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Experimental proof of Joule heating-induced switched-back regions in OLEDs

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Light(Science & Applications) 2020年第1期9卷 1951-1960页

作者： Anton kirch Axel Fischer Matthias Liero Jurgen Fuhrmann Annegret Glitzky Sebastian reineke Dresden Integrated Center for Applied Physics and Photonic Materials(IAPP)and Institute of Applied Physics Technische Universitat DresdenNothnitzer StraBe 6101187 DresdenGermany Weierstrass Institute Berlin MohrenstraBe 3910117 BerlinGermany

Organic light-emitting diodes(OLEDs)have become a major pixel technology in the display sector,with products spanning the entire range of current panel *** ability to freely scale the active area to large and random surfaces paired with flexible substrates provides additional application scenarios for OLEDs in the general lighting,automotive,and signage *** applications require higher brightness and,thus,current density operation compared to the specifications needed for general *** extended transparent electrodes pose a significant ohmic resistance,OLEDs suffering from Joule self-heating exhibit spatial inhomogeneities in electrical potential,current density,and hence *** this article,we provide experimental proof of the theoretical prediction that OLEDs will display regions of decreasing luminance with increasing driving *** a two-dimensional OLED model,we can conclude that these regions are switched back locally in voltage as well as current due to insufficient lateral thermal ***,we demonstrate this effect in lab-scale devices and derive that it becomes more severe with increasing pixel size,which implies its significance for large-area,high-brightness use cases of ***,these non-linear switching effects cannot be ignored with respect to the long-term operation and stability of OLEDs;in particular,they might be important for the understanding of sudden-death scenarios.

关键词： OLEDs switched proof

Prospective cohort comparison of flavonoid treatment in patients with resected colorectal cancer to prevent recurrence

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World Journal of Gastroenterology 2008年第14期14卷 2187-2193页

作者： Harald Hoensch Bertram Groh Lutz Edler Wilhelm kirch Kreiskrankenhaus Gross-Gerau Innere AbteilungWilhelm-Seipp-StrasseGross-Gerau D64521Germany Department of Clinical Pharmacology Medical FacultyTechnical University Dresden Fiedler Strasse 27 Dresden D01307 Germany German Cancer research Center Division of BiostatisticsIm Neuenheimer Feld 280 Heidelberg D69120 Germany

AIM: To investigate biological prevention with flavonoids the recurrence risk of neoplasia was studied in patients with resected colorectal cancer and after adenoma polypectomy. METHODS: Eighty-seven patients, 36 patients with resected colon cancer and 51 patients after polypectomy, were divided into 2 groups: one group was treated with a flavonoid mixture (daily standard dose 20 mg apigenin and 20 mg epigallocathechin-gallat, n = 31) and compared with a matched control group (n = 56). Both groups were observed for 3-4 years by surveillance colonoscopy and by questionnaire. rESULTS: Of 87 patients enrolled in this study, 36 had resected colon cancer and 29 of these patients had surveillance colonoscopy. Among the flavonoid-treated patients with resected colon cancer (n = 14), there was no cancer recurrence and one adenoma developed. In contrast the cancer recurrence rate of the 15 matched untreated controls was 20% (3 of 15) and adenomas evolved in 4 of those patients (27%). The combined recurrence rate for neoplasia was 7% (1 of 14) in the treated patients and 47% (7 of 15) in the controls (P = 0.027). CONCLUSION: Sustained long-term treatment with a flavonoid mixture could reduce the recurrence rate of colon neoplasia in patients with resected colon cancer.

关键词： Flavonoids Colorectal cancer recurrence risk Intestinal neoplasia Colon polyps

Interaction of the α2A domain of integrin with small collagen fragments

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Protein & Cell 2010年第4期1卷 393-405页

作者： Hans-Christian Siebert Monika Burg-roderfeld Thomas Eckert Sabine Stötzel Ulrike kirch Tammo Diercks Martin J.Humphries Martin Frank rainer Wechselberger Emad Tajkhorshid Steffen Oesser Institut für Biochemie und Endokrinologie Veterinärmedizinische FakultätJustus-Liebig-Universität GießenFrankfurter Str.10035392 GießenGermany CiC bioGUNE Parque Tecnológico de BizkaiaEdificio 80048160 DerioSpain Utrecht Facility for High-resolution NMr Bijvoetcenter for Biomolecular Research Utrecht UniversityPadualaan 83584CH UtrechtThe Netherlands Wellcome Trust Centre for Cell-Matrix research School of Biological SciencesUniversity of Manchester2.205 Stopford BuildingOxford RoadManchester M139PTUK Molecular Structure Analysis Core Facility Deutsches KrebsforschungszentrumIm Neuenheimer Feld 28069120 HeidelbergGermany Department of Biochemistry Beckman Instituteand Center for Biophysics and Computational BiologyUniversity of Illinois at Urbana-ChampaignUrbanaILUSA Collagen research Institute Schauenburgerstr.116D-24118 KielGermany

We here present a detailed study of the ligand-receptor interactions between single and triple-helical strands of collagen and the α2A domain of integrin(α2A),providing valuable new insights into the mechanisms and dynamics of collagen-integrin binding at a sub-molecular *** occurrence of single and triple-helical strands of the collagen fragments was scrutinized with atom force microscopy(AFM)*** interactions of the triple-stranded fragments comparable to those of collagen can only be detected for the 42mer triple-helical collagen-like peptide under study(which contains 42 amino acid residues per strand)by solid phase assays as well as by surface plasmon resonance(SPr)***,changes in NMr signals during titration and characteristic saturation transfer difference(STD)NMr signals are also detectable whenα2A is added to a solution of the 21mer single-stranded collagen *** dynamics(MD)simulations employing different sets of force field parameters were applied to study the interaction between triple-helical or single-stranded collagen fragments withα*** is remarkable that even single-stranded collagen fragments can form various complexes withα2A showing significant differences in the complex stability with identical *** results of MD simulations are in agreement with the signal alterations in our NMr experiments,which are indicative of the formation of weak complexes between single-stranded collagen andα2A in *** results provide useful information concerning possible interactions ofα2A with small collagen fragments that are of relevance to the design of novel therapeutic A-domain inhibitors.

关键词： integrin-collagen interaction NMr SPr AFM molecular modeling

3D Fluorescence Characterization of Synthetic Organic Dyes—Effect of pH

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American Journal of Analytical Chemistry 2013年第10期4卷 531-576页

作者： Leonard J. Soltzberg Sarah Flynn Vera kirch.richard Newman Department of Chemistry & Physics Simmons College Boston USA Scientific research Lab Museum of Fine Arts Boston USA

The fingerprint character and high sensitivity of 3D UV-vis fluorescence spectra offer special advantages for identification of dyes in a museum or forensic setting. However, the extraction process is likely to affect the pH of the medium and, in some cases, may alter the dye itself. We report a study of 65 dyes extracted from wool fibers that are part of the Schweppe Collection of Important Synthetic Dyes. The 3D fluorescence spectra of the dye extracts at pH 1 and pH 14 are compared with the same dyes from the Schweppe solution library, run under the same conditions, as well as with the 3D fluorescence spectra of the dyes taken directly from the solution library without pH control. This analysis leads to guidelines for the use of such spectra in identifying unknown dye samples.

关键词： Fluorescence Spectrophotometry Dye Analysis Textile Analysis

Evaluation of the effect of acupuncture on hand pain,functional deficits and health-related quality of life in patients with rheumatoid arthritis--A study protocol for a multicenter,double-blind,randomized clinical trial

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Journal of Integrative Medicine 2016年第3期14卷 219-227页

作者： Susana Seca Sebastian kirch António S.Cabrita Henry J.Greten Faculty of Medicine University of Coimbra3045-137 CoimbraPortugal Institute of Biomedical Sciences Abel Salazar University of Porto4050-313 PortoPortugal Heidelberg School of Chinese Medicine 69126 HeidelbergGermany

BACKGrOUND： rheumatoid arthritis（rA） is a systemic inflammatory disease characterized by functional disability and pain. Although acupuncture is widely used, until now Western acupuncture studies on rA have not shown conclusive positive results. Acupuncture is regarded as a reflex therapy that has effects on the human autonomic nervous system. By establishing a traditional Chinese medicine（TCM） diagnosis first, the practitioner is able to choose acupoints according to the state of each individual ***/DESIGN： We are interested if acupuncture, using a classical diagnostic procedure to allocate acupoints to the patient according to the shang Han Lun theory, can be effective in relieving pain, improving hand function and increasing health-related quality of life in *** authors intend to harmonize TCM diagnosis according to clinical and genetic profiles. Patients with the TCM diagnosis of a so-called Turning Point syndrome will be followed up in a randomized, prospective, double-blind, placebo-controlled, multicenter and three-armed parallel-group study with a standardized treatment in order to optimize potential therapeutic effects of acupuncture on pain, strength and muscle function of patients with rA as well as the influence on inflammation and quality of ***： The findings of this study will provide important clinical information about the feasibility and efficacy of acupuncture treatment for rA patients. In addition, it will explore the feasibility of further acupuncture *** rEGISTrATION NUMBEr： Clinical *** Identifier NCT02553005.

关键词： acupuncture rheumatoid arthritis quality of life pain hand strength study protocol randomized clinical trial double-blind method

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慢性肝病患者应用氨酰心安的临床经验

中国临床药理学杂志 1985年第1期 76-77页

作者： kirch W

氨酰心安(atenolol)系亲水性β-受体阻断剂,几乎全部经肾脏排泄。本实验旨在研究慢性肝病对氨酰心安药代动力学的影响。受试者为13名无腹水无脑病而病情稳定的慢性肝病患者和12名健康志愿者。除两名病人仍服地高辛外,其他受试者于实验... 详细信息

氨酰心安(atenolol)系亲水性β-受体阻断剂,几乎全部经肾脏排泄。本实验旨在研究慢性肝病对氨酰心安药代动力学的影响。受试者为13名无腹水无脑病而病情稳定的慢性肝病患者和12名健康志愿者。除两名病人仍服地高辛外,其他受试者于实验前二天停止一切治疗用药。首次给氨酰心安的前一天对全部受试者进行化验检查,包括肾小球滤过率(GFr)等指标。GFr用肌酐清除率测定,全部受试者GFr值均在正常范围(>90毫升/分钟)。全部受试者均于早餐前服用氨酰心安100mg。服药前及服药后1、2、3、4、

关键词：肝病患者健康志愿者慢性肝病清除率升/分毫微克

Disparities of conjugating protective enzyme activities in the colon of patients with adenomas and carcinomas

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World Journal of Gastroenterology 2013年第36期19卷 6020-6025页

作者： Harald P Hoensch Hennie MJ roelofs Lutz Edler Wilhelm kirch Wilbert HM Peters Internal Medicine Marien Hospital Department of Gastroenterology Radboud University Nijmegen Medical Center Division of Biostatistics German Cancer Research Center Department of Clinical Pharmacology Technical University of Dresden

AIM:To investigate the metabolic enzymatic capacity of the colon mucosa to detoxify noxious carcinogenic ***:We investigated the activity of 2 conjugating enzymes-the microsomal uridine glucuronosyltransferase(UGT)and the cytosomal glutathione S-transferase(GST)in the uninvolved mucosa of the colon transversum and sigmoideum in patients with adenomatous polyps and colorectal *** were taken from the mucosa during colonoscopies which were done for clinical(diagnostic)*** storage,the biopsy material was homogenized and after differential centrifugation the enzyme assays were performed with 4-nitrophenol(UGT)and 1-chloro 2,4-dinitrobenzene(GST)as ***:About 48 patients were included of which28 had adenomas and 20 had colorectal carcinomas confirmed by *** activities were expressed as nmol/mg per minute protein for the GST and as pmol/mg per minute protein for the *** of variance(F-test)indicated that both enzymes were more widely distributed in adenoma than in cancer *** means±SD were smaller for cancer patients:GST for adenomas 268±152 vs 241±69 for carcinomas and UGT for adenomas 197±200 vs 150±86 for ***:Compared to patients with adenomatous colon polyps those with colorectal carcinoma exhibited a lower capacity of detoxifying enzyme metabolism and their activities clustered over a smaller range.

关键词： Glutathione S-transferase UDP-glucuronosyltransferase Detoxification Colon adenoma Colon carcinoma

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下肢深静脉血栓溶栓治疗的短期和长期效果

心血管病学进展 2001年第4期22卷 255-256页

作者： Schweizer J,kirch W,Koch r,苏哲坦海南省人民医院

局部和全身溶栓治疗急性下肢深静脉血栓 (DVT)是否有优越性 ,对预防血栓后综合症是否优于抗凝治疗尚无定论 ,因此 ,作者采用不同溶栓疗法 ,并与常规肝素 /抗凝治疗对比 ,评价溶栓治疗的短期和长期效果。2 5 0例 [均龄 39.9± 10 .4岁 ]... 详细信息

局部和全身溶栓治疗急性下肢深静脉血栓 (DVT)是否有优越性 ,对预防血栓后综合症是否优于抗凝治疗尚无定论 ,因此 ,作者采用不同溶栓疗法 ,并与常规肝素 /抗凝治疗对比 ,评价溶栓治疗的短期和长期效果。2 5 0例 [均龄 39.9± 10 .4岁 ]急性下肢或骨盆血栓 [平均有症状期间为 5 .6± 2 .1天 ],但无相应的肺栓塞征象者被列入研究对象 ,本研究除外下列情况 :仅一个平面的 DVT;发生 DVT超过 9天 ;在同一下肢以前曾有 DVT或仅腓肠静脉血栓 ;生殖泌尿道或胃肠道出血 ;12个月内的炎症性肠病 ;急性胰腺炎 ;3个月内的外科干预或头部外伤 ;10天内曾作肌肉注射 ;高血压和糖尿病 (3～ 4期视网膜病变 ) ;颅脑疾病病史 ;恶性疾病 ;肾衰(肌酐 35 0μmol/ L ) ;肝衰 [天冬氨酸转氨酶 (ASAT) 10 0 U/L、凝血酶原时间 5 0 % ];出血素质 ;妊娠和哺乳 ;产后 2 0天内。用药方法和途径 :局部重组纤溶酶原激活因子 (rt- PA)组 :rt- PA(Alteplase) 2 0 mg直接于患肢脚背静脉滴注 4小时 /天 ,4～ 7天 ,同期...

关键词：溶栓治疗全身血栓下肢压力包扎四肢尿激酶组普通肝素血管造影静脉造影长期效果

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钙拮抗剂和其它药物的相互作用

国外医学（药学分册） 1991年第1期18卷 31-34页

作者： kirch W 沈洪兴

本文收集了有关钙拮抗剂和其它许多药物联合用药的疗效和副作用方面最重要的文献,综述了钙拮抗剂的药动学性质以及与其它药物相互作用的可能机制,指出这些相互作用的临床重要性,并根据临床相关性总结了它们可能具有的治疗意义。

关键词：钙拮抗剂药物相互作用