya-juan Xiang Pen-ju Liu Yang He Ting-Ting Yang Yang-YanpWang A Rong jun Zhang Guang-Zhi Liu Department of Neurology Peking University People's Hospital Beijing 1000441 China Department of Neurology The First Hospital of Tsinghua University Beijing 100016 China Deptartment of Neurology Beijing Anzhen Hospital Capital Medical University Beijing 100029 China Deptartment of Neurology Tsinghua Changgung Hospital Beijing 102218 China

Background： As a traditional Chinese medicine, Cordyceps sinensis （CS） possesses a variety of immunoregulatory properties. This study aimed to explore the therapeutic potential of CS in a mice model of multiple sclerosis （MS）-experimental autoimmune encephalomyelitis （EAE）. Methods： Female C57BL/6 mice were immunized with myelin oligodendrocyte glycoprotein35–55 to induce EAE, followed by an instant intragastric feeding with a low dosage of CS （low CS group, n = 5）, high dosage of CS （high-CS group, n = 5）, or the same volume of normal saline （control group, n = 5）.All the mice were observed for clinical assessment. Over the 30 days of CS treatment, flow cytometry was used to detect the frequency of helper T-cell （Th） subsets, Th1 and Th17, and CD4＋ CD25＋ regulatory T cells in the spleen and lymph nodes. Meanwhile, pathological changes in brain were determined using both hematoxylin-eosin and luxol fast blue staining. Data were analyzed using the one-way analysis of variance （ANOVA）. Results： Over the 15 and 30 days of CS treatment, the clinical assessment for EAE demonstrated that both high-CS group （2.51 ± 0.31 and 2.26 ± 0.39 scores, respectively） and low-CS group （2.99 ± 0.40 and 2.69 ± 0.46, respectively） had lower disease severity scores than those of control group （3.57 ± 0.53 and 3.29 ± 0.53, all P 〈 0.01, respectively）. Meanwhile, after 15 and 30 days, the high-CS group （19.18 ± 1.34 g and 20.41 ± 1.56 g, respectively） and low-CS group （18.07 ± 1.18 g and 19.48 ± 1.69 g, respectively） had a lower body weight, as compared with control group （16.85 ± 1.15 g and 18.22 ± 1.63 g, all P 〈 0.01, respectively）.At 30 days post-CS treatment, there was a lower Th1 frequency in the lymph nodes （2.85 ± 1.54% and 2.77 ± 1.07% vs. 5.35 ± 1.34%, respectively; P 〈 0.05） and spleens （3.96 ± 1.09% and 3.09 ± 0.84% vs. 5.07 ± 1.50%, respectively; P 〈 0.05） and less inflammatory infiltration and demyelination in the brain of CS-treated mice than that of control group. Conclusio

关键词： Autoimmune Cordyceps Encephalomyelitis Experimental Multiple Sclerosis

Epithelioid angiomyolipoma of the liver:Cross-sectional imaging findings of 10 immunohistochemically-verified cases

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第36期15卷 4576-4581页

作者： Peng-ju Xu Yan shan Fu-Hua Yan Yuan Ji Ying Ding Mei-Lin Zhou Department of Radiology Zhongshan Hospital FudanUniversity 180 Fenglin Road Shanghai 200032 China Department of Pathology Zhongshan Hospital Fudan University 180 Fenglin Road Shanghai 200032 China

AIM： To retrospectively evaluate the computed tomography （CT）/magnetic resonance imaging （MRI） imaging features of epithelioid angiomyolipoma of the liver （Epi-HAML）, with pathology as a reference. METhoDS： The CT/MRI findings （number, diameter, lobar location, and appearance of lesions） in a series of 10 patients with 12 pathologically proven epithelioid angiomyolipomas of the liver were retrospectively analyzed. The imaging features, including attenuation/ signal intensity characteristics, presence of fat, hypervascular, outer rim, and vessels within lesion, were evaluated and compared with that of non-Epi- HAML in 11 patients （13 lesions）. The Fisher exact test was used to compare difference in probability of imaging features between the two types. RESULTS： For 21 patients, CT images of 15 patients and MR images of six patients were available. No patient underwent two examinations. For the 15 patients with a CT scan, all HAML lesions in the two groups （10 Epi-HAML and seven non-Epi-HAML） manifested as hypoattenuation. For the six patients with MRI, all lesions （two Epi-HAML and six non-Epi- HAML） were hypointense on TlWI （fat suppression） and hyperintense on T2WI. There were 10 non-Epi-HAML, but only two Epi-HAML lesions showed the presence of fat, which significantly different between the two types （P = 0.005）. On the dynamic contrast enhancement （DCE） imaging, eight Epi-HAML, and 13 non-Epi lesions manifested as hypervascular. Punctate or curved vessels were displayed in 10 Epi-HAML as well as in nine non- Epi lesions and outer rim enhancement could be found with eight Epi-HAML as well as six non-Epi lesions. CONCLUSION： Little or no presence of adipose tissue was found to be an imaging feature of Epi- HAML, compared with the non-Epi type. In addition, hypervascularity with opacification of central punctiform or filiform vessels on DCE would be a characteristic enhancement pattern for Epi-HAML.

关键词： Epithelioid angiomyolipoma Liver Immunohistochemical staining Magnetic resonance imaging Computed X-ray tomography

Viral vectors as a novel tool for clinical and neuropsychiatric research applications

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

General Psychiatry 2018年第5期31卷 100-108页

作者： Yao Wang Zhiwei Hu Peijun ju shan Yin Fujie Wang Oudong Pan Jinghong Chen Research and development department OBiO Technology (Shanghai) Corp. Ltd. Marketing department OBiO Technology (Shanghai) Corp. Ltd. shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai Key Laboratory of Psychotic Disorders

Background A viral vector is a genetically modified vector produced by genetic engineering. As pathogenic genes in the virus are completely or largely eliminated, it is safe to be widely used in multidisciplinary research fields for expressing genes, such as neuroscience, metabolism, oncology and so on. Neuroscience and psychiatry are the most closely related disciplines in either basic research or clinical research, but the application of viral vectors in neuropsychiatry has not received much attention or not been widely *** This article will focus on the application of viral vectors in basic and clinical neuropsychiatric *** By using viral vectors, scientists can perform neurological labelling, gene expression regulation and physiological manipulation for investigating phenomenon from molecular mechanisms to behaviours. At the same time, to treat mental or neurological disorders, viral vectors can be designed for gene therapy, which alter gene expression levels or repair mutated genes in the brains of *** Viral vectors play an important role in basic research and clinical applications. To further understand brain function and prevent mental and neurological diseases, we hypothesize that viral vectors could be used along with various advanced technologies, such as sequencing and high-throughput expression analysis in the neuroscience research field.

关键词： Methods By using viral vectors Neuroscience and psychiatry

Life-threatening meningitis resulting from transrectal prostate biopsy

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2005年第4期7卷 453-455,页

作者： Zhou-jun Shen shan-Wen Chen Hua Wang Xie-Lai Zhou ju-Ping Zhao Department of Urology Ruijin Hospital School of Medicine Shanghai Jiaotong University Shanghai 200025 China Department of Urology First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

After antibiotic prophylaxis with metronidazole and levofloxacin, a transrectal sextant biopsy was performed under the guide of transrectal ultrasonography （TRUS） for a 75-year-old suspicious patient with prostate adenocarcinoma. Although antibiotics were also given after this procedure, the patient still developed fever, anxious, agrypnia and headache. Blood cultures remained negative. Lumbar puncture was performed and was consistent with Escherichia coli bacterial meningitis.

关键词： meningitis prostate diagnosis

Drug-coated balloons for the treatment of ostial left anterior descending or ostial left circumflex artery lesions:a patientlevel propensity score-matched analysis

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2023年第10期20卷 716-727,I0001-I0005页

作者： Liang PAN Wen-Jie LU Zhan-Ying HAN San-Cong PAN Xi WANG Ying-Guang shan Meng PENG Xiao-Fei QIN Guo-ju SUN Pei-Sheng ZHANG Jian-Zeng DONG Chun-Guang QIU Department of Cardiovascular Medicine the First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Department of Cardiology Jincheng People’s HospitalJinchengChina Department of Cardiology the Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhouChina

BACKGROUND Controversy exists as to the optimal treatment approach for ostial left anterior descending(LAD)or ostial left circumflex artery(LCx)***-coated balloons(DCB)may overcome some of the limitations of drug-eluting stents(DES).Therefore,we investigated the security and feasibility of the DCB policy in patients with ostial LAD or ostial LCx lesions,and compared it with the conventional DES-only *** We retrospectively enrolled patients with de novo ostial lesions in the LAD or LCx who underwent interventional *** were categorized into two groups based on their treatment approach:the DCB group and the DES *** treatment strategies in the DCB group involved the use of either DCB-only or hybrid strategies,whereas the DES group utilized crossover or precise stenting ***-year target lesion revascularization was the primary endpoint,while the rates of major adverse cardiovascular events,cardiac death,target vessel myocardial infarction,and vessel thrombosis were the secondary *** propensity score matching,we assembled a cohort with comparable baseline *** ensure result analysis reliability,we conducted sensitivity analyses,including interaction,and stratified *** Among the 397 eligible patients,6.25%of patients who were planned to undergo DCB underwent DES.A total of 108 patients in each group had comparable propensity scores and were included in the ***-year target lesion revascularization occurred in 5 patients(4.90%)and 16 patients(16.33%)in the DCB group and the DES group,respectively(odds ratio=0.264,95%CI:0.093–0.752,P=0.008).Compared with the DES group,the DCB group demonstrated a lower major adverse cardiovascular events rate(7.84%vs.19.39%,P=0.017).however,differences with regard to cardiac death,non-periprocedural target vessel myocardial infarction,and definite or probable vessel thrombosis between the groups were *** The utilization of

关键词： lesions balloon treatment

多孔泡沫金属换热器内流体流动和传热的均匀性分析

在线全文

学校读者我要写书评

暂无评论

华东理工大学学报（自然科学版） 2008年第6期34卷 897-901页

作者：李菊香涂善东南京工业大学能源学院南京210009 华东理工大学机械与动力工程学院上海200237

在恒定热流密度条件下,对单相流体分别强制轴向层流流经多孔泡沫金属换热器管内、外的流动和对流传热的均匀性进行了分析。结果表明:填充多孔泡沫金属后,流体的速度和温度分布的均匀性比光管时明显提高。对于壳程区域的全角点管间区域... 详细信息

在恒定热流密度条件下,对单相流体分别强制轴向层流流经多孔泡沫金属换热器管内、外的流动和对流传热的均匀性进行了分析。结果表明:填充多孔泡沫金属后,流体的速度和温度分布的均匀性比光管时明显提高。对于壳程区域的全角点管间区域与内部管间区域,多孔泡沫金属的孔隙率越大,两者间平均流速的差异越大,对流换热的差异越小;多孔泡沫金属的ppi数越大,两者间的平均流速和对流换热的差异越小;管间距越大,平均流速的差异越小。

关键词：多孔泡沫金属管壳式换热器流动传热均匀性

The Research on Micro Electronic-Magnetic Forming of Sheet Metal

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2012年第S1期19卷 434-437页

作者： ZHAO Qing-juan GUO Bin WANG Chun-ju shan De-bin YU Hai-ping LI Chun-feng School of Materials Science and Engineering Harbin Institute of Technology

Micro channel of T2 copper were molding through electronic-magnetic forming *** scanning confocal microscope and contourgraph were used to measure the section profile and sheet *** effects of voltage,shape of channel and discharge cycles on laws of metal flow were *** showed that forming depth of micro channel and thinning of sheet thickness increased as the increasing of the ***-filling capacity of components formed by two molds with different structures had been increased when the voltage was *** with semicircle structure facilitate the material flow and the forming depth of parts was relative *** structure was better than taper structure in mold-filling capacity.A number of small pulse discharges can improve the forming quality and deformation,but local thinning in sheet metal leads to non-uniform distribution of thickness.

关键词： electromagnetic forming array microstructure foil board micro forming micro channel

Early activated hepatic stellate cell-derived molecules reverse acute hepatic injury

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第14期21卷 4184-4194页

作者： Wen-ju Chang Lu-jun Song Tuo Yi Kun-Tang Shen hong-shan Wang Xiao-Dong Gao Min Li Jian-Min Xu Wei-Xin Niu Xin-Yu Qin Department of General Surgery Zhongshan HospitalInstitute of General SurgeryFudan University

AIM: To test whether hepatic stellate cells(HSCs) at different activation stages play different roles in acetaminophen(APAP)-induced acute liver injury(ALI).METhoDS: HSCs were isolated from mouse liver and cultured in *** changes of initiation HSCs [HSCs(5d)] and perpetuation HSCs [HSCs(p3)] were observed by immunofluorescence and transmission electron *** protective effects of HSCderived molecules, cell lysates and HSC-conditioned medium(HSC-CM) were tested in vivo by survival and histopathological *** injury was determined by measuring aminotransferase levels in the serum and by histologic examination of tissue sections under a light ***, to determine the molecular mediators of the observed protective effects of initiation HSCs, we examined HSC-CM using a highdensity protein ***: HSCs(5d) and HSCs(p3) had different morphological and phenotypic ***(5d) presented a star-shaped appearance with expressing α-SMA at non-uniform levels between ***, HSCs(p3) evolved into myofibroblast-like cells without lipid droplets and expressed a uniform and higher level of α-***-CM(5d), but not HSC-CM(p3), provided a significant survival benefit and showed a dramatic reduction of hepatocellular necrosis and panlobular leukocyte infiltrates in mice exposed to ***, this protective effect was abrogated at higher cell masses, indicating a therapeutic window of ***, the protein array screenrevealed that HSC-CM(5d) was composed of many chemokines and growth factors that correlated with inflammatory inhibition and therapeutic *** compared with HSC-CM(p3), higher levels of monocyte chemoattractant protein-1, macrophage inflammatory protein-1γ, hepatocyte growth factor, interleukin-10, and matrix metalloproteinase-2, but lower levels of stem cell factor and Fas-Ligand were observed in HSCCM(5d).CONCLUSION: These data indicated that initiation HSCs and perpetuation

关键词： Hepatic stellate cells Acute liver injury Initiati