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The Seropositivity Rate of Human Herpesvirus Type 6 among Infants in Diyala Province, Iraq

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Journal of Biosciences and Medicines 2019年第6期7卷 129-137页

作者： A. sh. Hasan sh. Mehdi A. Hasan Noor College of Medicine Diyala University Diyala Iraq

Background: Human herpesvirus type 6 (HHV-6) has been sh.wn to infect almost all children by 4 years of age. Primary infection causes an undifferentiated febrile illness, with approximately 30% of children exhibiting the classic clinical manifestations of roseola infantum. Objectives: The current study was carried out to explore the anti-HHV-6 IgG positivity rate as a marker of past infection among apparently healthy infants and to figure out the effect of certain infant and family characteristics on the infectivity rate. Materials and methods: This is a cross sectional study conducted in Diyala province during the period from August 2017-July 2018. A total of 180 apparently healthy infants were included, their ages ranged between 6 - 24 months. They consist of 100 males with mean age ± SD 15.05 ± 6.42 months and 80 females with mean age ± SD 15.56 ± 6.66 months. Human privacy was respected by obtaining parental consent. Venous blood samples were collected aseptically from each participant. Sera were separated and tested for the anti-HHV6 IgG (Sunlong Biotech, China) by Enzyme Linked Immunosorbant assay (ELISA) technique. Statistical analysis was done using SPSS version 23 and P value Conclusion: About one half of apparently healthy infants aged up to two years of Diyala population have anti-HHV6 IgG antibodies and the presence of intrafamilial primary HHV-6 positive case is markedly associated with increased rate of anti-HHV6 IgG among siblings.

关键词： Human Herpesvirus-6 Roseola Infantum Diyala

CircRNA-Tbpl1海绵吸附miR-214-3p调控自噬在低氧性肺动脉高压血管重塑中的作用及其机制

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浙江中西医结合杂志 2024年第5期34卷 415-423页

作者：何梦孙健沈巨信秦娥浙江省绍兴市人民医院呼吸与危重症医学科绍兴312000

目的探讨CircRNA-Tbpl1通过海绵吸附miR-214-3p调控自噬在低氧性肺动脉高压(HPH)血管重塑中的作用,并分析其机制。方法 12只8周龄C57BL/6雄性小鼠根据随机数字表法分为两组:对照组和HPH组,每组6只,通过低氧构建HPH模型小鼠,观察两组小... 详细信息

目的探讨CircRNA-Tbpl1通过海绵吸附miR-214-3p调控自噬在低氧性肺动脉高压(HPH)血管重塑中的作用,并分析其机制。方法 12只8周龄C57BL/6雄性小鼠根据随机数字表法分为两组:对照组和HPH组,每组6只,通过低氧构建HPH模型小鼠,观察两组小鼠血流动力学差异,HE染色检测肺组织病理学改变,蛋白免疫印迹(Western blot)检测选择性自噬接头蛋白(p62)、微管相关蛋白1轻链3(LC3)和重组人自噬效应蛋白(Beclin-1)水平,实时荧光定量PCR(qRT-PCR)检测CircRNA-Tbpl1和miR-214-3p表达水平。分离小鼠原代肺动脉平滑肌细胞(PASMCs)并进行高、低氧分组培养,低氧处理PASMCs,细胞计数试剂盒-8(CCK-8)检测细胞活性,Western blot检测自噬相关蛋白表达,qRT-PCR检测CircRNA-Tbpl1的相对表达水平。通过转染和自噬诱导剂雷帕霉素干预,分析CircRNA-Tbpl1与PASMCs自噬的相关性。通过共转染sh.ircRNA-Tbpl1和miR-214-3p抑制物,分析CircRNA-Tbpl1/miR-214-3p对低氧诱导的PASMCs自噬和细胞增殖活性的影响。结果与对照组小鼠比较,HPH组小鼠的右心室收缩压(RVSP)[(39.50±3.69)mmHg比(21.00±3.42)mmHg,Psh.NC组比较,sh.CircRNA-Tbpl1组的自噬水平减弱,细胞增殖活力降低[(71.13±8.17)%比(100.00±5.32)%,Psh.CircRNA-Tbpl1+miRNA-NC组比较,sh.CircRNA-Tbpl1+miR-214-3p抑制物组的自噬水平升高,细胞增殖活力增强[(85.78±5.37)%比(69.80±6.34)%,P<0.05]。结论CircRNA-Tbpl1可能通过海绵吸附miR-214-3p抑制低氧诱导的自噬,从而缓解HPH血管重塑。

关键词：小鼠低氧性肺动脉高压 CircRNA-Tbpl1 自噬 miR-214-3p 血管重塑

Radiation of Ultra Low Frequency Electromagnetic Waves from Atmosphere under the Influence of Strong sh.ck Waves

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Chinese Physics Letters 2015年第3期32卷 39-41页

作者： A. R. Aramyan S. A. Aramyan S. G. Bilen L. sh. Grigoryan H. F. Khachatryan Institute of Applied Problems of Physics National Academy of Sciences of Armenia Yerevan 0014 Republic of Armenia International Scientific and Educational Center National Academy of Sciences of Armenia Yerevan 0019 Republic of Armenia Pennsylvania State University University Park PA USA

We present preliminary results from the experimental investigation of the response of the atmosphere due to the impact of powerful sh.ck waves. The response is evidenced as ultra low frequency electromagnetic wave radiation at frequency of 2-5 kHz and in duration of 3 7s. We hypothesize that this radiation appears due to the following process： the sh.ck wave ionizes the neutral particles in the air and these charged and neutral particles continue their vertical motion, which forms in the trail of the sh.ck wave. Such motion can cause the cyclotron-like radiation measured.

关键词： Radiation of Ultra Low Frequency Electromagnetic Waves from Atmosphere under the Influence of Strong sh.ck Waves

Predicting the optical observables for nucleon scattering on even-even actinides

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Chinese Physics C 2017年第9期41卷 123-128页

作者： D. S. Martyanov E. sh. Soukhovitskii R. Capote J. M. Quesada S. Chiba Joint Institute for Energy and Nuclear Research 220109 Minsk-Sosny Belarus NAPC-Nuclear Data Section International Atomic Energy Agency Vienna A-1400 Austria Departamento de Fisica Atomica Molecular y Nuclear Universidad de Seviha Ap.1065 E-4i080 Sevilla Spain Research Laboratory for Nuclear Reactors Tokyo Institute of Technology 2-12-1-N1-90okuyama Meguro-ku Tokyo 152-8550 Japan

The previously derived Lane consistent dispersive coupled-channel optical model for nucleon scattering on 232Th and 23Su nuclei is extended to describe scattering on even-even actinides with Z=90-98. A soft-rotator- model （SRM） description of the low-lying nuclear structure is used, where the SRM Hamiltonian parameters are adjusted to the observed collective levels of the target nucleus. SRM nuclear wave functions （mixed in K quantum number） have been used to calculate the coupling matrix elements of the generalized optical model. The ＂effective＂ deformations that define inter-band couplings are derived from the SRM Hamiltonian parameters. Conservation of nuclear volume is enforced by introducing a dynamic monopolar term to the deformed potential, leading to additional couplings between rotational bands. The fitted static deformation parameters are in very good agreement with those derived by Wang and collaborators using the Weizs^cker-Skyrme global mass model （WS4）, allowing use of the latter to predict cross sections for nuclei without experimental data. A good description of the scarce ＂optical＇experimental database is achieved. SRM couplings and volume conservation allow a precise calculation of the compound-nucleus formation cross sections, which is significantly different from that calculated with rigid-rotor potentials coupling the ground-state rotational band. The derived parameters can be used to describe both neutron- and proton-induced reactions.

关键词： optical model soft-rotator model FRDM deformations WS4 deformations even-even actinides

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800 km客运班线事故特征及情景研究

公路交通科技 2024年第1期41卷 160-168页

作者：刘畅夏鸿文孟兴凯王雪然吴初娜交通运输部公路科学研究院汽车运输研究中心北京100088 北京交通大学北京100091

为降低800 km以上客运班线事故潜在发生性,提高企业安全防控能力,研究分析了800 km以上客运班线事故典型特征,构建事故发生重要情景。基于2014—2020年800 km以上客运班线道路交通事故数据展开致因分析及事故易发情景研究。以人、路、... 详细信息

为降低800 km以上客运班线事故潜在发生性,提高企业安全防控能力,研究分析了800 km以上客运班线事故典型特征,构建事故发生重要情景。基于2014—2020年800 km以上客运班线道路交通事故数据展开致因分析及事故易发情景研究。以人、路、环境为依据,选取关键特征构建了事故特征指标体系。利用决策树模型构建了安全风险模型,探索了运行时段、人因、天气状况、季度、事故发生地区、道路线形、路面状况、节假日情况、春运情况、公路技术等级和公路行政等系统关键因子与翻车、刮擦、碰撞、撞击固定物、追尾、坠车等事故形态间的潜在关系。剖析了事故发生时交通系统内人、路及环境等因素特征及形态,以此构建了800 km以上客运班线的事故易发情景。结果表明:运行时段、人因、天气状况是影响800 km以上客运班线事故发生的关键因子,且与季度、事故发生地区、道路线形、路面状况等因子存在多重耦合关系;节假日情况、春运情况、公路技术等级和公路行政等级不是影响800 km以上客运班线事故发生的关键因子。研究为降低800 km以上客运班线的事故潜在发生性及企业安全防控提供理论依据。未来,道路运输管理部门与道路运输企业应强化安全管理,规范驾驶员安全驾驶行为,普及事故易发情景下的防御性驾驶知识。

关键词：交通安全事故特征情景决策树模型 800 km以上客运班线事故致因分析

DLX2对乳腺癌细胞增殖、迁移、侵袭、凋亡及乳腺癌干细胞特性的影响

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实用肿瘤学杂志 2024年第2期38卷 88-95页

作者：孟凡岗陈飞甄立军大庆龙南医院普外科大庆163453

目的探索调控乳腺癌转移的关键基因,研究DLX2对乳腺癌细胞增殖、迁移、侵袭和凋亡的影响,探讨DLX2调控乳腺癌干细胞特性的作用及机制。方法构建DLX2基因敲除的乳腺癌细胞系MCF7,使用CCK-8法检测细胞增殖活力,流式细胞术检测细胞凋亡情... 详细信息

目的探索调控乳腺癌转移的关键基因,研究DLX2对乳腺癌细胞增殖、迁移、侵袭和凋亡的影响,探讨DLX2调控乳腺癌干细胞特性的作用及机制。方法构建DLX2基因敲除的乳腺癌细胞系MCF7,使用CCK-8法检测细胞增殖活力,流式细胞术检测细胞凋亡情况,Transwell实验检测细胞迁移和侵袭能力,免疫荧光检测细胞和组织中SOX4表达水平,Western blot实验检测细胞及组织中CD44和ALDH1的蛋白表达情况,TUNEL试剂盒检测组织的凋亡情况,HE染色评估肿瘤组织恶性程度。结果敲低DLX2后,细胞增殖活力减弱(Psh.DLX2组的肿瘤体积明显小于模型组(Psh.DLX2组的凋亡水平较模型组高,SOX4、CD44以及ALDH1的表达与细胞水平一致,均被抑制(P<0.05)。结论 DLX2抑制乳腺癌细胞增殖、迁移和侵袭,促进乳腺癌细胞凋亡,并通过SOX4调控乳腺癌细胞干细胞特性。

关键词：乳腺癌 DLX2 SOX4 肿瘤干性

Ergodicity and Invariance of Flows in Queuing Systems

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Journal of Applied Mathematics and Physics 2018年第7期6卷 1454-1459页

作者： G. sh. Tsitsiash.ili Institute for Applied mathematics Far Eastern Branch of Russian Academy Sciences Vladivostok Russia

In this paper, we investigate the flow of customers through queuing systems with randomly varying intensities. The analysis of the Kolmogorov-Chapman system of stationary equations for this model sh.wed that it is not possible to construct a convenient symbolic solution. In this paper an attempt is made to circumvent this requirement by referring to the ergodicity theorems, which gives the conditions for the existence of the limit distribution in the service processes, but do not require knowledge of them.

关键词： A Queuing System An Ergodicity An Input Flow A Randomly Varying Intensity

Activity of Peroxidase Enzyme in Grains of Some Varieties of Soybeans Grown in Uzbekistan

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American Journal of Plant Sciences 2020年第8期11卷 1270-1275页

作者： Mirzohid sh. Jaynaqov Yunusxanov sh.vkat Andijan State University Andijan Uzbekistan Institute of Genetics and Plant Experimental Biology Academy Science Republic of Uzbekistan Tashkent Uzbekistan

The article provides information on the activity of peroxidase enzyme in the composition of the seeds and bark of some varieties of soy cultivated in Uzbekistan and the importance of this enzyme in plant life. As is known, soybeans are one of the main nutritional plants of Agriculture. Orzu and Vilana varieties are resistant to other varieties, and the main thing is that they can be planted in crop fields in all regions of the Republic, achieve high fertility and thereby satisfy the demand of the population for feed products.

关键词： Soybeans Cereals Peroxidase Oxidoreduktase Enzyme

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大别山革命老区红色旅游景区可达性研究

平顶山学院学报 2024年第2期39卷 56-62页

作者：潘佳斌孟俞彤李晓云信阳农林学院旅游学院河南信阳464000

红色旅游景区可达性是革命老区振兴发展与红色旅游教育功能发挥的重要影响因素.基于大别山革命老区229个红色旅游景区数据样本,运用GIS空间分析与数理统计方法,研判红色旅游景区可达性空间格局.结果表明:大别山革命老区红色旅游景区区... 详细信息

红色旅游景区可达性是革命老区振兴发展与红色旅游教育功能发挥的重要影响因素.基于大别山革命老区229个红色旅游景区数据样本,运用GIS空间分析与数理统计方法,研判红色旅游景区可达性空间格局.结果表明:大别山革命老区红色旅游景区区域外可进入性表现为南部通畅、西北—东南两端闭塞的“南入位优、极端分化”非均衡状态,区域内服务可达性较好,对发挥红色旅游教育功能具有良好的支撑作用,景区间连通可达性已形成高品质景区为主导的“中心强两端弱、局域空间错位”的空间分异格局.

关键词：大别山革命老区红色旅游景区可达性 GIS