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Expression of altered retinoblastoma protein inversely correlates with tumor invasion in gastric carcinoma

第九届中国肿瘤学术大会暨第十五届海峡两岸肿瘤学术大会

作者： Chih-Jen Yang Jen-Yu Hung Ming-Ju Tsai Kuan-Li Wu Ta-Chih Liu shah-hwa chou Jui-Ying Lee Jui-Sheng Hsu Ming-Shyan Huang Inn-Wen Chong Department of Internal Medicine Kaohsiung Municipal Ta-Tung HospitalKaohsiung Medical University Division of Pulmonary and Critical Care Medicine Kaohsiung Medical University HospitalKaohsiung Medical University Faculty of Medicine College of MedicineKaohsiung Medical University Graduate Institute of Medicine College of MedicineKaohsiung Medical University Division of Chest Surgery Department of SurgeryKaohsiung Medical University HospitalKaohsiung Medical University Division of Hematology and Oncology Department of Internal MedicineKaohsiung Medical University HospitalKaohsiung Medical University Department of Medical Imaging Kaohsiung Medical University HospitalKaohsiung Medical University

＜正＞Background:Epidermal growth factor receptor-tyrosine kinase inhibitor（EGFR-TKI）,such as gefitinib,could provide better efficacy and prolonged progress free survival（PFS）than cytotoxic chemotherapy for metastatic lung non-squamous cell carcinoma harboring susceptible EGFR mutation when it was served as the first line ***,the cytotoxic chemotherapy was regarded as the standard second-line and third-line therapy to

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World Journal of Gastroenterology 2006年第44期12卷 7188-7191页

作者： Nan-Hua chou Hui-Chun Chen Nan-Song chou Ping-I Hsu Hui-hwa Tseng Department of Surgery Veterans General Hospital-Kaohsiung Taiwan China Department of Radiation Oncology Chang Gung Memorial Hospital-Kaohsiung Taiwan China Department of Surgery Chi Mei Foundation Hospital Taiwan China Department of Internal Medicine Veterans General Hospital-Kaohsiung Taiwan China Department of Pathology Veterans General Hospital-Kaohsiung Taiwan China

AIM: To investigate the clinical and pathological significance of altered retinoblastoma (Rb) encoding protein (pRb) in gastric carcinoma. METHODS: Expression of altered pRb was analyzed in 91 patients with gastric adenocarcinoma by immunohistochemistry. RESULTS: Sixty-five percent (59/91) of the tumors were positively stained and the staining in tumor nuclei of gastric carcinoma ranged 0%-90%. Moreover, strong expression of altered pRb was found in 35% (6/17), 24% (5/21), 17% (8/46) and 0% (0/7) of T1, T2, T3 and T4 gastric carcinomas, respectively. altered pRb expression was inversely correlated with the depth of tumor invasion (P = 0.047). Degree of immunoreactivity had no significant correlation with tumor grade, node metastasis and distant metastasis. In terms of prognostic significance, univariate analysis showed that poor differentiation [41 (66.1%) vs 34 (42.5%) P = 0.051], advanced tumor stage (P < 0.001) and weakly altered pRb expression [17 (80.5%) vs 58 (49.6%) P = 0.044] were associated with worse prognosis in these patients. However, multivariate analysis revealed that advanced tumor stage was the only independent poor prognostic factor (P < 0.001). CONCLUSION: The mutation of Rb gene is frequent in gastric carcinoma. The expression of altered pRb inversely correlates with tumor invasion and is not an independent prognostic marker in gastric adenocarcinoma.

关键词： Gastric adenocarcinoma Altered retinoblastoma protein Immunohlstochemistry

General solution model and its new progress

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International Journal of Minerals,Metallurgy and Materials 2022年第4期29卷 577-585页

作者： Kuo-Chih chou University of Science and Technology Beijing Beijing 100083China

The physicochemical properties of multicomponent systems are involved in all fields of chemistry and have received attention from various related areas such as minerals,metallurgy,material science,environment,biology,and *** present,the relevant data can be obtained by using two major calculation methods,namely,the first principle method and the empirical *** the former has achieved recent great progress,it is still a long way to offer practical data;while the latter has not received progress for almost half a ***,a new method that is theoretically reasonable and accurate in practical application is necessary to obtain practical and precise physicochemical data for ternary and multicomponent *** this paper,a new theoretical model is suggested based on its corresponding binary *** feasibility of this theoretical model is discussed in terms of both theoretical analysis and practical performance.

关键词： multicomponent system physicochemical properties solution model phenomenological theory

Turbulence and cavitation models for time-dependent turbulent cavitating flows

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Acta Mechanica Sinica 2011年第4期27卷 473-487页

作者： Chien-chou Tseng Department of Mechanical Engineering University of Michigan

Cavitation typically occurs when the fluid pressure is lower than the vapor pressure at a local thermodynamic state, and the flow is frequently unsteady and turbulent. To assess the state-of-the-art of computational capabilities for unsteady cavitating flows, different cavitation and turbulence model combinations are conducted. The selected cavitation models include several widely-used models including one based on phenomenological argument and the other utilizing interface dynamics. The k-e turbulence model with additional implementation of the filter function and density correction function are considered to reduce the eddy viscosity according to the computed turbulence length scale and local fluid density respectively. We have also blended these alternative cavitation and lustrate that the eddy viscosity turbulence treatments, to ilnear the closure region can significantly influence the capture of detached cavity. From the experimental validations regarding the force analysis, frequency, and the cavity visualization, no single model combination performs best in all aspects. Furthermore, the implications of parameters contained in different cavitation models are investigated. The phase change process is more pronounced around the detached cavity, which is better illustrated by the interfacial dynamics model. Our study provides insight to aid further modeling development.

关键词： Cavitation Turbulence model Cavitationmodel Hybrid model

Adaptive peer-to-peer streaming with MutualCast

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第5期7卷 737-748页

作者： chou Philip A Microsoft Research One Microsoft Way Redmond WA 98052 USA

Application Layer Multicast (ALM) can greatly reduce the load of a server by leveraging the outgoing bandwidth of the participating nodes. However, most proposed ALM schemes become quite complicated and lose bandwidth efficiency if they try to deal with networks that are significantly heterogeneous or time-varying. In earlier work, we proposed MutualCast, an ALM scheme with fully connected mesh that quickly adapts to the time-varying networks, while achieving provably optimal throughput performance. In this paper, we study how MutualCast can be paired with adaptive rate control for streaming media. Specifically, we combine Optimal Rate Control (ORC), our earlier control-theoretical framework for quality adaptation, with the MutualCast delivery scheme. Using multiple bit rate video content, we show that the proposed system can gracefully adjust the common quality received at all the nodes while maintaining a continuous streaming experience at each, even when the network undergoes severe, uncorrelated bandwidth fluctuations at different peer nodes.

关键词： Peer-to-peer streaming, Distribution capacity, Quality adaptation, MutualCast

Measuring the orbital periods of low mass X-ray binaries in the X-ray band

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Research in Astronomy and Astrophysics 2014年第11期14卷 1367-1382页

作者： Yi chou Graduate Institute of Astronomy National Central University

A low mass X-ray binary （LMXB） contains either a neutron star or a black hole accreting materials from its low mass companion star. It is one of the primary astrophysical sources for studying stellar-mass compact objects and accreting phe- nomena. As with other binary systems, the most important parameter of an LMXB is the orbital period, which allows us to learn about the nature of the binary system and constrain the properties of the system＇s components, including the compact ob- ject. As a result, measuring the orbital periods of LMXBs is essential for investigating these systems even though fewer than half of them have known orbital periods. This article introduces the different methods for measuring the orbital periods in the X-ray band and reviews their application to various types of LMXBs, such as eclipsing and dipping sources, as well as pulsar LMXBs.

关键词： X-rays: binaries -- binaries: close -- methods: data analysis

A new model for evaluating the electrical conductivity of nonferrous slag

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International Journal of Minerals,Metallurgy and Materials 2009年第5期16卷 500-504页

作者： Kuo-Chih chou School of Metallurgical and Ecological Engineering University of Science and Technology Beijing

Electrical conductivity of molten slag is an important physicochemical property for designing the refming process in electric smelting furnaces. Though conductivities of many slag systems have been measured, the quantitative relationships of conductivity with slag composition and temperature are still very limited. In this article, the Arrhenius law was used to describe the experimental data of conductivities for CaO-MgO-Al2O3-SiO2, CaO-Al2O3-SiO2, CaO-MnO-AlEO3-SiO2, as well as CaO-MgO-MnO- Al2O3-SiO： systems, and it is found that activation energy can be expressed as a linear function of the content of components, where the optical basicity of slag must be within the range of 0.58 to 0.68.

关键词： electrical conductivity Arrhenius law activation energy optical basicity

Path planning for mobile robot using self-adaptive learning particle swarm optimization

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Science China(Information Sciences) 2018年第5期61卷 267-284页

作者： Guangsheng LI Wusheng chou School of Mechanical Engineering and Automation Beihang University State Key Laboratory of Virtual Reality Technology and Systems Beihang University

As a challenging optimization problem, path planning for mobile robot refers to searching an optimal or near-optimal path under different types of constrains in complex environments. In this paper, a self-adaptive learning particle swarm optimization(SLPSO) with different learning strategies is proposed to address this problem. First, we transform the path planning problem into a minimisation multi-objective optimization problem and formulate the objective function by considering three objectives: path length, collision risk degree and smoothness. Then, a novel self-adaptive learning mechanism is developed to adaptively select the most suitable search strategies at different stages of the optimization process, which can improve the search ability of particle swarm optimization(PSO). Moreover, in order to enhance the feasibility of the generated paths, we further apply the new bound violation handling schemes to restrict the velocity and position of each particle. Finally, experiments respectively with a simulated robot and a real robot are conducted and the results demonstrate the feasibility and effectiveness of SLPSO in solving mobile robot path planning problem.

关键词： path planning self-adaptive learning particle swarm optimization learning strategy learning mechanism boundary violations handling

Study of Non-Ideal Effects for Extended Gate Field Effect Transistor Chlorine Ion Sensing Device

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稀有金属材料与工程 2006年第A3期35卷 242-243页

作者： Jung-Chuan chou Pei-Lan chou Graduate School of Electronic Engineering National Yunlin University of Science and TechnologyDouliouTaiwan 640China Graduate School of Optoelectronics National Yunlin University of Science and TechnologyDouliouTaiwan 640China

We use the extended gate field effect transistor (EGFET)as the structure of the chlorine ion sensor,and the chlorine ion ionophores (ETH9033 and TDDMAC1)are incorporated into solvent polymeric membrane (PVC/DOS),then the chlorine ion selective membrane is formed on the sensing window,and the fabrication of the EGFET chlorine ion sensing device is *** surface potential on the sensing membrane of the EGFET chlorine ion sensing device will be changed in the different chlorine ion concentration solutions,then changes further gate voltage and drain current to detect chlorine ion *** will study non-ideal effects such as temperature,hysteresis and drift effects for the EGFET chlorine ion sensing device in this paper,these researches will help us to improve the sensing characteristics of the EGFET chlorine ion sensing device.

关键词： extended gate field effect transistor chlorine ion ionophore chlorine ion sensing device temperature effect hysteresis effect drift effect

Extended Gate Field Effect Transistor Based Measuring of the Vitamin C content of Orange Juice

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稀有金属材料与工程 2006年第A3期35卷 342-343页

作者： Jung-Chuan chou Department of Electronic Engineering National Yunlin University of Science and TechnologyDouliouTaiwan 640China

An extended-gate field effect transistor (EGFET)of SnO_2/ITO glass was applied to manufacture the vitamin C ***,we immobilized the ascorbate oxidase with 3-glycidoxypropyltrimethoxysilane (GPTS)method to measure the different concentrations of the vitamin C solution in an optimum measurement *** order to find the best measurement conditions of the biosensor,we studied the vitamin C sensor in different pH values of the phosphate buffer solution (PBS).Additionally,we used experimental results to discuss the response time and response voltage to compare vitamin C with orange juice for the vitamin C sensor.

关键词： orange juice extended-gate field effect transistor SnO2/ITO glass vitamin C sensor