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A Study of Health Prescribing for Children with Tourette’s Disorders in Children’s Health Education Specialty Care Clinics

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Journal of Clinical and Nursing Research 2024年第7期8卷 261-266页

作者： Wenping Yang Le Wang sha.Wang Nannan Ma Li Mei sha.nxi Provincial People’s Hospital Xi’an 710000Shaanxi ProvinceChina

Objective:This study designs and implements the health prescription of children’s health education specialized nursing clinic based on the physical and mental characteristics of children with Tourette’s ***:Applying the evidence-based nursing model and nursing intervention theory based on the survey research by searching China Knowledge Network,Wanfang Database and Wipro Chinese Science and Technology Journal Database,the study collected the literature on the health prescription intervention research in children’s Tourette’s disorders health education in children’s health education of specialized nursing outpatient clinic for review and combined with the specialty characteristics to formulate“Children’s Tourette’s Disorder Health Education Prescription.”Results:Tourette’s syndrome in children is a common pediatric neurological disorder,mainly manifested as involuntary,rapid and repeated muscle twitching and vocal tics,which brings serious psychological pressure and life disturbance to the affected ***:For children with Tourette’s syndrome,healthcare professionals should give enough care and understanding to the children and their parents,provide timely and effective health education to them,help them improve their bad behavioral habits,establish correct cognitive attitudes,enhance self-confidence,improve patient compliance,reduce the frequency of recurrence,reduce the incidence of complications and promote children’s physical and mental health development.

关键词： Children’s health education Specialty care clinic Childhood Tourette’s disorder Health prescription

Frontier Progress of Landscape Character Assessment in China

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Journal of Landscape Research 2024年第1期16卷 1-6页

作者： LI sha.XIE Wanyu HUANG Tingting YANG Xin ZHU Jianning School of Architecture and Design China University of Mining and TechnologyXuzhouJiangsu 221116China School of Landscape Architecture Beijing Forestry UniversityBeijing 100083China School of Architecture and Art North China University of TechnologyBeijing 100144China

The role of Landscape Character Assessment(LCA)at the level of territorial landscape governance spans both natural and social *** analyzing the development history,research distribution,methods and applications of cutting-edge cases of LCA in China,the following conclusions are drawn:①the LCA research in China originated earlier than that in Europe,but has not yet been systematically applied to the implementation of urban and rural planning at all levels;②the fundamental theory of LCA in China has been well constructed,with three main research directions:technologyled,assessment-led,and assessment combined with other theories;③the development of LCA in rural areas is more mature than in urban areas,but the progress of research is uneven across regions;④the current research presents significant“bottom-up”academic characteristics,and there is an urgent need for government decision-making authorities and academia to jointly promote a“top-down”standardized governance mechanism to comprehensively promote the modernization of territorial landscape governance.

关键词： Landscape character assessment Territorial landscape Spatial planning Standardized mechanism Landscape governance modernization

Climate change drives flooding risk increases in the Yellow River Basin

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Geography and Sustainability 2024年第2期5卷 193-199页

作者： Hengxing Lan Zheng Zhao Langping Li Junhua Li Bojie Fu Naiman Tian Ruixun Lai sha.Zhou Yanbo Zhu fanyu Zhang Jianbing Peng John J.Clague State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China School of Geological Engineering and Geomatics Chang’an UniversityXi’an 710064China University of Chinese Academy of Sciences Beijing 10049China Yellow River Institute of Hydraulic Research Yellow River Conservancy CommissionZhengzhou 450003China State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China State Key Laboratory of Earth Surface Processes and Resources Ecology Beijing Normal UniversityBeijing 100875China Key Laboratory of Mechanics on Disaster and Environment in Western China The Ministry of Education of ChinaSchool of Civil Engineering and MechanicsLanzhou UniversityLanzhou 730000China Department of Earth Sciences Simon Fraser UniversityBurnabyCanada

The Yellow River Basin(YRB)has experienced severe floods and continuous riverbed elevation throughout *** climate change has been suggested to be driving a worldwide increase in flooding ***,owing to insufficient evidence,the quantitative correlation between flooding and climate change remains *** present a long time series of maximum flood discharge in the YRB dating back to 1843 compiled from historical documents and instrument *** in yearly maximum flood discharge show distinct periods:a dramatic decreasing period from 1843 to 1950,and an oscillating gentle decreasing from 1950 to 2021,with the latter period also showing increasing more extreme floods.A Mann-Kendall test analysis suggests that the latter period can be further split into two distinct sub-periods:an oscillating gentle decreasing period from 1950 to 2000,and a clear recent increasing period from 2000 to *** further predict that climate change will cause an ongoing remarkable increase in future flooding risk and an∼44.4 billion US dollars loss of floods in the YRB in 2100.

关键词： Flooding risk Risk management Climate change Flood discharge Extreme precipitation

First-line penpulimab(an anti-PD1 antibody)and anlotinib(an angiogenesis inhibitor)with nab-paclitaxel/gemcitabine(PAAG)in metastatic pancreatic cancer:a prospective,multicentre,biomolecular exploratory,phase II trial

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2960-2969页

作者： Huizi sha.fan Tong Jiayao Ni Yi Sun Yahui Zhu Liang Qi Xiaoqin Li Wei Li Yan Yang Qing Gu Xing Zhang Xiaoxuan Wang Chan Zhu Dongsheng Chen Baorui Liu Juan Du The Comprehensive Cancer Center Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing University&Clinical Cancer Institute of Nanjing UniversityNanjingChina The Comprehensive Cancer Center Nanjing Drum Tower HospitalClinical College of Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjingChina Department of Oncology The Affiliated Hospital of Jiangsu UniversityZhenjiangChina Department of Oncology The First Affiliated Hospital of Soochow UniversitySuzhouChina Department of Oncology The Affiliated Jiangning Hospital of Nanjing Medical UniversityNanjingChina National Institute of Healthcare Data Science at Nanjing University NanjingChina State Key Laboratory of Neurology and Oncology Drug Development Jiangsu Simcere Diagnostics Co.Ltd.Nanjing Simcere Medical Laboratory Science Co.Ltd.NanjingChina

Metastatic pancreatic cancer(mPC)has a dismal ***,we conducted a prospective,multicentre,single-arm,phase II trial evaluating the efficacy and safety of penpulimab and anlotinib in combination with nab-paclitaxel/gemcitabine(PAAG)in patients with first-line mPC(NCT05493995).The primary endpoints included the objective response rate(ORR)and disease control rate(DCR),while secondary endpoints encompassed progression-free survival(PFS),overall survival(OS),and *** 66 patients analysed for efficacy,the best response,indicated by the ORR,was recorded at 50.0%(33/66)(95%CI,37.4–62.6%),with 33 patients achieving partial response(PR).Notably,the DCR was 95.5%(63/66,95%CI,87.3–99.1%).The median PFS(mPFS)and OS(mOS)were 8.8(95%CI,8.1–11.6),and 13.7(95%CI,12.4 to not reached)months,*** 3/4 treatment-related adverse events(TRAEs)were reported in 39.4%of patients(26/66).In prespecified exploratory analysis,patients with altered SWI/SNF complex had a poorer ***,low serum CA724 level,high T-cell recruitment,low Th17 cell recruitment,and high NK CD56dim cell scores at baseline were potential predicative biomarkers for more favourable *** conclusion,PAAG as a first-line therapy demonstrated tolerability with promising clinical efficacy for *** biomolecular findings identified in this study possess the potential to guide the precise clinical application of the triple-combo regimen.

关键词： CA724 prospective centre

Research Progress on Combined Chinese and Western Medicine Treatment of Mycoplasma pneumoniae Pneumonia in Children

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Journal of Clinical and Nursing Research 2024年第6期8卷 117-122页

作者： Wenping Yang Le Wang sha.Wang Nannan Ma Li Mei sha.nxi Provincial People's Hospital Children's Hospital Xi'an 710000Shaanxi ProvinceChina

With the continuous development of medical technology,combined treatment of Chinese and Western medicine has gradually become a research *** a common disease in pediatrics,the treatment of Mycoplasma pneumoniae pneumonia(MPP)in children is also being explored and *** article summarizes the research progress of combined Chinese and Western medicine treatment of MPP in children in recent years,aiming to provide a useful reference for the combined treatment of MPP in *** article firstly introduces the etiology and pathogenesis of MPP in children,thereafter briefly introduces the Western anti-infective treatment and traditional Chinese medicine(TCM)diagnosis and treatment of MPP in children,and lastly introduces the methods of combined treatment of TCM and Western medicine in *** article points out that the combination of Chinese and Western medicine can give full play to the overall regulation of Chinese medicine and the precise treatment advantages of Western medicine,improve the therapeutic effect,reduce the use of antibiotics,and lower the recurrence rate of the disease,which is worthy of further research and promotion.

关键词： Children Mycoplasma pneumoniae pneumonia Combined Chinese and Western medicine Research progress

2008~2022年我国湖泊有机质相关指标时空演变

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中国环境科学 2024年第3期44卷 1426-1435页

作者：付蕊刘沙沙索诚宇任艺吴丰昌北京科技大学能源与环境工程学院北京100083 中国环境科学研究院北京100012

基于2008~2022年中国湖泊长时间序列水质数据,采用Mann—Kendall检验(M-K检验),Pearson相关分析以及主成分分析(PCA)等对有机质及相关营养指标在长时间序列上的变化规律,空间异质性特征及指标之间的相关关系进行研究.结果表明:2008~2022... 详细信息

基于2008~2022年中国湖泊长时间序列水质数据,采用Mann—Kendall检验(M-K检验),Pearson相关分析以及主成分分析(PCA)等对有机质及相关营养指标在长时间序列上的变化规律,空间异质性特征及指标之间的相关关系进行研究.结果表明:2008~2022年,全国湖泊溶解氧(DO)浓度以每年0.19mg/L的速度增加(P0.50, P<0.05);BOD5与TP呈现显著正相关性(r=0.61, P<0.05);COD与TP(r=0.80,P<0.05)以及Chla(r=0.61,P<0.05)显著正相关,表明TP浓度和叶绿素浓度可能是影响我国湖泊有机质变化的关键因素.在空间尺度上,COD,COD-Mn与BOD5等有机质相关指标为影响全国湖泊水质空间异质性特征的主要因素,且有机质浓度较高的湖泊地理分布较为明显,主要集中于蒙新湖区和云贵高原湖区.

关键词：湖泊有机质营养水平时空变化相关分析主成分分析

A pan‐cancer analysis of Wnt family member 7B in human cancers

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Cancer Innovation 2024年第5期3卷 84-101页

作者： Rui Wang Ni‐sha.Wu Li Wang Zhi‐zhao Zhang Cheng‐fang Wang Yan Wang Yan Liang Yi Zhang Xiao‐wei Qi Department of Breast and Thyroid Surgery Southwest HospitalArmy Medical UniversityChongqingChina 2Department of InfectionChina Academy of Chinese Medical Sciences Guang'anmen HospitalBeijingChina

Background: Previous studies have highlighted the crucial role of Wnt7B inthe development of various cancers, including breast, pancreatic, and gastriccancers. However, research into the involvement of Wnt7B is often confined tospecific tumor types, with a noticeable lack of comprehensive studies spanningmultiple cancer forms. The potential of Wnt7B as a diagnostic or prognosticcancer biomarker has not been fully ***: In this study, we combined bioinformatics and immunohistochemistryanalyses to examine the expression patterns and functions of Wnt7B in cancerousand adjacent noncancerous tissues across a range of ***: Our data indicate that Wnt7B may serve as a novel prognosticbiomarker and therapeutic target in certain ***: We found significant upregulation of Wnt7B expression levels in themajority of cancer cases examined. Furthermore, Wnt7B can influence cancerprognosis by modulating the tumor microenvironment, immune cell infiltration,and tumor stemness, among other factors. Additionally, we examined theassociations between anticancer drug sensitivity and Wnt7B expression, whichcould aid in the development of more precise clinical therapies.

关键词： bioinformatics immune infiltration immunotherapy pan‐cancer analysis Wnt7B

研究生扩招背景下的大团队学术指导链建设研究

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学位与研究生教育 2024年第10期 38-46页

作者：龙宝新周莎陕西师范大学教育学部西安710062

在研究生扩招背景下,大团队学术指导现象日渐普遍。全面提升学术力成为研究生学术指导面临的挑战,其集中体现是:师徒式学术指导难以为继,学术指导服务供给侧不足,研究生学术放养、指导延滞现象飙升。破解这些问题的科学思路是:在知识创... 详细信息

在研究生扩招背景下,大团队学术指导现象日渐普遍。全面提升学术力成为研究生学术指导面临的挑战,其集中体现是:师徒式学术指导难以为继,学术指导服务供给侧不足,研究生学术放养、指导延滞现象飙升。破解这些问题的科学思路是:在知识创新链理念指引下,建立学术指导的功能性链接与结构,致力于破解学术指导服务供给侧困境。研究生学术指导链建设的基本机理是:“双链”融合、纵横交合与节点链合。在该机理指引下,适时引入“三全”建设理念,针对性开展指导服务链的延链、补链、强链工作,是全方位提升学术指导链实效与性能的有力之策。

关键词：研究生扩招大团队指导知识创新链学术指导链研究生教育

基于过滤性传递概率的SFN最终事件发生概率计算方法研究

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模糊系统与数学 2024年第1期38卷 88-97页

作者：李莎莎崔铁军沈阳理工大学环境与化学工程学院辽宁沈阳110159

为研究系统故障演化过程(systemfaultevolutionprocess,SFEP)中事件之间的相互联系,确定最终事件的可能性,提出考虑过滤性传递概率的最终事件发生概率分布计算方法.过滤性传递概率认为只有当原因事件发生概率大于传递概率时才能导致结... 详细信息

为研究系统故障演化过程(systemfaultevolutionprocess,SFEP)中事件之间的相互联系,确定最终事件的可能性,提出考虑过滤性传递概率的最终事件发生概率分布计算方法.过滤性传递概率认为只有当原因事件发生概率大于传递概率时才能导致结果事件发生.给出三种数据形式,并针对这三种情况提出三种最终事件故障概率分布计算方法.同时,在空间故障网络(spacefaultnetwork,SFN)给出关系组的概念,用以描述原因事件-连接-结果事件的关系模式,将SFN中所有关系组成关系组,再通过演化顺序将关系组中关系叠加,计算最终事件故障概率分布.研究表明过滤性传递概率只有在一定范围内,SFN的最终事件概率分布才发生变化。同时,对比分析了延续性传递概率与过滤性传递概率的不同.

关键词：安全系统工程空间故障网络系统故障演化过程传递概率最终事件发生概率