新生儿肾静脉血栓形成的临床转归及血栓形成前疾病的发病率

作     者：Marks S.D. Massicotte M.P. Steele B.T. V.S. Shah 朱新菊 

作者机构：Department of Pa ediatrics Mount Sinai Hospital 600 University Ave Toronto Ont. M5G 1X5 Canada Dr. 

出 版 物：《世界核心医学期刊文摘（儿科学分册）》 (Dkgest of the World Latest Medical Information)

年 卷 期：2006年第2卷第1期

页      面：23-23页

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

主　　题：肾静脉血栓形成 临床转归 肾功能衰竭 回顾性诊断 存活者 终末期肾病 儿童中心 高发率 抗高血压药物 

摘      要：Objective: To determine clinical outcomes and the prevalence of prothrombotic conditions in patients who had neonatal renal venous thrombosis (RVT). Study des ign: A retrospective cohort of neonates with RVT who were admitted to 4 pediatri c centers from 1980 to 2001 was identified. Information on clinical presentation , laboratory and radiological investigation, and treatment were abstracted. Surv ivors were evaluated for renal status and prothrombotic conditions. Results: For tythree patients with neonatal RVT were identified. RVT was unilateral in 24 pat ients (56%) and associated with thrombi at other sites in 32 patienets (74%). Clinical presentations included renal failure in 24 patients (56%), thrombocyto penia, anemia, or both in 22 patients (51%), and renal mass in 21 patients (49 %). Neonatal interventions included anti-coagulants in 28 patients (65%), ant ihypertensive medications in 9 patients (21%), peritoneal dialysis in 2 patient s (5%), and nephrectomy in 2 patients (5%). The median age at follow-up was 3 .7 years (range, 0.5-20.2 years). Thirteen patients (34%) had hypertension, an d 11 patients (29%) had renal failure. End-stage renal disease developed in 3 patients, and they underwent live-related renal transplants. Twelve of the 28 p atients (43%) examined had prothrombotic abnormalities. Conclusion: Neonatal RV T is associated with significant renal morbidity and a high prevalence of prothr ombotic abnormalities.