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Patients with irritable bowel syndrome-diarrhea have lower disease-specific quality of life than irritable bowel syndrome-constipation

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World Journal of Gastroenterology 2015年第26期21卷 8103-8109页

作者： Prashant Singh Kyle Staller Kenneth Barshop Elaine Dai Jennifer Newman Sonia Yoon shahar castel Braden Kuo GI Unit GRJ 719Department of MedicineMassachusetts General Hospital Pritzker School of Medicine University of Chicago Division of Gastroenterology Weill Cornell Medical College

AIM: To determine effect of irritable bowel syndrome(IBS) subtype on IBS-specific quality of life(QOL) questionnaire and its ***: We studied IBS patients visiting our functional gastroenterology disorder clinic at a tertiary care center of Unites *** and IBS subtype were diagnosed using Rome-Ⅲ *** was assessed using IBS-QOL *** assesses quality of life along eight subscales: dysphoria,interference with activities,body image,health worry,food avoidance,social reactions,sexual health,and effect on ***-QOL and its subscales were both scored on a range of 0-100 with higher scores suggestive of better *** of overall IBS-QOL scores and subscale scores are expressed as means with 95%*** compared mean IBS-QOL score and its subscales among various *** of variance(ANOVA) was used to compare the mean difference between more than two groups after controlling for age and gender.A posthoc analysis using Bonferroni correction was used only when P value for ANOVA was less than ***: Of 542 patients screened,243 had IBS as per Rome-Ⅲ ***-mixed(IBS-M) was the most common IBS subtype(121 patients,49.8%) followed by IBS- diarrhea(IBS-D)(56 patients,23.1%),IBSconstipation(IBS-C)(54 patients,22.2%) and IBSunspecified(IBS-U)(12 patients,4.9%).Overall IBSQOL scores were significantly different among various IBS-subtypes(P = 0.01).IBS-QOL of patients with IBS-D(61.6,95%CI: 54.0-69.1) and IBS-M(63.0,95%CI: 58.1-68.0) was significantly lower than patients with IBS-C(74.5,95%CI: 66.9-82.1)(P = 0.03 and 0.02 respectively).IBS-D patients scored significantly lower than IBS-C on food avoidance(45.0,95%CI: 34.8-55.2 vs 61.1,95%CI: 50.8-71.3,P = 0.04) and interference with activity(59.6,95%CI: 51.4-67.7 vs 82.3,95%CI: 74.1-90.6,P < 0.001).IBS-M patients had more interference in their activities(61.6,95%CI: 56.3-66.9 vs 82.3,95%CI: 74.1-90.6,P = 0.001) and greater impact on their relationshi

关键词： Irritable bowel syndrome Irritable bowelsyndrome subtype Quality of life Irritable bowelsyndrome-quality of life Constipation Diarrhea

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Cardiovascular risk factors among older persons with cognitive frailty in middle income country

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World Journal of Clinical Cases 2024年第17期12卷 3076-3085页

作者： Azianah Mohamad Ibrahim Devinder Kaur Ajit Singh Arimi Fitri Mat Ludin Noor Ibrahim Mohamed Sakian Nurul Fatin Malek Rivan Suzana shahar Centre for Healthy Ageing and Wellness Faculty of Health SciencesUniversiti Kebangsaan MalaysiaWilayah Persekutuan Kuala Lumpur 50300Malaysia Basic Medical Sciences University of CyberjayaSelangor Darul EhsanMalaysia 63000Malaysia

BACKGROUND Cognitive frailty,characterized by the coexistence of cognitive impairment and physical frailty,represents a multifaceted challenge in the aging *** role of cardiovascular risk factors in this complex interplay is not yet fully *** To investigate the relationships between cardiovascular risk factors and older persons with cognitive frailty by pooling data from two cohorts of studies in *** A comprehensive approach was employed,with a total of 512 communitydwelling older persons aged 60 years and above,involving two cohorts of older persons from previous *** related to cardiovascular risks,namely sociodemographic factors,and cardiovascular risk factors,including hypertension,diabetes,hypercholesterolemia,anthropometric characteristics and biochemical profiles,were pooled for *** frailty was defined based on the Clinical Dementia Rating scale and Fried frailty *** risk was determined using Framingham risk *** analyses were conducted using SPSS version *** Of the study participants,46.3%exhibited cognitive *** risk factors including hypertension(OR:1.60;95%CI:1.12-2.30),low fat-free mass(OR:0.96;95%CI:0.94-0.98),high percentage body fat(OR:1.04;95%CI:1.02-1.06),high waist circumference(OR:1.02;95%CI:1.01-1.04),high fasting blood glucose(OR:1.64;95%CI:1.11-2.43),high Framingham risk score(OR:1.65;95%CI:1.17-2.31),together with sociodemographic factors,i.e.,being single(OR 3.38;95%CI:2.26-5.05)and low household income(OR 2.18;95%CI:1.44-3.30)were found to be associated with cognitive *** Cardiovascular-risk specific risk factors and sociodemographic factors were associated with risk of cognitive frailty,a prodromal stage of *** identification and management of cardiovascular risk factors,particularly among specific group of the population might mitigate the risk of cognitive frailty,hence preventing dementia.

关键词： Cognitive frailty Older persons Cardiovascular risk factors Frailty Mild cognitive impairment

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Derivatives of Meromorphic Functions with Multiple Zeros and Elliptic Functions

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Acta Mathematica Sinica,English Series 2013年第7期29卷 1257-1278页

作者： Pai YANG shahar NEVO Department of Mathematics East China Normal University College of Mathematics Chengdu University of Information Technology Department of Mathematics Bar-Ilan University

Let f be a nonconstant meromorphic function in the plane and h be a nonconstant elliptic function. We show that if all zeros of f are multiple except finitely many and T（r, h） = 0{T（r, f）} as r → ∞, then f′ = h... 详细信息

关键词： Normal family elliptic function

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Nanosphere molecularly imprinted polymers doped with gold nanoparticles for high selectivity molecular sensors

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Nano Research 2017年第3期10卷 1056-1063页

作者： Tehila shahar Tama Sicron Daniel Mandler Institute of Chemistry The Hebrew University of Jerusalem Jerusalem 9190401 Israel

We report the first attempt of using molecularly imprinted polymers （MIPs） in the shape of nanoparticles that were doped with gold nanoparticles （AuNPs） for surface enhanced Raman scattering （SERS）-based sensing of molecular spedes. Specifically, AuNPs doped molecularly imprinted nano-spheres （AuNPs@nanoMIPs） were synthesized by one-pot precipitation polymerization using Sudan IV as the template for the SERS sensing. The AuNPs@nanoMIPs were characterized by various modes of scanning transmission electron microscopy （STEM） that showed the exact location of the AuNPs inside the MIP particles. The effects of Au concentration and solution stirring on the shape and the polydispersity of the particles were studied. Significant enhancement of the Raman signals was observed only when the MIP particles were doped with the AuNPs. The SERS signal improved significantly with increase in the Au concentration inside the AuNPs@nanoMIPs. Selectivity measurements of the Sudan IV imprinted AuNPs@nanoMIPs carried out with different Sudan derivatives showed high selectivity of the AuNPs-doped MIP particles.

关键词： molecularly imprintedpolymers surface enhanced Ramanscattering (SERS) gold nanoparticles Sudan IV doping

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A Criterion of Normality Based on a Single Holomorphic Function

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Acta Mathematica Sinica,English Series 2011年第1期27卷 141-154页

作者： Xiao Jun LIU shahar NEVO Department of Mathematics University of Shanghai for Science and Technology Shanghai 200093 P. R. China Department of Mathematics Bar-Ilan University 52900 Ramat-Gan Israel

Let F be a family of functions holomorphic on a domain D C C. Let k ≥ 2 be an integer and let h be a holomorphic function on D, all of whose zeros have multiplicity at most k- 1, such that h（z） has no common zeros with any f∈F. Assume also that the following two conditions hold for every f ∈F ：（a） f（z） = 0 == f （z） = h（z）; and （b） y（z） = h（z） == ｜f（k）（z）｜ ≤ c, where c is a *** F is normal on D.

关键词： Normal family holomorphic functions zero points

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Completely irreducible sequences of meromorphic functions

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Science China Mathematics 2010年第3期53卷 827-830页

作者： NEVO shahar ZALCMAN Lawrence Department of Mathematics Bar-Ilan University

Given a sequence {fn } of meromorphic functions on a plane domain D, there exists a (possibly empty) open set U■D and a subsequence {f n k } which converges uniformly (with respect to the spherical metric on ) on compact subsets of U, while no subsequence of {f n k } converges uniformly on compact subsets of any larger open subset of D.

关键词： meromorphic functions convergence of sequences

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Diferential Inequalities,Normality and Quasi-normality

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Acta Mathematica Sinica,English Series 2014年第2期30卷 277-282页

作者： Xiao Jun LIU shahar NEVO Xue Cheng PANG Department of Mathematics University of Shanghai for Science and Technology Department of Mathematics Bar-Ilan University Department of Mathematics East China Normal University

We prove that ifD is a domain in C,α 〉 1 and C 〉 0,then the family F of functions f meromorphic in D such that ｜f′（z）｜/1 ＋｜f（z）｜α 〉 C for every z ∈ D is normal in *** α = 1,the same assumptions imply... 详细信息

关键词： Normal family quasi-normal family differential inequality

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High-Q ring resonators directly written in As2S3 chalcogenide glass films

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Photonics Research 2015年第3期3卷 63-67页

作者： shahar Levy Matvei Klebanov Avi Zadok Faculty of Engineering Bar-Ilan UniversityRamat-Gan 5290002Israel Department of Physics Ben-Gurion University of the NegevBeer-Sheva 8410501Israel

Planar ring resonator waveguides are fabricated in thin films of As2S3 chalcogenide glass,deposited on silicaon-silicon *** cores are directly written by scanning the focused illumination of a femtosecond Ti:sapphire laser at a central wavelength of 810 nm,through a two-photon photo-darkening process.A large photoinduced index change of 0.3–0.4 refractive index units is *** radius of the ring resonator is 1.9 mm,corresponding to a transmission free spectral range of 9.1 GHz.A high loaded（intrinsic） Q value of 110,000（180,000） is *** thermal dependence of the resonator transfer function is *** results provide the first report,to the best of our knowledge,of directly written high-Q ring resonators in chalcogenide glass films,and demonstrate the potential of this simple technique towards the fabrication of planar lightguide circuits in these materials.

关键词： ring As High-Q ring resonators directly written in As2S3 chalcogenide glass films

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World Journal of Gastroenterology 2014年第44期20卷 16782-16785页

作者： James Frydman shahar Grunner Yoram Kluger Department of General Surgery Rambam Health Care Campus

Ig G4-related disease is a recently recognized entity linked initially to autoimmune pancreatitis and has been subsequently described in nearly every organ system. Men over the age of 50 represent the most affected demographic group and a comprehensive set of diagnostic criteria has been developed to aid treating clinicians. Though elevated levels of Ig G4 in the serum are suggestive of the disease, definitive diagnosis is made on histopathology. Treatment is tailored to the clinical presentation with corticosteroid therapy known to have proven efficacy. Gastric manifestations of the Ig G4-related disease primarily come in two varieties, notably chronic ulceration or pseudotumor formation. Autoimmune pancreatitis conveys increased risk for Ig G4-related disease of the stomach, which is independent of Helicobacter pylori status. In this case report, we present an acute gastric-pericardial fistula secondary to Ig G4-related disease that required urgent operative management. To our knowledge, this is the first report in the medical literature describing this complication of Ig G4-related disease.

关键词： IgG4-related disease Autoimmune pancreatitis Gastric ulcer

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Thymoma and autoimmunity

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Cellular & Molecular Immunology 2011年第3期8卷 199-202页

作者： shahar Shelly Nancy Agmon-Levin Arie Altman Yehuda Shoenfeld The Zabludovicz Center for Autoimmune Diseases Sheba Medical CenterTel-Hashomeraffiliated with Sackler Faculty of MedicineTel Aviv UniversityIsrael Department of Medicine‘B’ Sheba Medical CenterTel-HashomerIsrael Sackler Faculty of Medicine Incumbent of the Laura Schwarz-Kip Chair for Research of Zabludowitz Center for Autoimmune DiseasesTel-Aviv UniversityTel-AvivIsrael

The thymus is a central lymphatic organ that is responsible for many immunological functions,including the production of mature,functional T cells and the induction of *** or malignant tumors may originate from the thymus gland,with thymoma being the most common and accounting for 50% of anterior mediastinal *** linked to thymoma include the loss of self-tolerance and the presence of *** this review,we compiled the current scientific evidence detailing the various interactions between thymoma and autoimmune diseases,including myasthenia gravis,systemic lupus erythematosus,inappropriate antidiuretic hormone secretion,pure red cell aplasia,pernicious anemia,pemphigus and autoimmune thyroid *** recent years,several mechanisms have been proposed to explain these *** are based on the assumption that the‘sick’thymus,like the‘normal’thymus,can generate mature T cells;however,the T cells generated by the sick thymus are impaired and thus may exert cellular ***,we present several theories that may shed light on the loss of self-tolerance associated with this epithelial tumor of the thymus.

关键词： autoimmune diseases autoimmunity self-tolerance thymoma thymus

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