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Hemorrhagic transformation after acute ischemic stroke caused by polycythemia vera:Report of two case

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World Journal of Clinical Cases 2021年第25期9卷 7551-7557页

作者： Ya-Yun Cao Jie Cao Zhua-Jin Bi sha-bei xu Chen-Chen Liu Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430000Hubei ProvinceChina Department of Radiology Zhongnan Hospital of Wuhan UniversityWuhan 430000Hubei ProvinceChina

BACKGROUNDPolycythemia vera (PV) is a chronic myeloproliferative disorder characterized byan increase in red blood cells in the peripheral blood. Previous work has reportedthe occurrence of thrombosis or hemorrhage arising in the cerebral vasculaturesecondary to PV. However, hemorrhagic transformation after PV-associated acuteischemic stroke has not been previously *** SUMMARYWe herein present two cases of PV where hemorrhagic transformation occurredafter an acute ischemic stroke. Case 1 was a 57-year-old woman with a history ofhypertension who was admitted for left-sided weakness. Case 2 was a 68-year-oldman who was admitted for a 10-d sudden left arm weakness. Imaging examinationsfor the two patients revealed hemorrhagic transformation after acuteischemic stroke. Both patients had JAK-2-V617F mutation and receivedantiplatelet therapy. Both of them had a good prognosis during the *** report suggested that hemorrhagic transformation may occur in acuteischemic stroke caused by PV. Antiplatelet drugs do not seem to influence thelong-term outcomes in such patients. Future research should focus on establishinga standard antiplatelet treatment strategy for this condition.

关键词： Polycythemia vera Acute ischemic stroke Hemorrhagic transformation Antiplatelet treatment Thrombosis Case report

Development of multi-functional anchorage support dynamic-static coupling performance test system and its application

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International Journal of Mining Science and Technology 2024年第3期34卷 339-349页

作者： Qi Wang Shuo xu bei Jiang Chong Zhang Zhe Sun Jingxuan Liu Cailin Jiao State Key Laboratory for Tunnel Engineering China University of Mining&Technology-BeijingBeijing 100083China Research Center of Geotechnical and Structural Engineering Shandong UniversityJinan 250061China

In underground engineering with complex conditions,the bolt(cable)anchorage support system is in an environment where static and dynamic stresses coexist,under the action of geological conditions such as high stresses and strong disturbances and construction conditions such as the application of high *** is essential to study the support components performance under dynamic-static coupling *** on this,a multi-functional anchorage support dynamic-static coupling performance test system(MAC system)is developed,which can achieve 7 types of testing functions,including single component performance,anchored net performance,anchored rock performance and so *** bolt and cable mechanical tests are conducted by MAC system under different prestress *** results showed that compared to the non-prestress condition,the impact resistance performance of prestressed bolts(cables)is significantly *** the prestress range of 50–160 k N,the maximum reduction rate of impact energy resisted by different types of bolts is 53.9%–61.5%compared to non-prestress *** the prestress range of 150–300 k N,the impact energy resisted by high-strength cable is reduced by76.8%–84.6%compared to non-prestress *** MAC system achieves dynamic-static coupling performance test,which provide an effective means for the design of anchorage support system.

关键词： Anchorage support system Development of test system Dynamic-static coupling test Combined stress

Prevalence and risk factors of stroke in China:a national serial cross-sectional study from 2003 to 2018

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Stroke & Vascular Neurology 2023年第3期8卷 238-248,I0086-I0095页

作者： Dai-Shi Tian Chen-Chen Liu Chao-Long Wang Chuan Qin Ming-Huan Wang Wen-Hua Liu Jian Liu Han-Wen Zhang Rong-Guo Zhang shao-Kang Wang Xiao-Xiang Zhang Liang Wang Deng-Ji Pan Jian-Ping Hu Xiang Luo sha-bei xu Wei Wang Department of Neurology Tongji Hospital of Tongji Medical College of Huazhong University of Science and TechnologyWuhanHubeiChina Department of Epidemiology and Biostatistics Tongji Medical College of Huazhong University of Science and TechnologyWuhanHubeiChina Department of Scientific Research Management Tongji Hospital of Tongji Medical College of Huazhong University of Science and TechnologyWuhanHubeiChina Infervision Medical Technology Co. LtdBeijingChina Department of Computer Center Tongji Hospital of Tongji Medical College of Huazhong University of Science and TechnologyWuhanHubeiChina Centre for Health Statistics Information National Health Commission of the People's Republic of ChinaBeijingChina

Stroke imposes a substantial burden *** the rapid economic and lifestyle transition in China,trends of the prevalence of stroke across different geographic regions in China remain largely *** on the data in the National Health Services Surveys(NHSS),we assessed the prevalence and risk factors of stroke in China from 2003 to *** this study,data from 2003,2008,2013,and 2018 NHSS were *** cases were based on participants’self-report of a previous diagnosis by *** estimated the trends of stroke prevalence for the overall population and subgroups by age,sex,and socioeconomic factors,then compared across different geographic *** applied multivariable logistic regression to assess associations between stroke and risk *** number of participants aged 15 years or older were 154,077,146,231,230,067,and 212,318 in 2003,2008,2013,and 2018,respectively,among whom,1435,1996,3781,and 6069 were stroke *** age and sex standardized prevalence per 100,000 individuals was 879 in 2003,1100 in 2008,1098 in 2013,and 1613 in *** per 100,000 individuals in rural areas increased from 669 in 2003 to 1898 in 2018,while urban areas had a stable trend from 1261 in 2003 to 1365 in *** geographic regions,the central region consistently had the highest prevalence,but the western region has an alarmingly increasing trend from 623/100,000 in 2003 to 1898/100,000 in 2018(Ptrend<0.001),surpassing the eastern region in *** age,male sex,rural area,central region,hypertension,diabetes,depression,low education and income level,retirement or unemployment,excessive physical activity,and unimproved sanitation facilities were significantly associated with *** conclusion,the increasing prevalence of stroke in China was primarily driven by economically underdeveloped *** is important to develop targeted prevention programs in underdeveloped *** traditional risk factors,more attenti

关键词： prevention sectional income

Self-powered stimuli responsive material for dual stimulation of heat and guest molecules

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Chinese Chemical Letters 2024年第2期35卷 590-593页

作者： Jintao Men Ke xu Taiting sha Lei He Yan xu Jie Mu Tijian Yin Qiong Ye Jiangsu Key Laboratory for Science and Applications of Molecular Ferroelectrics and School of Chemistry and Chemical Engineering Southeast UniversityNanjing 211189China

Stimuli-responsive smart materials exhibit reverse chemical/physical changes in response to external stimuli and research on stimuli-responsive smart materials with self-powered properties is still uncultivated ***,we report perovskite crystalline self-powered multiple stimuli-responsive materials triggered by chemical and thermal stimuli.[HMEP]PbI_(3)·(H_(2)O)(1;HMEP is a hydroxytris(1-methylethyl)phosphorus cation)crystallizes in a chiral space group P 21 at 293 K and has the piezoelectric reaction(d_(33)=10 pC/N and output voltage=1 V)of self-powered modes,this value is larger than the value of 3 pC/N for the classical piezoelectric material *** materials can generate energy due to mechanical deformation,and using thermal heating to lose water,[HMEP]PbI_(3)(2)can be obtained.2 crystallizes in the non-centrosymmetric space group,undergoes two reversible phase transitions at 243/255 K and 315/348 K,and shows second harmonic generation ***,2 can return to the hydrated form 1 after absorbing *** work will lay the foundation for self-powered stimuli-responsive compounds and contribute to the construction of novel organic-inorganic hybrid materials with second harmonic generation switching.

关键词： Self-powered Dual stimulation reactive Phase transition SHG switch Organic-inorganic hybrid perovskite

Drilling-based measuring method for the c-φ parameter of rock and its field application

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International Journal of Mining Science and Technology 2024年第1期34卷 65-76页

作者： bei Jiang Fenglin Ma Qi Wang Hongke Gao Dahu Zhai Yusong Deng Chuanjie xu Liangdi Yao State Key Laboratory for Tunnel Engineering China University of Mining and Technology-BeijingBeijing 100083China State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China Research Center of Geotechnical and Structural Engineering Shandong UniversityJinan 250061China

The technology of drilling tests makes it possible to obtain the strength parameter of rock accurately in situ. In this paper, a new rock cutting analysis model that considers the influence of the rock crushing zone(RCZ) is built. The formula for an ultimate cutting force is established based on the limit equilibrium principle. The relationship between digital drilling parameters(DDP) and the c-φ parameter(DDP-cφ formula, where c refers to the cohesion and φ refers to the internal friction angle) is derived, and the response of drilling parameters and cutting ratio to the strength parameters is analyzed. The drillingbased measuring method for the c-φ parameter of rock is constructed. The laboratory verification test is then completed, and the difference in results between the drilling test and the compression test is less than 6%. On this basis, in-situ rock drilling tests in a traffic tunnel and a coal mine roadway are carried out, and the strength parameters of the surrounding rock are effectively tested. The average difference ratio of the results is less than 11%, which verifies the effectiveness of the proposed method for obtaining the strength parameters based on digital drilling. This study provides methodological support for field testing of rock strength parameters.

关键词： Digital drilling Rock crushing zone c-u parameter Measurement method Field application

Should Low-Frequency-High-Consumption Enterprises Add Online-to-Offline Platforms?An Empirical Study Using the VAR Model

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Journal of Systems Science and Information 2024年第1期12卷 81-95页

作者： Wei LI Ying LIU Haizhen YANG sha ZHANG Binhong xu School of Economics and Management Univeristy of Chinese Academy of SciencesBeijing 100190China School of Business University of Chinese Academy of Social SciencesBeijing 102488China

This study investigates the impact of online-to-offline(O2O)platforms,such as *** and Meituan,on offline sales in low-frequency-high-consumption industries,specifically a mid-to-highend liquor distribution *** data from 77 offline stores in beijing collected during 2019-2022,the study employs a VAR model to analyze the relationship between offline sales and the use of O2O *** results reveal a long-term equilibrium between the two,with most indicators showing a positive impact of O2O platforms on offline *** research provides valuable insights for lowfrequency-high-consumption enterprises in making multi-channel decisions and quantifies the impact of O2O platforms on offline sales.

关键词： O2O platform low-frequency-high-consumption liquor distribution chain enterprise store sales VAR model

Simulation and fabrication of in vitro microfluidic microelectrode array chip for patterned culture and electrophysiological detection of neurons

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Nanotechnology and Precision Engineering 2024年第2期7卷 1-10页

作者： Yan Yang Shihong xu Yu Deng Yaoyao Liu Kui Zhang Shiya Lv Longze sha Qi xu Xinxia Cai Jinping Luo State Key Laboratory of Transducer Technology Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100190China School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China

To enable the detection and modulation of modularized neural networks in vitro,this study proposes a microfluidic microelectrode array chip for the cultivation,compartmentalization,and control of neural *** chip was designed based on the specific structure of neurons and the requirements for detection and ***-element analysis of the chip’s flow field was conducted using the COMSOL Multiphysics software,and the simulation results show that the liquid within the chip can flow smoothly,ensuring stable flow fields that facilitate the uniform growth of neurons within the microfluidic *** employing MEMS technology in combination with nanomaterial modification techniques,the microfluidic microelectrode array chip was fabricated *** hippocampal neurons were cultured on the chip,forming a well-defined neural *** electrical activity of the detected neurons was recorded,exhibiting a 23.7%increase in amplitude compared to neuronal discharges detected on an open-field microelectrode *** study provides a platform for the precise detection and modulation of patterned neuronal growth in vitro,potentially serving as a novel tool in neuroscience research.

关键词： Microfluidic Microelectrode array In vitro Neural chip

Fibroblast growth factor 21 inhibits ferroptosis following spinal cord injury by regulating heme oxygenase-1

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Neural Regeneration Research 2024年第7期19卷 1568-1574页

作者： Qi Gu Weiping sha Qun Huang Jin Wang Yi Zhu Tianli xu Zhenhua xu Qiancheng Zhu Jianfei Ge Shoujin Tian Xiaolong Lin Department of Orthopaedic Surgery Zhangjiagang Hospital Affiliated to Soochow UniversitySuzhouJiangsu ProvinceChina Orthopedics Laboratory The First People’s Hospital of Zhangjiagang CitySuzhouJiangsu ProvinceChina Department of Anesthesiology Zhangjiagang Hospital Affiliated to Soochow UniversitySuzhouJiangsu ProvinceChina

Interfering with the ferroptosis pathway is a new strategy for the treatment of spinal cord *** growth factor 21 can inhibit ferro ptosis and promote neurofunctional recovery,while heme oxygenase-1 is a regulator of iron and reactive oxygen species *** relationship between heme oxygenase-1and ferroptosis remains controve *** this study,we used a spinal co rd injury rat model to show that the levels of fibroblast growth factor 21 in spinal co rd tissue decreased after spinal cord *** addition,there was a significant aggravation of ferroptosis and a rapid increase in heme oxygenase-1 expression after spinal cord *** r,heme oxygenase-1 aggravated fe rroptosis after spinal cord injury,while fibroblast growth factor 21 inhibited fe rroptosis by downregulating heme ***,the activation of fibroblast growth factor 21 may provide a potential treatment for spinal co rd *** findings could provide a new potential mechanistic explanation for fibroblast growth factor 21 in the treatment of spinal cord injury.

关键词： ferroptosis fibroblast growth factor 21 functional recovery heme oxygenase-1 lipid peroxidation neuron reactive oxygen species spinal cord injury

MRI Features and Site-specific Factors of Ischemic Changes in White Matter： A Retrospective Study

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Current Medical Science 2018年第2期38卷 318-323页

作者： You-ping ZHANG Na LIU Kai-yan LIU Chao PAN xuan CAI Shi-qi YANG Zhou-ping TANG sha-bei xu Department of Emergency Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Neurology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Radiology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Neurology Luoyang Central Hospital Zhengzhou University Luoyang 471000 China

Brain magnetic resonance imaging （MRI） of the elderly often reveals white matter changes （WMCs） with substantial variability across individuals. Our study was designed to explore MRI features and site-specific factors of ischemic WMCs. Clinical data of consecutive patients diagnosed with ischemic cerebral vascular disease who had undergone brain MRI were collected and analyzed. Multi-logistic regression analysis comparing patients with mild versus severe WMCs was performed to detect independent associations. Analyses of variance （ANOVAs） were used to detect regionally specific differences in lesions. We found that lesion distribution differed significantly across five cerebral areas, with lesions being predominant in the frontal lobe and parieto-occipital area. To explore WMCs risk factors, after adjusting for gender, diabetes mellitus, and hypertension, only age （P〈0.01）, creatinine （P=0.01）, alkaline phosphatase （ALP）（P=0.01） and low-density lipoprotein cholesterol （LDL-C）（P=0.03） were found to be independently associated with severe WMCs. Age （P〈0.001） was strongly associated with WMCs in the frontal lobe while hypertension was independently related to lesions in the basal ganglia （P=0.048） or infratentorial area （P=0.016）. In conclusion, MRI of WMCs showed that ischemic WMCs occurred mostly in the frontal lobe and parieto-occipital area. The infratentorial area was least affected by WMCs. Typically, age-related WMCs were observed in the frontal lobes, while hypertension-related WMCs tended to occur in the basal ganglia and infratentorial area.

关键词： white matter changes ischemic cerebral vascular disease MRI features sitespecific factors