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Vulnerability and Conservation of Nearshore Cetaceans to Increasing Vessel Traffic:The Indo-Pacific Humpback Dolphin in the South China Sea

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Journal of Ocean University of China 2024年第4期23卷 1003-1014页

作者： LUO Dingyu GUO Lang HUANG Nuoyan WANG Hongri ZENG Chen TANG Xikai XU Zhuo WU Yuping SUN xian School of Marine Sciences Zhuhai Key Laboratory of Marine Bioresources and EnvironmentGuangdong Provincial Key Laboratory of Marine Resources and Coastal EngineeringPearl River Estuary Marine Ecosystem Research Sta-tionMinistry of EducationSun Yat-Sen UniversitySouthern Marine Science and Engineering Guangdong Labora-tory(Zhuhai)Zhuhai 519082China

A comprehensive risk assessment to evaluate the vulnerability of the nearshore cetaceans to increasing marine traffic is *** this study,the risk to Indo-Pacific humpback dolphins(Sousa chinensis)in the main habitats in China was assessed based on a semiquantitative spatial vulnerability analysis.85%of the(sub)population which overlapped with the lanes of ferries and/or cargo vessels,with exposure scores of 1.23±0.31(calculated based on the proportion of sea routes that overlap the dolphin’s range).A combination of high exposure to the sea routes and sensitivity to marine traffic would render the(sub)populations to be highly vulnerable(EPRE:5.21 and XM:4.47).A low frequency of vessels and an awareness of the ecology assures a low vulnerability(sh:2.43,EZ:2.73).Uncertainty scores were commonly lower for the higher vulnerable populations,and higher for the lower vulnerable populations,suggesting additional field data and more monitoring are *** years of field data have been used to analyze the influences of various types of marine traffic on humpback dolphin *** and non-fishing vessels were significantly different(χ^(2)=65.19,pshing vessels(83.1%)but avoided non-fishing vessels(95.2%).We recommend a management with seasonal and geographical constraints,to balance economic development and environmental conservation.

关键词： Indo-Pacific humpback dolphin vessel impacts risk analysis protection strategy

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智能电子产品典型材料中7种二甲基环硅氧烷含量的测定

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分析测试学报 2024年第4期43卷 643-648页

作者：幸苑娜彭先芝中国科学院广州地球化学研究所广东广州510640 中国科学院大学北京100049

智能电子产品中残留的二甲基环硅氧烷(DMCs)可能随设备报废而进入环境。该研究针对智能电子产品材料基质复杂且溶解性和分散性差的特点,选取硅橡胶、胶黏剂和塑料3种典型材料为代表,采用丙酮对颗粒度为0.5 cm×0.5 cm的样品进行超声萃取... 详细信息

智能电子产品中残留的二甲基环硅氧烷(DMCs)可能随设备报废而进入环境。该研究针对智能电子产品材料基质复杂且溶解性和分散性差的特点,选取硅橡胶、胶黏剂和塑料3种典型材料为代表,采用丙酮对颗粒度为0.5 cm×0.5 cm的样品进行超声萃取,选择sh-Rxi-5Sil MS毛细管柱(30 m×0.25 mm×0.25µm)进行气相色谱-质谱(GC-MS)分离,通过特征碎片离子实现了7种DMCs(D3、D4、D5、D6、D7、D8、D9)的定性定量分析。7种DMCs在0.1~10.0 mg/L质量浓度范围内呈良好的线性关系(r^(2)≥0.9993),方法定量下限为0.5µg/g;7种DMCs在智能电子产品3种典型材料中的平均加标回收率为83.8%~105%,相对标准偏差(RSD,n=6)为1.5%~4.6%。将该方法用于7种不同智能电子产品材料中DMCs的分布分析,结果在6个样品中检出DMCs,总含量为30.0~1.6×10^(3)µg/g。

关键词：二甲基环硅氧烷气相色谱-质谱智能电子产品硅橡胶胶黏剂塑料

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Beam-focused sh wave transducer based on YSr_(3)(PO_(4))_(3)piezoelectric crystal for high temperature structural health monitoring

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Journal of Materiomics 2023年第3期9卷 577-586页

作者： Yuehao du Guangda Wu Fapeng Yu Hongchen Miao xian Zhao Applied Mechanics and Structure Safety Key Laboratory of Sichuan Province School of Mechanics and Aerospace EngineeringSouthwest Jiaotong UniversityChengduSichuan610031China State Key Laboratory of Crystal Materials Center for Optics Research and EngineeringShandong UniversityJinan250100China

Guided-wave-based structural health monitoring(shM)technology is of great importance for real-time inspection of high-temperature *** fundamental shear horizontal(sh_(0))wave is believed to be an ideal wave mode for developing shM systems due to its nondispersive ***,currently very limited sh_(0)wave transducers can be used for shM of high-temperature structures due to the limitation of ***,a novel YSr_(3)(PO_(4))_(3)(YSP)piezoelectric crystal in the space group I43d was *** show that the face-shear piezoelectric coefficient d_(14)(d_(14)=d_(25)=d_(36))is 9.7 pC/N and varies little from 25 to 800℃.Then a beam-focused sh_(0)wave piezoelectric transducer is developed based on face-shear-mode YSP *** finite element simulations and experimental results indicate that the YSP-based transducer can excite pure sh_(0)wave and focus the wave energy along two opposite main ***,the obtained sh_(0)wave beam is highly concentrated with a small divergence angle of less than 30°,originating from the high working frequency range from 300 to 400 *** excellent temperature stability of the as-grown YSP crystal makes the proposed sh_(0)wave piezoelectric transducer very suitable for shM of high-temperature structures.

关键词： YSP piezoelectric crystal Pure face-shear vibration mode shear horizontal wave Bidirectional transducer Structural health monitoring

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超声影像组学及联合基因检测筛选高侵袭性甲状腺乳头状癌研究进展

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中国医学影像技术 2024年第7期40卷 1100-1103页

作者：马梦娇王娴钱晓芹江苏大学附属人民医院超声医学科江苏镇江212002 苏北人民医院超声医学科江苏扬州225001

近年甲状腺癌发病率迅速升高,以甲状腺乳头状癌(PTC)最为常见。部分PTC具有高侵袭性,主要表现为早期颈部淋巴结转移(CLNM)、甲状腺外侵犯(ETE)及基因突变等。超声影像组学(USR)及其联合基因检测有助于诊断及评估PTC。本文就USR及其联合... 详细信息

近年甲状腺癌发病率迅速升高,以甲状腺乳头状癌(PTC)最为常见。部分PTC具有高侵袭性,主要表现为早期颈部淋巴结转移(CLNM)、甲状腺外侵犯(ETE)及基因突变等。超声影像组学(USR)及其联合基因检测有助于诊断及评估PTC。本文就USR及其联合基因检测筛选高侵袭性PTC研究进展进行综述。

关键词：甲状腺癌,乳头状肿瘤转移基因超声检查影像组学

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Preclinical efficacy against acute myeloid leukaemia of sh1573, a novel mutant IDH2 inhibitor approved for clinical trials in China

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Acta Pharmaceutica Sinica B 2021年第6期11卷 1526-1540页

作者： Zhiqiang Wang Zhibo Zhang Yong Li Li Sun Dezhen Peng Danyu du xian Zhang Luwei Han Liwen Zhao Ligong Lu Hongzhi du shengtao Yuan Meixiao Zhan Jiangsu Key Laboratory of Drug Screening China Pharmaceutical UniversityNanjing 210003China Zhuhai Interventional Medical Center Zhuhai Precision Medical CenterZhuhai People's HospitalZhuhai Hospital Affiliated with Jinan UniversityJinan UniversityZhuhai 519000China Sanhome Pharmaceutical Co. Ltd.Nanjing 210000China School of Pharmacy Hubei University of Chinese MedicineWuhan 430065China

Acute myeloid leukaemia(AML) is the most common form of acute leukaemia in adults,with increasing incidence with age and a generally poor *** 20% of AML patients express mutant isocitrate dehydrogenase 2(mIDH2),which leads to the accumulation of the carcinogenic metabolite 2-hydroxyglutarate(2-HG),resulting in poor ***,global institutions have been working to develop mIDH2 ***1573 is a novel mIDH2 inhibitor that we independently designed and *** have conducted a comprehensive study on its pharmacodynamics,pharmacokinetics and ***,sh1573 exhibited a strong selective inhibition of mIDH2 R140 Q protein,which could effectively reduce the production of 2-HG in cell lines,serum and tumors of an animal *** could also promote the differentiation of mutant AML cell lines and granulocytes in PDX ***,it was confirmed that sh1573 possessed characteristics of high bioavailability,good metabolic stability and wide tissue ***,toxicological data showed that sh1573 had no effects on the respiratory system,cardiovascular system and nervous system,and was genetically *** research successfully promoted the approval of sh1573 for clinical trials(CTR20200247).All experiments demonstrated that,as a potential drug against mIDH2 R140 Q acute myeloid leukaemia,sh1573 was effective and safe.

关键词： Acute myeloid leukaemia Tumor metabolism Mutant isocitrate dehydrogenase 2(mIDH2) mIDH2 inhibitor sh1573 2-Hydroxyglutarate Differentiation Preclinical efficacy

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利妥昔单抗联合DHAX方案与CHOP方案一线治疗老年初诊弥漫大B细胞淋巴瘤的回顾性研究

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中国实验血液学杂志 2024年第3期32卷 718-722页

作者：韦卫萍余先球王丽霞张硕费小明江苏大学附属医院血液科江苏镇江212001

目的:探讨R±DHAX方案与R-CHOP方案一线治疗老年初诊弥漫大B细胞淋巴瘤(DLBCL)患者的临床疗效及预后。方法:回顾性分析江苏大学附属医院血液科2011年8月—2021年8月收治并至少完成3疗程的36例老年DLBCL患者,根据治疗方案分为利妥昔单抗... 详细信息

目的:探讨R±DHAX方案与R-CHOP方案一线治疗老年初诊弥漫大B细胞淋巴瘤(DLBCL)患者的临床疗效及预后。方法:回顾性分析江苏大学附属医院血液科2011年8月—2021年8月收治并至少完成3疗程的36例老年DLBCL患者,根据治疗方案分为利妥昔单抗±DHAX(R±DHAX)方案组(18例)和利妥昔单抗联合CHOP(R-CHOP)方案组(18例),观察患者的临床特征、疗效及生存。结果:与R-CHOP组比较,R±DHAX组患者更高龄、体能状态更差及IPI评分更高,在年龄、ECOG评分、IPI评分上两组间差异有统计学意义(P=0.005,P=0.018,P=0.035),而在性别、有无B症状、LDH是否升高、有无结外累及、细胞来源、有无骨髓浸润、是否联合使用利妥昔单抗上两组间差异均无统计学意义(P=0.738,P=1,P=0.315,P=0.305,P=0.413,P=0.177,P=0.711,P=0.229)。36例患者均可评价疗效,其中CR 14例(38.9%)、PR 17例(47.2%)、PD 5例(13.9%),ORR为86.1%(31/36)。R±DHAX组和R-CHOP组CR[27.8%(5/18)对50.0%(9/18)]、PR[44.4%(8/18)对50.0%(9/18)]差异无统计学意义,但ORR[72.2%(13/18)对100.0%(18/18)]差异有统计学意义(P=0.045)。R±DHAX组和R-CHOP组1年OS率分别为(38.9±11.5)%和(94.4±7.4)%,2年OS率分别为(16.7±8.8)%和(72.2±10.6)%,组间比较差异有统计学意义(P=0.001,P=0.002)。R±DHAX组中位生存时间11个月(95%CI:8.9-13.1),R-CHOP组中位生存时间未达到,组间存在统计学差异(P<0.001)。结论:对于老年DLBCL患者,在OS方面R±DHAX方案可能不优于R-CHOP方案,且ECOG评分、IPI评分、年龄可能影响老年DLBCL患者生存。但R±DHAX方案安全、可耐受且具有一定疗效,可作为临床上老年DLBCL治疗选择之一。

关键词：非霍奇金淋巴瘤老年临床特征疗效预后

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多发性骨髓瘤患者带状疱疹危险因素分析及预防性抗病毒治疗的作用

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中国实验血液学杂志 2024年第1期32卷 171-175页

作者：王丽霞季艳萍雷芳余先球费小明江苏大学附属医院血液科江苏镇江212001

目的:研究多发性骨髓瘤患者带状疱疹的发病情况及其危险因素,并评价预防性抗病毒治疗的效果。方法:回顾性分析合并带状疱疹的多发性骨髓瘤患者的临床特征,分析带状疱疹的危险因素以及抗病毒预防的作用。结果:180例多发性骨髓瘤患者中,2... 详细信息

目的:研究多发性骨髓瘤患者带状疱疹的发病情况及其危险因素,并评价预防性抗病毒治疗的效果。方法:回顾性分析合并带状疱疹的多发性骨髓瘤患者的临床特征,分析带状疱疹的危险因素以及抗病毒预防的作用。结果:180例多发性骨髓瘤患者中,23例发生带状疱疹(12.8%),其中合并肾功能不全的患者的带状疱疹发生率为19.1%。自体造血干细胞移植(AHSCT)患者在术后带状疱疹的发生率为23.5%(4/17)。23例患者中21例接受含有硼替佐米的方案治疗,2例接受不含硼替佐米的方案治疗,接受含硼替佐米方案的患者带状疱疹发生率(21/137,15.3%)高于不含硼替佐米方案的患者的发生率(2/43,4.7%),但未显示统计学差异(P=0.067)。在未采取抗病毒预防的患者中,带状疱疹发生率为21.7%(15/69),而在接受抗病毒预防的患者中,带状疱疹发生率为7.2%(8/111),两者具有显著统计学差异(P=0.005)。65.2%的带状疱疹患者没有接受抗病毒预防。多因素分析结果显示,接受硼替佐米治疗、AHSCT、肾功能不全均为多发性骨髓患者带状疱疹发生的独立危险因素,而抗病毒预防与降低带状疱疹发生风险独立相关。带状疱疹对多发性骨髓瘤患者的OS无影响。结论:多发性骨髓瘤患者发生带状疱疹的风险增加,预防性使用抗病毒药物可降低基于硼替佐米治疗的多发性骨髓瘤患者带状疱疹的发生风险。

关键词：多发性骨髓瘤带状疱疹抗病毒预防

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三峡水库中小洪水调度对支流库湾浮游植物的影响及机制

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环境科学 2024年第9期45卷 5308-5317页

作者：黎睿汤显强刘新波陈文重王丹阳任玉峰长江水利委员会长江科学院流域水环境研究所武汉430010 长江水利委员会长江科学院流域水资源与生态环境科学湖北省重点实验室武汉430010 中国长江电力股份有限公司智慧长江与水电科学湖北省重点实验室宜昌443000 长江水利委员会水文局长江三峡水文水资源勘测局宜昌443000

中小洪水调度已成为三峡水库汛期的主要调度方式,为研究三峡水库支流库湾浮游植物对中小洪水调度的响应,以三峡水库典型富营养化支流香溪河为对象,调查监测了2020~2021年汛期干支流浮游植物、营养盐及水体理化参数的时空分布特征,分析... 详细信息

中小洪水调度已成为三峡水库汛期的主要调度方式,为研究三峡水库支流库湾浮游植物对中小洪水调度的响应,以三峡水库典型富营养化支流香溪河为对象,调查监测了2020~2021年汛期干支流浮游植物、营养盐及水体理化参数的时空分布特征,分析了支流库湾浮游植物对中小洪水调度的响应特征.结果表明,中小洪水调度期间,香溪河库湾水体叶绿素a(Chl-a)随着坝前水位升高而降低,而在汛末蓄水期,Chl-a浓度再次升高.中小洪水调度期间,香溪河浮游植物以绿藻门和硅藻门为主,其群落组成随中小洪水调度而改变,当水位变幅增大时,以硅藻为主,当水位变幅较小时,以蓝、绿藻为主.Chl-a浓度对库湾水体TN浓度变化更为敏感,当库湾水体流速>0.25 m·s^(−1),或者悬浮泥沙浓度>10 mg·L^(−1)时,水体Chl-a浓度受到抑制.2010年以后,香溪河库湾典型水华暴发时间转变为以汛期为主,非汛期水华仅有2次,需要进一步关注汛期库湾藻类对中小洪水调度的响应.

关键词：三峡水库中小洪水调度浮游植物悬浮泥沙水动力条件

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Piezo1 channel activation in response to mechanobiological acoustic radiation force in osteoblastic cells

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Bone Research 2021年第2期9卷 223-232页

作者： Guangdao Zhang Xiaofei Li Lin Wu Yi-xian Qin Department of Biomedical Engineering Stony Brook UniversityStony BrookNY 11794USA Department of Prosthodontics School of StomatologyChina Medical UniversityShenyangChina

Mechanobiological stimuli,such as low-intensity pulsed ultrasound(LIPUS),have been shown to promote bone regeneration and fresh fracture repair,but the fundamental biophysical mechanisms involved remain ***,we propose that a mechanosensitive ion channel of Piezo1 plays a pivotal role in the noninvasive ultrasound-induced mechanical transduction pathway to trigger downstream cellular signal *** study aims to investigate the expression and role of Piezo1 in MC3T3-E1 cells after LIPUS *** analysis shows that Piezo1 was present on MC3T3-E1 cells and could be ablated by shRNA ***3T3-E1 cell migration and proliferation were significantly increased by LIPUS stimulation,and knockdown of Piezo1 restricted the increase in cell migration and *** labeling with Fluo-8,MC3T3-E1 cells exhibited fluorescence intensity traces with several high peaks compared with the baseline during LIPUS *** obvious change in the fluorescence intensity tendency was observed after LIPUS stimulation in shRNA-Piezo1 cells,which was similar to the results in the GsMTx4-treated *** phosphorylation ratio of ERK1/2 in MC3T3-E1 cells was significantly increased(Pduce LIPUS-induced mechanical signals into intracellular *** influx of Ca2+serves as a second messenger to activate ERK1/2 phosphorylation and perinuclear F-actin filament polymerization,which regulate the proliferation of MC3T3-E1 cells.

关键词： stimulation Piezo1 activation

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Relationships between changes of kernel nutritive components and seed vigor during development stages of F_1 seeds of sh_2 sweet corn

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第12期9卷 964-968页

作者： Dong-dong CAO Jin HU Xin-xian HUANG xian-ju WANG Ya-jing GUAN Zhou-fei WANG Seed Science Center College of Agriculture and Biotechnology Zhejiang University Hangzhou 310029 China State Key Laboratory of Crop Genetics and Germplasm Enhancement Nanjing Agricultural University Nanjing 210095 China

The changes of kernel nutritive components and seed vigor in F1 seeds of sh2 sweet corn during seed development stage were investigated and the relationships between them were analyzed by time series regression (TSR) analysis. The results show that total soluble sugar and reducing sugar contents gradually declined, while starch and soluble protein contents increased throughout the seed development stages. Germination percentage, energy of germination, germination index and vigor index gradually increased along with seed development and reached the highest levels at 38 d after pollination (DAP). The TSR showed that, during 14 to 42 DAP, total soluble sugar content was independent of the vigor parameters determined in present experiment, while the reducing sugar content had a significant effect on seed vigor. TSR equations between seed reducing sugar and seed vigor were also developed. There were negative correlations between the seed reducing sugar content and the germination percentage, energy of germination, germination index and vigor index, respectively. It is suggested that the seed germination, energy of germination, germination index and vigor index could be predicted by the content of reducing sugar in sweet corn seeds during seed development stages.

关键词： sh2 sweet corn Kernel nutritive component Seed vizor Time series regression (TSR) analysis

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