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Poly-L-ornithine blocks the inhibitory effects of fibronectin on oligodendrocyte differentiation and promotes myelin repair

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Neural Regeneration Research 2023年第4期18卷 832-839页

作者： Ya-Jie Xiong shahid hussain soomro Zhong-Hai Huang Pan-Pan Yu Jie Ping Hui Fu Department of Anatomy School of Basic Medical SciencesWuhan UniversityWuhanHubei ProvinceChina Guangdong-Hongkong-Macao Institute of CNS Regeneration Ministry of Education Joint International Research Laboratory of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Pharmacology School of Basic Medical SciencesWuhan UniversityWuhanHubei ProvinceChina

The extracellular matrix surrounding oligodendrocytes plays an important role during myelination and remyelination in the *** many cases,the microenvironment surrounding demyelination lesions contains inhibitory molecules,which lead to repair ***,blocking the activity of these inhibitory factors in the extracellular matrix should lead to more successful *** the central nervous system,oligodendrocytes form the myelin *** performed primary cell culture and found that a natural increase in fibronectin promoted the proliferation of oligodendrocyte progenitors during the initial stage of remyelination while inhibiting oligodendrocyte ***-L-ornithine blocked these inhibitory effects without compromising fibronectin’s pro-proliferation *** showed that poly-L-ornithine activated the Erk1/2 signaling pathway that is necessary in the early stages of differentiation,as well as PI3K signaling pathways that are needed in the mid-late *** poly-L-ornithine was tested in a lysolecithin-induced animal model of focal demyelination,it enhanced myelin regeneration and promoted motor function *** findings suggest that poly-L-ornithine has the potential to be a treatment option for clinical myelin sheath injury.

关键词： differentiation Erk1/2 extracellular matrix fibronectin lysolecithin-induced demyelination oligodendrocyte PI3K poly-L-ornithine proliferation remyelination

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Experimental Study on Heat Storage Properties Comparison of Paraffin/Metal Foams Phase Change Material Composites

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Journal of Thermal Science 2024年第2期33卷 469-478页

作者： Waqar AHMED Abid hussain Hanzla shahid Imran ALI Hafiz Muhammad ALI Department of Mechanical Engineering University of Engineering and TechnologyTaxila47080Pakistan Department of Mechanical Engineering Institute of Space TechnologyIslamabadPakistan Department of Mechanical Mechatronics and Manufacturing EngineeringUniversity of Engineering and Technology LahoreFaisalabad CampusPunjabPakistan Mechanical Engineering Department King Fahd University of Petroleum and MineralsDhahran31261Saudi Arabia Interdisciplinary Research Center for Renewable Energy and Power Systems(IRC-REPS) King Fahd University of Petroleum and MineralsDhahran31261Saudi Arabia

Heat storage properties of phase change materials(PCMs) are essential characteristics that perform a key role in thermal heat energy storage *** thermal properties of PCMs can be improved by developing metal foam/PCM *** addition of metal foam in PCMs has a significant effect on the thermal characteristics of *** this paper,the heat storage properties of two different metal foam/PCM composites were experimentally *** behavior of paraffin in metal foam(copper and iron-nickel)/paraffin composites concerning pure paraffin at a constant heat flux of 1000 W/m^(2) in three directions simultaneously(x,y,and z) was *** was infiltrated into copper and iron-nickel foams to develop composite materials which resulted in enhancing the thermal conductivity of the paraffin.A comparative analysis is made on the heat storage properties of paraffin in copper and iron-nickel foams/paraffin *** temperature distribution during the phase transition process is experimentally *** comparison indicates that temperature uniformity in copper foam/paraffin composite is better than in iron-nickel foam/paraffin composite and pure paraffin at the same heat *** results show that at heat flux of 1000 W/m^(2),the heat storage time for copper foam/paraffin composite is 20.63% of that of iron-nickel foam/paraffin composite.

关键词： heat storage capacity paraffin/metal foam composite temperature uniformity heat storage rate phase transition process

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Einstein Hybrid Structure of q-Rung Orthopair Fuzzy Soft Set and Its Application for Diagnosis of Waterborne Infectious Disease

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1863-1892页

作者： Rana Muhammad Zulqarnain Hafiz Khalil ur Rehman Imran Siddique HijazAhmad Sameh Askar shahid hussain Gurmani School of Mathematical Sciences Zhejiang Normal UniversityJinhua321004China Department of Mathematics Government College UniversityFaisalabad38000Pakistan Department of Mathematics University of SargodhaSargodha40100Pakistan Section of Mathematics International Telematic University UninettunoCorso Vittorio Emanuele IIRoma3900186Italy Near East University Operational Research Center in HealthcareNear East BoulevardNicosia/Mersin 1099138Turkey Department of Statistics and Operations Research College of ScienceKing Saud UniversityPO Box 2455Riyadh11451Saudi Arabia

This research is devoted to diagnosing water-borne infectious diseases caused by floods employing a novel diagnosis approach,the Einstein hybrid structure of q-rung orthopair fuzzy soft *** approach integrates parts of fuzzy logic and soft set theory to develop a robust alternative for disease detection in stressful situations,especially in areas affected by *** to the traditional intuitionistic fuzzy soft set and Pythagorean fuzzy soft set,the q-rung orthopair fuzzy soft set(q-ROFSS)adequately incorporates unclear and indeterminate *** major objective of this investigation is to formulate the q-rung orthopair fuzzy soft Einstein hybrid weighted average(q-ROFSEHWA)operator and its specific ***,our stated operator is implementing intelligentmulti-criteria group decision-making(MCGDM)*** are severe natural catastrophes that raise the risk of diseases and epidemics,particularly those caused by contaminants in the water,such as gastrointestinal diseases,respiratory infections,vector-borne diseases,skin infections,and water-borne *** designed MCGDM strategy tackles the prevalence of certain conditions in flood-affected patients.A comparative investigation determined that the suggested method for detecting water-borne infectious disease due to floods is more effective and productive than conventional methods because of its logical structure.

关键词： q-rung orthopair fuzzy soft set q-ROFSEHWA operator MCGDM environmental disaster water-born infection disease

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Emerging strategies and developments in oxygen reduction reaction using high-performance platinum-based electrocatalysts

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Nano Research 2024年第5期17卷 3516-3532页

作者： Asad Ali Aatto Laaksonen Guo Huang shahid hussain Shuiping Luo Wen Chen Pei Kang Shen Jinliang Zhu Xiaoyan Ji Energy Engineering Division of Energy ScienceLuleåUniversity of Technology97187 LuleåSweden Department of Materials and Environmental Chemistry Arrhenius LaboratoryStockholm UniversitySE-10691 StockholmSweden Center of Advanced Research in Bionanoconjugates and Biopolymers “Petru Poni”Institute of Macromolecular ChemistryIasi 700469Romania State Key Laboratory of Materials-Oriented and Chemical Engineering Nanjing Tech UniversityNanjing 211816China College of Materials Science and Engineering Shenzhen UniversityShenzhen 518060China School of Resources Environment and MaterialsState Key Laboratory of Processing for Non-ferrous Metal and Featured MaterialsGuangxi UniversityNanning 530004China

The global practical implementation of proton exchange membrane fuel cells(PEMFCs)heavily relies on the advancement of highly effective platinum(Pt)-based electrocatalysts for the oxygen reduction reaction(ORR).To achieve high ORR performance,electrocatalysts with highly accessible reactive surfaces are needed to promote the uncovering of active positions for easy mass *** this critical review,we introduce different approaches for the emerging development of effective ORR electrocatalysts,which offer high activity and *** strategies,including morphological engineering,geometric configuration modification via supporting materials,alloys regulation,core-shell,and confinement engineering of single atom electrocatalysts(SAEs),are discussed in line with the goals and requirements of ORR performance *** review the ongoing development of Pt electrocatalysts based on the syntheses,nanoarchitecture,electrochemical performances,and *** eventually explore the obstacles and research directions on further developing more effective electrocatalysts.

关键词： oxygen reduction reaction(ORR) Pt-based electrocatalysts proton exchange membrane fuel cells(PEMFCs) morphology and alloys strategies single atom electrocatalysts(SAEs)

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M_(4)X_(3) MXenes:Application in Energy Storage Devices

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Nano-Micro Letters 2024年第10期16卷 522-542页

作者： Iftikhar hussain Waqas Ul Arifeen shahid Ali Khan Sikandar Aftab Muhammad Sufyan Javed Sajjad hussain Muhammad Ahmad Xi Chen Jiyun Zhao PRosaiah Khaled Fahmi Fawy Adnan Younis Sumanta Sahoo Kaili Zhang Department of Mechanical Engineering City University of Hong Kong83 Tat Chee AvenueKowloon TongHong KongPeople's Republic of China School of Mechanical Engineering Yeungnam UniversityDaehak-roGyeongsan-siGyeongbuk-do 38541South Korea Department of Semiconductor Systems Engineering and Clean Energy Sejong UniversitySeoul 05006Republic of Korea School of Physical Science and Technology Lanzhou UniversityLanzhou 730000People's Republic of China Department of Nanotechnology and Advanced Materials Engineering Sejong UniversitySeoul 05006Republic of Korea Department of Physics Saveetha School of EngineeringSaveetha Institute of Medical and Technical Sciences(SIMATS)ThandalamChennai 602105India Department of Chemistry Faculty of ScienceKing Khalid UniversityP.O.Box 900461413 AbhaSaudi Arabia Department of Physics College of ScienceUnited Arab Emirates UniversityP.O.Box 15551Al-AinUnited Arab Emirates School of Chemical Engineering Yeungnam UniversityGyeongsanGyeongbuk 38541South Korea

MXene has garnered widespread recognition in the scientific com-munity due to its remarkable properties,including excellent thermal stability,high conductivity,good hydrophilicity and dispersibility,easy processability,tunable surface properties,and admirable *** have been categorized into different families based on the number of M and X layers in M_(n+1)X_(n),such as M_(2)X,M_(3)X_(2),M_(4)X_(3),and,recently,M_(5)X_(4).Among these families,M_(2)X and M_(3)X_(2),par-ticularly Ti_(3)C_(2),have been greatly explored while limited studies have been given to M_(5)X_(4)MXene ***,studies on the M_(4)X_(3)MXene family have developed recently,hence,demanding a compilation of evaluated ***,this review provides a systematic overview of the latest advancements in M_(4)X_(3)MXenes,focusing on their properties and applications in energy storage *** objective of this review is to provide guidance to researchers on fostering M_(4)X_(3)MXene-based nanomaterials,not only for energy storage devices but also for broader applications.

关键词： MXene M_(4)X_(3)MXenes 2D materials Energy storage Properties

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MicroRNAs modulation in lung cancer: exploring dual mechanisms and clinical prospects

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BIOCELL 2024年第3期48卷 403-413页

作者： shahid hussain HABIB BOKHARI XINGXING FAN SHAUKAT IQBAL MALIK SUNDAS IJAZ MUHAMMAD ADNAN SHEREEN AIMAN FATIMA Department of Biotechnology Kohsar University MurreeMurreePakistan Macao University of Science and Technology State Key Laboratory of Quality Research in Chinese Medicines TaipaMacao Department of Bioinformatics and Biosciences Capital University of Science and TechnologyIslamabadPakistan Department of Microbiology Kohsar University MurreeMurreePakistan

The global incidence of lung cancer is marked by a considerably elevated mortality ***(miRNAs)exert pivotal inﬂuence in the intricate orchestration of gene regulation,and their dysregulation can precipitate dire consequences,notably *** this context,miRNAs encapsulated in exosomes manifest a diversiﬁed impact on the landscape of lung cancer,wherein their actions may either foster angiogenesis,cell proliferation,and metastasis,or counteract these *** comprehensive review article discerns potential targets for the prospective development of therapeutic agents tailored for lung ***-suppressive miRNAs,such as miR-204,miR-192,miR-30a,miR-34a,miR-34b,miR-203,and miR-212,exhibit heightened expression and demonstrate the capacity to inhibit cellular proliferation and ***,the deleterious effects of tumor-promoting miRNAs like miR-21,miR-106a,miR-155,miR-205,and miR-210 can be attenuated through the application of their respective *** miRNAs selectively target various oncogenes,including NUAK Family Kinase 1(NUAK1),Snail Family Transcriptional Repressor 1(Snai1),Astrocyte elevated gene-1(AEG-1),Vimentin,Proliferation and apoptosis adaptor protein 15(PEA-15/PED),Hypoxia-inducible factor 1-alpha(HIF1),as well as tumor suppressor genes such as phosphatase and tensin homolog(PTEN),Suppressor of cytokine signaling 1(SOCS1),Tumor protein P53 binding protein 1(TP53BP1),and PH Domain and Leucine Rich Repeat Protein Phosphatase 2(PHLP22).This investigative approach proves invaluable in elucidating the speciﬁc miRNAs implicated in the deregulation of crucial genes pivotal to the pathogenesis of cancer.

关键词： miRNAs Oncogenes Tumor suppressive genes Lung cancer therapy

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Association of spiritual well-being with quality of life among undergraduate nursing students

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Journal of Integrative Nursing 2024年第1期6卷 49-54页

作者： Ahmad shahid Hina hussain Nazia SHUAIB Ahmad RASOOL Fatima YOUNIS Zoya NASAB Department of Nursing Professional College of Nursing and Health SciencesIslamabadPakistan Department of Nursing Rawal Institute of Health SciencesIslamabadPakistan Department of Nursing Rawal College of NursingIslamabadPakistan School of Nursing and Health Zhengzhou UniversityZhengzhouChina

Objective:The study was conducted with the aim of determining the spiritual well-being(SWB)of nursing students and its association with quality of life(QOL).Materials and Methods:A cross-sectional analytical study was conducted with a sample size of 504 nursing students collected from January 2023 to March 2023 in the nursing institutes of Khyber Pakhtunkhwa,Pakistan,using convenient sampling techniques.A Spiritual Health and Life-Orientation Measure(SHALOM)questionnaire for SWB and K-27 QOL(K-27 QOL)instrument were used for data collection that contains three ***:The number of female participants was in the majority(50.4%)compared to male nurses(49.6%).The overall mean score of SWB of the students was 3.79±0.48,while the mean K-27 QOL score was 3.73±*** were significant differences between the groups of gender(P=0.001),while no significant difference within the groups of semester(P=0.061)and college status(0.285).In QOL,there were significant differences within the groups of semester(P=0.000)and college status(P=0.036)while no significant difference in gender category(P=0.480).SHALOM score is positively and moderately correlated with QOL score(r=0.597,P<0.05).Conclusion:Spiritual practices are one of the important factors that are associated positively with QOL,therefore to enhance the QOL,it will require spiritual practices.

关键词： Nursing education nursing student quality of life spiritual nursing care spirituality well‑being

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能源地带和绿色道路 ——以伊朗、巴基斯坦和安哥拉的一带一路为例

能源地带和绿色道路 ——以伊朗、巴基斯坦和安哥拉的一带一路为例

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作者： hussain shahid 吉林大学

学位级别：硕士

在资本主义世界经济中,2008年的全球金融危机对全球经济产生了深远的影响,促使中国认识到迫切需要加强主权国家之间的合作和相互依存,以遏制和缓解当前和未来的金融危机。从2013年开始,中国政府决定启动“一带一路”倡议,即现在广为人... 详细信息

在资本主义世界经济中,2008年的全球金融危机对全球经济产生了深远的影响,促使中国认识到迫切需要加强主权国家之间的合作和相互依存,以遏制和缓解当前和未来的金融危机。从2013年开始,中国政府决定启动“一带一路”倡议,即现在广为人知的“一带一路”倡议(The BRI Initiative)。基本上,除了中国的国内因素外,“一带一路”倡议旨在支持全球欠发达国家,特别关注跨区域基础设施发展和能源合作。截至2023年8月,根据《2023年中国“一带一路”倡议投资报告》,过去10年累计参与“一带一路”倡议达到1万亿美元大关(1.016万亿美元)的历史纪录。这主要由约5,960亿美元的基础设施建设合同和4,200亿美元的非金融投资组成。其中,自2013年宣布“一带一路”倡议以来,能源领域一直是“一带一路”跨区域合作计划中最重要的部分之一。在此背景下,在本IR硕士论文中,笔者计划研究中国与三个东道国在“一带一路”框架下的跨区域能源合作关系:(1)伊朗、(2)巴基斯坦和(3)安哥拉。具体而言,在研究设计方面,这是为了发现“一带一路”倡议对这些东道国绿色能源合作项目的积极影响。然后,我们考察了三个不同东道国在同一时期内如何体验“一带一路”跨区域绿色能源合作及发展情况。首先,本文概述了有关2008年全球金融危机的背景知识,进而概述了在所谓“(全球性的)地缘经济碎片化”的宏观背景下中国如何通过“一带一路”倡议做出新的应对方案。时至今日,根据“一带一路”总体规划,中国一直强调中国与“一带一路”成员国之间能源合作的重要性,以及基础设施合作作为支持互利发展的积极作用。本文的主要研究问题如下:“一带一路”倡议如何推进与其他发展中国家的绿色能源合作项目?为了回答这个问题,我们将对(1)伊朗、(2)巴基斯坦和(3)安哥拉进行较为深入的案例研究,特别关注它们在“一带一路”倡议下的跨区域绿色能源合作项目。在此背景下,我们分别分析了三个东道国的全球、区域和国内的不同情况。这与全球市场在宏观层面上的“地缘经济碎片化”以及它们在微观层面与中国的绿色能源合作项目密切相关。这将包括部分塑造“一带一路”结果的其他外部因素。譬如,从案例分析的视角看,这与它们的地缘政治现实密切相关:①对伊朗在中东地区形成的一种‘国际政治性的遏制’状态、②对巴基斯坦在南亚地区形成的一种‘地缘政治性的半遏制’状态以及 ③对安哥拉在非洲大陆形成的一种‘历史性的边缘化’状态。因此,这些案例研究的结果可以阐明中国与东道国之间相当复杂的地缘政治和地缘经济的互动关系,澄清“一带一路”的跨区域绿色能源合作项目所带来的新挑战和新机遇基于上述内容,这篇IR硕士论文由五章组成。在第一章中,它通过列出研究问题并简要概述‘债务陷阱外交’等争议及其在IR研究中的辩论作为引言。在这里,我们还通过关注中国与东道国之间的基础设施建设和(绿色)能源合作,探讨了“一带一路”不断增长的全球网络。更具体地说,这源于他们对绿色能源基础设施项目的迫切需求。有鉴于此,笔者试图深入研究“一带一路”的这些新绿色能源合作项目所带来的积极性经济影响然后,这部分将包括与中国“一带一路”相关的在全球经济方面‘地缘经济碎片化’的文献综述。因此,它为以下章节奠定了基础,并帮助我们建立一种分析框架。值得注意的是,在分析框架上,首先考察从“一带一路”到“能源带、绿色之路”范式的概念转变。通过这种方式,我们可以了解“一带一路”对能源合作及其绿色能源合作领域的积极影响。然后,在方法论上,笔者计划对三个“一带一路”东道国进行较为深入的案例研究:①中东的伊朗 ②南亚的巴基斯坦、③非洲的安哥拉。它可以为我们提供与“一带一路”倡议在不同区域和不同国家实施相关的具体挑战、机遇和结果之间的逻辑关系的见解。第二章重点研究伊朗与中国的绿色能源合作的第一个案例。为此,首先它提供了有关伊朗在21世纪资本主义世界经济中的‘不利’地缘政治地位的背景知识。这一部分对于理解伊朗在中国“一带一路”倡议背景下伊朗所面临的地缘政治挑战和经济机遇具有重要意义。然后,针对伊朗这个中东国家,我们深入探讨了伊朗在全球、区域和国内的现实情况,涉及国际社会宏观层面的‘地缘经济的碎片化’以及伊朗与中国在微观层面的全面能源合作关系。在此背景下,从双边全面能源合作关系的角度看,笔者继续分析“一带一路”倡议如何推动与伊朗的跨区域合作,如何促进伊朗的国内经济及其在中东地区的可持续性发展。具体而言,就伊朗与中国的全面能源合作而言,这可分为三个相互独立而又相互关联的领域:(1)“一带一路”倡议中以化石燃料为导向合作项目;(2)“一带一路”倡议中以绿色能源为导向的合作项目;(3)“一带一路”倡议中以可持续发展为导向的合作项目。基于这些,“一带一路”倡议显然可以改善伊朗以全面能源合作为中心的基础设施欠

关键词：一带一路绿色能源合作基础设施建设跨区域交通运输地缘政治

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Heavy Metal/Metalloid Indexing and Balances in Agricultural Soils: Methodological Approach for Research

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Phyton-International Journal of Experimental Botany 2022年第12期91卷 2687-2697页

作者： shahid hussain Department of Soil Science Faculty of Agricultural Sciences and TechnologyBahauddin Zakariya UniversityMultan60800Pakistan

Heavy metal(loid)accumulation in agricultural soils is a threat to the soil capacity,quality,and *** also increases human exposure to heavy metal(loid)s via consumption of contaminated plant-based *** detrimental effects of soil contamination also deteriorate the environment of plants and *** sustainable agriculture,therefore,the soil must be protected from toxic levels of heavy metal(loid)*** on heavy metal(loid)balances in agricultural soils are important in predicting future risks to sustainable production from agro-ecological zones and human exposure to heavy metal(loid)*** latest and continuous indexing of the problem seems a prerequisite for sustainable *** review provides some background information and then summarizes key methodological approaches for studies on indexing and balance of heavy metal(loid)s in agricultural *** the end,important soil and health indices are explained that may be useful in understanding the extent of the *** provided information would contribute to sustainable heavy metal(loid)management in the agricultural soils,high crop production,better soil protection,and ultimately to human health.

关键词： Food crops health risks soil contamination sustainable agriculture

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Bioinspired Multi-material Polyjet-printed Frog Robot for Synchronous and Asynchronous Swimming

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Journal of Bionic Engineering 2023年第3期20卷 923-933页

作者： Afaque Manzoor soomro Jae-Wook Lee Fida hussain Memon Faheem Ahmed Kashif hussain Kyung Hyun Choi Department of Mechatronics Engineering Jeju National UniversityJeju63243South Korea Department of Electrical Engineering Sukkur IBA UniversitySukkur65200Pakistan

This paper proposes the bioinspired soft frog robot. All printing technology was used for the fabrication of the robot. Polyjet printing was used to print the front and back limbs, while ultrathin filament was used to print the body of the robot, which makes it a complete soft swimming robot. Dual thrust generation approach has been proposed by embedding the main muscle and antagonistic muscle in all the limbs, which enables it to attain high speed (18 mm/s), significant control to swim in dual mode (synchronous and asynchronous modes). To achieve the swimming motion of frog, four SMA (BMF 300) muscle wires were used. The frog robot is named as (FROBOT). The hind limbs are 60 mm long and 10 mm thick on average, while the front limbs are 35 mm long and 7 mm thick. Model-based design and rigorous analysis of the dynamics of real frogs have allowed FROBOT to be developed to swim at a level that is remarkably consistent with real frogs. Electrical and mechanical characteristics have been performed. In addition, the test data were further processed using TRACKER to analyze angle, displacement and velocity. FROBOT (weighs 65 g) can swim at different controllable frequencies (0.5–2 Hz), can rotate in any direction on command from custom built LabVIEW software allowing it to swim with speed up to 18 mm/s on deep water surface (100 cm) with excellent weight balance.

关键词： Bioinspired Soft robotics Frog FROBOT Asynchronous swimming

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