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The Beneficial Effect of Combination of Mycophenolate with Low-Dose Corticosteroids and Calcineurin-Inhibitor as Well as Angiotensin-Converting Enzyme Inhibitor or Angiotensin II Blocker in Induction and Maintenance of Remission in Corticosteroid- and Rituximab-Resistant Minimal Change Nephrotic Syndrome in Adults

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Open Journal of Nephrology 2022年第1期12卷 15-22页

作者： Kamel El-Reshaid shaikha al-bader Hossameldin Tawfik Sallam Department of Medicine Faculty of Medicine Kuwait University Kuwait city Kuwait Department of Medicine Nephrology Unit Amiri Hospital Ministry of Health Kuwait city Kuwait

Management of steroid-resistant minimal change disease remains elusive with international guidelines suggesting high-dose corticosteroids and/or Calcineurin inhibitors for months similar to those with refractory idiopathic FSGS. Unfortunately, with such approach, the overall remission rates were 47% - 66%. Moreover, complete remission rates were 32% - 47% and partial remission ones were 19% - 29%. Those limited options of treatment and their poor outcomes led us to conduct the present study to assess the efficacy and safety of a new combined drug-therapy at induction and subsequent maintenance of such disease. The regimen consisted of an initial induction phase of 3-month Prednisone, Calcineurin-inhibitor, Mycophenolate and ACEI/ARB. The latter was followed by a maintenance phase of minimal dose Prednisone and nearly 1/2 the induction dose of Calcineurin inhibitors to decrease their long-term side effects. The results were satisfactory with 14 of the 22 patients, had complete remission. Moreover, 5 patients manifested partial remission and only 3 did not respond. Creatinine clearance was maintained in patients with complete remission yet, was mildly reduced in the partial and non-responsive ones. The safety and efficacy of such new combined drug-therapy provide new tool and future prospective in management of such relentless disease.

关键词： ACEI ARB Calcineurin Inhibitors Cyclosporine A Minimal Change Disease Mycophenolate Nephrotic Syndrome Prednisone Tacrolimus

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Superior rectus/levator complex in acquired anophthalmic socket repaired with spheric implant—a computed tomography scan and topographic study

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1483-1488页

作者： shaikha al Eid Hamad M alSulaiman Sahar M Elkhamary Osama al Sheikh alicia Ferrero-Galindo Rajiv Kandekhar Silvana A Schellini Oculoplastic Division King Khaled Eye Specialist HospitalRiyadh 11462Saudi Arabia Radiology Division King Khaled Eye Specialist HospitalRiyadh 11462Saudi Arabia Department of Diagnostic Radiology Mansoura Faculty of MedicineMansoura 35511Egypt University Hospital Rio Hortega Valladolid 47012Spain Research Department King Khaled Eye Specialist HospitalRiyadh 11462Saudi Arabia Ophthalmology Department Medical SchoolState University of Sao PauloBotucatu 18618-687Brazil

AIM:To determine whether the levator palpebrae superioris(LPS)/superior rectus(SR)muscle complex,can influence the position of the upper lid and fornix in acquired anophthalmic ***:This comparative non-randomized and non-interventional study included retrospective data of 21 patients with unilateral acquired anophthalmic sockets repaired with spheric ***-resolution computed tomography(CT)measurements of the LPM/SR muscle complex and clinical topographic position of the upper lid,superior and inferior fornix depth in primary gaze position were *** data were presented as frequency and percentage proportions and quantitative variables comparing the socket measurements with the normal contralateral orbit was statistically analyzed using non-parametric tests considering Palmic orbits had a significantly shorter LPS length(P=0.01)and significantly thicker SR(P=0.02)than the normal *** was present in anophthalmic sockets but not in normal orbits(P=0.002),while levator function was normal in both(P>0.05,all comparisons).The superior fornix depth was similar in the anophthalmic socket and the contralateral normal orbit(P=0.192)as well the inferior fornix depth(P=0.351).CONCLUSION:Acquired anophthalmic sockets repaired with spheric implants have shorter LPS,thicker SR,and more lagophthalmos than normal *** relationship of the LPS and SR with other orbital structures,associated with passive or active forces acting in the final position of the lids and external ocular prosthesis should be further investigated.

关键词： anophthalmic socket spheric implant levator palpebrae superioris superior rectus lagophthalmos fornix depth

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The Role of AI in Cyber Security: Safeguarding Digital Identity

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Journal of Information Security 2024年第2期15卷 245-278页

作者： Mohammad Binhammad shaikha alqaydi Azzam Othman Laila Hatim Abuljadayel Department of Computer Science British University Dubai Dubai The United Arab Emirates Department of Cybersecurity Dar Al Hekma University Jeddah Saudi Arabia

This article signals the use of Artificial Intelligence (AI) in information security where its merits, downsides as well as unanticipated negative outcomes are noted. It considers AI based models that can strengthen or undermine infrastructural functions and organize the networks. In addition, the essay delves into AI’s role in Cyber security software development and the need for AI-resilient strategies that could anticipate and thwart AI-created vulnerabilities. The document also touched on the socioeconomic ramifications of the emergence of AI in Cyber security as well. Looking into AI and security literature, the report outlines benefits including made threat detection precision, extended security ops efficiency, and preventive security tasks. At the same time, it emphasizes the positive side of AI, but it also shows potential limitations such as data bias, lack of interpretability, ethical concerns, and security flaws. The work similarly focuses on the characterized of misuse and sophisticated cyberattacks. The research suggests ways to diminish AI-generating maleficence which comprise ethical AI development, robust safety measures and constant audits and updates. With regard to the AI application in Cyber security, there are both pros and cons in terms of socio-economic issues, for example, job displacement, economic growth and the change in the required workforce skills.

关键词： Artificial Intelligence Cyber Attack Cyber Security Real-Time Mitigation Social Media Security AI-Driven Threat Intelligence

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Pediatric and adult liver transplantation in Bahrain: The experiences in a country with no available liver transplant facilities

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World Journal of Transplantation 2024年第1期14卷 96-111页

作者： Hasan M Isa Fatema A alkharsi Jawad K Khamis Sawsan A Hasan Zainab A Naser Zainab N Mohamed Afaf M Mohamed shaikha A altamimi Department of Pediatrics Salmaniya Medical ComplexManama 26671Bahrain Department of Pediatrics Arabian Gulf UniversityManama 26671Bahrain Department of Medicine Salmaniya Medical ComplexManama 26671Bahrain Public Health Directorate Ministry of HealthManama 26671Bahrain The Overseas Office Supreme Committee for Treatment AbroadMinistry of HealthManama 26671Bahrain

BACKGROUND Liver transplantation(LT)is a life-saving procedure for patients with end-stage liver disease and has become the standard and most effective treatment method for these *** are many indications for LT that vary between countries and *** outcome of LT depends on the available facilities and surgical expertise,as well as the types of liver graft donors *** To assess the clinical characteristics of patients from Bahrain who underwent LT overseas,and analyze factors affecting their *** In this retrospective cohort study,we reviewed the medical records and overseas committee registry information of all pediatric and adult patients who were sent overseas to undergo LT by the Pediatric and Medical Departments of Salmaniya Medical Complex and Bahrain Defence Force Hospital via the Overseas Treatment Office,Ministry of Health,Kingdom of Bahrain,between 1997 and *** data,LT indication,donor-recipient relationship,overseas LT center,graft type,post-LT medications,and LT complications,were *** measured included the overall and 5-year LT survival ***’s exact,Pearsonχ2,and Mann-Whitney U tests were used to compare the pediatric and the adults’group in terms of clinical characteristics,donor-recipient relationship,medication,complications,and *** analysis was estimated via the Kaplan-Meier’s *** and multivariate analyses were used to detect predictors of *** Of the 208 eligible patients,170(81.7%)were sent overseas to undergo LT while 38(18.3%)remained on the waiting *** the 170 patients,167(80.3%)underwent LT and were included in the *** majority of the patients were Bahraini(91.0%),and most were males(57.5%).One-hundred-and-twenty(71.8%)were adults and 47(28.3%)were *** median age at transplant was 50.0[interquartile range(IQR):14.9–58.4]*** main indication for pediatric LT was biliary atresia(31.9%),while that of adult LT was

关键词： Overseas liver transplantation End-stage liver disease Liver transplant facilities Liver donor Biliary atresia Hepatitis C

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Synthesis and Antimicrobial Studies of New Trifluoromethylpyrimidine Analogues

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Journal of Pharmacy and Pharmacology 2015年第1期3卷 9-19页

作者： shaikha Saif al-Neyadi alaa Eldin Salem Ibrahim Mahmoud Abdou Department of Chemistry University of United Arab Emirates Abu Dhabi AI-Ain 15551 United Arab Emirates

This paper describes the synthesis of a new series of trifluoromethylpyrimidine and their potential antimicrobial evaluation. We have prepared 10 novel pyrimidine derivatives in high yields and short reaction time using microwave irradiation. Compounds 4a,b and 6a,b showed good antimicrobial activity against Gram-positive bacteria; Clostridium perfringens, Bacillus pumilus and Enterococcusfaecalis. These compounds were found to be the most potent antimicrobials compared to ampicillin, tetracycline, and streptomycin that showed no activity against Enterococcusfaecalis. Compounds 4a,b and 6a,b exhibited great antimicrobial potency against all tested bacteria strains at a MIC of 3.125-100 μg/mL whereas only 4a showed the antimicrobial activity against Gram-negative bacteria Klebsiella pneumonia with a MIC value 12.5 pg/mL.

关键词： Synthesis microwave fluoropyrimidine antimicrobial.

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Dietary Habits and Oral Hygiene Practice amongst Dental Students at the College of Dentistry, Princess Nourah University

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Open Journal of Stomatology 2016年第1期6卷 28-35页

作者： Ebtissam M. al-Madi Manar alJamie shaikha al-Dukhail Zakariya Mohammed Neamat Hassan Abubakr College of Dentistry Princess Nourah bint Abdulrahman University Riyadh Kingdom of Saudi Arabia College of Dentistry King Saud University Riyadh Kingdom of Saudi Arabia Faculty of Science Northern Border University Arar Kingdom of Saudi Arabia

The aim of the present study was to assess the dietary habits and oral hygiene practice of dental students in a new dental school. A self-administered structured closed-ended questionnaire on demographic characteristics, medical history, oral hygiene and dietary habits was distributed to dental students. Results showed that One third of students indicated that they don’t consume low pH beverages (soft drinks) at all, while 48.9% drink a soft drink or two a day. Students took varying amount of time to consume their drinks. The majority of participants consumed citric juices, fruits and/or pickles at least once a day. 91.3% of students use either soft (41.8%) or medium (49.5%) toothbrush. Only a fifth (16.9%) of the students brush their teeth after drinking soft drinks and 58.2% brush their teeth after vomiting. In conclusion, young adults need to be aware about their dietary habits & oral hygiene, and also a proper dental health program needs to be applied.

关键词： Dietary Habits Oral Hygiene Practice Low pH Soft Drinks

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Accidental ingestion of foreign bodies/harmful materials in children from Bahrain:A retrospective cohort study

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世界临床儿科杂志 2023年第4期12卷 205-219页

作者： Hasan M Isa shaikha A aldoseri Aysha S Abduljabbar Khaled A alsulaiti Department of Pediatrics Salmaniya Medical ComplexManama 26671Bahrain Department of Pediatrics Arabian Gulf UniversityManama 26671Bahrain Department of Radiology Salmaniya Medical ComplexManama 26671Bahrain

BACKGROUND Children like to discover their environment by putting substances in their *** behavior puts them at risk of accidentally ingesting foreign bodies(FBs)or harmful materials,which can cause serious *** To study the clinical characteristics,diagnosis,complications,management,and outcomes of accidental ingestion of FBs,caustics,and medications in *** We conducted a retrospective cohort study of all children admitted for accidental ingestion to the Department of Pediatrics,Salmaniya Medical Complex,Bahrain,between 2011 and *** data,type of FB/harmful material ingested,and investigations used for diagnosis and management were *** patients were divided into three groups based on the type of ingested material(FBs,caustics,and medications).The three groups were compared based on patient demographics,socioeconomic status(SES),symptoms,ingestion scenario,endoscopic and surgical complications,management,and *** FB anatomical location was categorized as the esophagus,stomach,and bowel and compared with respect to *** Fisher’s exact,Pearson’s χ^(2),Mann-Whitney U,and Kruskal-Wallis tests were used for *** A total of 161 accidental ingestion episodes were documented in 153 *** children were boys(n=85,55.6%),with a median age of 2.8(interquartile range:1.8-4.4)*** participants ingested FBs(n=108,70.6%),31(20.3%)ingested caustics,and the remaining 14(9.2%)ingested *** with caustic ingestion were younger at the time of presentation(Pal FBs were symptomatic(n=14/16,87.5%),whereas most gastric(n=34/56,60.7%)and intestinal FBs(n=19/32,59.4%)were asymptomati

关键词： Pediatric Accidental ingestion Foreign body Caustic Complication Bahrain

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Targeting PPAR<i>γ</i>Receptor Using New Phosphazene Derivative Containing Thiazolidinedione: Design, Synthesis, and Glucose Uptake

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Open Journal of Medicinal Chemistry 2020年第2期10卷 35-45页

作者： shaikha S. al Neyadi Abdu Adem Naheed Amir Ibrahim M. Abdou Department of Chemistry College of Science UAE University Al-Ain UAE Department of Pharmacology College of Health and Science UAE University Al-Ain UAE

The peroxisome proliferator activator receptor-γ (PPAR-γ) remained the most effective target for management of diabetes mellitus. The present work endeavors rational designing new PPAR-γ agonist bearing cyclotriphosphazene and thiazolidine-2,4-dione scaffolds. Thiazolidinedione (TZD) derivatives are the novel class of oral antidiabetic drugs which are selective agonist for the nuclear PPARγ that enhances the transcription of several insulin responsive genes but TZDs are known to cause weight gain, hepatotoxicity and fluid retention. So, cyclotriphosphazene containing thiazolidine-2,4-dione was designed, synthesized as PPARγ agonist. The in-vitro antidiabetic activity showed that compound 8 has similar activity and exhibited higher glucose uptake in comparison to pioglitazone as reference drugs. This research opened new avenues for smart designing of molecules with high efficiency towards the management of hyperglycemia.

关键词： Type 2 Diabetes PPARs TZD Compound Cyclotriphosphazene

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Design, Synthesis, <i>in Vitro</i>Antibacterial Activity, and Docking Studies of New Rhodanine Derivatives

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Open Journal of Medicinal Chemistry 2020年第1期10卷 15-34页

作者： Aisha Abusetta Jowhara alumairi Mariam Y. alkaabi Ruba al Ajeil Asma Abu Shkaidim Dana Akram J. Pajak Mohammad A. Ghattas Noor Atatreh shaikha S. alNeyadi Department of Chemistry College of Science UAE University Al-Ain UAE College of Pharmacy Al Ain University of Science and Technology Al Ain UAE

Bacterial infections present a serious challenge to healthcare practitioners due to the emergence of resistance to numerous conventional antibacterial drugs. Therefore, new bacterial targets and new antimicrobials are unmet medical needs. Rhodanine derivatives are known to possess potent antimicrobial activities. In this study, we determined the activity spectrum of a series of new rhodanine derivatives against representative Gram-positive and Gram-negative bacterial strains. Compounds 3a and 5a had the highest activity with minimum inhibitory concentrations in the range of 1.12 - 2.5 μg/mL. Transmission electron microscope results confirmed that activities against bacteria occurred via rupturing of the cell wall. Molecular modeling results suggested that rhodanine derivatives have the potential to irreversibly bind to the penicillin-binding protein (PBP) Ser62 residue in the active site. Thus, our results suggested that these rhodanine derivatives could be potential antibacterial drug candidates with strong activity against Gram-negative bacteria.

关键词： Rhodanine Compounds PBP β-Lactamase Enzyme Docking

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Predictors of Complications after Sheath Removal Post Transfemoral Percutaneous Coronary Interventions

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Open Journal of Nursing 2016年第6期6卷 497-504页

作者： Abdul-Monim Batiha Hayat Sulieman Abu-shaikha Fadwa N. alhalaiqa Reem Ahmad Jarrad Hasan Jamal Abu Ramadan Faculty of Nursing Philadelphia University Amman Jordan Faculty of Nursing The University of Jordan Amman Jordan Saudi Red Crescent Riyadh Saudi Arabia

Background: Complications post percutaneous coronary interventions (PCI) are more threatening than it was previously thought so that necessary measures should be taken to minimize those risks. Objective: To identify the risk factors related to patient and procedure which could be used as predictors of complications after sheath removal post PCI. Methods: The study used a prospective non-experimental correlational descriptive. Design: The sample was chosen conveniently from three different hospitals and included 118 patients who were subjected to PCI. Results: Three models were used to predict complications. In the first model, none of the baseline variables were predictive of complications. In the second model, the only type of procedure (diagnostic, stent or balloon) was predictive of complications. In the third model, compression time was found to be a risk factor and a predictor of complications after sheath removal. Conclusion: Nurses and medical professionals are in a vital position to prevent, detect and manage PCI complications at the earliest possible opportunity. It is a must to assess and categorize patients in accordance with their risk level to develop post PCI and post sheath removal complications, in order to plan management strategies to decrease the health costs and the suffering.

关键词： Complications Jordan Percutaneous Coronary Interventions Sheath Removal Transfemoral

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