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Hepatobiliary & Pancreatic Diseases International 2022年第6期21卷 577-582页

作者： sha Chen Meng-Qi Li Wei-Jia Duan Bu-Er Li Shu-Xiang Li Ting-Ting Lv Lin Ma Ji-Dong Jia Liver Research Center Beijing Friendship HospitalCapital Medical UniversityBeijing Key Laboratory of Translational Medicine on Liver CirrhosisNational Clinical Research Center for Digestive Diseases95 Yong’an RoadBeijing 100050China

Background:Primary biliary cholangitis(PBC)patients often have concomitant extrahepatic autoimmune(EHA)diseases including Sjögren’s syndrome(SS),systemic sclerosis(SSc),rheumatoid arthritis(ra),and autoimmune thyroid *** present study aimed to describe the prevalence of EHA diseases in PBC and explore the impact of EHA diseases on the long-term outcomes of PBC in Chinese ***:Medical records of PBC patients diagnosed in our institute were retrospectively ***-tients were followed up by a standardized telephone *** endpoints were defined as liver-related death and/or liver ***:Totally 247 of the 985(25.1%)PBC patients enrolled in the study had at least one concomi-tant EHA ***ögren’s syndrome(n=140,14.2%)was the most frequent one,followed by rheuma-toid arthritis(ra)(n=56,5.7%)and Hashimoto’s thyroiditis(n=45,4.6%).Patients with EHA dis-eases were more common in females(Prall,no differences were found between PBC patients with and without EHA dis-eases in terms of biochemical response rates to ursodeoxycholic acid,the incidence of hepatic events,or transplant-free *** and EHA≥2 were protective factors for hepatic events in univariate Cox analysis,but the results became insignificant in multivariate ***:Concomitant EHA diseases were common in PBC patients but did not compromise the long-term outcomes of PBC.

关键词： Primary biliary cholangitis Extrahepatic autoimmune diseases Sjögren’s syndrome Rheumatoid arthritis Prognosis

Enhanced entanglement and asymmetric EPR steering between magnons

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Science China(Physics,Mechanics & Astronomy) 2021年第1期64卷 55-63页

作者： sha-sha Zheng Feng-Xiao Sun Huai-Yang Yuan Zbigniew Ficek Qi-Huang Gong Qiong-Yi He State Key Laboratory for Mesoscopic Physics and Frontiers Science Center for Nano-Optoelectronics School of Physics&Collaborative Innovation Center of Quantum MatterPeking UniversityBeijing100871China Beijing Academy of Quantum Information Sciences Beijing100193China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan030006China Institute for Theoretical Physics Utrecht University3584CCUtrechtThe Netherlands Quantum Optics and Engineering Division Institute of PhysicsUniversity of Zielona GóraZielona Góra65-516Poland

The generation and manipulation of strong entanglement and Einstein-Podolsky-Rosen(EPR)steering in macroscopic systems are outstanding challenges in modern ***,the observation of asymmetric EPR steering is important for both its fundamental role in interpreting the nature of quantum mechanics and its application as resource for the tasks where the levels of trust at different parties are highly ***,we study the entanglement and EPR steering between two macroscopic magnons in a hybrid ferrimagnet—light *** the absence of light,the two types of magnons on the two sublattices can be entangled,but no quantum steering occurs when they are damped with the same *** the presence of the cavity field,the entanglement can be significantly enhanced,and strong two-way asymmetric quantum steering appears between two magnons with equal *** is very different from the conventional protocols to produce asymmetric steering by imposing additional unbalanced losses or noises on the two parties at the cost of reducing *** essential physics is well understood by the unbalanced population of acoustic and optical magnons under the cooling effect of cavity *** finding may provide a novel platform to manipulate the quantum steering and the detection of bi-party steering provides a knob to probe the magnetic damping on each sublattice of a magnet.

关键词： quantum information magnon entanglement Einstein-Podolsky-Rosen steering cavity induced cooling

中医药调控肠道菌群从白细胞介素-6治疗类风湿性关节炎的研究进展

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世界中西医结合杂志 2024年第2期19卷 421-424页

作者：熊浪蒋总唐芳马武开兰维娅陈学勇蔡珊珊贵州中医药大学贵州贵阳550002 贵州中医药大学第二附属医院贵州贵阳550003

类风湿性关节炎(Rheumatoid arthritis, ra)是一种关节滑膜组织出现炎症与增生为临床特征的慢性自身免疫性疾病,其发病机制尚未明确。目前,研究发现ra与肠道菌群密切相关,肠道菌群失调激活促炎因子白细胞介素-6(Interleukin-6,IL-6)的表... 详细信息

类风湿性关节炎(Rheumatoid arthritis, ra)是一种关节滑膜组织出现炎症与增生为临床特征的慢性自身免疫性疾病,其发病机制尚未明确。目前,研究发现ra与肠道菌群密切相关,肠道菌群失调激活促炎因子白细胞介素-6(Interleukin-6,IL-6)的表达,促使关节发生炎症反应,进而诱导骨与软骨组织的破坏。对此,研究证实中医药及现代医学可调节肠道菌群的稳态和丰度,抑制促炎因子IL-6对关节的侵袭,改善ra的症状。故文中从肠道菌群对IL-6的作用进行综述,以期从新的靶点治疗ra提供新的临床方案。

关键词： IL-6 类风湿关节炎肠道菌群中医药研究进展

Metal-Free C_(3)N_(4) with plentiful nitrogen vacancy and increased specific surface area for electrocatalytic nitrogen reduction

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Journal of Energy Chemistry 2021年第9期30卷 546-555页

作者： Ziming Zhao Yu Long sha Luo Yutong Luo Ming Chen Jiantai Ma State Key Laboratory of Applied Organic Chemistry(SKLAOC) College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000GansuChina

As a substitute for synthetic ammonia under mild condition, electrocatalytic nitrogen reduction reaction(NRR) provides a hopeful approach for the development of ammonia. Nevertheless, the current development of NRR electrocatalysts is far from enough and a systematic research is needed to gain a better improvement. This article presents that 2 D C_(3)N_(4)-NV with a large specific surface area and abundant nitrogen vacancies is prepared by a simple and feasible method, and used as a metal-free catalyst for electrocatalytic NRR. Experiment result and density functional theory(DFT) calculation reveal that nitrogen vacancies in 2 D C_(3)N_(4)-NV can act as an efficient active site for catalytic NRR, which is conducive to capturing and activating N_(2), lowering Gibbs free energy(DG) in reaction and inhibiting hydrogen evolution reaction(HER) at the same time. In addition, the larger specific surface area also makes more active site exposed, which is good for the contact between the electrolyte and the active site, thus enhancing its NRR activity. The electrocatalyst shows an excellent catalytic activity for NRR in 0.1 M HCl, including Faradaic efficiency of 10.96%, NH_(3) yields of 17.85 lg h^(-1) mg_(cat)^(-1)., and good stability(over 20 h).

关键词： 2D C_(3)N_(4)-NV Larger specific surface area Nitrogen vacancy Electrocatalyst NRR

中国西北地表能量分配影响因子及特征空间法适用性

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中国沙漠 2022年第6期42卷 1-13页

作者：王丽娟郭铌沙莎胡蝶中国气象局兰州干旱气象研究所甘肃省干旱气候变化与减灾重点实验室/中国气象局干旱气候变化与减灾重点实验室甘肃兰州730020

利用2009年地面实测资料,分析中国西北地区不同气候区潜热、感热及其与净辐射之比随土壤体积含水量、土壤温度及入射辐射的变化特征,并结合2000—2018年中分辨率成像光谱仪(MODIS)产品讨论特征空间法在中国西北地区的适用性。结果表明:... 详细信息

利用2009年地面实测资料,分析中国西北地区不同气候区潜热、感热及其与净辐射之比随土壤体积含水量、土壤温度及入射辐射的变化特征,并结合2000—2018年中分辨率成像光谱仪(MODIS)产品讨论特征空间法在中国西北地区的适用性。结果表明:在以玛曲站为代表的高寒湿润区,入射能量始终是潜热的主导因素,用于潜热估算的斜率φ可直接取1.26,潜热估算精度依赖于净辐射的反演结果。在以兰州大学半干旱气候与环境监测站(SACOL,榆中站)和长武站为代表的半干旱、半湿润区,当入射能量充足时,土壤水分成为潜热的主导因子,这时候使用特征空间法估算的斜率φ值与实测值相关性显著,φ的估算精度将直接影响潜热估算结果。所以,特征空间法适用于以水分为潜热主导因子的地区和时段,且要满足植被指数与地表温度呈负相关。另外需要注意的是在选择特征空间法研究区时必须保证植被指数与地表温度的散点呈规则的“三角形”。

关键词：地表能量通量特征空间法土壤体积含水量 Priestley-Taylor

Iguratimod promotes transformation of mononuclear macrophages in elderly patients with rheumatoid arthritis by nuclear factor-κB pathway

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World Journal of Clinical Cases 2021年第10期9卷 2181-2191页

作者： sha Liu Li-Ping Song Rong-Bin Li Le-Heng Feng Hui Zhu Department of Rheumatism The First Hospital of QiqiharAffiliated Qiqihar Hospital of Southern Medical UniversityQiqihar 161005Heilongjiang ProvinceChina

BACKGROUND The role of macrophages in rheumatoid arthritis(ra)and its mechanism have attracted much attention in ra *** accumulate in the synoviums of ra,and the proportion of M1 type pro-inflammatory macrophages is higher than that of M2 type anti-inflammatory macrophages,leading to the secretion of inflammatory molecules and the aggravation of inflammatory reaction,which has made macrophages a potential target of ra *** is a kind of cyclo-oxygenase-2 inhibitor that affects macrophage *** is speculated that its anti-inflammatory and anti-rheumatic effects may be related to the regulation of macrophage M1/M2 *** To investigate the effects of Iguratimod on the polarity of mononuclear macrophages in elderly patients with *** Elderly patients with ra and joint effusion were selected,including 10 men and 25 women,with an average age of 66.37±4.42 *** were treated with oral administration of 25 mg Iguratimod(Iremod,State Food and Drug Administration Approval No.H20110084)twice daily for 12 *** Activity Score 28 and Health Assessment Questionnaire score were collected according to the disease severity before and after *** blood and joint effusion fluid were collected,mononuclear macrophages were extracted and expression of cell surface markers CD86,CD64,CD163,and CD206 was analyzed by flow *** concentration of inflammatory factors interleukin(IL)-6,IL-1β,transforming growth factor-β,and IL-4 in the joint effusion fluid was analyzed by enzyme-linked immunosorbent *** of mononuclear cells inhibitor of nuclear factor-κB(IκB)and phosphorylated IκB in peripheral blood was analyzed by western *** Disease Activity Score 28 score and Health Assessment Questionnaire score of patients treated with Iguratimod decreased *** percentage of cell surface markers CD86 and CD64 decreased significantly,and the percentage of CD163 and CD206 increased signifi

关键词： Rheumatoid arthritis Iguratimod Macrophage Polarity Nuclear factor-κB

Natural radioactivity level of associated bone-coal mining area in Zhejiang Province

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Nuclear Science and Techniques 2005年第5期16卷 310-314页

作者： YE Ji-Da ZHENG Hui-Di SONG Wei-Li ZENG Guang-Jian WANG sha-Ling WU Zong-Mei Environmental radiation Monitoring Station of Zhejiang Province Hangzhou 310012

The geographic distribution, γ-radiation level and specific activity of radionuclides of the bone-coal mines in Zhejiang Province were reported. The weighted average of γ-radiation dose rate of the bone-coal mines is 566 nGy/h for 107 main bone-coal mines. The weighted mean activity of 238U, 226ra, 232Th and 40K in the samples are 949, 918, 34 and 554 Bq/kg for 171 samples of bone-coal, respectively.

关键词：浙江放射性物质放射性污染骨煤海洋污染

Mesh migration into the sigmoid colon after inguinal hernia repair presenting as a colonic polyp:A case report and review of literature

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World Journal of Clinical Cases 2018年第12期6卷 564-569页

作者： sha Liu Xin-Xin Zhou Lin Li Mo-Sang Yu Hong Zhang Wei-Xiang Zhong Feng Ji Department of Gastroenterology the First Affiliated HospitalCollege of MedicineZhejiang University Department of Pathology the First Affiliated HospitalCollege of MedicineZhejiang University

Mesh migration and penetration into abdominal visce-ra rarely occur after laparoscopic inguinal hernia repair. We present the first case of mesh migration into the sigmoid colon identified as a colonic polyp at initial co-lonoscopic examination. The patient complained of mild abdominal distention in the lower abdomen over the previous year without changes in bowel habits or stool appearance and without weight loss. By complement-ary endoscopic ultrasonography, a cavity--like structure beneath the suspected polyp was further confirmed. Enhanced abdominal computed tomography merely re-vealed local bowel wall thickening and inflammation of the colosigmoid junction. The migrating mesh, which was lodged in the sigmoid colon and caused intra--abdomi-nal adhesion in the lower abdominal cavity, was finally identified via exploratory surgery. The components of inflammatory granulation tissue around the mesh mate-rial were diagnosed based on histological examination of the surgical specimen after sigmoidectomy. In this patient, nonspecific endoscopic and imaging outcomes during clinical work--up led to the diagnostic dilemma of mesh migration. Therefore, the clinical, radiological and endoscopic challenges specific to this case as well as the underlying reasons for mesh migration are discussed in detail.

关键词： Colonoscopy Surgical mesh Hernia repair Sigmoid colon Colonic polyps Computed tomography Foreign bodies

糖尿病合并冠心病患者使用胰岛素强化治疗后转换为司美格鲁肽治疗1例

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中华糖尿病杂志 2022年第S1期14卷 61-63页

作者：翟莎孟午生北京市门头沟区医院内分泌科北京102300

报道1例在北京市门头沟区医院内分泌科住院的2型糖尿病合并冠心病患者使用胰岛素强化治疗后转换为司美格鲁肽序贯治疗的诊疗过程。患者为60岁男性,因“多尿多饮8年,加重伴血糖控制不佳1个月”入院。既往有高血压、冠心病、高脂血症病史... 详细信息

报道1例在北京市门头沟区医院内分泌科住院的2型糖尿病合并冠心病患者使用胰岛素强化治疗后转换为司美格鲁肽序贯治疗的诊疗过程。患者为60岁男性,因“多尿多饮8年,加重伴血糖控制不佳1个月”入院。既往有高血压、冠心病、高脂血症病史。入院后完善化验检查明确糖尿病相关并发症,予胰岛素泵强化降糖后转换为司美格鲁肽联合达格列净治疗,血糖控制良好。司美格鲁肽是一种新型长效胰高糖素样肽-1受体激动剂(GLP-1ra),其给合并有心血管疾病的2型糖尿病患者治疗带来新的选择。

关键词：糖尿病,2型司美格鲁肽胰岛素泵强化

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细粒度金刚石砂轮超精密磨削硅片的表面质量

中国机械工程 2023年第2期34卷 245-251页

作者：王紫光刘金鑫尹剑周平沙智华康仁科大连交通大学辽宁省复杂零件精密制造重点实验室大连116028 大连理工大学精密与特种加工教育部重点实验室大连116023

为实现硅片高质量表面的超精密磨削,研究了5000目、8000目和30000目金刚石砂轮磨削硅片的表面质量。利用数学模型预测了硅片磨削表面的粗糙度ra并对预测结果进行了试验验证,分析了硅片磨削表面的形貌特征;通过磨床主轴电机的电流变化对... 详细信息

为实现硅片高质量表面的超精密磨削,研究了5000目、8000目和30000目金刚石砂轮磨削硅片的表面质量。利用数学模型预测了硅片磨削表面的粗糙度ra并对预测结果进行了试验验证,分析了硅片磨削表面的形貌特征;通过磨床主轴电机的电流变化对比分析了5000目、8000目和30000目砂轮磨削过程中的磨削力变化趋势。研究结果表明:8000目砂轮磨削后的单晶硅表面粗糙度ra小于10 nm,亚表面损伤深度小于150 nm,磨削过程中的磨削力稳定,磨削质量优于5000目砂轮,磨削过程的稳定性优于30000目砂轮。

关键词：磨削金刚石砂轮单晶硅表面质量

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