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Microbiological assessment of indoor air of a teaching hospital in Nigeria

Asian Pacific Journal of Tropical Biomedicine 2012年第6期2卷 465-468页

作者： Awosika sa Olajubu fa Amusa NA Department of Microbiology Olabisi Onabanjo University Department of Medical Microbiology & Parasitology Olabisi Onabanjo University Teaching Hospital Department of Plant Science & Applied Zoology Olabisi Onabanjo University

Objective:To investigate the quality of indoor air of different wards and units of Olabisi Onabanjo University Teaching Hospital, sagamu, to ascertain their contribution to infection rate in the ***:The microbial quality of indoor air of nine wards/units of Olabisi Onabanjo University Teaching Hospital, sagamu, Nigeria was conducted. Sedimentation technique using open Petri-dishes containing different culture media was employed and samplings were done twice daily, one in the morning shortly after cleaning and before influx of people/patients into the wards/units and the other in the evening when a lot of activities would have taken place in these wards. Isolates were identified according to standard ***:Results showed that there was a statistically significant difference(氈2= 6.0167) in the bacteria population of the different sampling time whereas it was not so for fungi population(氈2= 0.2857). Male medical ward(MMW) and male surgical general(MSG) recorded the highest bacterial and fungal growth while the operating theatre(OT) was almost free of microbial burden. The bacteria isolates were Staphylococcus aureus, Klebsiellasp., Bacillus cereus, Bacillus subtilis, Streptococcus pyogenes andSerratia marscenceswhile the fungi isolates includedAspergillus flavus, Penicilliumsp.,Fusariumsp.,Candida *** aureuswas the predominantly isolated bacterium whilePenicilliumsp. was the most isolated ***:Though most of the microbial isolates were potential and or opportunistic pathogens, there was no correlation between the isolates in this study and the surveillance report of nosocomial infection during the period of study, hence the contribution of the indoor air cannot be established. From the reduction noticed in the morning samples, stringent measures such as proper disinfection and regular cleaning, restriction of patient relatives' movement in and out of the wards/units need to be enforced so as to imp

关键词： Indoor air OOUTH Open-plate technique Nosocomial infections Staphylococcus aureus Microbiological assessment Microbial quality Bacterial isolate Fungal isolate Opportunistic pathogen Nosocomial infection Infection rate Microbial isolate Penicilliumsp Sedimentation technique

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Snake Model for the Extraction of Loess Shoulder-line from DEMs

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Journal of Mountain Science 2014年第6期11卷 1552-1559页

作者： YAN Shi-jiang TANG Guo'an LI fa-yuan ZHANG Lei Key laboratory of Virtual Geographic Environment Ministry of Education Nanjing Normal University School of Resource and Environmental Engineering Anhui University

Shoulder lines are the most important landform demarcations for geographical analysis,soil erosion modeling and land use planning in the Loess Plateau area of *** paper proposes an automatic,effective and accurate method of determining loess shoulder line from DEMs by integrating a hydrological D8 algorithm and a snake *** watershed boundary line is adopted as the initial contour which evolves to identify the exact position of loess shoulder-line by the guidance of an external force of snake model from *** show that the method overcomes the difficulties in both threshold selection for edge detection and the disconnecting issues in former extraction *** accuracy evaluation of shoulder-line maps from the two test sites of the loess plateau area show obvious improvements in the *** average contour matching distance of the new method is 12.0 m on 5 m resolution DEM,and shows improvement in the accuracy and *** comparisons of accuracy evaluations of the two test sites show that the snake model method performs better in the loess plain area than in the area with high gully density.

关键词： Snake model DEM loess shoulder-line

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Generation and evolution of multiple operation states in passively mode-locked thulium-doped fiber laser by using a graphene-covered-microfiber

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Chinese Physics B 2018年第8期27卷 301-307页

作者： Xiao-fa Wang Jun-Hong Zhang Xlao-Llng Peng Xue-Feng Mao College of Optoelectronic Engineering Chongqing University of Posts and TelecommunicationsKey Laboratory of Optica/Fiber Communication TechnologyChongqing Education CommissionChongqing 400065China

Using graphene-covered-microfiber （GCM） as a saturable absorber, the generation and evolution of multiple operation states are proposed and demonstrated in passively mode-locked thulium-doped fiber laser. The microfiber was fabricated using the flame brushing method to an interaction length of - 1.2 cm with a waist diameter of -10 μm. Graphene layers were grown on copper foils by chemical vapor deposition and transferred onto the polydimethylsiloxane （PDMS） to form a PDMS/graphene film, which allowed light-graphene interaction via evanescent field. With the increase of the pump power from 1.25 W to 2.15 W, five different lasing regimes, including continuous-wave, conventional soliton mode-locking, multi- soliton mode-locking, a period of transition, and noise-like mode-locking, were achieved in a fiber ring cavity. To the best of our knowledge, it is the first report of the generation and evolution of multiple operation states by covering graphene on the microfiber in the 2-μ.m region. The results demonstrate that GCM can be a promising method for fabricating all fiber sa, and the switchable operation states can provide more portability in complex application domain.

关键词： fiber lasers mode-locked, thulium-doped fiber graphene microfiber

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海面远距离目标运动属性判别方法

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电光与控制 2014年第1期21卷 15-17,90页

作者：杨士英花良发马飒飒空军预警学院黄陂士官学校武汉430345 军械工程学院军械技术研究所石家庄050003

基于临近空间平台的T1R1系统,以对海面远距离目标运动属性的快速判别为需求,提出了对目标运动属性的快速判别方法。该方法不用计算目标位置,仅需根据单侦察时差参数观测值的统计特征来判别目标的运动属性。仿真结果验证了该方法的有效性。

关键词：海面远距离目标运动属性时差临近空间平台

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Expression of NF-kappaB in rotavirus-induced damage to the liver and biliary tract in neonatal mice

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Hepatobiliary & Pancreatic Diseases International 2007年第2期6卷 188-193页

作者： Huang, Lei Gu, Wei-Zhong Si, Xin-Min Wei, Ming-fa Feng, Jie-Xiong Huazhong Univ Sci & Technol Dept Pediat Surg Tongji Hosp Wuhan 430030 Peoples R China Zhejiang Univ Sch Med Dept Pathol Childrens Hosp Hangzhou 310003 Peoples R China Wuhan Univ Renmin Hosp Dept Gastroenterol Wuhan 430060 Peoples R China

BACKGROUND: Biliary atresia, the etiology of which still remains unclear, occurs exclusively in newborns and most are infected with rotavirus. In this study, we aimed to investigate the histopathological patterns of different kinds of rotavirus in the liver and biliary tract of neonatal mice and the expression of NF-kappa B in the liver and biliary tract of infected mice. METHODS: Twenty-three adult mice (8 were male and 15 female) were divided into 8 breeding pairs, and each pair (I male and 2 females) was housed in a cage in a laminar flow hood. Newborn mice, 24-48 hours old were randomly divided into A, B and C groups. The A and B groups were respectively inoculated with MMU18006 and sa11 rotavirus through the intraperitoneal route, while group C as blank control was only inoculated with culture medium. The liver was dissected after 5, 10, 15, 21 and 28 days; the weight of each mouse and the histopathological patterns in the liver were recorded. The expression of NF-kappa B in the liver and intrahepatic bile ducts was detected by immunohistochemical staining and the expression intensity was analyzed with a GT-2 imaging instrument. RESULTS: The average increase in weight of infected mice was significantly slower than that of the normal control, while the growth rate of group A (injected with MMU18006 rotavirus) was slower than that of group B (sa11 rotavirus). In infected mice, the acute and chronic inflammation of liver and intra- and extra-hepatic bile ducts was more significant in group A. Stenosis was found in most intrahepatic bile ducts, and sporadically in extrahepatic bile ducts. The expression of NF-kappa B in infected mice was dramatically higher than that of the normal control, while the expression in group A was higher than in group B. CONCLUSIONS: Significant damage to the liver and biliary tract of neonatal mice can be induced by inoculating MMU18006 rotavirus through the intraperitoneal route, which is very similar to the pathology of biliary atresi

关键词： rotavirus biliary atresia NF-kappa B

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Controlled Synthesis of Dendritic Polyaniline Fibers with Diameters from Nanosize to Submicrometersize

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Chinese Chemical Letters 2005年第11期16卷 1523-1526页

作者： Xiao Cong WANG Shu Jiang DING Jing CAO fa Lun WU Chen ZHOU Zhen Zhong YANG College of Science Tianjin University of Science and Technology Tianjin 300022 State Key Laboratory of Polymer Physics and Chemistry Institute of Chemistry Chinese Academy of Sciences Beijing 100080

Dendritic polyaniline nanofibers and submicrometer-sized fibers have been synthesized by chemical oxidative polymerization of aniline （An） doped with salicylic acid （sa）. The diameters of the fibers could be controlled easily from 30 to 400 nm by varying the concentration of aniline and salicylic acid at room temperature. Scanning electron microscopy （SEM） and typical transmission electron microscopy （TEM） were applied to investigate their morphologies. . Fourier transform infrared （FTIR） spectrum indicated that the state of the dendritic polyaniline fibers is emerialdine rather than solely the leucoemeraldine or permigraniline forms. The dendritic polyaniline fibers have potential applications as chemical sensors or actuators and neuron devices.

关键词： Dendritic polyaniline synthesis nanofiber.

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Herbivore-induced rice resistance against rice blast mediated by salicylic acid

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Insect Science 2020年第1期27卷 49-57页

作者： Kai-Li Zhang Qing-Song Liu Hou-Xiang Kang Xiao-Mei Liu Xiu-Ping Chen Yu-fa Peng Yun-He Li College of Environment and Plant Protection Hainan UniversityHaikouChina State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijingChina College of Life Sciences Xinyang Normal UniversityXinyangHenanChina

In agro-ecosystems,plants are important mediators of interactions between their associated herbivorous insects and microbes,and any change in plants induced by one species may lead to cascading effects on interactions with other ***,such effects are regulated by phytohormones such as jasmonic acid(JA)and salicylic acid(sa).Here,we investigated the tripartite interactions among rice plants,three insect herbivores(Chilo suppressalis,Cnaphalocrocis medinalis or Nilapai-vata lugens),and the causal agent of rice blast disease,the fungus Magnaporthe *** found that pre-infestation of rice by *** or *** but not by *** conferred resistance to *** *** and ***,insect infestation without fungal inoculation induced the accumulation of both JA and sa in rice *** contrast,infestation by *** increased JA levels but reduced sa *** exogenous application of sa but not of JA conferred resistance against *** results suggest that preinfestation by C suppressalis or *** conferred resistance against *** by increasing sa *** findings enhance our understanding of the interactions among rice plant,insects and pathogens,and provide valuable information for developing an ecologically sound strategy for controlling rice blast.

关键词： induced defense jasmonic acid plant-insect-pathogen interaction rice salicylic acid

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Effects of continuous tracheal gas insufflation during pressure limited ventilation on pulmonary surfactant in rabbits with acute lung injury

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Chinese Medical Journal 2006年第17期119卷 1415-1420页

作者： ZHU Guang-fa ZHANG Wei ZONG Hua LIANG Ying Department of Respiratory Medicine Beijing Anzhen HospitalCapital University of Medical Science Beijing 100029 China

Background Pulmonary surfactant dysfunction may contribute to the development of ventilator induced lung injury （VILI）. Tracheal gas insuffiation （TGI） is a technique in which fresh gas is introduced into the trachea and augment ventilation by reducing the dead space of ventilatory system, reducing ventilatory pressures and tidal volume （VT） while maintaining constant partial arterial CO2 pressure （PaCO2）. We hypothesised that TGI limited peak inspiratory pressure （PIP） and VT and would minimize conventional mechanical ventilation （CMV） induced pulmonary surfactant dysfunction and thereby attenuate VILI in rabbits with acute lung injury （ALI）. Methods ALI was induced by intratracheal administration of lipopolysaccharide in anaesthetized, ventilated healthy adult rabbits randomly assigned to continuous TGI at 0.5 L/min （TGI group） or CMV group （n=8 for each group）, and subsequently ventilated with limited PIP and VT to maintain PaCO2 within 35 to 45 mmHg for 4 hours. Physiological dead space to VT ratio （VD/VT）, dynamic respiratory compliance （Cdyn） and partial arterial O2 pressure （PaO2） were monitored. After ventilation, lungs were analysed for total phospholipids （TPL）, total proteins （TP）, pulmonary surfactant small to large aggregates ratio （sa/LA） in bronchoalveolar lavage fluid （BALF） and for determination of alveolar volume density （Vv）, myeloperoxidase and interleukin （IL）-8. Results TGI resulted in significant （P〈0.05 or P〈0.01） decrease in PIP [（22.4±1.8） cmH20 vs （29.5±1.1） cmH2O], VT [（6.9±1.3） ml/kg vs （9.8±1.11） ml/kg], VD/VT [（32±5）% vs （46±2）%], TP [（109±22） mg/kg vs （187±25） mg/kg], sa/LA （2.5±0.4 vs 5.4±0.7）, myeloperoxidase [（6.2±0.5） U/g tissue vs （12.3±0.8） U/g tissue] and IL-8 [（987±106） ng/g tissue vs （24±3） mN/m] of BALF, and significant （P〈0.05） increase in Cdyn [（0.47±0.02） ml·cmH2O^-1·kg^-1 vs （0.31±0.02） ml·cmH2O^-1·kg^-1], PaO2 [（175±24） mmHg vs （135±26） mmHg], TPL/TP （52±8 vs 33±11） and Vv （0.65±0.05 vs 0.44±0.07） as compared with CMV

关键词： tracheal gas insufflation acute lung injury pulmonary surfactant ventilator induced lung injury mechanical ventilation

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HPLC测定扎托洛芬片的含量及有关物质

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中国药学杂志 2007年第5期42卷 389-390页

作者：汪涛邓树海徐丽洒万发里山东大学药学院济南250012 青岛大学药学系山东青岛266021

目的建立HPLC测定扎托洛芬片的含量及有关物质的方法。方法色谱柱为Diamonsil C18柱（4．6mm×150mm，5μm），流动相为乙腈-水-醋酐（60：40：0．5），检测波长332nm。结果扎托洛芬在30～70mg·L^-1内线性关系良好（r=0．9999），平均... 详细信息

目的建立HPLC测定扎托洛芬片的含量及有关物质的方法。方法色谱柱为Diamonsil C18柱（4．6mm×150mm，5μm），流动相为乙腈-水-醋酐（60：40：0．5），检测波长332nm。结果扎托洛芬在30～70mg·L^-1内线性关系良好（r=0．9999），平均回收率为99．7％（RSD=0．74％）。结论本方法操作简单，分离效果好，灵敏度高，结果准确可靠。

关键词：高效液相色谱法扎托洛芬含量测定有关物质

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3D-printed aerogels as theranostic implants monitored by fluorescence bioimaging

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Bioactive Materials 2024年第11期41卷 471-484页

作者： Ana Iglesias-Mejuto Rui Pinto Pedro faísca JoséCatarino João Rocha Luisa Durães Maria Manuela Gaspar Catarina Pinto Reis Carlos A.García-González AerogelsLab I+D Farma Group(GI-1645)Department of PharmacologyPharmacy and Pharmaceutical TechnologyFaculty of PharmacyiMATUS and Health Research Institute of Santiago de Compostela(IDIS)Universidade de Santiago de CompostelaE-15782Santiago de CompostelaSpain Research Institute for Medicines(iMed.ULisboa) Faculty of PharmacyUniversidade de LisboaAv.Professor Gama Pinto1649-003LisboaPortugal Joaquim Chaves saúde Joaquim Chaves Laboratório de Análises ClínicasMiraflores1495069AlgésPortugal CECAV-faculty of Veterinary Medicina-Lusófona University-Lisbon University Center Campo Grande 3761749-024LisboaPortugal faculty of Veterinary Medicina-Lusófona University-Lisbon University Center Campo Grande 3761749-024LisboaPortugal University of Coimbra CERES-Chemical Engineering and Renewable Resources for SustainabilityDepartment of Chemical Engineering3030-790CoimbraPortugal Instituto de Biofísica e Engenharia Biomédica(IBEB) Faculdade de CiênciasUniversidade de LisboaCampo Grande1749-016LisboaPortugal

Aerogel scaffolds are nanostructured materials with beneficial properties for tissue engineering *** tracing of the state of the aerogels after their implantation is challenging due to their variable biodegradation rate and the lack of suitable strategies capable of in vivo monitoring the *** nanoparticles(UCNPs)have emerged as advanced tools for in vitro bioimaging because of their fluorescence *** this work,highly fluorescent UCNPs were loaded into aerogels to obtain theranostic implants for tissue engineering and bioimaging applications.3D-printed alginate-hydroxyapatite aerogels labeled with UCNPs were manufactured by 3D-printing and supercritical CO2 drying to generate personalize-to-patient *** physicochemical performance of the resulting structures was evaluated by printing fidelity measurements,nitrogen adsorption-desorption analysis,and different microscopies(confocal,transmission and scanning electron microscopies).Stability of the aerogels in terms of physicochemical properties was also tested after 3 years of *** was evaluated in vitro by different cell and hemocompatibility assays,in ovo and in vivo by safety and bioimaging studies using different murine *** profile,tissue index and histological evaluations of the main organs unveiled an in vivo downregulation of the inflammation after implantation of the ***-decorated aerogels were first-time manufactured and long-term traceable by fluorescence-based bioimaging until 3 weeks post-implantation,thereby endorsing their suitability as tissue engineering and theranostic nanodevices(*** implants).

关键词： Upconversion nanoparticles Aerogels Theranostic implants In vivo fluorescence

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