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心脏磁共振评估肾素-血管紧张素-醛固酮系统的心血管相互作用：动脉粥样硬化的多种族研究

中华高血压杂志(中英文) 2024年第6期 600-600页

作者： Varadarajan V Marques MD Venkatesh BA Allison M Ostovaneh MR Yoneyama K Donekal S shah rv Murthy VL Wu CO Tracy RP Ouyang P Rochitte EC Bluemke DA Lima JAC 袁源练桂丽

小型研究已描述了肾素-血管紧张素-醛固酮系统在心血管系统中的作用。该研究旨在探讨醛固酮和血浆肾素活性（plasma renin activity,PRA）与心血管结构和功能的关系。方法：研究者评估在2003-2005年进行醛固酮和PRA检测，并在2010年接...

小型研究已描述了肾素-血管紧张素-醛固酮系统在心血管系统中的作用。该研究旨在探讨醛固酮和血浆肾素活性（plasma renin activity,PRA）与心血管结构和功能的关系。方法：研究者评估在2003-2005年进行醛固酮和PRA检测，并在2010年接受心脏磁共振检查的动脉粥样硬化多种族研究参与者的随机样本。排除服用血管紧张素转换酶抑制药或血管紧张素受体阻滞药的参与者。结果：醛固酮组615例，平均年龄（61.6±8.9）岁；肾素组580例，平均年龄（61.5±8.8）岁，两组女性占比均约50%。

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综合代谢特征可改善年轻人的心血管病风险预测

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中华高血压杂志 2020年第11期28卷 1099-1099页

作者： Murthy VL Reis JP Pico AR Kitchen R Lima JAC Lloyd-Jones D Allen NB Carnethon M Lewis GD Nayor M Vasan RS Freedman JE Clish CB shah rv 刘青(译) 刘莉(摘/审校) 不详

虽然心血管病指标定义了年龄≥40岁个体的风险,但心血管病的最早期病变在40岁以前就出现了。尽管代谢在心血管病先兆中起重要作用,然而在年轻、混血人群中确定精确代谢风险的研究尚缺乏。研究者获取青年冠状动脉风险发展(coronary arter... 详细信息

虽然心血管病指标定义了年龄≥40岁个体的风险,但心血管病的最早期病变在40岁以前就出现了。尽管代谢在心血管病先兆中起重要作用,然而在年轻、混血人群中确定精确代谢风险的研究尚缺乏。研究者获取青年冠状动脉风险发展(coronary artery risk development in young adults,CARDIA)研究中的2330名白人和非洲裔青年(平均年龄32岁,45%为非洲裔)资料进行分析,以确定代谢情况与20年后不良心血管病现象(心肌结构/功能、适应性、血管钙化)、机制及预后的相关性。

关键词：早期病变代谢情况心血管病心肌结构血管钙化代谢特征指标定义 artery

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The Concordance Rates between LV Hypertrophy and rv Hypertrophy in Patients with Hypertrophic Cardiomyopathy as Diagnosed by Cardiovascular MRI with Fibrosis Imaging

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World Journal of Cardiovascular Diseases 2015年第7期5卷 171-180页

作者： Nessim N. Amin Saundra B. Grant June A. Yamrozik Ronald B. Williams Diane V. Thompson Mark Doyle Moneal shah Robert W. W. Biederman Gerald McGinnis Cardiovascular Institute Allegheny General Hospital Pittsburgh Pennsylvania USA

Introduction: CMR has become the leading modality to define the clinical impact of hypertrophic cardiomyopathy (HCM). Late gadolinium enhancement (LGE) accurately identifies regions of myocardial fibrosis. It is well known that myocardial fibrosis can occur in patients with HCM and is independently linked to a poorer prognosis than those without fibrosis by CMR. Hypothesis: We hypothesize that there is significant rv involvement in HCM when incorporates a CMR analysis for rv hypertrophy and fibrosis. Methods: A retrospective review of all patients referred for HCM was performed. SSFP/LGE techniques were used to diagnose patients with HCM, using gadolinium administration (0.15 mmol/kg). Post-injection (10 minutes) LGE images were obtained using manual T1-weighted, IR-preparations. Regions of myocardium with LGE signals were visually designated as fibrotic. LV/rv mass indices (LVMI/rvMI) and ejection fractions were calculated. Results: Via 72 patients referred for HCM, 47(65%) were CMR confirmed. The mean LVMI was 108 ± 44 g/m2 while the mean rvMI was 30 ± 21 g/m2. As well, 34/47 (72%) had evidence of LV fibrosis while 24/47 (51%) had evidence for rv fibrosis. Of the rvH positive patients, 26/34 (76%) patients were LV LGE positive and 18/34 (52%) were rv LGE positive. Conclusion: The high frequency of rvH and rv fibrosis in the setting of HCM is surprising in that this phenomenon is rarely described. However, there is no reason to expect the phenotypic expression should be limited to the LV. Interestingly, as for the LV, the presence or absence of rv fibrosis has little predictive power towards the systolic function.

关键词： Cardiac MRI Right Ventricle Hypertrophic Cardiomyopathy Fibrosis Imaging Hypertrophy

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新生儿肾静脉血栓形成的临床转归及血栓形成前疾病的发病率

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世界核心医学期刊文摘（儿科学分册） 2006年第1期2卷 23-23页

作者： Marks S.D. Massicotte M.P. Steele B.T. V.S. shah 朱新菊 Department of Pa ediatrics Mount Sinai Hospital 600 University Ave Toronto Ont. M5G 1X5 Canada Dr.

Objective: To determine clinical outcomes and the prevalence of prothrombotic conditions in patients who had neonatal renal venous thrombosis (rvT). Study des ign: A retrospective cohort of neonates with rvT who were admitted to 4 pediatri c centers from 1980 to 2001 was identified. Information on clinical presentation , laboratory and radiological investigation, and treatment were abstracted. Surv ivors were evaluated for renal status and prothrombotic conditions. Results: For tythree patients with neonatal rvT were identified. rvT was unilateral in 24 pat ients (56%) and associated with thrombi at other sites in 32 patienets (74%). Clinical presentations included renal failure in 24 patients (56%), thrombocyto penia, anemia, or both in 22 patients (51%), and renal mass in 21 patients (49 %). Neonatal interventions included anti-coagulants in 28 patients (65%), ant ihypertensive medications in 9 patients (21%), peritoneal dialysis in 2 patient s (5%), and nephrectomy in 2 patients (5%). The median age at follow-up was 3 .7 years (range, 0.5-20.2 years). Thirteen patients (34%) had hypertension, an d 11 patients (29%) had renal failure. End-stage renal disease developed in 3 patients, and they underwent live-related renal transplants. Twelve of the 28 p atients (43%) examined had prothrombotic abnormalities. Conclusion: Neonatal rv T is associated with significant renal morbidity and a high prevalence of prothr ombotic abnormalities.

关键词：肾静脉血栓形成临床转归肾功能衰竭回顾性诊断存活者终末期肾病儿童中心高发率抗高血压药物

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