Antimicrobial Agents from Selected Medicinal Plants in Libya

作     者：Hasan MH Muhaisen Miftah Mailoud Ab-Mous Fadel A Ddeeb Aboclaid All Rtemi Omer M Taba Mehtab Parveen 

作者机构：Faculty of Science and Arts Sharora University of Najran Saudi Arabia Faculty of Science University of Al-Jabal AI- Gharbi EI-Zintan- Libya Department of Chemistry Aligarh Muslim University Aligarh 202002 India 

出 版 物：《Chinese Journal of Integrative Medicine》 (中国结合医学杂志（英文版）)

年 卷 期：2016年第22卷第3期

页      面：177-184页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

主　　题：medicinal plant extracts antimicrobial activity minimum inhibitory concentration Ubyan folk medicine 

摘      要：Objective： To test the in vitro antimicrobial efficacy of water and methanol extracts of 23 plant species that are commonly used in Libyan folk medicine. Methods： The antimicrobial activity was determined using the well-diffusion method. Four test microorganisms were used namely, Escherichia coil, Salmonella species, Staphylococcus aureus and Bacillus subtilis. The minimum inhibitory concentration （MIC） was determined for the high biologically active crude plant extracts. Results： Among 23 medicinal plants used in the study, only 5 methanolic extracts [Rosmarinus offcinalis L., Carduus marianium L., Lantana camara L., Rhus tripartite （ueria） Grande, and Thymus capitatus （L.） Hoffm （link）] showed the highest antimicrobial activity against Staphylococcus aureus, Bacillus subtilis and Salmonella species, while 22 methanolic and aqueous extracts showed moderate to weak antimicrobial activity on all tested organisms. However 19 of the extracts showed no activity at all against Gram -ve and Gram ＋ve microorganisms. MIC was found to be 1.25 mg/mL （Thymus capitatus）, 3 mg/mL （Rhus tripartite）, 4 mg/mL （Carduus marianium）, 5 mg/mL （Rosamarinus officinalis） and 5 mg/mL （Lantana camara）, respectively. Condusions： The present results revealed that, crude methanolic extracts of the investigated Libyan folk medicinal plants exhibited mild to high in vitro antibactedal activities against Gram-positive and Gram-negative microorganisms.