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Identifying potential compounds from Bacopa monnieri(brahmi)against coxsackievirus A16 RdRp targeting HFM disease(tomato flu)

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Medicine in Novel Technology and Devices 2023年第4期20卷 87-104页

作者： parveen Punia Arun Prajapati Priyasha Maitra Avinash Mishra Pt.Neki Ram Sharma Government College RohtakHaryana124001India Growdea Technologies Pvt.Ltd. Gurugram.Haryana122004India

Hand,foot,and mouth disease(HFMD),primarily instigated by Coxsackievirus A16(CVA16),poses a serious health concern,necessitating effective therapeutic *** RNA-dependent RNA polymerase(RdRp)of CVA16 emerges as a promising drug target for HFMD *** study presents an in-silico pipeline for the identification of potential RdRp inhibitors against CVA16.A library of 91 natural compounds derived from Bacopa monnieri(brahmi)was virtually screened against the CVA16 ***,Bacobitacin D emerged as a promising hit molecule,forming 8 hydrogen bonds including key catalytic site residues(Asp^(238)and Asp^(329))within the RdRp active ***,molecular dynamics(MD)simulations and MM/GBSA binding free energy calculations was applied on the top three hits that were selected based on exhaustive docking scores(≤-9.55 kcal/mol).Bacobitacin D exhibited sustainable stability,as evidenced by minimal deviation(RMSD=0.75±0.02 nm)during a 100 ns MD ***,Bacopaside IV exhibited the lowestΔGTOTAL binding free energy(-23.70 kcal/mol),while Bacobitacin D displayed a comparableΔGTOTAL of19.14 kcal/*** interpretation of the most populated cluster derived from MD simulations showed direct interactions of Bacobitacin D with pivotal catalytic residues,including Asp^(238)and Ser^(289).This comprehensive study confirmed Bacobitacin D as a potent inhibitor of CVA16 RdRp,offering a potential avenue for therapeutic intervention against *** validation is required to confirm the inhibitory action of Bacobitacin D against HFMD.

关键词： RNA-Dependent RNA polymerase Hand Foot And mouth disease Coxsackievirus Molecular dynamics simulation Molecular mechanics with generalized born andsurface area solvation binding free energy Virtual screening

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Systematic study of the product((E(2_2^+)/E(2_1^+)) * B(E2)↑) through the asymmetric rotor model

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Chinese Physics C 2016年第9期40卷 58-62页

作者： parveen Kumari H.M.Mittal Dr.B.R.Ambedkar National Institute of Technology

A systematic study of the product（（E（22^＋）/E（21^＋））＊B（E2）↑） is carried out in the major shell space Z=50-82,N=82-126 within the framework of the asymmetric rotor model where the asymmetry parameter γ0reflects change in the nuclear structure.A systematic study of the product（（E（2^＋）/E（2^＋））＊B（E2）↑） with neutron number N is also *** product（（E（22^＋）/E（21^＋））＊B（E2）↑） provides a direct correlation with the asymmetry parameter γ*** effect of subshells is visible in Ba-Gd nuclei with N 〉 82,but not in Hf-Pt nuclei with N 〉 *** study,for the first time,the dependency of the product（（E（22^＋）/E（21^＋））＊B（E2）↑） on the asymmetry parameterγ0.

关键词： nuclear structure asymmetric rotor model reduced electric quadrupole transition probability

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Analysis of biomarkers for the cross-linkage of formaldehyde with bovine serum albumin peptides

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Chinese Science Bulletin 2008年第21期53卷 3287-3293页

作者： AHMAD Waqar DENG YuLin LI Bo LI LiLi AHAMD Manzoor IQBAL Zafar parveen Zahida School of Life Science and Technology Beijing Institute of Technology Beijing 100081 China HEJ Research Institute of Chemistry University of Karachi Karachi-75270 Pakistan Department of Pharmacy University of Peshawar Peshawar-25000 Pakistan

Formaldehyde,a well-known environmental toxic hazard,has been found to produce endogenously via semicarbazide-sensitive amine oxidase-catalyzed oxidative deamination of *** diabetes,the activity of SSAO has been found to increase with a subsequent increase in endogenous formalde-hyde *** has been postulated that SSAO-induced production of formaldehyde may be in-volved in the alteration of protein structure,which may subsequently cause protein deposition associ-ated with chronic pathological *** has also been found to react(cross-link) with amino group of the N-terminal amino acid residue and with the side-chains of arginine,cysteine,his-tidine and lysine ***,formaldehyde may be responsible,at least in part,for protein cross-linkage,oxidative stress and *** cross-linking of formaldehyde with bovine serum albumin was studied using LC-MS and Mascot *** peptides sequence for control BSA(un-treated) digested with trypsin was matched in the online database search query by exporting the MS/MS data to online MASCOT *** this way,a total of twenty-seven peptides were matched in the database search *** twenty-seven peptides were then searched manually in all of the tryptic BSA samples treated with different concentrations of FA that were incubated in different time *** formaldehyde-treated BSA peptides(FKDLGEEHFK,HLVDEPQNLIK,KVPQVSTPTLVEVSR,RPCFSALTPDETYVPK,LVNELTEFAK,DAFLGSFLYEYSR) were found to be the possible markers for formaldehyde-protein/peptides adducts.

关键词：甲醛牛血清白蛋白时标生物标志物

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Characterization of Endophytic Microorganisms of Rice(Oryza sativa L.)Potentials for Blast Disease Biocontrol and Plant Growth Promoting Agents

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Phyton-International Journal of Experimental Botany 2023年第11期92卷 3021-3041页

作者： Shugufta parveen Fayaz A.Mohiddin M.Ashraf Bhat Zahoor Ahmed Baba Fehim Jeelani M.Anwar Bhat Sajad Un Nabi Burhan Hamid Saba Bandey Farhanaz Rasool Zakir Amin Ibrahim Al-Ashkar Muhammad Adnan Ayman El Sabagh Division of Plant Pathology Faculty of AgricultureSher-e-Kashmir University of Agricultural Sciences and Technology of KashmirWaduraIndia Mountain Research Centre for Field Crops SKUAST-KashmirKhudwaniIndia Division of Genetics and Plant Breeding Faculty of AgricultureSher-e-Kashmir University of Agricultural Sciences and Technology of KashmirWaduraIndia Division of Microbiology Faculty of AgricultureSher-e-Kashmir University of Agricultural Sciences and Technology of KashmirWaduraIndia Division of Statistics Faculty of AgricultureSher-e-Kashmir University of Agricultural Sciences and Technology of KashmirWaduraIndia Division of Agronomy Faculty of AgricultureSher-e-Kashmir University of Agricultural Sciences and Technology of KashmirWaduraIndia Indian Council of Agricultural Research-Central institute of Temperate Horticulture(ICAR-CITH) Old AirportRangrethSrinagarIndia Division of Plant Pathology Faculty of HorticultureSher-e-Kashmir University of Agricultural Sciences and Technology of KashmirShalimarIndia Directorate of Extension Sher-e-Kashmir University of Agricultural Sciences and Technology of KashmirShalimarIndia Department of Plant Production College of Food and Agriculture SciencesKing Saud UniversityRiyadhSaudi Arabia College of Food Agricultural and Environmental SciencesThe Ohio State UniversityColumbusOHUSA Department of Agronomy Faculty of AgricultureUniversity of KafrelsheikhKafrelsheikhEgypt

One hundred twenty-five endophytic microorganisms were isolated from the roots,stems,and leaves of four prominent rice cultivars growing in temperate *** potential to combat rice blast disease and promote plant growth was *** dual culture tests highlighted the strong antagonistic activity of five fungal(ranging from 89%–70%)and five bacterial(72%–61%)*** examination focused on volatile compounds produced by selected isolates to counter the blast *** these,the highest chitinase(13.76μg mL−1)and siderophore(56.64%),was exhibited by Aspergillus flavus,and the highest HCN production was shown by Stenotrophomonas maltophilia(36.15μM mL−1).In terms of growth promotion traits,Aspergillus flavus and Enterobacter cloacae excelled in activities viz,phosphorous solubilization,ammonia production,auxin and gibberellic acid production,and nitrogen *** Identity of these endophytes was confirmed through molecular analysis as Trichoderma afroharzianum,Trichoderma harzianum,Penicillium rubens,Aspergillus flavus,Stenotrophomonas rhizophila,Stenotrophomonas maltophilia,Bacillus cereus,Enterobacter cloacae,and Bacillus *** greenhouse conditions,the highest disease control was shown by isolate Bacillus licheniformis and *** with an inhibition of 79%,followed by ***(77%)and ***(73%).The overall results of this study showed that Bacillus licheniformis and Stenotrophomonas rhizophila have great potential to be used as bio-stimulant and biocontrol agents to manage rice blast disease.

关键词： Endophytes phylogeny antagonistic activity Pyricularia phytohormones

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Effect of Y-Methacryloxypropyltrimethoxysilane (MPS) and Tetraethoxysilane (TEOS) Towards Preparation of Oil Absorbent Foams from Polyvinyl Alcohol (PVA) Reinforced with Microfibrillated Cellulose (MFC)

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Journal of Renewable Materials 2020年第7期8卷 739-757页

作者： Dzun Noraini Jimat Sharifah Shahira Syed Putra parveen Jamal Wan Mohd Fazli Wan Nawawi Mohammed Saedi Jami Department of Biotechnology Engineering Kulliyyah of EngineeringInternational Islamic University MalaysiaKuala Lumpur50728Malaysia

Increasing usage of foams in various industry sectors had causing serious disposal problems once it reaches the end of its ***,PVA-MFC foam was prepared by freeze-drying using polyvinyl alcohol(PVA)and microfibrillated cellulose(MFC)as a reinforced material from sugarcane bagasse(SCB).In this study,the PVA-MFC foam was chemically silylated with Y-methacryloxypropyltrimethoxysilane(MPS)and tetraethoxysilane(TEOS).The wetting ability and mechanical strength of the silylated_(2,20)PVA-MFC foam was greatly enhanced compared with unmodified_(2,20)PVA-MFC *** silane chemicals(MPS and TEOS)had been confirmed grafted on_(2,20)PVA-MFC foam due to the presence of Si-C and Si-O-C stretching vibration as showed in Fourier Transform Infrared(FTIR)spectra and cloud-like coating of porous pore was observed in scanning electron microscopy(SEM)*** silylated_(2,20)PVA-MFC foam(MPS and TEOS)exhibited a series of desirable properties such as lower swelling ratio and high absorption capacity of solvents and oils but had low thermal stability in thermogravimetric(TGA)*** characterization of_(2,20)PVA-MFC foam using TEOS was further investigated.A significant difference in morphology was clearly observed between the unmodified and silylated_(2,20)PVA-MFC-TEOS foam through field emission scanning electron microscopy(FESEM)*** X-ray photoelectron(XPS)analysis of silylated_(2,20)PVA-MFC-TEOS foam confirmed the presence of C,O and trace amount of Si *** synthesized_(2,20)PVA-MFC foam could be a promising material for broad range of polymer foam applications.

关键词： Polyvinyl alcohol foam microfibrillated cellulose sugarcane bagasse Y-methacryloxypropyltrimethoxysilane tetraethoxysilane and oil absorbent

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Isolated tuberculous splenic abscess in an immunocompetent individual

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Asian Pacific Journal of Tropical Medicine 2011年第1期4卷 81-82页

作者： parveen Rana Kundu SK Mathur Sunita Singh Amrita Duhan Garima Aggarwal Rajeev Sen Department of Pathology Pt.B.D.Sharma PGIMSIndia

Tuberculosis(TB) of the spleen is an extremely rare clinical entity particularly among immunocompetent *** report a case of isolated tuberculous abscess of spleen in a 13- years- old *** primary focus of infection was detected in lungs or any other *** patient was treated by splenectomy after a therapeutic failure with standard antituberculous medication.

关键词： Spleen Tuberculosis Abscess

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Antimicrobial Agents from Selected Medicinal Plants in Libya

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Chinese Journal of Integrative Medicine 2016年第3期22卷 177-184页

作者： Hasan MH Muhaisen Miftah Mailoud Ab-Mous Fadel A Ddeeb Aboclaid All Rtemi Omer M Taba Mehtab parveen Faculty of Science and Arts Sharora University of Najran Saudi Arabia Faculty of Science University of Al-Jabal AI- Gharbi EI-Zintan- Libya Department of Chemistry Aligarh Muslim University Aligarh 202002 India

Objective： To test the in vitro antimicrobial efficacy of water and methanol extracts of 23 plant species that are commonly used in Libyan folk medicine. Methods： The antimicrobial activity was determined using the well-diffusion method. Four test microorganisms were used namely, Escherichia coil, Salmonella species, Staphylococcus aureus and Bacillus subtilis. The minimum inhibitory concentration （MIC） was determined for the high biologically active crude plant extracts. Results： Among 23 medicinal plants used in the study, only 5 methanolic extracts [Rosmarinus offcinalis L., Carduus marianium L., Lantana camara L., Rhus tripartite （ueria） Grande, and Thymus capitatus （L.） Hoffm （link）] showed the highest antimicrobial activity against Staphylococcus aureus, Bacillus subtilis and Salmonella species, while 22 methanolic and aqueous extracts showed moderate to weak antimicrobial activity on all tested organisms. However 19 of the extracts showed no activity at all against Gram -ve and Gram ＋ve microorganisms. MIC was found to be 1.25 mg/mL （Thymus capitatus）, 3 mg/mL （Rhus tripartite）, 4 mg/mL （Carduus marianium）, 5 mg/mL （Rosamarinus officinalis） and 5 mg/mL （Lantana camara）, respectively. Condusions： The present results revealed that, crude methanolic extracts of the investigated Libyan folk medicinal plants exhibited mild to high in vitro antibactedal activities against Gram-positive and Gram-negative microorganisms.

关键词： medicinal plant extracts antimicrobial activity minimum inhibitory concentration Ubyan folk medicine

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Effect of Special Finishes on the Functional Properties of Cotton Fabrics

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Journal of Textile Science and Technology 2018年第2期4卷 49-66页

作者： Kawser parveen Chowdhury Department of Wet Process Engineering Faculty of Textile Chemical Engineering Bangladesh University of Textiles Dhaka Bangladesh

This study demonstrated that the changes in functional properties of both woven and knit cotton fabrics were determined to evaluate the performance of different special finishes. Here, 100% cotton fabrics were treated with different types of finishing chemicals at different formulations. To assess the performance of different finishes on fabric properties, GSM, bursting strength, tensile strength, dimensional stability, absorbency, crease recovery angle with ASTM and AATCC methods were done. The results showed that the functional properties of the finished cotton fabrics both woven and knit depend to a great extent on the type of finish.

关键词： Water Repellent Finish Wrinkle Free Finish Soft Finish Paper Touch Finish Knit Fabric Woven Fabric Performance

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Impact of Different Water Repellent Finishes on Cotton Double Jersey Fabrics

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Journal of Textile Science and Technology 2018年第3期4卷 85-99页

作者： Kawser parveen Chowdhury Department of Wet Process Engineering Bangladesh University of Textiles Dhaka Bangladesh

This study demonstrated that the variation in physical and chemical performance on cotton double jersey knit fabrics was decided by the knit structure, water repellent chemicals types and their concentration. Here, two types of double jersey fabrics were treated with different types of water repellent chemicals at different formulations to evaluate the performance of water repellent finishes on knit fabrics properties. The levels of water repellency of the fabrics were assessed by AATCC 127 hydrostatic head test method and by ISO 4920:2012 spray rating test method. To evaluate the performance of water repellent finishes on knit fabric properties, GSM, bursting strength test according to ASTM (D 3786-87) method, air permeability, color fastness to wash, water, perspiration, chlorinated water and color fastness to rubbing with ISO method were done. The results showed that both physical and chemical properties of the finished cotton knits, depend to a great extent on knit structure, the water repellent finish type and concentration to obtain water repellent fabrics with desirable properties.

关键词： Water Repellency Water Repellent Finish Double Jersey Fabric Fluorocarbon

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A selective approach to the surgical management of periampullary cancer patients and its outcome

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Hepatobiliary & Pancreatic Diseases International 2014年第6期13卷 628-633页

作者： Omar J Shah Irfan Robbani parveen Shah Sadaf A Bangri Irfan J Khan Mohammad Y Bhat Manmohan Singh Departments of Surgical Gastroenterology Sher-i-Kashmir Institute of Medical Sciences Srinagar Kashmir India Radiodiagnosis & Imaging Sher-i-Kashmir Institute of Medical Sciences Srinagar Kashmir India Pathology Sher-i-Kashmir Institute of Medical Sciences Srinagar Kashmir India Departments of Surgical Gastroenterology Sher-i-Kashmir Institute of Medical Sciences Srinagar Kashmir India Departments of Surgical Gastroenterology Sher-i-Kashmir Institute of Medical Sciences Srinagar Kashmir India

BACKGROUND： Pancreaticoduodenectomy is a high risk, complex, technically challenging operation associated with significant perioperative morbidity and mortality. This study on the surgical management of periampullary cancer patients is based on our experience in a period of nearly 13 years. METHODS： The study was conducted on two groups of patients： group A included 42 patients who were treated between January 2000 and September 2005 and group B included 134 patients who were treated between October 2005 to October 2012. Preoperative, intraoperative and postoperative details of all these patients were collected, tabulated and analyzed to assess the impact of the selective approach introduced in the department with effect from October 2005. RESULTS： Intraoperative details revealed highly significant differences in the management of the two groups of patients in respect of operative time （250.4 vs 126.6 minutes; P〈0.001）, operative blood loss （1070.2 vs 414.9 mL; P〈0.001） and intraoperative blood transfusion （1A vs 0.2 units; P〈0.001）. Variations between the two groups in the frequency of complications were found to be statistically insignificant. However, the difference between the two groups in the overall morbidity of patients （47.6% vs 26.1%; P=0.009） and the length of their hospital stay （11.8 vs 7.8 days; P〈0.001） were significant. CONCLUSION： A selective approach applied to the surgical management of periampullary cancer patients is a step in the right direction.

关键词： pancreaticoduodenectomy superior approach technique Whipple's operation

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