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DEAD-box RNA helicases with special reference to p68:Unwinding their biology,versatility,and therapeutic opportunity in cancer

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Genes & Diseases 2023年第4期10卷 1220-1241页

作者： shaheda tabassum Mrinal K.Ghosh Cancer Biology and Inflammatory Disorder Division Council of Scientific and Industrial Research-Indian Institute of Chemical Biology(CSIR-IICB)TRUE CampusSalt LakeKolkata 700091India

In the era of advancement,the entire world continues to remain baffled by the increased rate of progression of *** has been an unending search for novel thera-peutic targets and prognostic markers to curb the oncogenic *** DEAD-box RNA he-licases are a large family of proteins characterized by their evolutionary conserved D-E-A-D(Asp-Glu-Ala-Asp)domain and merit consideration in the oncogenic *** perform multidimensional functions in RNA metabolism and also in the pathology of *** bio-logical role ranges from ribosome biogenesis,RNA unwinding,splicing,modification of second-ary and tertiary RNA structures to acting as transcriptional coactivators/repressors of various important oncogenic *** also play a crucial role in accelerating oncogenesis by pro-moting cell proliferation and ***5(p68)is one of the archetypal members of this family of proteins and has gained a lot of attention due to its oncogenic *** is found to be overexpressed in major cancer types such as colon,brain,breast,and prostate *** exhibits its multifaceted nature by not only coactivating genes implicated in cancers but also mediating crosstalk across major signaling pathways in ***,in this review,we aim to illustrate a comprehensive overview of DEAD-box RNA helicases especially p68 by focusing on their multifaceted roles in different cancers and the various signaling pathways affected by ***,we have also briefly discoursed the therapeutic interventional approaches with the DEAD-box RNA helicases as the pharmacological targets for designing in-hibitors to pave way for cancer therapy.

关键词： Cancer DDX5 DEAD-box RNA helicases Gene expression Oncogene Signaling Therapy Transcription factor

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Comparative evaluation of effect of injectable platelet-rich fibrin with collagen membrane compared with collagen membrane alone for gingival recession coverage

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World Journal of Experimental Medicine 2022年第4期12卷 68-91页

作者： Laxmikanta Patra Subash Chandra Raj Neelima Katti Devapratim Mohanty Shib Shankar Pradhan shaheda tabassum Asit Kumar Mishra Kaushik Patnaik Annuroopa Mahapatra Department of Periodontics SCB Dental College and HospitalOdisha 753007India

BACKGROUND Collagen membrane and platelet-rich fibrin(PRF)have emerged as vital biomaterials in the field of periodontal *** invasive techniques are being preferred by most periodontists,as it is patient compliant with fewer post-surgical complications as compared to conventional surgical ***,in this study we have evaluated the effect of injectable PRF(i-PRF)with collagen membrane compared with collagen membrane alone using vestibular incision subperiosteal tunnel access(VISTA)technique for gingival recession *** To compare the efficacy of VISTA using collagen membrane with collagen membrane soaked in injectable PRF for gingival recession *** A split mouth randomized controlled clinical trial was designed;13 subjects having at least 2 teeth indicated for recession coverage were enrolled in this *** sites were randomly assigned to control group(VISTA using collagen membrane alone)and the test group(VISTA using collagen membrane with i-PRF).The clinical parameters assessed were pocket depth,recession depth(RD),recession width(RW),relative attachment level,keratinised tissue width(KTW),keratinised tissue thickness(KTT),and percentage root *** RD showed a statistically significant difference between the test group at 3 mo(0.5±0.513)and 6 mo(0.9±0.641)and the control group at 3 mo(0.95±0.51)and 6 mo(1.5±0.571),with P values of 0.008 and 0.04,*** also showed a statistically significant difference between the test group at 3 mo(1±1.026)and 6 mo(1.65±1.04)and the control group at 3 mo(1.85±0.875)and 6 mo(2.25±0.759),with P values of 0.008 and 0.001,*** for KTW showed statistically significant results between the test group at 1 mo(2.85±0.489),3 mo(3.5±0.513),and 6 mo(3.4±0.598)and the control group at 1 mo(2.45±0.605),3 mo(2.9±0.447),and 6 mo(2.75±0.444),with P values of 0.04,0.004,and 0.003,*** for KTT also showed statistically significant results between t

关键词： Vestibular incision subperiosteal tunnel access Injectable platelet-rich fibrin Collagen membrane Gingival recessions Treatment

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A Holistic Secure Communication Mechanism Using a Multilayered Cryptographic Protocol to Enhanced Security

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Computers, Materials & Continua 2024年第3期78卷 4417-4452页

作者： Fauziyah Zhaoshun Wang Mujahid tabassum School of Computer and Communication Engineering University of Science and TechnologyBeijing100000China Noroff School of Technology and Digital Media(Noroff Accelerate) Noroff University CollegeKristiansand4612Norway

In an era characterized by digital pervasiveness and rapidly expanding datasets,ensuring the integrity and reliability of information is *** cyber threats evolve in complexity,traditional cryptographic methods face increasingly sophisticated *** article initiates an exploration into these challenges,focusing on key exchanges(encompassing their variety and subtleties),scalability,and the time metrics associated with various cryptographic *** propose a novel cryptographic approach underpinned by theoretical frameworks and practical *** to this approach is a thorough analysis of the interplay between Confidentiality and Integrity,foundational pillars of information *** method employs a phased strategy,beginning with a detailed examination of traditional cryptographic processes,including Elliptic Curve Diffie-Hellman(ECDH)key *** also delve into encrypt/decrypt paradigms,signature generation modes,and the hashes used for Message Authentication Codes(MACs).Each process is rigorously evaluated for performance and *** gain a comprehensive understanding,a meticulously designed simulation was conducted,revealing the strengths and potential improvement areas of various ***,our cryptographic protocol achieved a confidentiality metric of 9.13 in comprehensive simulation runs,marking a significant advancement over existing ***,with integrity metrics at 9.35,the protocol’s resilience is further *** metrics,derived from stringent testing,underscore the protocol’s efficacy in enhancing data security.

关键词： Cryptographic security privacy preservation decryption integrity

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Potential role of tubulin glutamylation in neurodegenerative diseases

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Neural Regeneration Research 2024年第6期19卷 1191-1192页

作者： Abdullah Md.Sheikh Shatera tabassum Department of Laboratory Medicine Shimane University Faculty of Medicine

The differentiation of neuronal stem cells into mature neurons is a complex process that involves both structural and functional changes. As cells undergo differentiation, there are notable functional changes, including the expression of various transcription factors, cytokines, and neurotransmitiers. Additionally, structural changes occur as the cells develop various processes from the cell body and establish synaptic contacts with other cells.

关键词： POLARITY

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Vibration-reduced anxiety-like behavior relies on ameliorating abnormalities of the somatosensory cortex and medial prefrontal cortex

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Neural Regeneration Research 2024年第6期19卷 1351-1359页

作者： Afzal Misrani Sidra tabassum Tintin Wang Huixian Huang Jinxiang Jiang Hongjun Diao Yanping Zhao Zhen Huang Shaohua Tan Cheng Long Li Yang South China Normal University-Panyu Central Hospital Joint Laboratory of Translational Medical Research Panyu Central Hospital School of Life Sciences Guangzhou University School of Life Sciences South China Normal University Guangzhou Hongai Cultural Development Inc. 5. Yinguo Health Management Team College of Biophotonics South China Normal University

Tibetan singing bowls emit low-frequency sounds and produce perceptible harmonic tones and vibrations through manual tapping. The sounds the singing bowls produce have been shown to enhance relaxation and reduce anxiety. However, the underlying mechanism remains unclear. In this study, we used chronic restraint stress or sleep deprivation to establish mouse models of anxiety that exhibit anxiety-like behaviors. We then supplied treatment with singing bowls in a bottomless cage placed on the top of a cushion. We found that unlike in humans, the combination of harmonic tones and vibrations did not improve anxietylike behaviors in mice, while individual vibration components did. Additionally, the vibration of singing bowls increased the level of N-methyl-D-aspartate receptor 1 in the somatosensory cortex and prefrontal cortex of the mice, decreased the level of γ-aminobutyric acid A(GABA) receptor α 1 subtype, reduced the level of CaMKII in the prefrontal cortex, and increased the number of GABAergic interneurons. At the same time, electrophysiological tests showed that the vibration of singing bowls significantly reduced the abnormal low-frequency gamma oscillation peak frequency in the medial prefrontal cortex caused by stress restraint pressure and sleep deprivation. Results from this study indicate that the vibration of singing bowls can alleviate anxiety-like behaviors by reducing abnormal molecular and electrophysiological events in somatosensory and medial prefrontal cortex.

关键词： anxiety medial prefrontal cortex parvalbumin interneuron pressure somatosensory cortex Tibetan singing bowl vibration

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Comparative analysis of SIMILAR to RCD ONE(SRO)family from tetraploid cotton species and their diploid progenitors depict their significance in cotton growth and development

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Journal of Cotton Research 2024年第1期7卷 45-57页

作者： SHABAN Muhammad tabassum Riaz RANA Iqrar Ahmad ATIF Rana Muhammad AZMAT Muhammad Abubakkar IQBAL Zubair MAJEED Sajid AZHAR Muhammad Tehseen Department of Plant Breeding and Genetics University of Agriculture FaisalabadSub-Campus BurewalaVehari 61010Pakistan Department of Chemistry and Biochemistry University of AgricultureFaisalabad 38400Pakistan Centre of Agricultural Biochemistry and Biotechnology University of AgricultureFaisalabad 38400Pakistan Department of Plant Breeding and Genetics University of AgricultureFaisalabad 38400Pakistan Precision Agriculture and Analytics Lab National Centre in Big Data and Cloud ComputingCentre for Advanced Studies in Agriculture and Food SecurityUniversity of Agriculture FaisalabadFaisalabad 38400Pakistan Department of Plant Pathology University of CaliforniaDavisCA 95616USA State Key Laboratory of Cotton Biology Institute of Cotton ResearchChinese Academy of Agricultural SciencesAnyangHenan 455000China Federal Seed Certification and Registration Department Ministry of National Food Security and ResearchIslamabad 44090Pakistan School of Agriculture Sciences Zhengzhou UniversityZhengzhou 450000China

Background SRO(Similar to RCD1)genes family is largely recognized for their importance in the growth,develop-ment,and in responding to environmental ***,genome-wide identification and functional characteri-zation of SRO genes from cotton species have not been reported so *** A total of 36 SRO genes were identified from four cotton *** analysis divided these genes into three groups with distinct *** and chromosomal distribution analysis indicated uneven distribu-tion of GaSRO,GrSRO,GhSRO,and GbSRO genes on A2,D5 genomes,Gh-At,Gh-Dt,Gb-At,and Gb-Dt subgenomes,*** duplication analysis revealed the presence of six duplicated gene pairs among GhSRO *** promoter analysis,several elements responsive to the growth,development and hormones were found in GhSRO genes,implying gene induction during cotton growth and *** miRNAs responsive to plant growth and abiotic stress were predicted to target 12 GhSRO ***-specific expression profiling demonstrated the roles of GhSRO genes in one or more *** addition,specific expression pattern of some GhSRO genes dur-ing ovule development depicted their involvement in these developmental *** The data presented in this report laid a foundation for understanding the classification and functions of SRO genes in cotton.

关键词： Cotton SRO miRNAs Gene duplications Gene expression Ovule development

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Development and Characterization of Calcium Based Biocomposites Using Waste Material (Calcite Stones) for Biomedical Applications

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Materials Sciences and Applications 2024年第5期15卷 113-135页

作者： Tasmim Adry Nuzhat tabassum Maisha Md. Abdul Gafur Suraya Sabrin Soshi Maruf Hasan Department of Biomedical Engineering Military Institute of Science and Technology Dhaka Bangladesh Pilot Plant and Process Development Center Bangladesh Council of Scientific and Industrial Research (BCSIR) Dhaka Bangladesh Department of Mechanical Engineering Ahsanullah University of Science and Tecnology (AUST) Tejgaong Dhaka Bangladesh

Calcium-based biocomposite materials have a pivotal role in the biomedical field with their diverse properties and applications in combating challenging medical problems. The study states the development and characterization of Calcium-based biocomposites: Hydroxyapatite (HAP), and PVA-Gelatin-HAP films. For the preparation of Calcium-based biocomposites, an unconventional source, the waste material calcite stone, was used as calcium raw material, and by the process of calcination, calcium oxide was synthesized. From calcium oxide, HAP was prepared by chemical precipitation method, which was later added in different proportions to PVA-Gelatin solution and finally dried to form biocomposite films. Then the different properties of PVA/Gelatin/HAP composite, for instance, chemical, mechanical, thermal, and swelling properties due to the incorporation of various proportions of HAP in PVA-Gelatin solution, were investigated. The characterization of the HAP was conducted by X-ray Diffraction Analysis, and the characterization of HAP-PVA-Gelatin composites was done by Fourier Transform Infrared Spectroscopy, Thermomechanical Analysis, Tensile test, Thermogravimetric Differential Thermal Analysis, and Swelling Test. The produced biocomposite films might have applications in orthopedic implants, drug delivery, bone tissue engineering, and wound healing.

关键词： Hydroxyapatite Calcium-Based Biocomposites PVA-Gelatin Films Drug Delivery Bone Tissue Engineering

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碳水化合物酶对家禽生长性能和肠道健康的影响

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国外畜牧学（猪与禽） 2024年第2期44卷 110-112页

作者：王晶晶(译) 王丽萍(译) 夏俊花(审) Ahmad Raza Saira Bashir Romana tabassum 不详

家禽可提供优质的蛋白质和微量营养物质。在家禽生产中,饲料是主要的投入品,其成本占总生产成本的70%~75%。家禽的饲料主要由谷物组成,能为家禽提供所需的能量。然而,这些谷物含有不同水平的抗营养因子,如非淀粉多糖。由于家禽自身缺乏... 详细信息

家禽可提供优质的蛋白质和微量营养物质。在家禽生产中,饲料是主要的投入品,其成本占总生产成本的70%~75%。家禽的饲料主要由谷物组成,能为家禽提供所需的能量。然而,这些谷物含有不同水平的抗营养因子,如非淀粉多糖。由于家禽自身缺乏重要的内源性酶(碳水化合物酶),无法消化这些非淀粉多糖,从而会增加肠道食糜的黏度,影响营养物质的运输和吸收。这些非淀粉多糖还可通过引起肠道微生物群对可消化营养物质的竞争增加家禽感染有害微生物的机会。这不仅会影响家禽的健康,还会增加生产成本。因此,找到效率高和起作用的解决方法极为重要。在非淀粉多糖含量高的日粮中添加碳水化合物酶是解决方案之一,对家禽生产具有重要的作用。多年来,饲用酶一直被用于提高动物消化率和生产性能,但对某些饲料原料的活性有限。新一代碳水化合物酶具有广泛的活性和稳定性,有助于降解日粮中复杂的底物,提高家禽的生产性能。本综述总结了使用碳水化合物酶改善家禽生产性能和肠道健康的最新研究成果。

关键词：营养学兽医学生理学微生物学结构生物学生物技术

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碳水化合物酶对家禽生长性能和肠道健康的影响(续1)

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国外畜牧学（猪与禽） 2024年第3期44卷 115-119页

作者：王晶晶(译) 王丽萍(译) 夏俊花(审) Ahmad Raza Saira Bashir Romana tabassum 不详

家禽可提供优质的蛋白质和微量营养物质。在家禽生产中,饲料是主要的投入品,其成本占总生产成本的70%~75%。家禽的饲料主要由谷物组成,能为家禽提供所需的能量。然而,这些谷物含有不同水平的抗营养因子,如非淀粉多糖。由于家禽自身缺乏重要的内源性酶(碳水化合物酶),无法消化这些非淀粉多糖,从而会增加肠道食糜的黏度,影响营养物质的运输和吸收。这些非淀粉多糖还通过引起肠道微生物群对可消化营养物质的竞争增加家禽感染有害微生物的机会。这不仅会影响家禽的健康,还会增加生产成本。因此,找到效率高和起作用的解决方法极为重要。在非淀粉多糖含量高的日粮中添加碳水化合物酶是解决方案之一,对家禽生产具有重要的影响。多年来,饲用酶一直被用于提高动物消化率和生产性能,但对某些饲料原料的活性有限。新一代碳水化合物酶具有广泛的活性和稳定性,有助于降解日粮中复杂的底物,提高家禽的生产性能。本综述总结了使用碳水化合物酶改善家禽生产性能和肠道健康的最新研究成果。

关键词：营养学兽医学生理学微生物学结构生物学生物技术

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An advanced anaerobic biofilter with effluent recirculation for phenol removal and methane production in treatment of coal gasification wastewater

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Journal of Environmental Sciences 2016年第9期28卷 23-33页

作者： Yajie Li Salma tabassum Zhenjia Zhang School of Environmental Science and Engineering Shanghai Jiao Tong University LCM-Laboratory of Catalysis and Materials Associate Laboratory LSRE-LCMDepartamento de Engenharia QuímicaFaculdade de EngenhariaUniversidade do Porto

An advanced anaerobic biofilter（AF） was introduced for the treatment of coal gasification wastewater（CGW）,and effluent recirculation was adopted to enhance phenol removal and methane *** results indicated that AF was reliable in treating diluted CGW,while its efficiency and stability were seriously reduced when directly treating raw ***,its performance could be greatly enhanced by effluent *** optimal effluent recirculation of 0.5 to the influent,concentrations of chemical oxygen demand（COD） and total phenol in the effluent could reach as low as 234.0 and 14.2 mg/L,***,the rate of methane production reached 169.0 m L CH_4/L/*** CGW seemed to restrain the growth of anaerobic microorganisms,especially methanogens,the inhibition was temporary and reversible,and anaerobic bacteria presented strong *** activities of methanogens cultivated in CGW could quickly recover on feeding with glucose wastewater（GW）.However,the adaptability of anaerobic bacteria to the CGW was very poor and the activity of methanogens could not be improved by long-term *** analysis using the Haldane model,it was further confirmed that high effluent recirculation could result in high activity for hydrolytic bacteria and substrate affinity for toxic matters,but only suitable effluent recirculation could result in high methanogenic activity.

关键词： Coal gasification wastewater Effluent recirculation Methane production Anaerobic biofilters

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