Synthesis and Antimicrobial Studies of New Trifluoromethylpyrimidine Analogues
Synthesis and Antimicrobial Studies of New Trifluoromethylpyrimidine Analogues作者机构：Department of Chemistry University of United Arab Emirates Abu Dhabi AI-Ain 15551 United Arab Emirates
出 版 物：《Journal of Pharmacy and Pharmacology》 (药剂与药理学（英文版）)
年 卷 期：2015年第3卷第1期
页 面：9-19页
学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学]
主 题：Synthesis microwave fluoropyrimidine antimicrobial.
摘 要：This paper describes the synthesis of a new series of trifluoromethylpyrimidine and their potential antimicrobial evaluation. We have prepared 10 novel pyrimidine derivatives in high yields and short reaction time using microwave irradiation. Compounds 4a,b and 6a,b showed good antimicrobial activity against Gram-positive bacteria; Clostridium perfringens, Bacillus pumilus and Enterococcusfaecalis. These compounds were found to be the most potent antimicrobials compared to ampicillin, tetracycline, and streptomycin that showed no activity against Enterococcusfaecalis. Compounds 4a,b and 6a,b exhibited great antimicrobial potency against all tested bacteria strains at a MIC of 3.125-100 μg/mL whereas only 4a showed the antimicrobial activity against Gram-negative bacteria Klebsiella pneumonia with a MIC value 12.5 pg/mL.
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