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Journal of Bionic Engineering 2021年第1期18卷 103-117页

作者： shailendra singh shera Rathindra Mohan Banik Bioprocess Technology Laboratory Sschool of Biochemical Engineeringndian Institute of Technology(Banaras Hindu University)Varanasi 221005India Department of Biotechnology Faculty of Engineering&TechnologyRAMA Universit Uittar PradeshKanpur 209217India

Skin acts as protective barrier against a number of factors such as dust,opportunistic microbial and viral infections,regulates body temperature and waste *** cell population plays an important role in devclopment of skin architecturc.A scaffold having capability to support and enhance fibroblast growth is a viable option for wound dressing material which can shorten the time for wound to *** this work,Silk Fibroin(SF)and Xanthan(Xa)were blended in three ratios 80 SF:20 Xa(SFX82),60 SF:40 Xa(SFX64),and 50SF:50 Xa(SFX55)to create SF/Xa *** and other physicochemical properties of SF/Xa scaffold are functions of blending ratios and blend with the ratio 80 SF:20 Xa has the highest *** properties of SF/Xa blends are a function of miscibility with SFX82 having superior thermal propertis of all fabricated *** porosity of SF/Xa scaffolds is in the range of 67%to 50%,with pore size of 58.1 um-45.5 um,water uptake capacity of 92%-86%,and surface roughness of 49.95 nm-385 ***82 shows highest growth rate of L929 fibroblast cells indicating its superiority over other scaffolds for providing biological cues for the growth and proliferation of fibroblastic cells in natural ***82 scaffold is found to be most suitable for fibroblastic cells thereby enhancing the tissue regeneration at wound site.

关键词： blends miscibility FTIR imaging Atomic Force Microscopy(AFM) cytocompatibility wound healing

Invitro Biodegradability of Silk Fibroin/Xanthan Biopolymeric Composite Scaffolds

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Journal of Bionic Engineering 2019年第2期16卷 299-310页

作者： shailendra singh shera Shraddha Sahu Rathindra Mohan Banik Bioprocess Technology Laboratory School of Biochemical Engineering Indian Institute of TechnologyBanaras Hindu UniversityVaranasi 221005India

Silk fibroin/xanthan scaffolds were prepared by blending silk fibroin and xanthan in the ratios 80SF:20Xa(SFX82),60SF:40Xa(SFX64),and 50SF:50Xa(SFX55)using freeze drying ***-vitro degradation behavior of the prepared scaffolds was studied for 37 days in phosphate buffer *** degradation rate was the function of silk fibroin,xanthan and^-crystallite contents in the silk fibroin/xanthan ***82 degraded extremely slowly whereas SFX55 showed faster degradation *** xanthan was the main contributor of weight ***82 and SFX64 exhibited surface degradation whereas SFX55 showed bulk degradation which indicated that higher silk fibroin ratios favor surface *** to bulk degradation,SFX55 showed maximum surface roughness among the composite *** FTIR spectrum revealed total loss of xanthan from the composites after *** broad and low-intensity peaks in the FTIR spectrum of composite scaffolds con finned reduction in 0-sheet crystallite content during *** analysis also confirmed reduction in 0-sheet crystals and revealed that degraded composite scaffold had predominantly amorphous *** degraded scaffold showed higher porous structure than the non-degraded *** in vitro degradability testing gives a good approximation of degradation of scaffold in vivo and helps in designing a robust biopolymeric composite scaffold for tissue engineering.

关键词： biopolymer composites surface roughness biopolymer degradation surface degradation tissue engineering

Numerical Analysis of Phase Change and Container Materials for Thermal Energy Storage in the Storage Tank of Solar Water Heating System

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Journal of Thermal Science 2024年第2期33卷 408-421页

作者： singh shailendra ANAND Abhishek SHUKLA Amritanshu SHARMA Atul Non-Conventional Energy Laboratory Rajiv Gandhi Institute of Petroleum TechnologyJais Amethi229304India

This study evaluates the effectiveness of phase change materials(PCMs) inside a storage tank of warm water for solar water heating(SWH) system through the theoretical simulation based on the experimental model of *** et *** model is explained by five fundamental equations for the calculation of various parameters like the effectiveness of PCMs,the mass of hot water,total heat content,and duration of *** study simulated eleven PCMs to analyze their effectiveness like Sodium hydrogen phosphate dodecahydrate(SHPD),OM 37,N-Eicosane(NE),Lauric acid(LA),Paraffin wax(PW),OM 48,Paraffin wax C_(20-33)(PW-C20-33),Sodium acetate trihydrate(SAT),Palmitic acid(PA),Myristic acid(MA),and Stearic acid(SA).Among all PCMs,the SHPD has found the highest value of effectiveness factor of ***,it is the most recommended PCM for the storage tank of the SWH *** study also includes the melt fraction analysis of all enumerated PCMs corresponding to container materials of stainless steel,glass,aluminum mixed,tin,aluminum,and *** melt fraction analysis is performed by making a coding program in the FORTRAN programming *** the analysis,copper container material is found to have high melting rate for all PCMs so it is superior to other container materials.

关键词： theoretical model solar water heating system phase change material effectiveness factor melt fraction

Artificial Neural Network Modeling to Predict the Non-Linearity in Reaction Conditions of Cholesterol Oxidase from <i>Streptomyces olivaceus</i><i>MTCC</i>6820

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Journal of Biosciences and Medicines 2019年第4期7卷 14-24页

作者： Shraddha Sahu shailendra singh shera Rathindra Mohan Banik Bioprocess Technology Laboratory School of Biochemical Engineering Indian Institute of Technology (Banaras Hindu University) Varanasi India

Cholesterol oxidase (COX) is widely used enzyme for total cholesterol estimation in human serum and for the fabrication of electro-chemical biosensors. COX is also used for the bioconversion of cholesterol;for the production of precursors of steroidal drugs and hormones. Enzyme activity depends decisively on defined conditions with respect to pH, temperature, ionic strength of the buffer, substrate concentration, enzyme concentration, reaction time. Standardization of these parameters is desirable to attain optimum activity of the enzyme. The present work aims to build a neural network model using five input parameters (pH, cholesterol concentration, 4-aminoantipyrine concentration, crude COX volume and horseradish peroxidase) and one output i.e., COX activity (U/ml) as a response. A feed forward back propagation neural network with Levenberg-Marquardt training algorithm was used to train the network. The network performance was assessed in terms of regression (R2), Mean Squared Error (MSE) and Mean Absolute Percentage Error (MAPE). A network topology of 5-10-1 was found to be optimum. The MSE, MAPE and R2 values of the neural model were 0.0075%, 0.12% and 0.9792% respectively. The maximum predicted activity of COX was 1.073 U/ml, which was close to the experimental value i.e., 1.1 U/ml at simulated optimum assay conditions. MSE and MAPE depicted the precision in the prediction efficiency of the developed ANN model. Higher R2 value showed a good correlation between the experimental and ANN predicted values. This proved the robustness of the ANN model to predict similar type of system (COX from other Streptomyces sp.) within the limits of the trained data set. The COX activity was enhanced by 1.71 folds after optimization of the reaction conditions.

关键词： Cholesterol Oxidase Artificial Neural Network Optimization Streptomyces olivaceus Prediction

Impact of index admission cholecystectomy vs interval cholecystectomy on readmission rate in acute cholangitis: National Readmission Database survey

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World Journal of Gastrointestinal Endoscopy 2024年第6期16卷 350-360页

作者： Abdullah Sohail Ahmed Shehadah Ammad Chaudhary Khadija Naseem Amna Iqbal Ahmad Khan shailendra singh Department of Internal Medicine University of Iowa Roy J and Lucille A Carver College of MedicineIowaIA 52242United States Department of Internal Medicine Rochester General HospitalRochesterNY 14621United States Department of Internal Medicine Henry Ford HospitalDetroitMI 48202United States Department of Internal Medicine Cleveland Clinic FoundationClevelandOH 44195-0001United States Department of Internal Medicine University of ToledoToledoOH 43606United States Department of Gastroenterology and Hepatology Case Western Reserve University HospitalClevelandOH 44106United States Division of Gastroenterology and Hepatology West Virginia University School of MedicineMorgantownWV 26505United States

BACKGROUND Elective cholecystectomy(CCY)is recommended for patients with gallstone-related acute cholangitis(AC)following endoscopic decompression to prevent recurrent biliary ***,the optimal timing and implications of CCY remain *** To examine the impact of same-admission CCY compared to interval CCY on patients with gallstone-related AC using the National Readmission Database(NRD).METHODS We queried the NRD to identify all gallstone-related AC hospitalizations in adult patients with and without the same admission CCY between 2016 and *** primary outcome was all-cause 30-d readmission rates,and secondary outcomes included in-hospital mortality,length of stay(LOS),and hospitalization *** Among the 124964 gallstone-related AC hospitalizations,only 14.67%underwent the same admission *** all-cause 30-d readmissions in the same admission CCY group were almost half that of the non-CCY group(5.56%vs 11.50%).Patients in the same admission CCY group had a longer mean LOS and higher hospitalization costs attrib-utable to *** the most common reason for readmission was sepsis in both groups,the second most common reason was AC in the interval CCY *** Our study suggests that patients with gallstone-related AC who do not undergo the same admission CCY have twice the risk of readmission compared to those who undergo CCY during the same *** readmis-sions can potentially be prevented by performing same-admission CCY in appropriate patients,which may reduce subsequent hospitalization costs secondary to readmissions.

关键词： Acute cholangitis Gallstone-related complications National Readmission Database 30-d readmission rates Resource utilization In-hospital mortality

State of the art in finite element approaches for milling process:a review

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Advances in Manufacturing 2023年第4期11卷 708-751页

作者： shailendra Chauhan Rajeev Trehan Ravi Pratap singh Department of Industrial and Production Engineering Dr.B R Ambedkar National Institute of TechnologyJalandharPunjabIndia

Over a century,metal cutting has been observed as a vital process in the domain of *** the numerous available metal-cutting processes,milling has been considered as one of the most employable processes to machine a variety of engineering materials *** the milling process,material removal occurs when the workpiece is fed against a rotating tool with multiple cutting *** order to maximize the profitability of metal cutting operations,it is essential that the various input and output variable relationships are analyzed and *** experimental method of studying milling processes is costly and time demanding,particularly when a large variety of elements such as cutting tool shape,materials,cutting conditions,and so on,are *** to these issues,other alternatives emerged in the form of mathematical simulations that employ numerical *** finite element approaches have well-proven to be the most practical and commonly utilized numerical *** finite element model(FEM)can be used to determine the various physical interactions occurring during the machining process along with the prediction of various milling characteristics,such as cutting forces,cutting temperature,stresses,etc.,with the help of milling *** the present article,various research studies in the broad milling process domain practiced with numerous finite element approaches have been critically reviewed and *** further highlights the several experimental and finite element approaches-based research studies that attempted to analyze and optimize the overall performance of the different milling *** recent years,various investigators have explored numerous ways to enhance milling performance by probing the different factors that influence the quality *** of the studies have also been found to be focused on the economic impacts of milling and various process inputs that affect milling ***,various milli

关键词： Milling Finite element modeling(FEM) Micro milling Turn-milling

Painlevé analysis,auto-Bäcklund transformation and new exact solutions of(2+1)and(3+1)-dimensional extended Sakovich equation with time dependent variable coefficients in ocean physics

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Journal of Ocean Engineering and Science 2023年第3期8卷 246-262页

作者： shailendra singh S.Saha Ray National Institute of Technology Department of MathematicsRourkela 769008India

This article considers time-dependent variable coefficients(2+1)and(3+1)-dimensional extended Sakovich ***éanalysis and auto-Bäcklund transformation methods are used to examine both the considered ***éanalysis is appeared to test the integrability while an auto-Bäcklund transformation method is being presented to derive new analytic soliton solution families for both the considered *** new family of exact analytical solutions are being obtained success-fully for each of the considered *** soliton solutions in the form of rational and exponential functions are being *** results are also expressed graphically to illustrate the potential and physical behaviour of both *** the considered equations have applications in ocean wave theory as they depict new solitary wave soliton solutions by 3D and 2D graphs.

关键词： (2+1)-dimensional extended Sakovich equation (3+1)-dimensional extended Sakovich equation Auto-Bäcklund transformation Painlevéanalysis Solitary wave solution

Risk of pancreatic cancer in individuals with celiac disease in the United States:A population-based matched cohort study

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World Journal of Gastrointestinal Oncology 2023年第3期15卷 523-532页

作者： Arunkumar Krishnan Yousaf Bashir Hadi Sarah Shabih Diptasree Mukherjee Ruhee A Patel Rushik Patel shailendra singh Shyam Thakkar Section of Gastroenterology&Hepatology West Virginia University School of MedicineMorgantownWV 26505United States Department of Medicine Apex Institute of Medical ScienceKolkata 700075West BengalIndia

BACKGROUND Celiac disease(CD)has been associated with gastrointestinal ***,the magnitude of the risk of pancreatic cancer(PC)associated with CD is much less clear,and risks have not been estimated from large *** To assess the risk of PC in CD *** We conducted a population-based,multicenter,propensity score-matched cohort study with consecutive patients diagnosed with CD using the TriNeTx research network *** examined the incidence of PC in patients with CD compared with a matched cohort of patients without CD(non-CD,controls).Each patient in the main group(CD)was matched to a patient in the control group using 1:1 propensity score matching to reduce confounding *** incidence of PC was estimated using a Cox proportional hazards model with a hazard ratio(HR)and 95%confidence interval(CI).RESULTS A total of 389980 patients were included in this *** them,155877 patients had a diagnosis of CD,and the remaining 234103 individuals without CD were considered a control *** mean duration of follow-up for patients in the CD and control cohorts was 5.8±1.8 and 5.9±1.1 years,*** the follow-up,309 patients with CD developed PC,whereas 240 patients developed PC in the control group(HR=1.29;95%CI:1.09-1.53).In the secondary analyses in the first year after diagnosis of CD,patients with CD were at a significant increase in risk for PC;151 patients with CD had an incidence of PC compared with 96 incidences of PC among the patients in the non-CD control group(HR=1.56;95%CI:1.20-2.01)and sensitivity analysis showed similar magnitude to the one generated in the primary and secondary *** Patients with CD are at increased risk of *** elevation persists beyond the first year after diagnosis to reference individuals without CD from the general population.

关键词： Celiac disease Cancer Epidemiology Pancreas Pancreatic cancer Malignancy Carcinoma

Biomedical Perspective of Electrochemical Nanobiosensor

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Nano-Micro Letters 2016年第3期8卷 193-203页

作者： Priti singh shailendra Kumar Pandey Jyoti singh Sameer Srivastava Sadhana Sachan Sunil Kumar singh Department of Biotechnology Motilal Nehru National Institute of Technology Department of Chemical Engineering Motilal Nehru National Institute of Technology

Electrochemical biosensor holds great promise in the biomedical area due to its enhanced specificity, sensitivity, label-free nature and cost effectiveness for rapid point-of-care detection of diseases at bedside. In this review, we are focusing on the working principle of electrochemical biosensor and how it can be employed in detecting biomarkers of fatal diseases like cancer, AIDS, hepatitis and cardiovascular diseases. Recent advances in the development of implantable biosensors and exploration of nanomaterials in fabrication of electrodes with increasing the sensitivity of biosensor for quick and easy detection of biomolecules have been elucidated in detail. Electrochemical-based detection of heavy metal ions which cause harmful effect on human health has been discussed. Key challenges associated with the electrochemical sensor and its future perspectives are also addressed.

关键词： Biomarkers Point-of-care detection Nanomaterials Electroactive species Potentiometric Amperometric Implantable

Clinical characteristics and outcomes of COVID-19 in patients with autoimmune hepatitis:A population-based matched cohort study

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World Journal of Hepatology 2023年第1期15卷 68-78页

作者： Arunkumar Krishnan Ruhee A Patel Yousaf Bashir Hadi Diptasree Mukherjee Sarah Shabih Shyam Thakkar shailendra singh Tinsay A Woreta Saleh A Alqahtani Section of Gastroenterology and Hepatology West Virginia University School of MedicineMorgantownWV 26505United States Division of Gastroenterology and Hepatology Johns Hopkins University School of MedicineBaltimoreMD 21287United States Department of Medicine Apex Institute of Medical ScienceKolkata 700075West BengalIndia Liver Transplant Center King Faisal Specialist Hospital and Research CenterRiyadh 12713Saudi Arabia

BACKGROUND Patients with autoimmune hepatitis(AIH)require life-long immunosuppressive agents that may increase the risk of poor coronavirus disease 2019(COVID-19)*** is a paucity of large data at the population level to assess whether patients with AIH have an increased risk of severe *** To evaluate the impact of pre-existing AIH on the clinical outcomes of patients with *** We conducted a population-based,multicenter,propensity score-matched cohort study with consecutive adult patients(≥18 years)diagnosed with COVID-19 using the TriNeTx research network *** outcomes of patients with AIH(main group)were compared to a propensity score-matched cohort of patients:(1)Without chronic liver disease(CLD);and(2)Patients with CLD except AIH(non-AIH CLD)control *** patient in the main group was matched to a patient in the control group using 1:1 propensity score matching to reduce confounding *** primary outcome was all-cause mortality,and secondary outcomes were hospitalization rate,need for critical care,severe disease,mechanical ventilation,and acute kidney injury(AKI).For each outcome,the risk ratio(RR)and confidence intervals(CI)were calculated to compare the association of AIH with the *** We identified 375 patients with AIH,1647915 patients with non-CLD,and 15790 patients with non-AIH CLD with COVID-19 *** to non-CLD patients,the AIH cohort had an increased risk of all-cause mortality(RR=2.22;95%CI:1.07-4.61),hospitalization rate(RR=1.78;95%CI:1.17-2.69),and severe disease(RR=1.98;95%CI:1.19-3.26).The AIH cohort had a lower risk of hospitalization rate(RR=0.72;95%CI:0.56-0.92),critical care(RR=0.50;95%CI:0.32-0.79),and AKI(RR=0.56;95%CI:0.35-0.88)compared to the non-AIH CLD *** Patients with AIH are associated with increased hospitalization risk,severe disease,and all-cause mortality compared to patients without pre-existing CLD from the diagnosis of ***,p

关键词： Autoimmune hepatitis SARS-CoV-2 COVID-19 Mortality Outcomes Liver disease Severe