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COVID-19 Vaccine Acceptance and Hesitancy among Pregnant Women: A Knowledge, Attitude, and Perceived Risks Survey in Lusaka, Zambia

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Pharmacology & Pharmacy 2024年第5期15卷 147-166页

作者： Steward Mudenda Ruth Mbewe Manal Hadi Ghaffoori Kanaan shafiq mohamed Department of Pharmacy School of Health Sciences University of Zambia Lusaka Zambia Department of Agriculture Technical Institute of Suwaria Middle Technical University Baghdad Iraq Medicines Management and Pharmacy Services St. James University Hospital Leeds Teaching Hospitals NHS Trust Leeds United Kingdom

Introduction: The coronavirus disease 2019 (COVID-19) is an infectious disease of the respiratory tract caused by SARS-CoV-2. Since its emergence, there have been increased rates of transmission and spread, morbidity and mortality which led to the development of COVID-19 vaccines to address the pandemic. This study assessed acceptance, knowledge, attitude, and perceived risks regarding COVID-19 vaccines among pregnant women attending antenatal care at two First-Level Hospitals in Lusaka, Zambia. Materials and Methods: This was a cross-sectional study that was conducted among 241 pregnant women using a questionnaire from August 2023 to October 2023 in two First-Level Hospitals in Lusaka district, Zambia. The collected data were analyzed using IBM Statistical Package for Social Sciences (SPSS) version 22.0. Statistical analysis was performed using a Chi-square test. The statistical significance was set at a 95% confidence level. Results: Of the 241 participants, 107 (42.7%) were aged between 24 and 34 years. Overall, 64.3% accepted the COVID-19 vaccines, of which 122 (50.6%) were already vaccinated. Further, 203 (84.6%) of the pregnant women had good knowledge, and 199 (82.6%) had positive attitudes towards COVID-19 vaccines. However, 58.5% thought COVID-19 vaccines were not safe and could cause infertility. Alongside this, 70.1% thought that COVID-19 vaccines were harmful during pregnancy. Having good knowledge of COVID-19 vaccines was associated with age (p = 0.049), education status (p = 0.001), and employment status (p = 0.001). Having a positive attitude towards COVID-19 vaccines was associated with education status (p = 0.001) and employment status (p = 0.001). Conclusion: This study found that most pregnant women had good knowledge, and positive attitudes, and the majority accepted the COVID-19 vaccine. Encouragingly, most of the pregnant women who accepted the COVID-19 vaccines were already vaccinated. Most pregnant women thought that COVID-19 vaccines had sid

关键词： COVID-19 Vaccines Pregnant Women Vaccine Acceptance Vaccine Hesitancy Zambia

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Knowledge, Attitudes, and Practices of Poultry Farmers on Antimicrobial Use and Resistance in Kitwe, Zambia: Implications on Antimicrobial Stewardship

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Open Journal of Animal Sciences 2023年第1期13卷 60-81页

作者： Samuel Chilawa Steward Mudenda Victor Daka Misheck Chileshe Scott Matafwali Billy Chabalenge Prudence Mpundu Webrod Mufwambi shafiq mohamed Ruth Lindizyani Mfune Department of Public Health Michael Chilufya Sata School of Medicine Copperbelt University Ndola Zambia Department of Pharmacy School of Health Sciences University of Zambia Lusaka Zambia Mary Begg Health Services Ndola Zambia Clinical Research Department Faculty of Infectious and Tropical Diseases London School of Hygiene & Tropical Medicine London UK Department of Medicines Control Zambia Medicines Regulatory Authority Lusaka Zambia Department of Environmental and Occupational Health School of Health Sciences Levy Mwanawasa Medical University Lusaka Zambia Remedium Pharmaceuticals Limited Lusaka Zambia

Introduction: The inappropriate antimicrobial usage (AMU) in chicken production has led to an increase in the prevalence of antimicrobial resistance (AMR). In Zambia, there is little information documented regarding the knowledge, attitude, and practices of poultry farmers on AMU and AMR. Therefore, this study assessed the knowledge, attitude and practices regarding AMU and AMR among poultry farmers in Kitwe, Zambia. Methods: This was a cross-sectional study conducted among 106 poultry farmers from November to December 2021 using a structured questionnaire. Data analysis was done using IBM Statistical Package for Social Sciences (SPSS) version 26. Results: Overall, of the 106 participants, 90.6% knew what antimicrobials were, but only 29.2% were aware of AMR. The study showed that 46.2% of the participants had low knowledge, 71.7% had negative attitudes, and 61.3% had poor practices regarding AMR. The prevalence of antibiotic use in poultry production was 83%. The most used antimicrobials were tetracycline (84%) and gentamicin (35.2%). The commonly reported reason for the use of antimicrobials was for the treatment (93.2%) and prevention (89.8%) of diseases. Further, 76.9% of the administered antimicrobials were usually done without veterinarian consultation or prescription. Conclusion: The study shows that there was high AMU in poultry farms in Kitwe. However, there was low knowledge, negative attitude, and poor practices towards AMU and AMR. Therefore, there is a need for educational and sensitisation programmes regarding AMU and AMR among poultry farmers in Kitwe, Zambia. Alongside this, antimicrobial stewardship and surveillance systems should be strengthened in the livestock production sector. This will ensure food safety and public health.

关键词： Antibiotics Antimicrobials Antimicrobial Resistance Antimicrobial Stewardship Attitudes Knowledge Livestock Poultry Farmers Practices

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Global Strategies to Combat Antimicrobial Resistance: A One Health Perspective

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Pharmacology & Pharmacy 2023年第8期14卷 271-328页

作者： Steward Mudenda Billy Chabalenge Victor Daka Ruth Lindizyani Mfune Kyembe Ignitius Salachi shafiq mohamed Webrod Mufwambi Maisa Kasanga Scott Kaba Matafwali Department of Pharmacy School of Health Sciences University of Zambia Lusaka Zambia Department of Medicines Control Zambia Medicines Regulatory Authority Lusaka Zambia Department of Public Health Michael Chilufya Sata School of Medicine Copperbelt University Ndola Zambia Medicines Management and Pharmacy Services St James University Hospital Leeds Teaching Hospitals NHS Trust Leeds UK Department of Epidemiology and Biostatistics School of Public Health Zhengzhou University Zhengzhou China Clinical Research Department Faculty of Infectious and Tropical Diseases London School of Hygiene & Tropical Medicine London UK

Background: Antimicrobial resistance (AMR) is a global health challenge that has escalated due to the inappropriate use of antimicrobials in humans, animals, and the environment. Developing and implementing strategies to reduce and combat AMR is critical. Purpose: This study aimed to highlight some global strategies that can be implemented to address AMR using a One Health approach. Methods: This study employed a narrative review design that included studies published from January 2002 to July 2023. The study searched for literature on AMR and antimicrobial stewardship (AMS) in PubMed and Google Scholar using the 2020 PRISMA guidelines. Results: This study reveals that AMR remains a significant global public health problem. Its severity has been markedly exacerbated by inappropriate use of antimicrobials in humans, animals, and the broader ecological environment. Several strategies have been developed to address AMR, including the Global Action Plan (GAP), National Action Plans (NAPs), AMS programs, and implementation of the AWaRe classification of antimicrobials. These strategies also involve strengthening surveillance of antimicrobial consumption and resistance, encouraging the development of new antimicrobials, and enhancing regulations around antimicrobial prescribing, dispensing, and usage. Additional measures include promoting global partnerships, combating substandard and falsified antimicrobials, advocating for vaccinations, sanitation, hygiene and biosecurity, as well as exploring alternatives to antimicrobials. However, the implementation of these strategies faces various challenges. These challenges include low awareness and knowledge of AMR, a shortage of human resources and capacity building for AMR and AMS, in adequate funding for AMR and AMS initiatives, limited laboratory capacities for surveillance, behavioural change issues, and ineffective leadership and multidisciplinary teams. Conclusion: In conclusion, this study established that AMR is prevale

关键词： Antimicrobial Resistance Antimicrobial Stewardship AWaRe Classification One Health Approach One Health Perspective Strategies Surveillance

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Antibiotic Prescribing Patterns in Adult Patients According to the WHO AWaRe Classification: A Multi-Facility Cross-Sectional Study in Primary Healthcare Hospitals in Lusaka, Zambia

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Pharmacology & Pharmacy 2022年第10期13卷 379-392页

作者： Steward Mudenda Mary Chomba Billy Chabalenge Christabel Nang’andu Hikaambo Michelo Banda Victor Daka Annie Zulu Abraham Mukesela Maxwell Kasonde Peter Lukonde Enock Chikatula Lloyd Matowe Ronald Kampamba Mutati Tyson Lungwani Muungo Tobela Mudenda shafiq mohamed Scott Matafwali Department of Pharmacy School of Health Sciences University of Zambia Lusaka Zambia Department of Medicines Control Zambia Medicines Regulatory Authority Lusaka Zambia Department of Public Health Michael Chilufya Sata School of Medicine Copperbelt University Ndola Zambia Bell Pharmacy Kabulonga Centro Mall Lusaka Zambia Ministry of Health Headquarters Ndeke House Lusaka Zambia Department of Pharmacy Levy Mwanawasa University Teaching Hospital Lusaka Zambia Faculty of Pharmacy School of Pharmacy Eden University Lusaka Zambia Department of Pathology Ndola Teaching Hospital Ndola Zambia Remedium Pharmaceuticals Limited Lusaka Zambia Clinical Research Department Faculty of Infectious and Tropical Diseases London School of Hygiene & Tropical Medicine London UK

Introduction: Indiscriminate prescribing and using of antibiotics have led to the development of antimicrobial resistance (AMR). To reduce this problem, the World Health Organization (WHO) developed the “Access”, “Watch”, and “Reserve” (AWaRe) classification of antibiotics that promotes antimicrobial stewardship (AMS). In Zambia, there are gaps in practice regarding prescribing of antibiotics based on the AWaRe protocol. This study assessed antibiotic prescribing patterns in adult in-patients in selected primary healthcare hospitals in Lusaka, Zambia. Materials and Methods: This retrospective cross-sectional study was conducted using 388 patient medical files from September 2021 to November 2021, five primary healthcare hospitals namely;Chawama, Matero, Chilenje, Kanyama, and Chipata. Data analysis was performed using the Statistical Package for Social Sciences version 23. Results: Of the selected medical files, 52.3% (n = 203) were for male patients. Overall, the prevalence of antibiotic use was 82.5% (n = 320) which was higher than the WHO recommendation of a less than 30% threshold. The most prescribed antibiotic was ceftriaxone (20.3%), a Watch group antibiotic, followed by metronidazole (17.8%) and sulfamethoxazole/trimethoprim (16.3%), both belonging to the Access group. Furthermore, of the total antibiotics prescribed, 41.9% were prescribed without adhering to the standard treatment guidelines. Conclusion: This study found a high prescription of antibiotics (82.5%) that can be linked to non-adherence to the standard treatment guidelines in primary healthcare hospitals. The most prescribed antibiotic was ceftriaxone which belongs to the Watch group, raising a lot of concerns. There is a need for rational prescribing of antibiotics and implementation of AMS programs in healthcare facilities in Zambia, and this may promote surveillance of irrational prescribing and help reduce AMR in the future.

关键词： Antibiotic Prescribing Antimicrobial Resistance Antimicrobial Stewardship AWaRe Classification Prescribing Patterns Primary Healthcare Surveillance Zambia

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Psychological Impact of COVID-19 on Healthcare Workers in Africa, Associated Factors and Coping Mechanisms: A Systematic Review

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Advances in Infectious Diseases 2022年第3期12卷 518-532页

作者： Steward Mudenda Billy Chabalenge Scott Matafwali Victor Daka Misheck Chileshe Webrod Mufwambi Ruth Lindizyani Mfune Josephine Chali Mukuka Chomba Michelo Banda Racheal Mwaweza Ronald Kampamba Mutati Tyson Lungwani Muungo John Balidawa Christabel Nang’andu Hikaambo James Mwanza Maisa Kasanga shafiq mohamed Department of Pharmacy School of Health Sciences University of Zambia Lusaka Zambia Department of Medicines Control Zambia Medicines Regulatory Authority Lusaka Zambia Clinical Research Department Faculty of Infectious and Tropical Diseases London School of Hygiene & Tropical Medicine London United Kingdom Department of Public Health Michael Chilufya Sata School of Medicine Copperbelt University Ndola Zambia MaryBegg Health Services Ndola Zambia Faculty of Paediatrics and Child Health Lusaka College of Nursing Lusaka Zambia Unicaf University Kampala Uganda Department of Pharmacy School of Health Sciences University of Zambia Lusaka Zambia College of Public Health Zhengzhou University Zhengzhou China Department of Pathology and Microbiology University Teaching Hospitals Lusaka Zambia Remedium Pharmaceuticals limited Salama Park Lusaka Zambia

Background: The coronavirus disease 2019 (COVID-19) is a public health problem that has caused harm to the mental health of healthcare workers. In Africa, the COVID-19 pandemic has led healthcare workers to experience mental health disorders such as anxiety, depression, stress, insomnia and burnout. This study aimed to review published studies on the effect of COVID-19 on the mental health of healthcare workers, associated factors and coping strategies that have been employed in Africa. Methods: This was a systematic review that was conducted through searching databases including;PubMed/Medline and Google Scholar. The study included published literature from January 2020 to May 2022 that met the inclusion criteria. The selection of articles was conducted following the 2020 PRISMA guidelines. Results: A total of 39 articles were retrieved, of which only 18 met the inclusion criteria and were used in this study. Our review revealed that healthcare workers experienced mental health disorders such as anxiety, depression, insomnia, stress and burnout that were associated with the COVID-19 pandemic. Coping strategies such as religious practices, support from family members and colleagues and avoiding listening to social media about COVID-19 were used to minimize mental health problems. Conclusion: The COVID-19 pandemic has caused increased mental health disorders among healthcare workers in Africa. Identification of factors associated with mental health problems is cardinal in developing coping mechanisms against the psychological impact of COVID-19. Therefore, there is a need for governments to develop and implement strategies for protecting the mental health of healthcare workers during crises such as the COVID-19 pandemic.

关键词： Africa Coping Mechanisms COVID-19 Factors Healthcare Workers Mental Health Pandemic Psychological Impact

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Experimental investigation of the influence of carbonated water on sandstone and carbonate rock properties

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Petroleum Research 2023年第3期8卷 316-323页

作者： Hisham Ben Mahmud mohamed Khalifa Mian shafiq Ausama Giwelli Department of Chemical and Energy Engineering Curtin University MalaysiaFaculty of Engineering and ScienceMiri98009SarawakMalaysia Energy and Environmental Research Cluster Faculty of Engineering and ScienceCurtin University MalaysiaSarawak98009Malaysia Department of Earth Sciences School of Basic SciencesLibyan Academy of Postgraduate StudiesPO Box79031JanzourLibya Department of Chemical and Petroleum Engineering UCSI University56000Malaysia Australian Resources Research Centre CSIROKensingtonAustralia

Laboratory measurements using nuclear magnetic resonance,scanning electron microscopy,and gas porosity and permeability analysis were conducted to acquire a petrophysical interpretation of the Carbon Tan Sandstone and Savonnieres Carbonate for potential carbon dioxide storage in subsurface *** relationships between pore structures,such as pore-size distribution,pore geometry,and porosity/permeability,were investigated near and far from the *** operating pressures of 2500psi(17.24 MPa)and temperatures of 176F(50℃),carbonated water was injected into a composite core constructed of two similar core samples bounded by a compact disc located between *** current results showed that a strong calcite dissolution took place near the injection position of both rock samples and led to improvements in the primary intergranular permeability and porosity,while the carbonate sample showed significant improvement compared to *** durable heterogeneous dissolution of calcite grains also led to the creation of new pores as intra-granular *** at deeper depths from the injection position,it noticed an insignificant development in pore structure and its populations as well as rock hydraulic properties of both rock *** conclusion,the study revealed that the injected carbonated brine had a valuable impact on fluid-formation interactive,which improved rock's inlet properties compared with outlet.

关键词： CO_(2)ebrine injection Fluid-carbonate/sandstone interaction Petrophysical properties Pore structure NMR SEM analysis

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Petrophysical interpretations of subsurface stratigraphic correlations,Baram Delta,Sarawak,Malaysia

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Energy Geoscience 2020年第3期1卷 100-114页

作者： Hisham Ben Mahmud Muhammad Hilmi Bin Muhammad Hisham Walid mohamed Mahmud Van Hong Leong Mian Umer shafiq Curtin University Malaysia CDT250Miri98000SarawakMalaysia Emerson Automation Solutions KlangSelangorMalaysia University of Tripoli TripoliLibya Xiamen University Malaysia Jalan SunsuriaBandar Sunsuria43900SepangSelangorMalaysia NFC IET Petroleum and Gas EngineeringMultanPakistan

Petrophysical well log data help to predict hydrocarbon reserves before field development which involves huge financial *** this study,reservoir characterization was performed with a view to obtain information on the geological formation type and petrophysical *** log data obtained from five wells were used to develop a 3D model of X-field in the Baram Delta which was in turn evaluated using the PETREL *** of gamma ray,sonic,density,resistivity and neutron logs aided the delineation and correlation of the sandstone *** hydrocarbon-bearing sands were defined from well log data and divided into two-reservoir zones,shallow and *** correlation assisted in the delineation of the reservoir sands across the *** quality of the reservoir formation was evaluated from average petrophysical properties:with an average thickness of 62 m,an average porosity of 0.19,an average net-to-gross ratio of 0.068,an average V-shale of 0.45,and an average water saturation of 0.95.A rollover anticline structure was identified across the field using the fault as a description *** of petrophysical parameters and uncertainty in the reservoir properties were included to predict the effect on the volume of oil in *** study revealed that the discovered hydrocarbon reserve resource accumulations in the Field X for the fourteen-mapped reservoir sands have a total proven reserve resource estimate of 740MMSTB at P90,655MMSTB at P50 and 593MMSTB at *** A and B are the only intervals with the highest recoverable oil,a volume of 256MMSTB at P90,215MMSTB at P50 and 181MMSTB at P10,*** analyses facilitated an improved reservoir description of shaly sandstone,which contributes to better planning of hydrocarbon re-development and future recovery,and thereby improving the energy supply security of the regions.

关键词： Oil reserve Well logging Effective porosity Shale volume Water saturation Oil saturation

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On the development of modular polyurethane-based bioelastomers for rapid hemostasis and wound healing

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Regenerative Biomaterials 2023年第1期10卷 640-654页

作者： Wanxin Guo Binan Zhao Muhammad shafiq Xiao Yu Yihong Shen Jie Cui Yujie Chen Pengfei Cai Zhengchao Yuan mohamed EL-Newehy Hany EL-Hamshary Yosry Morsi Binbin Sun Jianfeng Pan Xiumei Mo State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineCollege of Biological Science and Medical EngineeringDonghua UniversitySongjiangShanghai 201620P.R.China Department of Orthopedics Shanghai Tongji HospitalSchool of MedicineTongji UniversityPutuoShanghai 200065China Department of Chemical Engineering Faculty of EngineeringGraduate SchoolKyushu UniversityFukuoka 819-0395Japan Department of Chemistry College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Faculty of Engineering and Industrial Sciences Swinburne University of TechnologyBoroondaraVIC 3122Australia Department of Orthopedics Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityJinganShanghai 200072China

Massive hemorrhage may be detrimental to the patients,which necessitates the advent of new materials with high hemostatic efficiency and good *** objective of this research was to screen for the effect of the different types of bio-elastomers as hemostatic dressings.3D loose nanofiber sponges were prepared;PU-TA/Gel showed promising ***(PU)was synthesized and electrospun to afford porous sponges,which were crosslinked with glutaraldehyde(GA).FTIR and 1H-NMR evidenced the successful synthesis of *** prepared PU-TA/Gel sponge had the highest porosity and water absorption ***,PU-TA/Gel sponges exhibited cytocompatibility,negligible hemolysis and the shortest clotting ***-TA/Gel sponge rapidly induced stable blood clots with shorter hemostasis time and less bleeding volume in a liver injury model in ***,PU-TA/Gel sponges also induced good skin regeneration in a full-thickness excisional defect model as revealed by the histological *** results showed that the PU-TA/Gel-based sponges may offer an alternative platform for hemostasis and wound healing.

关键词： polyurethane electrospinning hemostasis material wound healing tissue regeneration regenerative medicine

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Multi‑Functional Fibrous Dressings for Burn Injury Treatment with Pain and Swelling Relief and Scarless Wound Healing

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Advanced Fiber Materials 2023年第6期5卷 1963-1985页

作者： Zhengchao Yuan Yue Zhao Muhammad shafiq Jiahui Song Jing Hou Yuqing Liang Xiao Yu Yujie Chen Fan Yu mohamed EL‑Newehy Hany EL‑Hamshary Yosry Morsi Shichao Jiang Hui Zheng Xiumei Mo State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano‑Biomaterials and Regenerative MedicineCollege of Biological Science and Medical EngineeringDonghua UniversityShanghai 201620People’s Republic of China Department of Chemical Engineering Faculty of EngineeringGraduate SchoolKyushu UniversityFukuoka 819‑0395Japan United Graduate School of Drug Discovery and Medical Information Sciences Gifu University1‑1 YanagidoGifu 501‑1193Japan Department of Orthopedics Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021People’s Republic of China Department of Chemistry College of ScienceKing Saud UniversityP.O.Box 245511451 RiyadhSaudi Arabia Faculty of Engineering and Industrial Sciences Swinburne University of TechnologyBoroondaraVIC 3122Australia Medical Science and Technology Innovation Center Shandong First Medical University&Shandong Academy of Medical SciencesJinan 250117People’s Republic of China Department of Thoracic Surgery Shanghai Pulmonary HospitalTongji University School of MedicineShanghai 200443People’s Republic of China

As one of the most common forms of skin injuries,skin burns are often accompanied by edema pain,suppuration of infection,slow tissue regeneration,and severe scar formation,which significantly delay wound healing as well as affect the quality of *** prepared multifunctional electrospun poly(L-lactide-co-glycolide)/gelatin(P/G)-based dressings to synergistically harness the therapeutic benefits of peppermint essential oil(T),burn ointment(B),and Oregano essential oil(O)(P/G@TBO)for skin regeneration in punch and burn injury *** P/G@TBO can afford the sustained release of bioactive cues for up to 72 h as well as remarkably promote cell migration(ca.P/G@TBO,89%*** group,51%)at 24 *** P/G@TBO membranes also showed significant angiogenic effect as well as antibacterial and anti-inflammatory properties than that of the control group in ***,P/G@TBO dressings enabled fast wound healing(ca.P/G@TBO,100%wound closure *** group,95%)in a full-thickness excisional defect model up to 14 days in *** evaluation of membranes in different animal models,including tail wagging model,facial itch model,and hot burn injury model showed significant pain relieve effect as well as itching and swelling relief functions during earlier stages of wound *** were next transplanted into a scalded wound model in rats and an ear punch wound model in rabbits,which manifested antibacterial and anti-inflammatory properties and promoted re-epithelialization to achieve scarless wound healing percentage wound closure at day 28:P/G@TBO,96%*** group 66%.Taken together our approach of simultaneously harnessing T,B,and O to enable multifunctionality to fibrous dressings may hold great promise for burn wound healing applications and other related disciplines.

关键词： Burn injury Wound healing Skin regeneration Pain and swelling relief Nanofiber membrane

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Flexible Copper‑Doped Silica Fibers Promote Infected Conjunctival Tissue Repair Through Antibacterial and Anti‑inflammatory Effects

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Advanced Fiber Materials 2024年第1期6卷 278-296页

作者： Jie Cui Yuchen Cai Xiao Yu Yihong Shen Tianyi Zhou Binbin Sun Pengfei Cai Zhengchao Yuan Muhammad shafiq mohamed EL‑Newehy Hany EL‑Hamshary Xingping Zhou Yao Fu Xiumei Mo State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano‑Biomaterials and Regenerative MedicineCollege of Biological Science and Medical EngineeringDonghua UniversityShanghai 201620People’s Republic of China Department of Ophthalmology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011People’s Republic of China Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology Shanghai 200011People’s Republic of China Innovation Center of NanoMedicine Kawasaki Institute of Industrial Promotion3‑25‑14 Tono‑machiKawasaki‑kuKanagawa 210‑0821Japan United Graduate School of Drug Discovery and Medical Information Sciences Gifu University1‑1 YanagidoGifu 501‑1193Japan Department of Chemistry College of ScienceKing Saud UniversityP.O.Box 245511451 RiyadhSaudi Arabia

The conjunctiva is crucial in safeguarding the eye from harm or infection,thereby ensuring the preservation of the *** repair of infected conjunctival damage is *** objective of this study is to develop copper-doped flexible silica nanofibers(SiO_(2)@Cu NFs)with multifunctional antibacterial and anti-inflammatory *** continuous release of copper ions from electrospun membranes is shown to be effective to promote antibacterial and bioactive *** membranes also exhibit biocompatibility and promote cell growth,angiogenesis,and inflammation *** vivo evaluations further reveal the therapeutic efficacy of SiO_(2)@Cu NFs to promote the structural and the functional recoveries of the *** together,SiO_(2)@Cu NFs may hold significant promise for the fabrication of alterna-tive ocular bandage to suppress bacterial infection and promote repair of ocular tissues and may potential be also used for related disciplines.

关键词： Conjunctival reconstruction Inorganic nanofiber Bacterial infection Angiogenesis Anti-inflammation

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